{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:23:19Z","timestamp":1792131799638,"version":"4.4.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7116","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1038\/nature05285","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T13:16:28Z","timestamp":1162991788000},"page":"208-212","source":"Crossref","is-referenced-by-count":304,"title":["Spider toxins activate the capsaicin receptor to produce inflammatory pain"],"prefix":"10.1038","volume":"444","author":[{"given":"Jan","family":"Siemens","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharleen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Piskorowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Nikai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen A.","family":"Lumpkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan I.","family":"Basbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Julius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnature05285_CR1","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1146\/annurev.en.27.010182.002011","volume":"27","author":"JO Schmidt","year":"1982","unstructured":"Schmidt, J. O. Biochemistry of insect venoms. Annu. Rev. Entomol. 27, 339\u2013368 (1982)","journal-title":"Annu. Rev. Entomol."},{"key":"BFnature05285_CR2","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/0304-3959(75)90003-2","volume":"1","author":"LA Chahl","year":"1975","unstructured":"Chahl, L. A. & Kirk, E. J. Toxins which produce pain. Pain 1, 3\u201349 (1975)","journal-title":"Pain"},{"key":"BFnature05285_CR3","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.toxicon.2004.02.007","volume":"43","author":"P Escoubas","year":"2004","unstructured":"Escoubas, P. & Rash, L. Tarantulas: eight-legged pharmacists and combinatorial chemists. Toxicon 43, 555\u2013574 (2004)","journal-title":"Toxicon"},{"key":"BFnature05285_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/0896-6273(95)90057-8","volume":"15","author":"C Miller","year":"1995","unstructured":"Miller, C. The charybdotoxin family of K+ channel-blocking peptides. Neuron 15, 5\u201310 (1995)","journal-title":"Neuron"},{"key":"BFnature05285_CR5","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1152\/physrev.00020.2003","volume":"84","author":"H Terlau","year":"2004","unstructured":"Terlau, H. & Olivera, B. M. Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol. Rev. 84, 41\u201368 (2004)","journal-title":"Physiol. Rev."},{"key":"BFnature05285_CR6","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1038\/39807","volume":"389","author":"MJ Caterina","year":"1997","unstructured":"Caterina, M. J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816\u2013824 (1997)","journal-title":"Nature"},{"key":"BFnature05285_CR7","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/0896-6273(95)90184-1","volume":"15","author":"KJ Swartz","year":"1995","unstructured":"Swartz, K. J. & MacKinnon, R. An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron 15, 941\u2013949 (1995)","journal-title":"Neuron"},{"key":"BFnature05285_CR8","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/S0959-4388(03)00101-6","volume":"13","author":"SE Jordt","year":"2003","unstructured":"Jordt, S. E., McKemy, D. D. & Julius, D. Lessons from peppers and peppermint: the molecular logic of thermosensation. Curr. Opin. Neurobiol. 13, 487\u2013492 (2003)","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnature05285_CR9","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nchembio0705-85","volume":"1","author":"T Voets","year":"2005","unstructured":"Voets, T., Talavera, K., Owsianik, G. & Nilius, B. Sensing with TRP channels. Nature Chem. Biol. 1, 85\u201392 (2005)","journal-title":"Nature Chem. Biol."},{"key":"BFnature05285_CR10","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1096\/fj.02-1044fje","volume":"17","author":"S Zhu","year":"2003","unstructured":"Zhu, S., Darbon, H., Dyason, K., Verdonck, F. & Tytgat, J. Evolutionary origin of inhibitor cystine knot peptides. FASEB J. 17, 1765\u20131767 (2003)","journal-title":"FASEB J."},{"key":"BFnature05285_CR11","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/S0896-6273(00)80307-4","volume":"18","author":"KJ Swartz","year":"1997","unstructured":"Swartz, K. J. & MacKinnon, R. Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron 18, 675\u2013682 (1997)","journal-title":"Neuron"},{"key":"BFnature05285_CR12","doi-asserted-by":"publisher","first-page":"34443","DOI":"10.1074\/jbc.M202715200","volume":"277","author":"RE Oswald","year":"2002","unstructured":"Oswald, R. E., Suchyna, T. M., McFeeters, R., Gottlieb, P. & Sachs, F. Solution structure of peptide toxins that block mechanosensitive ion channels. J. Biol. Chem. 277, 34443\u201334450 (2002)","journal-title":"J. Biol. Chem."},{"key":"BFnature05285_CR13","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1006\/jmbi.2000.3609","volume":"297","author":"H Takahashi","year":"2000","unstructured":"Takahashi, H. et al. Solution structure of hanatoxin1, a gating modifier of voltage-dependent K+ channels: common surface features of gating modifier toxins. J. Mol. Biol. 297, 771\u2013780 (2000)","journal-title":"J. Mol. Biol."},{"key":"BFnature05285_CR14","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1085\/jgp.200309005","volume":"123","author":"JM Wang","year":"2004","unstructured":"Wang, J. M. et al. Molecular surface of tarantula toxins interacting with voltage sensors in Kv channels. J. Gen. Physiol. 123, 455\u2013467 (2004)","journal-title":"J. Gen. Physiol."},{"key":"BFnature05285_CR15","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1124\/mol.62.1.48","volume":"62","author":"P Escoubas","year":"2002","unstructured":"Escoubas, P., Diochot, S., Celerier, M. L., Nakajima, T. & Lazdunski, M. Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol. Pharmacol. 62, 48\u201357 (2002)","journal-title":"Mol. Pharmacol."},{"key":"BFnature05285_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0041-0101(03)00095-3","volume":"42","author":"PF Zhang","year":"2003","unstructured":"Zhang, P. F., Chen, P., Hu, W. J. & Liang, S. P. Huwentoxin-V, a novel insecticidal peptide toxin from the spider Selenocosmia huwena, and a natural mutant of the toxin: indicates the key amino acid residues related to the biological activity. Toxicon 42, 15\u201320 (2003)","journal-title":"Toxicon"},{"key":"BFnature05285_CR17","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1038\/nature02732","volume":"430","author":"T Voets","year":"2004","unstructured":"Voets, T. et al. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430, 748\u2013754 (2004)","journal-title":"Nature"},{"key":"BFnature05285_CR18","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1523\/JNEUROSCI.19-02-00529.1999","volume":"19","author":"J Jung","year":"1999","unstructured":"Jung, J. et al. Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J. Neurosci. 19, 529\u2013538 (1999)","journal-title":"J. Neurosci."},{"key":"BFnature05285_CR19","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/S0092-8674(02)00637-2","volume":"108","author":"SE Jordt","year":"2002","unstructured":"Jordt, S. E. & Julius, D. Molecular basis for species-specific sensitivity to \u2018hot\u2019 chili peppers. Cell 108, 421\u2013430 (2002)","journal-title":"Cell"},{"key":"BFnature05285_CR20","doi-asserted-by":"publisher","first-page":"20283","DOI":"10.1074\/jbc.M312577200","volume":"279","author":"NR Gavva","year":"2004","unstructured":"Gavva, N. R. et al. Molecular determinants of vanilloid sensitivity in TRPV1. J. Biol. Chem. 279, 20283\u201320295 (2004)","journal-title":"J. Biol. Chem."},{"key":"BFnature05285_CR21","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1113\/jphysiol.2005.095810","volume":"570","author":"M Salinas","year":"2006","unstructured":"Salinas, M. et al. The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a. J. Physiol. (Lond.) 570, 339\u2013354 (2006)","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnature05285_CR22","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/nature02632","volume":"430","author":"SY Lee","year":"2004","unstructured":"Lee, S. Y. & MacKinnon, R. A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature 430, 232\u2013235 (2004)","journal-title":"Nature"},{"key":"BFnature05285_CR23","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nature02743","volume":"430","author":"TM Suchyna","year":"2004","unstructured":"Suchyna, T. M. et al. Bilayer-dependent inhibition of mechanosensitive channels by neuroactive peptide enantiomers. Nature 430, 235\u2013240 (2004)","journal-title":"Nature"},{"key":"BFnature05285_CR24","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/S0896-6273(00)80564-4","volume":"21","author":"M Tominaga","year":"1998","unstructured":"Tominaga, M. et al. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21, 531\u2013543 (1998)","journal-title":"Neuron"},{"key":"BFnature05285_CR25","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/nature04880","volume":"442","author":"Y Ramu","year":"2006","unstructured":"Ramu, Y., Xu, Y. & Lu, Z. Enzymatic activation of voltage-gated potassium channels. Nature 442, 696\u2013699 (2006)","journal-title":"Nature"},{"key":"BFnature05285_CR26","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1146\/annurev.physiol.68.040204.100431","volume":"68","author":"IS Ramsey","year":"2006","unstructured":"Ramsey, I. S., Delling, M. & Clapham, D. E. An introduction to TRP channels. Annu. Rev. Physiol. 68, 619\u2013647 (2006)","journal-title":"Annu. Rev. Physiol."},{"key":"BFnature05285_CR27","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/nature03873","volume":"436","author":"LR Phillips","year":"2005","unstructured":"Phillips, L. R. et al. Voltage-sensor activation with a tarantula toxin as cargo. Nature 436, 857\u2013860 (2005)","journal-title":"Nature"},{"key":"BFnature05285_CR28","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/nature02282","volume":"427","author":"SE Jordt","year":"2004","unstructured":"Jordt, S. E. et al. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427, 260\u2013265 (2004)","journal-title":"Nature"},{"key":"BFnature05285_CR29","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/BF00656997","volume":"391","author":"OP Hamill","year":"1981","unstructured":"Hamill, O. P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F. J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pfl\u00fcgers Arch. 391, 85\u2013100 (1981)","journal-title":"Pfl\u00fcgers Arch."},{"key":"BFnature05285_CR30","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1097\/00001756-200004270-00014","volume":"11","author":"L Martinez-Caro","year":"2000","unstructured":"Martinez-Caro, L. & Laird, J. M. Allodynia and hyperalgesia evoked by sciatic mononeuropathy in NKI receptor knockout mice. Neuroreport 11, 1213\u20131217 (2000)","journal-title":"Neuroreport"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature05285.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature05285","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature05285.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:00:09Z","timestamp":1684418409000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature05285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":30,"journal-issue":{"issue":"7116","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["BFnature05285"],"URL":"https:\/\/doi.org\/10.1038\/nature05285","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1048365.503297","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1048365.500275","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}