{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T07:30:06Z","timestamp":1792740606282,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7071","license":[{"start":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T00:00:00Z","timestamp":1133395200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1038\/nature04302","type":"journal-article","created":{"date-parts":[[2005,12,21]],"date-time":"2005-12-21T13:00:23Z","timestamp":1135170023000},"page":"1162-1166","source":"Crossref","is-referenced-by-count":708,"title":["NMDA receptors are expressed in oligodendrocytes and activated in ischaemia"],"prefix":"10.1038","volume":"438","author":[{"given":"Ragnhildur","family":"K\u00e1rad\u00f3ttir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Cavelier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda H.","family":"Bergersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Attwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnature04302_CR1","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1203\/00006450-200111000-00003","volume":"50","author":"JJ Volpe","year":"2001","unstructured":"Volpe, J. J. Neurobiology of periventricular leukomalacia in the premature infant. Pediatr. Res. 50, 553\u2013562 (2001)","journal-title":"Pediatr. Res."},{"key":"BFnature04302_CR2","doi-asserted-by":"publisher","first-page":"113","DOI":"10.2174\/1566524043479220","volume":"4","author":"PK Stys","year":"2004","unstructured":"Stys, P. K. White matter injury mechanisms. Curr. Mol. Med. 4, 113\u2013130 (2004)","journal-title":"Curr. Mol. Med."},{"key":"BFnature04302_CR3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S0166-2236(00)01746-X","volume":"24","author":"C Matute","year":"2001","unstructured":"Matute, C. et al. The link between excitotoxic oligodendroglial death and demyelinating diseases. Trends Neurosci. 24, 224\u2013230 (2001)","journal-title":"Trends Neurosci."},{"key":"BFnature04302_CR4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1097\/01.WCB.0000053472.41007.F9","volume":"23","author":"D Dewar","year":"2003","unstructured":"Dewar, D., Underhill, S. M. & Goldberg, M. P. Oligodendrocytes and ischemic brain injury. J. Cereb. Blood Flow Metab. 23, 263\u2013274 (2003)","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"BFnature04302_CR5","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1016\/0896-6273(88)90162-6","volume":"1","author":"DW Choi","year":"1988","unstructured":"Choi, D. W. Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623\u2013634 (1988)","journal-title":"Neuron"},{"key":"BFnature04302_CR6","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/0896-6273(94)90277-1","volume":"12","author":"DK Patneau","year":"1994","unstructured":"Patneau, D. K., Wright, P. W., Winters, C., Mayer, M. L. & Gallo, V. Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor. Neuron 12, 357\u2013371 (1994)","journal-title":"Neuron"},{"key":"BFnature04302_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/jnr.490310104","volume":"31","author":"T Berger","year":"1992","unstructured":"Berger, T., Walz, W., Schnitzer, J. & Kettenmann, H. GABA- and glutamate-activated currents in glial cells of the mouse corpus callosum slice. J. Neurosci. Res. 31, 21\u201327 (1992)","journal-title":"J. Neurosci. Res."},{"key":"BFnature04302_CR8","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1523\/JNEUROSCI.13-04-01441.1993","volume":"13","author":"A Oka","year":"1993","unstructured":"Oka, A., Belliveau, M. J., Rosenberg, P. A. & Volpe, J. J. Vulnerability of oligodendroglia to glutamate: pharmacology, mechanisms, and prevention. J. Neurosci. 13, 1441\u20131453 (1993)","journal-title":"J. Neurosci."},{"key":"BFnature04302_CR9","doi-asserted-by":"publisher","first-page":"9235","DOI":"10.1523\/JNEUROSCI.20-24-09235.2000","volume":"20","author":"PL Follett","year":"2000","unstructured":"Follett, P. L., Rosenberg, P. A., Volpe, J. J. & Jensen, F. E. NBQX attenuates excitotoxic injury in developing white matter. J. Neurosci. 