{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:54:45Z","timestamp":1791294885544,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6937","license":[{"start":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T00:00:00Z","timestamp":1051747200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2003,5]]},"DOI":"10.1038\/nature01631","type":"journal-article","created":{"date-parts":[[2003,5,14]],"date-time":"2003-05-14T13:20:47Z","timestamp":1052918447000},"page":"298-301","source":"Crossref","is-referenced-by-count":326,"title":["A progeroid syndrome in mice is caused by defects in A-type lamins"],"prefix":"10.1038","volume":"423","author":[{"given":"Leslie C.","family":"Mounkes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serguei","family":"Kozlov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnature01631_CR1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/S1043-2760(02)00595-7","volume":"13","author":"J Uitto","year":"2002","unstructured":"Uitto, J. Searching for clues to premature aging. Trends Endocrinol. Metab. 13, 140\u2013141 (2002)","journal-title":"Trends Endocrinol. Metab."},{"key":"BFnature01631_CR2","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0003-3995(02)01119-X","volume":"45","author":"GH de Paula Rodriguez","year":"2002","unstructured":"de Paula Rodriguez, G. H. et al. Severe bone changes in a case of Hutchinson-Gilford syndrome. Ann. Genet. 45, 151\u2013155 (2002)","journal-title":"Ann. Genet."},{"key":"BFnature01631_CR3","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nrm879","volume":"3","author":"B Burke","year":"2002","unstructured":"Burke, B. & Stewart, C. L. Life at the edge: the nuclear envelope and human disease. Nature Rev. Mol. Cell Biol. 3, 575\u2013585 (2002)","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"BFnature01631_CR4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1242\/jcs.95.4.587","volume":"95","author":"R-A Roeber","year":"1990","unstructured":"Roeber, R.-A., Sauter, H., Weber, K. & Osborn, M. Cells of the cellular immune and hemopoietic system of the mouse lack lamins A\/C: distinction versus other somatic cells. J. Cell Sci. 95, 587\u2013598 (1990)","journal-title":"J. Cell Sci."},{"key":"BFnature01631_CR5","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1038\/nrm950","volume":"3","author":"C Hutchison","year":"2002","unstructured":"Hutchison, C. Lamins: building blocks or regulators of gene expression? Nature Rev. Mol. Cell Biol. 3, 848\u2013858 (2002)","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"BFnature01631_CR6","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1083\/jcb.200112047","volume":"156","author":"TP Spann","year":"2002","unstructured":"Spann, T. P., Goldman, A. E., Wang, C., Huang, S. & Goldman, R. D. Alteration of nuclear lamin organization inhibits RNA polymerase II-dependent transcription. J. Cell Biol. 156, 603\u2013608 (2002)","journal-title":"J. Cell Biol."},{"key":"BFnature01631_CR7","first-page":"2649","volume":"9","author":"T Ozaki","year":"1994","unstructured":"Ozaki, T. et al. Complex formation between lamin A and the retinoblastoma gene product: identification of the domain on lamin A required for its interaction. Oncogene 9, 2649\u20132653 (1994)","journal-title":"Oncogene"},{"key":"BFnature01631_CR8","doi-asserted-by":"publisher","first-page":"6969","DOI":"10.1074\/jbc.M208811200","volume":"278","author":"JM Holaska","year":"2003","unstructured":"Holaska, J. M., Lee, K. K., Kowalski, A. K. & Wilson, K. L. Transcriptional repressor Germ Cell-less (GCL) and Barrier to Autointegration Factor (BAF) compete for binding to Emerin in vitro. J. Biol. Chem. 278, 6969\u20136975 (2003)","journal-title":"J. Biol. Chem."},{"key":"BFnature01631_CR9","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S0962-8924(02)02401-7","volume":"12","author":"HJ Worman","year":"2002","unstructured":"Worman, H. J. & Courvalin, J. C. The nuclear lamina and inherited disease. Trends Cell Biol. 12, 591\u2013598 (2002)","journal-title":"Trends Cell Biol."},{"key":"BFnature01631_CR10","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/s002560000280","volume":"29","author":"JC Hoeffel","year":"2000","unstructured":"Hoeffel, J. C., Mainard, L., Chastagner, P. & Hoeffel, C. C. Mandibulo-acral dysplasia. Skeletal Radiol. 29, 668\u2013671 (2000)","journal-title":"Skeletal Radiol."},{"key":"BFnature01631_CR11","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/6799","volume":"21","author":"G Bonne","year":"1999","unstructured":"Bonne, G. et al. Mutations in the gene encoding lamin A\/C cause autosomal dominant Emery-Dreifuss muscular dystrophy. Nature Genet. 21, 285\u2013288 (1999)","journal-title":"Nature Genet."},{"key":"BFnature01631_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/pdp.21.1.1.13","volume":"21","author":"J Ackerman","year":"2002","unstructured":"Ackerman, J. & Gilbert-Barness, E. Hutchinson-Gilford progeria syndrome: a pathologic study. Pediatr. Pathol. Mol. Med. 21, 1\u201313 (2002)","journal-title":"Pediatr. Pathol. Mol. Med."},{"key":"BFnature01631_CR13","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1136\/pmj.77.907.312","volume":"77","author":"PK Sarkar","year":"2001","unstructured":"Sarkar, P. K. & Shinton, R. A. Hutchinson-Guilford progeria syndrome. Postgrad. Med. J. 77, 312\u2013317 (2001)","journal-title":"Postgrad. Med. J."