{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:05:41Z","timestamp":1792501541502,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7083","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1038\/nature04606","type":"journal-article","created":{"date-parts":[[2006,3,8]],"date-time":"2006-03-08T14:08:06Z","timestamp":1141826886000},"page":"540-544","source":"Crossref","is-referenced-by-count":1092,"title":["CD69 acts downstream of interferon-\u03b1\/\u03b2 to inhibit S1P1 and lymphocyte egress from lymphoid organs"],"prefix":"10.1038","volume":"440","author":[{"given":"Lawrence R.","family":"Shiow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u011b\u017eda","family":"Brdi\u010dkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinping","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis L.","family":"Lanier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason G.","family":"Cyster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Matloubian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,3,8]]},"reference":[{"key":"BFnature04606_CR1","first-page":"450","volume":"46","author":"JG Hall","year":"1965","unstructured":"Hall, J. G. & Morris, B. The immediate effect of antigens on the cell output of a lymph node. Br. J. Exp. Pathol. 46, 450\u2013454 (1965)","journal-title":"Br. J. Exp. Pathol."},{"key":"BFnature04606_CR2","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.3181\/00379727-142-37182","volume":"142","author":"M Degre","year":"1973","unstructured":"Degre, M. Influence of polyinosinic:polycytidylic acid on the circulating white blood cells in mice. Proc. Soc. Exp. Biol. Med. 142, 1087\u20131091 (1973)","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"BFnature04606_CR3","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.4049\/jimmunol.130.5.2236","volume":"130","author":"R Korngold","year":"1983","unstructured":"Korngold, R., Blank, K. J. & Murasko, D. M. Effect of interferon on thoracic duct lymphocyte output: induction with either poly I:poly C or vaccinia virus. J. Immunol. 130, 2236\u20132240 (1983)","journal-title":"J. Immunol."},{"key":"BFnature04606_CR4","first-page":"56","volume":"1","author":"AN Kalaaji","year":"1988","unstructured":"Kalaaji, A. N., Abernethy, N. J., McCullough, K. & Hay, J. B. Recombinant bovine interferon-alpha I 1 inhibits the migration of lymphocytes from lymph nodes but not into lymph nodes. Reg. Immunol. 1, 56\u201361 (1988)","journal-title":"Reg. Immunol."},{"key":"BFnature04606_CR5","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/1521-4141(200001)30:1<327::AID-IMMU327>3.0.CO;2-T","volume":"30","author":"AJ Young","year":"2000","unstructured":"Young, A. J., Seabrook, T. J., Marston, W. L., Dudler, L. & Hay, J. B. A role for lymphatic endothelium in the sequestration of recirculating gamma delta T cells in TNF-alpha-stimulated lymph nodes. Eur. J. Immunol. 30, 327\u2013334 (2000)","journal-title":"Eur. J. Immunol."},{"key":"BFnature04606_CR6","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature02284","volume":"427","author":"M Matloubian","year":"2004","unstructured":"Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355\u2013360 (2004)","journal-title":"Nature"},{"key":"BFnature04606_CR7","doi-asserted-by":"publisher","first-page":"15396","DOI":"10.1074\/jbc.M314291200","volume":"279","author":"ML Allende","year":"2004","unstructured":"Allende, M. L., Dreier, J. L., Mandala, S. & Proia, R. L. Expression of the sphingosine-1-phosphate receptor, S1P1, on T-cells controls thymic emigration. J. Biol. Chem. 279, 15396\u201315401 (2004)","journal-title":"J. Biol. Chem."},{"key":"BFnature04606_CR8","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1093\/intimm\/dxf020","volume":"14","author":"C Feng","year":"2002","unstructured":"Feng, C. et al. A potential role for CD69 in thymocyte emigration. Int. Immunol. 14, 535\u2013544 (2002)","journal-title":"Int. Immunol."},{"key":"BFnature04606_CR9","doi-asserted-by":"publisher","first-page":"87","DOI":"10.4049\/jimmunol.168.1.87","volume":"168","author":"T Nakayama","year":"2002","unstructured":"Nakayama, T. et al. The generation of mature, single-positive thymocytes in vivo is dysregulated by CD69 blockade or overexpression. J. Immunol. 