{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:37:08Z","timestamp":1791297428296,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"6978","license":[{"start":{"date-parts":[[2004,2,11]],"date-time":"2004-02-11T00:00:00Z","timestamp":1076457600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1038\/nature02328","type":"journal-article","created":{"date-parts":[[2004,2,11]],"date-time":"2004-02-11T12:56:34Z","timestamp":1076504194000},"page":"93-97","source":"Crossref","is-referenced-by-count":165,"title":["Tension between two kinetochores suffices for their bi-orientation on the mitotic spindle"],"prefix":"10.1038","volume":"428","author":[{"given":"Hilary","family":"Dewar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Nasmyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki U.","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,2,11]]},"reference":[{"key":"BFnature02328_CR1","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0955-0674(02)00328-9","volume":"14","author":"TU Tanaka","year":"2002","unstructured":"Tanaka, T. U. Bi-orienting chromosomes on the mitotic spindle. Curr. Opin. Cell Biol. 14, 365\u2013371 (2002)","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFnature02328_CR2","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1101\/gad.13.5.532","volume":"13","author":"S Biggins","year":"1999","unstructured":"Biggins, S. et al. The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast. Genes Dev. 13, 532\u2013544 (1999)","journal-title":"Genes Dev."},{"key":"BFnature02328_CR3","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/S0092-8674(01)00438-X","volume":"106","author":"X He","year":"2001","unstructured":"He, X., Rines, D. R., Espelin, C. W. & Sorger, P. K. Molecular analysis of kinetochore\u2013microtubule attachment in budding yeast. Cell 106, 195\u2013206 (2001)","journal-title":"Cell"},{"key":"BFnature02328_CR4","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1083\/jcb.153.4.865","volume":"153","author":"RR Adams","year":"2001","unstructured":"Adams, R. R., Maiato, H., Earnshaw, W. C. & Carmena, M. Essential roles of Drosophila inner centromere protein (INCENP) and aurora B in histone H3 phosphorylation, metaphase chromosome alignment, kinetochore disjunction, and chromosome segregation. J. Cell Biol. 153, 865\u2013880 (2001)","journal-title":"J. Cell Biol."},{"key":"BFnature02328_CR5","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/S0960-9822(02)00820-5","volume":"12","author":"S Kaitna","year":"2002","unstructured":"Kaitna, S., Pasierbek, P., Jantsch, M., Loidl, J. & Glotzer, M. The aurora B kinase AIR-2 regulates kinetochores during mitosis and is required for separation of homologous chromosomes during meiosis. Curr. Biol. 12, 798\u2013812 (2002)","journal-title":"Curr. Biol."},{"key":"BFnature02328_CR6","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/S0092-8674(02)00633-5","volume":"108","author":"TU Tanaka","year":"2002","unstructured":"Tanaka, T. U. et al. Evidence that the Ipl1\u2013Sli15 (Aurora kinase\u2013INCENP) complex promotes chromosome bi-orientation by altering kinetochore\u2013spindle pole connections. Cell 108, 317\u2013329 (2002)","journal-title":"Cell"},{"key":"BFnature02328_CR7","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1083\/jcb.200208092","volume":"161","author":"S Hauf","year":"2003","unstructured":"Hauf, S. et al. The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore\u2013microtubule attachment and in maintaining the spindle assembly checkpoint. J. Cell Biol. 161, 281\u2013294 (2003)","journal-title":"J. Cell Biol."},{"key":"BFnature02328_CR8","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1038\/35019529","volume":"2","author":"T Tanaka","year":"2000","unstructured":"Tanaka, T., Fuchs, J., Loidl, J. & Nasmyth, K. Cohesin ensures bipolar attachment of microtubules to sister centromeres and resists their precocious separation. Nature Cell Biol. 2, 492\u2013499 (2000)","journal-title":"Nature Cell Biol."