},{"key":"BFnature01631_CR14","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1083\/jcb.147.5.913","volume":"147","author":"T Sullivan","year":"1999","unstructured":"Sullivan, T. et al. Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J. Cell Biol. 147, 913\u2013920 (1999)","journal-title":"J. Cell Biol."},{"key":"BFnature01631_CR15","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S1568-1637(02)00044-2","volume":"2","author":"M Lewis","year":"2003","unstructured":"Lewis, M. PRELP, collagen, and a theory of Hutchinson-Gilford progeria. Ageing Res. Rev. 2, 95\u2013105 (2003)","journal-title":"Ageing Res. Rev."},{"key":"BFnature01631_CR16","doi-asserted-by":"crossref","first-page":"4459","DOI":"10.1242\/jcs.114.24.4459","volume":"114","author":"C Vigouroux","year":"2001","unstructured":"Vigouroux, C. et al. Nuclear envelope disorganization in fibroblasts from lipodystrophic patients with heterozygous R482Q\/W mutations in the lamin A\/C gene. J. Cell Sci. 114, 4459\u20134468 (2001)","journal-title":"J. Cell Sci."},{"key":"BFnature01631_CR17","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1016\/S1471-4914(01)02128-1","volume":"7","author":"GE Morris","year":"2001","unstructured":"Morris, G. E. The role of the nuclear envelope in Emery-Dreifuss muscular dystrophy. Trends Mol. Med. 7, 572\u2013577 (2001)","journal-title":"Trends Mol. Med."},{"key":"BFnature01631_CR18","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1242\/jcs.114.24.4447","volume":"114","author":"WH Raharjo","year":"2001","unstructured":"Raharjo, W. H., Enarson, P., Sullivan, T., Stewart, C. L. & Burke, B. Nuclear envelope defects associated with LMNA mutations cause dilated cardiomyopathy and Emery-Dreifuss muscular dystrophy. J. Cell Sci. 114, 4447\u20134457 (2001)","journal-title":"J. Cell Sci."},{"key":"BFnature01631_CR19","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1083\/jcb.17.2.299","volume":"17","author":"GJ Todaro","year":"1963","unstructured":"Todaro, G. J. & Green, H. Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines. J. Cell Biol. 17, 299\u2013313 (1963)","journal-title":"J. Cell Biol."},{"key":"BFnature01631_CR20","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0047-6374(01)00411-0","volume":"123","author":"JM Taylor-Jones","year":"2002","unstructured":"Taylor-Jones, J. M. et al. Activation of an adipogenic program in adult myoblasts with age. Mech. Ageing Dev. 123, 649\u2013661 (2002)","journal-title":"Mech. Ageing Dev."},{"key":"BFnature01631_CR21","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0531-5565(02)00014-1","volume":"37","author":"JL Kirkland","year":"2002","unstructured":"Kirkland, J. L., Tchkonia, T., Pirtskhalava, T., Han, J. & Karagiannides, I. Adipogenesis and aging: does aging make fat go MAD? Exp. Gerontol. 37, 757\u2013767 (2002)","journal-title":"Exp. Gerontol."},{"key":"BFnature01631_CR22","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/0076-6879(93)25053-5","volume":"225","author":"CL Stewart","year":"1993","unstructured":"Stewart, C. L. Production of chimeras between embryonic stem cells and embryos. Methods Enzymol. 225, 823\u2013855 (1993)","journal-title":"Methods Enzymol."},{"key":"BFnature01631_CR23","doi-asserted-by":"publisher","first-page":"E69","DOI":"10.1093\/nar\/28.12.e69","volume":"28","author":"DA Upchurch","year":"2000","unstructured":"Upchurch, D. A., Shankarappa, R. & Mullins, J. I. Position and degree of mismatches and the mobility of DNA heteroduplexes. Nucleic Acids Res. 28, E69 (2000)","journal-title":"Nucleic Acids Res."},{"key":"BFnature01631_CR24","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1101\/SQB.1997.062.01.021","volume":"62","author":"M Lewandoski","year":"1997","unstructured":"Lewandoski, M., Meyers, E. N. & Martin, G. R. Analysis of Fgf8 gene function in vertebrate development. Cold Spring Harb. Quant. Biol. 62, 159\u2013168 (1997)","journal-title":"Cold Spring Harb. Quant. Biol."},{"key":"BFnature01631_CR25","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/359835a0","volume":"359","author":"T Lufkin","year":"1992","unstructured":"Lufkin, T. et al. Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene. Nature 359, 835\u2013841 (1992)","journal-title":"Nature"},{"key":"BFnature01631_CR26","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1083\/jcb.144.4.631","volume":"144","author":"LA Sabourin","year":"1999","unstructured":"Sabourin, L. A. et al. Reduced differentiation potential of primary MyoD-\/- myogenic cells derived from adult skeletal muscle. J. Cell Biol. 144, 631\u2013643 (1999)","journal-title":"J. Cell Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature01631.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature01631","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nature01631","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nature01631.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:14:59Z","timestamp":1684419299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature01631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,5]]},"references-count":26,"journal-issue":{"issue":"6937","published-print":{"date-parts":[[2003,5]]}},"alternative-id":["BFnature01631"],"URL":"https:\/\/doi.org\/10.1038\/nature01631","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1013568.191170","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1013568.193450","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,5]]}}}