20, 9235\u20139241 (2000)","journal-title":"J. Neurosci."},{"key":"BFnature04302_CR10","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1523\/JNEUROSCI.21-12-04237.2001","volume":"21","author":"SB Tekk\u00f6k","year":"2001","unstructured":"Tekk\u00f6k, S. B. & Goldberg, M. P. AMPA\/kainate receptor activation mediates hypoxic oligodendrocyte death and axonal injury in cerebral white matter. J. Neurosci. 21, 4237\u20134248 (2001)","journal-title":"J. Neurosci."},{"key":"BFnature04302_CR11","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1523\/JNEUROSCI.17-03-01055.1997","volume":"17","author":"SK Agrawal","year":"1997","unstructured":"Agrawal, S. K. & Fehlings, M. G. Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J. Neurosci. 17, 1055\u20131063 (1997)","journal-title":"J. Neurosci."},{"key":"BFnature04302_CR12","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1006\/exnr.1997.6506","volume":"145","author":"JR Wrathall","year":"1997","unstructured":"Wrathall, J. R., Teng, Y. D. & Marriott, R. Delayed antagonism of AMPA\/kainate receptors reduces long-term functional deficits resulting from spinal cord trauma. Exp. Neurol. 145, 565\u2013573 (1997)","journal-title":"Exp. Neurol."},{"key":"BFnature04302_CR13","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/71555","volume":"6","author":"D Pitt","year":"2000","unstructured":"Pitt, D., Werner, P. & Raine, C. S. Glutamate excitotoxicity in a model of multiple sclerosis. Nature Med. 6, 67\u201370 (2000)","journal-title":"Nature Med."},{"key":"BFnature04302_CR14","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1038\/71548","volume":"6","author":"T Smith","year":"2000","unstructured":"Smith, T., Groom, A., Zhu, B. & Turski, L. Autoimmune encephalomyelitis ameliorated by AMPA antagonists. Nature Med. 6, 62\u201366 (2000)","journal-title":"Nature Med."},{"key":"BFnature04302_CR15","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1083\/jcb.135.6.1565","volume":"135","author":"C Wang","year":"1996","unstructured":"Wang, C. et al. Functional N-methyl-d-aspartate receptors in O\u20132A glial precursor cells: a critical role in regulating polysialic acid-neural cell adhesion molecule expression and cell migration. J. Cell Biol. 135, 1565\u20131581 (1996)","journal-title":"J. Cell Biol."},{"key":"BFnature04302_CR16","first-page":"365","volume":"47","author":"D Ziak","year":"1998","unstructured":"Ziak, D., Chvatal, A. & Sykova, E. Glutamate, kainate and NMDA-evoked membrane currents in identified glial cells in rat spinal cord slice. Physiol. Res. 47, 365\u2013375 (1998)","journal-title":"Physiol. Res."},{"key":"BFnature04302_CR17","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1161\/01.STR.31.7.1709","volume":"31","author":"W-R Sch\u00e4bitz","year":"2000","unstructured":"Sch\u00e4bitz, W.-R., Li, F. & Fisher, M. The N-methyl-d-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke 31, 1709\u20131714 (2000)","journal-title":"Stroke"},{"key":"BFnature04302_CR18","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/0022-510X(95)00339-4","volume":"137","author":"E Wallstr\u00f6m","year":"1996","unstructured":"Wallstr\u00f6m, E. et al. Memantine abrogates neurological deficits, but not CNS inflammation, in Lewis rat experimental autoimmune encephalomyelitis. J. Neurol. Sci. 137, 89\u201396 (1996)","journal-title":"J. Neurol. Sci."},{"key":"BFnature04302_CR19","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1523\/JNEUROSCI.21-04-01302.2001","volume":"21","author":"SA Back","year":"2001","unstructured":"Back, S. A. et al. Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury. J. Neurosci. 21, 1302\u20131312 (2001)","journal-title":"J. Neurosci."},{"key":"BFnature04302_CR20","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/35012083","volume":"405","author":"DE Bergles","year":"2000","unstructured":"Bergles, D. E., Roberts, J. D. B., Somogyi, P. & Jahr, C. E. Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature 405, 187\u2013191 (2000)","journal-title":"Nature"},{"key":"BFnature04302_CR21","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1469-7793.1999.00099.x","volume":"521","author":"ED Kirson","year":"1999","unstructured":"Kirson, E. D., Schirra, C., Konnerth, A. & Yaari, Y. Early postnatal switch in magnesium sensitivity of NMDA receptors in rat CA1 pyramidal cells. J. Physiol. (Lond.) 521, 99\u2013111 (1999)","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnature04302_CR22","doi-asserted-by":"publisher","first-page":"3549","DOI":"10.1523\/JNEUROSCI.16-11-03549.1996","volume":"16","author":"T Kuner","year":"1996","unstructured":"Kuner, T. & Schoepfer, R. Multiple structural elements determine subunit specificity of Mg2+ block in NMDA receptor channels. J. Neurosci. 16, 3549\u20133558 (1996)","journal-title":"J. Neurosci."},{"key":"BFnature04302_CR23","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1152\/jn.00531.2001","volume":"87","author":"YF Sasaki","year":"2002","unstructured":"Sasaki, Y. F. et al. Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons. J. Neurophysiol. 87, 2052\u20132063 (2002)","journal-title":"J. Neurophysiol."},{"key":"BFnature04302_CR24","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1002\/jnr.490420416","volume":"42","author":"K Borges","year":"1995","unstructured":"Borges, K. & Kettenmann, H. Blockade of K+ channels induced by AMPA\/kainate receptor activation in mouse oligodendrocyte precursor cells is mediated by Na+ entry. J. Neurosci. Res. 42, 579\u2013593 (1995)","journal-title":"J. Neurosci. Res."},{"key":"BFnature04302_CR25","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1523\/JNEUROSCI.4157-04.2005","volume":"25","author":"NJ Allen","year":"2005","unstructured":"Allen, N. J., K\u00e1rad\u00f3ttir, R. & Attwell, D. A preferential role for glycolysis in preventing the anoxic depolarization of rat hippocampal area CA1 pyramidal cells. J. Neurosci. 25, 848\u2013859 (2005)","journal-title":"J. Neurosci."},{"key":"BFnature04302_CR26","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1242\/dev.125.15.2901","volume":"125","author":"X Yuan","year":"1998","unstructured":"Yuan, X., Eisen, A. M., McBain, C. J. & Gallo, V. A role for glutamate and its receptors in the regulation of oligodendrocyte development in cerebellar tissue slices. Development 125, 2901\u20132914 (1998)","journal-title":"Development"},{"key":"BFnature04302_CR27","doi-asserted-by":"crossref","unstructured":"Salter, M. G. & Fern, R. NMDA receptors are expressed in developing oligodendrocyte processes and mediate injury. Nature doi:10.1038\/nature04301 (this issue)","DOI":"10.1038\/nature04301"},{"key":"BFnature04302_CR28","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1023\/A:1025735513560","volume":"31","author":"M Berry","year":"2002","unstructured":"Berry, M., Hubbard, P. & Butt, A. M. Cytology and lineage of NG2-positive glia. J. Neurocytol. 31, 457\u2013467 (2002)","journal-title":"J. Neurocytol."},{"key":"BFnature04302_CR29","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1113\/jphysiol.2004.074252","volume":"561","author":"R Chittajulu","year":"2004","unstructured":"Chittajulu, R., Aguirre, A. & Gallo, V. NG2-positive cells in the mouse white and grey matter display distinct physiological properties. J. Physiol. (Lond.) 561, 109\u2013122 (2004)","journal-title":"J. Physiol. (Lond.)"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature04302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature04302","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature04302.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:51:23Z","timestamp":1684417883000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature04302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":29,"journal-issue":{"issue":"7071","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["BFnature04302"],"URL":"https:\/\/doi.org\/10.1038\/nature04302","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]}}}