168, 87\u201394 (2002)","journal-title":"J. Immunol."},{"key":"BFnature04606_CR10","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1182\/blood.V95.7.2312","volume":"95","author":"P Lauzurica","year":"2000","unstructured":"Lauzurica, P. et al. Phenotypic and functional characteristics of hematopoietic cell lineages in CD69-deficient mice. Blood 95, 2312\u20132320 (2000)","journal-title":"Blood"},{"key":"BFnature04606_CR11","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1093\/intimm\/dxg102","volume":"15","author":"K Murata","year":"2003","unstructured":"Murata, K. et al. CD69-null mice protected from arthritis induced with anti-type II collagen antibodies. Int. Immunol. 15, 987\u2013992 (2003)","journal-title":"Int. Immunol."},{"key":"BFnature04606_CR12","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/0167-5699(94)90193-7","volume":"15","author":"R Testi","year":"1994","unstructured":"Testi, R., D'Ambrosio, D., De Maria, R. & Santoni, A. The CD69 receptor: a multipurpose cell-surface trigger for hematopoietic cells. Immunol. Today 15, 479\u2013483 (1994)","journal-title":"Immunol. Today"},{"key":"BFnature04606_CR13","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.it.2004.12.006","volume":"26","author":"D Sancho","year":"2005","unstructured":"Sancho, D., Gomez, M. & Sanchez-Madrid, F. CD69 is an immunoregulatory molecule induced following activation. Trends Immunol. 26, 136\u2013140 (2005)","journal-title":"Trends Immunol."},{"key":"BFnature04606_CR14","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.4049\/jimmunol.146.12.4105","volume":"146","author":"A Risso","year":"1991","unstructured":"Risso, A. et al. CD69 in resting and activated T lymphocytes. Its association with a GTP binding protein and biochemical requirements for its expression. J. Immunol. 146, 4105\u20134114 (1991)","journal-title":"J. Immunol."},{"key":"BFnature04606_CR15","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/ni1083","volume":"5","author":"G Cinamon","year":"2004","unstructured":"Cinamon, G. et al. Sphingosine 1-phosphate receptor 1 promotes B cell localization in the splenic marginal zone. Nature Immunol. 5, 713\u2013720 (2004)","journal-title":"Nature Immunol."},{"key":"BFnature04606_CR16","doi-asserted-by":"publisher","first-page":"21.1","DOI":"10.1186\/1475-4924-2-21","volume":"2","author":"P Chu","year":"2003","unstructured":"Chu, P. et al. Systematic identification of regulatory proteins critical for T-cell activation. J. Biol. 2, 21.1\u201321.16 (2003)","journal-title":"J. Biol."},{"key":"BFnature04606_CR17","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1111\/j.1600-6143.2004.00476.x","volume":"4","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann, V., Cyster, J. G. & Hla, T. FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function. Am. J. Transplant. 4, 1019\u20131025 (2004)","journal-title":"Am. J. Transplant."},{"key":"BFnature04606_CR18","doi-asserted-by":"publisher","first-page":"10907","DOI":"10.1073\/pnas.1832725100","volume":"100","author":"H Rosen","year":"2003","unstructured":"Rosen, H., Alfonso, C., Surh, C. D. & McHeyzer-Williams, M. G. Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist. Proc. Natl Acad. Sci. USA 100, 10907\u201310912 (2003)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature04606_CR19","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1126\/science.1113640","volume":"309","author":"SR Schwab","year":"2005","unstructured":"Schwab, S. R. et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science 309, 1735\u20131739 (2005)","journal-title":"Science"},{"key":"BFnature04606_CR20","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1126\/science.1070884","volume":"296","author":"H Arase","year":"2002","unstructured":"Arase, H., Mocarski, E. S., Campbell, A. E., Hill, A. B. & Lanier, L. L. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296, 1323\u20131326 (2002)","journal-title":"Science"},{"key":"BFnature04606_CR21","doi-asserted-by":"publisher","first-page":"21545","DOI":"10.1074\/jbc.270.37.21545","volume":"270","author":"M Lopez-Cabrera","year":"1995","unstructured":"Lopez-Cabrera, M. et al. Transcriptional regulation of the gene encoding the human C-type lectin leukocyte receptor AIM\/CD69 and functional characterization of its tumor necrosis factor-alpha-responsive elements. J. Biol. Chem. 270, 21545\u201321551 (1995)","journal-title":"J. Biol. Chem."