{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T22:52:55Z","timestamp":1791413575770,"version":"4.3.3"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"7084","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1038\/nature04524","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T06:57:43Z","timestamp":1143701863000},"page":"692-696","source":"Crossref","is-referenced-by-count":694,"title":["Regulation of cancer cell migration and bone metastasis by RANKL"],"prefix":"10.1038","volume":"440","author":[{"given":"D. Holstead","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto H.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivona","family":"Kozieradzki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana V.","family":"Komarova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ildiko","family":"Sarosi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Morony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Rubin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Sarao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo V.","family":"Hojilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vukoslav","family":"Komnenovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Yun","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Schreiber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Jeffrey","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen M.","family":"Sims","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rama","family":"Khokha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teiji","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef M.","family":"Penninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnature04524_CR1","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1038\/nrc865","volume":"2","author":"AF Chambers","year":"2002","unstructured":"Chambers, A. F., Groom, A. C. & MacDonald, I. C. Dissemination and growth of cancer cells in metastatic sites. Nature Rev. Cancer 2, 563\u2013572 (2002)","journal-title":"Nature Rev. Cancer"},{"key":"BFnature04524_CR2","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1038\/nrc867","volume":"2","author":"GR Mundy","year":"2002","unstructured":"Mundy, G. R. Metastasis to bone: causes, consequences and therapeutic opportunities. Nature Rev. Cancer 2, 584\u2013593 (2002)","journal-title":"Nature Rev. Cancer"},{"key":"BFnature04524_CR3","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1007\/s00018-002-8524-5","volume":"59","author":"EK Sloan","year":"2002","unstructured":"Sloan, E. K. & Anderson, R. L. Genes involved in breast cancer metastasis to bone. Cell. Mol. Life Sci. 59, 1491\u20131502 (2002)","journal-title":"Cell. Mol. Life Sci."},{"key":"BFnature04524_CR4","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/S0140-6736(00)49915-0","volume":"1","author":"S Paget","year":"1889","unstructured":"Paget, S. The distribution of secondary growths in cancer of the breast. Lancet 1, 571\u2013572 (1889)","journal-title":"Lancet"},{"key":"BFnature04524_CR5","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1002\/bies.1095","volume":"23","author":"MA Moore","year":"2001","unstructured":"Moore, M. A. The role of chemoattraction in cancer metastases. Bioessays 23, 674\u2013676 (2001)","journal-title":"Bioessays"},{"key":"BFnature04524_CR6","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/35065016","volume":"410","author":"A Muller","year":"2001","unstructured":"Muller, A. et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 410, 50\u201356 (2001)","journal-title":"Nature"},{"key":"BFnature04524_CR7","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/16852","volume":"397","author":"YY Kong","year":"1999","unstructured":"Kong, Y. Y. et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397, 315\u2013323 (1999)","journal-title":"Nature"},{"key":"BFnature04524_CR8","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"DL Lacey","year":"1998","unstructured":"Lacey, D. L. et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93, 165\u2013176 (1998)","journal-title":"Cell"},{"key":"BFnature04524_CR9","first-page":"6876","volume":"48","author":"F Arguello","year":"1988","unstructured":"Arguello, F., Baggs, R. B. & Frantz, C. N. A murine model of experimental metastasis to bone and bone marrow. Cancer Res. 48, 6876\u20136881 (1988)","journal-title":"Cancer Res."},{"key":"BFnature04524_CR10","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/36593","volume":"390","author":"DM Anderson","year":"1997","unstructured":"Anderson, D. M. et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390, 175\u2013179 (1997)","journal-title":"Nature"},{"key":"BFnature04524_CR11","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","volume":"289","author":"SL Teitelbaum","year":"2000","unstructured":"Teitelbaum, S. L. Bone resorption by osteoclasts. Science 289, 1504\u20131508 (2000)","journal-title":"Science"},{"key":"BFnature04524_CR12","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/S0092-8674(00)00103-3","volume":"103","author":"JE Fata","year":"2000","unstructured":"Fata, J. E. et al. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell 103, 41\u201350 (2000)","journal-title":"Cell"},{"key":"BFnature04524_CR13","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1002\/jlb.55.4.552","volume":"55","author":"H Verschueren","year":"1994","unstructured":"Verschueren, H. et al. Metastatic competence of BW5147 T-lymphoma cell lines is correlated with in vitro invasiveness, motility and F-actin content. J. Leukoc. Biol. 55, 552\u2013556 (1994)","journal-title":"J. Leukoc. Biol."},{"key":"BFnature04524_CR14","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/35077241","volume":"411","author":"LA Liotta","year":"2001","unstructured":"Liotta, L. A. & Kohn, E. C. The microenvironment of the tumour\u2013host interface. Nature 411, 375\u2013379 (2001)","journal-title":"Nature"},{"key":"BFnature04524_CR15","doi-asserted-by":"publisher","first-page":"14205","DOI":"10.1073\/pnas.2234372100","volume":"100","author":"SJ Bakewell","year":"2003","unstructured":"Bakewell, S. J. et al. Platelet and osteoclast \u03b23 integrins are critical for bone metastasis. Proc. Natl Acad. Sci. USA 100, 14205\u201314210 (2003)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature04524_CR16","doi-asserted-by":"publisher","first-page":"8286","DOI":"10.1074\/jbc.M206421200","volume":"278","author":"SV Komarova","year":"2003","unstructured":"Komarova, S. V., Pilkington, M. F., Weidema, A. F., Dixon, S. J. & Sims, S. M. RANK ligand-induced elevation of cytosolic Ca2+ accelerates nuclear translocation of nuclear factor \u03baB in osteoclasts. J. Biol. Chem. 278, 8286\u20138293 (2003)","journal-title":"J. Biol. Chem."},{"key":"BFnature04524_CR17","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/S0959-8049(97)00513-3","volume":"33","author":"OH Sanchez-Sweatman","year":"1997","unstructured":"Sanchez-Sweatman, O. H., Lee, J., Orr, F. W. & Singh, G. Direct osteolysis induced by metastatic murine melanoma cells: role of matrix metalloproteinases. Eur. J. Cancer 33, 918\u2013925 (1997)","journal-title":"Eur. J. Cancer"},{"key":"BFnature04524_CR18","doi-asserted-by":"publisher","first-page":"2027","DOI":"10.1359\/jbmr.2001.16.11.2027","volume":"16","author":"O Peyruchaud","year":"2001","unstructured":"Peyruchaud, O. et al. Early detection of bone metastases in a murine model of fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions. J. Bone Miner. Res. 16, 2027\u20132034 (2001)","journal-title":"J. Bone Miner. Res."},{"issue":"Suppl.","key":"BFnature04524_CR19","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1002\/1097-0142(20000615)88:12+<2892::AID-CNCR2>3.0.CO;2-Y","volume":"88","author":"TA Guise","year":"2000","unstructured":"Guise, T. A. Molecular mechanisms of osteolytic bone metastases. Cancer 88 (Suppl.), 2892\u20132898 (2000)","journal-title":"Cancer"},{"key":"BFnature04524_CR20","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1172\/JCI11685","volume":"107","author":"J Zhang","year":"2001","unstructured":"Zhang, J. et al. Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumour growth in the bone. J. Clin. Invest. 107, 1235\u20131244 (2001)","journal-title":"J. Clin. Invest."},{"key":"BFnature04524_CR21","first-page":"4432","volume":"61","author":"S Morony","year":"2001","unstructured":"Morony, S. et al. Osteoprotegerin inhibits osteolysis and decreases skeletal tumour burden in syngeneic and nude mouse models of experimental bone metastasis. Cancer Res. 61, 4432\u20134436 (2001)","journal-title":"Cancer Res."},{"key":"BFnature04524_CR22","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1023\/A:1006689719505","volume":"17","author":"M Lelekakis","year":"1999","unstructured":"Lelekakis, M. et al. A novel orthotopic model of breast cancer metastasis to bone. Clin. Exp. Metastasis 17, 163\u2013170 (1999)","journal-title":"Clin. Exp. Metastasis"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature04524.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature04524","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature04524.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:53:23Z","timestamp":1684418003000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature04524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":22,"journal-issue":{"issue":"7084","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["BFnature04524"],"URL":"https:\/\/doi.org\/10.1038\/nature04524","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13507.471043","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.13507.368993","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.13507.374051","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}