},{"key":"BFnature02328_CR9","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/S1534-5807(01)00088-0","volume":"1","author":"E Sonoda","year":"2001","unstructured":"Sonoda, E. et al. Scc1\/Rad21\/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells. Dev. Cell 1, 759\u2013770 (2001)","journal-title":"Dev. Cell"},{"key":"BFnature02328_CR10","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1083\/jcb.43.1.40","volume":"43","author":"RB Nicklas","year":"1969","unstructured":"Nicklas, R. B. & Koch, C. A. Chromosome micromanipulation. III. Spindle fiber tension and the reorientation of mal-oriented chromosomes. J. Cell Biol. 43, 40\u201350 (1969)","journal-title":"J. Cell Biol."},{"key":"BFnature02328_CR11","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1126\/science.275.5300.632","volume":"275","author":"RB Nicklas","year":"1997","unstructured":"Nicklas, R. B. How cells get the right chromosomes. Science 275, 632\u2013637 (1997)","journal-title":"Science"},{"key":"BFnature02328_CR12","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1083\/jcb.129.6.1601","volume":"129","author":"M Winey","year":"1995","unstructured":"Winey, M. et al. Three-dimensional ultrastructural analysis of the Saccharomyces cerevisiae mitotic spindle. J. Cell Biol. 129, 1601\u20131615 (1995)","journal-title":"J. Cell Biol."},{"key":"BFnature02328_CR13","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/bies.950150704","volume":"15","author":"JH Hegemann","year":"1993","unstructured":"Hegemann, J. H. & Fleig, U. N. The centromere of budding yeast. BioEssays 15, 451\u2013460 (1993)","journal-title":"BioEssays"},{"key":"BFnature02328_CR14","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1128\/MCB.7.7.2397","volume":"7","author":"A Hill","year":"1987","unstructured":"Hill, A. & Bloom, K. Genetic manipulation of centromere function. Mol. Cell. Biol. 7, 2397\u20132405 (1987)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature02328_CR15","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0092-8674(00)80699-6","volume":"100","author":"G Goshima","year":"2000","unstructured":"Goshima, G. & Yanagida, M. Establishing biorientation occurs with precocious separation of the sister kinetochores, but not the arms, in the early spindle of budding yeast. Cell 100, 619\u2013633 (2000)","journal-title":"Cell"},{"key":"BFnature02328_CR16","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S0092-8674(00)80888-0","volume":"101","author":"X He","year":"2000","unstructured":"He, X., Asthana, S. & Sorger, P. K. Transient sister chromatid separation and elastic deformation of chromosomes during mitosis in budding yeast. Cell 101, 763\u2013775 (2000)","journal-title":"Cell"},{"key":"BFnature02328_CR17","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1128\/jb.172.2.610-618.1990","volume":"172","author":"H Matsuzaki","year":"1990","unstructured":"Matsuzaki, H., Nakajima, R., Nishiyama, J., Araki, H. & Oshima, Y. Chromosome engineering in Saccharomyces cerevisiae by using a site-specific recombination system of a yeast plasmid. J. Bacteriol. 172, 610\u2013618 (1990)","journal-title":"J. Bacteriol."},{"key":"BFnature02328_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/S0092-8674(01)80007-6","volume":"91","author":"C Michaelis","year":"1997","unstructured":"Michaelis, C., Ciosk, R. & Nasmyth, K. Cohesins: chromosomal proteins that prevent premature separation of sister chromatids. Cell 91, 35\u201345 (1997)","journal-title":"Cell"},{"key":"BFnature02328_CR19","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1083\/jcb.125.3.517","volume":"125","author":"V Guacci","year":"1994","unstructured":"Guacci, V., Hogan, E. & Koshland, D. Chromosome condensation and sister chromatid pairing in budding yeast. J. Cell Biol. 125, 517\u2013530 (1994)","journal-title":"J. Cell Biol."},{"key":"BFnature02328_CR20","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1091\/mbc.12.9.2800","volume":"12","author":"DA Thrower","year":"2001","unstructured":"Thrower, D. A. & Bloom, K. Dicentric chromosome stretching during anaphase reveals roles of Sir2\/Ku in chromatin compaction in budding yeast. Mol. Biol. Cell 12, 2800\u20132812 (2001)","journal-title":"Mol. Biol. Cell"},{"key":"BFnature02328_CR21","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1073\/pnas.81.9.2616","volume":"81","author":"S DiNardo","year":"1984","unstructured":"DiNardo, S., Voelkel, K. & Sternglanz, R. DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication. Proc. Natl Acad. Sci. USA 81, 2616\u20132620 (1984)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature02328_CR22","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S0092-8674(85)80028-3","volume":"41","author":"C