{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:33:09Z","timestamp":1791271989612,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7129","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1038\/nature05528","type":"journal-article","created":{"date-parts":[[2007,2,14]],"date-time":"2007-02-14T13:09:19Z","timestamp":1171458559000},"page":"785-788","source":"Crossref","is-referenced-by-count":275,"title":["Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase"],"prefix":"10.1038","volume":"445","author":[{"given":"Ya-Chieh","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Chern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Wook","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnature05528_CR1","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/ncb995","volume":"5","author":"H Stocker","year":"2003","unstructured":"Stocker, H. et al. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nature Cell Biol. 5, 559\u2013565 (2003)","journal-title":"Nature Cell Biol."},{"key":"BFnature05528_CR2","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/ncb996","volume":"5","author":"LJ Saucedo","year":"2003","unstructured":"Saucedo, L. J. et al. Rheb promotes cell growth as a component of the insulin\/TOR signalling network. Nature Cell Biol. 5, 566\u2013571 (2003)","journal-title":"Nature Cell Biol."},{"key":"BFnature05528_CR3","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/ncb999","volume":"5","author":"Y Zhang","year":"2003","unstructured":"Zhang, Y. et al. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nature Cell Biol. 5, 578\u2013581 (2003)","journal-title":"Nature Cell Biol."},{"key":"BFnature05528_CR4","doi-asserted-by":"publisher","first-page":"1829","DOI":"10.1101\/gad.1110003","volume":"17","author":"K Inoki","year":"2003","unstructured":"Inoki, K., Li, Y., Xu, T. & Guan, K. L. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17, 1829\u20131834 (2003)","journal-title":"Genes Dev."},{"key":"BFnature05528_CR5","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/S1097-2765(03)00220-X","volume":"11","author":"A Garami","year":"2003","unstructured":"Garami, A. et al. Insulin activation of Rheb, a mediator of mTOR\/S6K\/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11, 1457\u20131466 (2003)","journal-title":"Mol. Cell"},{"key":"BFnature05528_CR6","doi-asserted-by":"publisher","first-page":"6209","DOI":"10.1128\/MCB.22.17.6209-6221.2002","volume":"22","author":"FR Yarm","year":"2002","unstructured":"Yarm, F. R. Plk phosphorylation regulates the microtubule-stabilizing protein TCTP. Mol. Cell. Biol. 22, 6209\u20136221 (2002)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature05528_CR7","doi-asserted-by":"publisher","first-page":"3117","DOI":"10.1128\/MCB.25.8.3117-3126.2005","volume":"25","author":"H Liu","year":"2005","unstructured":"Liu, H., Peng, H.-W., Cheng, Y.-S., Yuan, H. S. & Yang-Yen, H.-F. Stabilization and enhancement of the antiapoptotic activity of Mcl-1 by TCTP. Mol. Cell. Biol. 25, 3117\u20133126 (2005)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature05528_CR8","doi-asserted-by":"publisher","first-page":"4778","DOI":"10.1038\/sj.onc.1208666","volume":"24","author":"Y Yang","year":"2005","unstructured":"Yang, Y. et al. An N-terminal region of translationally controlled tumor protein is required for its antiapoptotic activity. Oncogene 24, 4778\u20134788 (2005)","journal-title":"Oncogene"},{"key":"BFnature05528_CR9","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/90415","volume":"8","author":"P Thaw","year":"2001","unstructured":"Thaw, P. et al. Structure of TCTP reveals unexpected relationship with guanine nucleotide-free chaperones. Nature Struct. Biol. 8, 701\u2013704 (2001)","journal-title":"Nature Struct. Biol."},{"key":"BFnature05528_CR10","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/S1046-2023(03)00051-3","volume":"30","author":"YS Lee","year":"2003","unstructured":"Lee, Y. S. & Carthew, R. W. Making a better RNAi vector for Drosophila: use of intron spacers. Methods 30, 322\u2013329 (2003)","journal-title":"Methods"},{"key":"BFnature05528_CR11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","volume":"118","author":"AH Brand","year":"1993","unstructured":"Brand, A. H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401\u2013415 (1993)","journal-title":"Development"},{"key":"BFnature05528_CR12","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1093\/genetics\/152.4.1631","volume":"152","author":"RS Stowers","year":"1999","unstructured":"Stowers, R. S. & Schwarz, T. L. A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype. Genetics 152, 1631\u20131639 (1999)","journal-title":"Genetics"},{"key":"BFnature05528_CR13","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/S0896-6273(00)80701-1","volume":"22","author":"T Lee","year":"1999","unstructured":"Lee, T. & Luo, L. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 22, 451\u2013461 (1999)","journal-title":"Neuron"},{"key":"BFnature05528_CR14","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1242\/jcs.00661","volume":"116","author":"PH Patel","year":"2003","unstructured":"Patel, P. H. et al. Drosophila Rheb GTPase is required for cell cycle progression and cell growth. J. Cell Sci. 116, 3601\u20133610 (2003)","journal-title":"J. Cell Sci."},{"key":"BFnature05528_CR15","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1101\/gad.845700","volume":"14","author":"S Oldham","year":"2000","unstructured":"Oldham, S., Montagne, J., Radimerski, T., Thomas, G. & Hafen, E. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 14, 2689\u20132694 (2000)","journal-title":"Genes Dev."},{"key":"BFnature05528_CR16","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1101\/gad.835000","volume":"14","author":"H Zhang","year":"2000","unstructured":"Zhang, H., Stallock, J. P., Ng, J. C., Reinhard, C. & Neufeld, T. P. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 14, 2712\u20132724 (2000)","journal-title":"Genes Dev."},{"key":"BFnature05528_CR17","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0960-9822(01)00068-9","volume":"11","author":"W Brogiolo","year":"2001","unstructured":"Brogiolo, W. et al. An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr. Biol. 11, 213\u2013221 (2001)","journal-title":"Curr. Biol."},{"key":"BFnature05528_CR18","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0092-8674(01)00332-4","volume":"105","author":"N Tapon","year":"2001","unstructured":"Tapon, N., Ito, N., Dickson, B. J., Treisman, J. E. & Hariharan, I. K. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105, 345\u2013355 (2001)","journal-title":"Cell"},{"key":"BFnature05528_CR19","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0092-8674(01)00333-6","volume":"105","author":"CJ Potter","year":"2001","unstructured":"Potter, C. J., Huang, H. & Xu, T. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105, 357\u2013368 (2001)","journal-title":"Cell"},{"key":"BFnature05528_CR20","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/S0092-8674(00)80657-1","volume":"96","author":"N Ito","year":"1999","unstructured":"Ito, N. & Rubin, G. M. gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle. Cell 96, 529\u2013539 (1999)","journal-title":"Cell"},{"key":"BFnature05528_CR21","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1006\/dbio.2000.9680","volume":"221","author":"X Gao","year":"2000","unstructured":"Gao, X., Neufeld, T. P. & Pan, D. Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways. Dev. Biol. 221, 404\u2013418 (2000)","journal-title":"Dev. Biol."},{"key":"BFnature05528_CR22","doi-asserted-by":"publisher","first-page":"3244","DOI":"10.1101\/gad.13.24.3244","volume":"13","author":"DC Goberdhan","year":"1999","unstructured":"Goberdhan, D. C., Paricio, N., Goodman, E. C., Mlodzik, M. & Wilson, C. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico\/PI3-kinase signaling pathway. Genes Dev. 13, 3244\u20133258 (1999)","journal-title":"Genes Dev."},{"key":"BFnature05528_CR23","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1242\/dev.126.23.5365","volume":"126","author":"H Huang","year":"1999","unstructured":"Huang, H. et al. PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development. Development 126, 5365\u20135372 (1999)","journal-title":"Development"},{"key":"BFnature05528_CR24","doi-asserted-by":"publisher","first-page":"14976","DOI":"10.1073\/pnas.222470799","volume":"99","author":"M Tuynder","year":"2002","unstructured":"Tuynder, M. et al. Biological models and genes of tumor reversion: cellular reprogramming through tpt1\/TCTP and SIAH-1. Proc. Natl Acad. Sci. USA 99, 14976\u201314981 (2002)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature05528_CR25","doi-asserted-by":"publisher","first-page":"15364","DOI":"10.1073\/pnas.0406776101","volume":"101","author":"M Tuynder","year":"2004","unstructured":"Tuynder, M. et al. Translationally controlled tumor protein is a target of tumor reversion. Proc. Natl Acad. Sci. USA 101, 15364\u201315369 (2004)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature05528_CR26","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1083\/jcb.137.7.1495","volume":"137","author":"C Walch-Solimena","year":"1997","unstructured":"Walch-Solimena, C., Collins, R. N. & Novick, P. J. Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J. Cell Biol. 137, 1495\u20131509 (1997)","journal-title":"J. Cell Biol."},{"key":"BFnature05528_CR27","doi-asserted-by":"publisher","first-page":"13207","DOI":"10.1074\/jbc.M208896200","volume":"278","author":"X Guo","year":"2003","unstructured":"Guo, X. et al. A Rac\/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. J. Biol. Chem. 278, 13207\u201313215 (2003)","journal-title":"J. Biol. Chem."},{"key":"BFnature05528_CR28","doi-asserted-by":"publisher","first-page":"4029","DOI":"10.1038\/sj.onc.1203741","volume":"19","author":"FC von Lintig","year":"2000","unstructured":"von Lintig, F. C., Pilz, R. B. & Boss, G. R. Quantitative determination of Rap 1 activation in cyclic nucleotide-treated HL-60 leukemic cells: lack of Rap 1 activation in variant cells. Oncogene 19, 4029\u20134034 (2000)","journal-title":"Oncogene"},{"key":"BFnature05528_CR29","doi-asserted-by":"publisher","first-page":"6356","DOI":"10.1038\/sj.onc.1205792","volume":"21","author":"E Im","year":"2002","unstructured":"Im, E. et al. Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells. Oncogene 21, 6356\u20136365 (2002)","journal-title":"Oncogene"},{"key":"BFnature05528_CR30","doi-asserted-by":"publisher","first-page":"18528","DOI":"10.1074\/jbc.273.29.18528","volume":"273","author":"PM Sharma","year":"1998","unstructured":"Sharma, P. M. et al. Inhibition of phosphatidylinositol 3-kinase activity by adenovirus-mediated gene transfer and its effect on insulin action. J. Biol. Chem. 273, 18528\u201318537 (1998)","journal-title":"J. Biol. Chem."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature05528.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature05528","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature05528.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:01:59Z","timestamp":1684418519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature05528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":30,"journal-issue":{"issue":"7129","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["BFnature05528"],"URL":"https:\/\/doi.org\/10.1038\/nature05528","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1066999.519971","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1066999.521751","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2]]}}}