},{"key":"BFnature04606_CR22","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1096\/fj.02-0548com","volume":"16","author":"M Graeler","year":"2002","unstructured":"Graeler, M. & Goetzl, E. J. Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells. FASEB J. 16, 1874\u20131878 (2002)","journal-title":"FASEB J."},{"key":"BFnature04606_CR23","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1084\/jem.20021337","volume":"197","author":"E Esplugues","year":"2003","unstructured":"Esplugues, E. et al. Enhanced antitumor immunity in mice deficient in CD69. J. Exp. Med. 197, 1093\u20131106 (2003)","journal-title":"J. Exp. Med."},{"key":"BFnature04606_CR24","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1084\/jem.180.3.1147","volume":"180","author":"R Ramirez","year":"1994","unstructured":"Ramirez, R., Carracedo, J., Zamzami, N., Castedo, M. & Kroemer, G. Pertussis toxin inhibits activation-induced cell death of human thymocytes, pre-B leukemia cells and monocytes. J. Exp. Med. 180, 1147\u20131152 (1994)","journal-title":"J. Exp. Med."},{"key":"BFnature04606_CR25","doi-asserted-by":"publisher","first-page":"3868","DOI":"10.4049\/jimmunol.165.7.3868","volume":"165","author":"D Sancho","year":"2000","unstructured":"Sancho, D. et al. Functional analysis of ligand-binding and signal transduction domains of CD69 and CD23 C-type lectin leukocyte receptors. J. Immunol. 165, 3868\u20133875 (2000)","journal-title":"J. Immunol."},{"key":"BFnature04606_CR26","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/80841","volume":"1","author":"G Bikah","year":"2000","unstructured":"Bikah, G., Pogue-Caley, R. R., McHeyzer-Williams, L. J. & McHeyzer-Williams, M. G. Regulating T helper cell immunity through antigen responsiveness and calcium entry. Nature Immunol. 1, 402\u2013412 (2000)","journal-title":"Nature Immunol."},{"key":"BFnature04606_CR27","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/S1367-5931(03)00085-1","volume":"7","author":"H Rosen","year":"2003","unstructured":"Rosen, H. & Liao, J. Sphingosine 1-phosphate pathway therapeutics: a lipid ligand-receptor paradigm. Curr. Opin. Chem. Biol. 7, 461\u2013468 (2003)","journal-title":"Curr. Opin. Chem. Biol."},{"key":"BFnature04606_CR28","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1126\/science.8009221","volume":"264","author":"U Muller","year":"1994","unstructured":"Muller, U. et al. Functional role of type I and type II interferons in antiviral defense. Science 264, 1918\u20131921 (1994)","journal-title":"Science"},{"key":"BFnature04606_CR29","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1084\/jem.20041509","volume":"201","author":"CG Lo","year":"2005","unstructured":"Lo, C. G., Xu, Y., Proia, R. L. & Cyster, J. G. Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. J. Exp. Med. 201, 291\u2013301 (2005)","journal-title":"J. Exp. Med."},{"key":"BFnature04606_CR30","doi-asserted-by":"publisher","first-page":"7796","DOI":"10.4049\/jimmunol.175.12.7796","volume":"175","author":"DB Rosen","year":"2005","unstructured":"Rosen, D. B. et al. Cutting edge: Lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor. J. Immunol. 175, 7796\u20137799 (2005)","journal-title":"J. Immunol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature04606.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature04606","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature04606.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:54:03Z","timestamp":1684418043000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature04606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":30,"journal-issue":{"issue":"7083","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["BFnature04606"],"URL":"https:\/\/doi.org\/10.1038\/nature04606","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1006198.373861","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1006198.365697","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1006198.370770","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}