Holm","year":"1985","unstructured":"Holm, C., Goto, T., Wang, J. C. & Botstein, D. DNA topoisomerase II is required at the time of mitosis in yeast. Cell 41, 553\u2013563 (1985)","journal-title":"Cell"},{"key":"BFnature02328_CR23","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/0092-8674(87)90518-6","volume":"50","author":"T Uemura","year":"1987","unstructured":"Uemura, T. et al. DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe. Cell 50, 917\u2013925 (1987)","journal-title":"Cell"},{"key":"BFnature02328_CR24","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/sj.embor.7400077","volume":"5","author":"P Vagnarelli","year":"2004","unstructured":"Vagnarelli, P. et al. Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores. EMBO Rep. 5, 167\u2013171 (2004)","journal-title":"EMBO Rep."},{"key":"BFnature02328_CR25","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1083\/jcb.145.7.1381","volume":"145","author":"JH Kim","year":"1999","unstructured":"Kim, J. H., Kang, J. S. & Chan, C. S. Sli15 associates with the Ipl1 protein kinase to promote proper chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol. 145, 1381\u20131394 (1999)","journal-title":"J. Cell Biol."},{"key":"BFnature02328_CR26","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1016\/S0960-9822(00)00721-1","volume":"10","author":"S Kaitna","year":"2000","unstructured":"Kaitna, S., Mendoza, M., Jantsch-Plunger, V. & Glotzer, M. INCENP and an Aurora-like kinase form a complex essential for chromosome segregation and efficient completion of cytokinesis. Curr. Biol. 10, 1172\u20131181 (2000)","journal-title":"Curr. Biol."},{"key":"BFnature02328_CR27","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/S0960-9822(00)00673-4","volume":"10","author":"RR Adams","year":"2000","unstructured":"Adams, R. R. et al. INCENP binds the Aurora-related kinase AIRK2 and is required to target it to chromosomes, the central spindle and cleavage furrow. Curr. Biol. 10, 1075\u20131078 (2000)","journal-title":"Curr. Biol."},{"key":"BFnature02328_CR28","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0092-8674(02)00973-X","volume":"111","author":"IM Cheeseman","year":"2002","unstructured":"Cheeseman, I. M. et al. Phospho-regulation of kinetochore\u2013microtubule attachments by the Aurora kinase Ipl1p. Cell 111, 163\u2013172 (2002)","journal-title":"Cell"},{"key":"BFnature02328_CR29","doi-asserted-by":"publisher","first-page":"3004","DOI":"10.1101\/gad.249202","volume":"16","author":"A Losada","year":"2002","unstructured":"Losada, A., Hirano, M. & Hirano, T. Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis. Genes Dev. 16, 3004\u20133016 (2002)","journal-title":"Genes Dev."},{"key":"BFnature02328_CR30","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1083\/jcb.153.3.517","volume":"153","author":"D Cimini","year":"2001","unstructured":"Cimini, D. et al. Merotelic kinetochore orientation is a major mechanism of aneuploidy in mitotic mammalian tissue cells. J. Cell Biol. 153, 517\u2013527 (2001)","journal-title":"J. Cell Biol."},{"key":"BFnature02328_CR31","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/S0092-8674(00)81518-4","volume":"98","author":"T Tanaka","year":"1999","unstructured":"Tanaka, T., Cosma, M. P., Wirth, K. & Nasmyth, K. Identification of cohesin association sites at centromeres and along chromosome arms. Cell 98, 847\u2013858 (1999)","journal-title":"Cell"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature02328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature02328","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature02328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:21:17Z","timestamp":1684419677000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature02328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,11]]},"references-count":31,"journal-issue":{"issue":"6978","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["BFnature02328"],"URL":"https:\/\/doi.org\/10.1038\/nature02328","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1017445.202481","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1017445.203297","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1017445.206616","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,11]]}}}