{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:01:52Z","timestamp":1791273712649,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7177","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1038\/nature06469","type":"journal-article","created":{"date-parts":[[2008,1,23]],"date-time":"2008-01-23T18:45:10Z","timestamp":1201113910000},"page":"465-469","source":"Crossref","is-referenced-by-count":347,"title":["Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina"],"prefix":"10.1038","volume":"451","author":[{"given":"Masahito","family":"Yamagata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua R.","family":"Sanes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnature06469_CR1","first-page":"119","volume-title":"La Cellule","author":"S Ram\u00f3n y Cajal","year":"1892","unstructured":"Ram\u00f3n y Cajal, S. La r\u00e9tine des vert\u00e9br\u00e9s. La Cellule 9, 119\u2013257 (1892); reprinted in The Vertebrate Retina (ed. Rodieck, R. W.) 775\u2013904 (Freeman, San Francisco, 1974)"},{"key":"BFnature06469_CR2","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1038\/nn0901-877","volume":"4","author":"RH Masland","year":"2001","unstructured":"Masland, R. H. The fundamental plan of the retina. Nature Neurosci. 4, 877\u2013886 (2001)","journal-title":"Nature Neurosci."},{"key":"BFnature06469_CR3","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nrn1497","volume":"5","author":"H W\u00e4ssle","year":"2004","unstructured":"W\u00e4ssle, H. Parallel processing in the mammalian retina. Nature Rev. Neurosci. 5, 747\u2013757 (2004)","journal-title":"Nature Rev. Neurosci."},{"key":"BFnature06469_CR4","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/35069068","volume":"410","author":"B Roska","year":"2001","unstructured":"Roska, B. & Werblin, F. Vertical interactions across ten parallel, stacked representations in the mammalian retina. Nature 410, 583\u2013587 (2001)","journal-title":"Nature"},{"key":"BFnature06469_CR5","doi-asserted-by":"publisher","first-page":"4693","DOI":"10.1523\/JNEUROSCI.22-11-04693.2002","volume":"22","author":"JJ Pang","year":"2002","unstructured":"Pang, J. J., Gao, F. & Wu, S. M. Segregation and integration of visual channels: layer-by layer computation of ON-OFF signals by amacrine cell dendrites. J. Neurosci. 22, 4693\u20134701 (2002)","journal-title":"J. Neurosci."},{"key":"BFnature06469_CR6","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1093\/hmg\/7.2.227","volume":"7","author":"K Yamakawa","year":"1998","unstructured":"Yamakawa, K. et al. DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Hum. Mol. Genet. 7, 227\u2013237 (1998)","journal-title":"Hum. Mol. Genet."},{"key":"BFnature06469_CR7","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/S0169-328X(00)00108-X","volume":"79","author":"KL Agarwala","year":"2000","unstructured":"Agarwala, K. L. et al. Down syndrome cell adhesion molecule DSCAM mediates homophilic intercellular adhesion. Brain Res. Mol. Brain Res. 79, 118\u2013126 (2000)","journal-title":"Brain Res. Mol. Brain Res."},{"key":"BFnature06469_CR8","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1006\/bbrc.2001.5214","volume":"285","author":"KL Agarwala","year":"2001","unstructured":"Agarwala, K. L. et al. Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion. Biochem. Biophys. Res. Commun. 285, 760\u2013772 (2001)","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnature06469_CR9","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.ydbio.2004.12.001","volume":"279","author":"D Yimlamai","year":"2005","unstructured":"Yimlamai, D. et al. The zebrafish down syndrome cell adhesion molecule is involved in cell movement during embryogenesis. Dev. Biol. 279, 44\u201357 (2005)","journal-title":"Dev. Biol."},{"key":"BFnature06469_CR10","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0092-8674(02)00910-8","volume":"110","author":"M Yamagata","year":"2002","unstructured":"Yamagata, M., Weiner, J. A. & Sanes, J. R. Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina. Cell 110, 649\u2013660 (2002)","journal-title":"Cell"},{"key":"BFnature06469_CR11","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/S0092-8674(00)80878-8","volume":"101","author":"D Schmucker","year":"2000","unstructured":"Schmucker, D. et al. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell 101, 671\u2013684 (2000)","journal-title":"Cell"},{"key":"BFnature06469_CR12","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S0896-6273(02)00570-6","volume":"33","author":"J Wang","year":"2002","unstructured":"Wang, J., Zugates, C. T., Liang, I. H., Lee, C. H. & Lee, T. Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons. Neuron 33, 559\u2013571 (2002)","journal-title":"Neuron"},{"key":"BFnature06469_CR13","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0896-6273(02)01183-2","volume":"37","author":"T Hummel","year":"2003","unstructured":"Hummel, T. et al. Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam. Neuron 37, 221\u2013231 (2003)","journal-title":"Neuron"},{"key":"BFnature06469_CR14","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.neuron.2004.07.020","volume":"43","author":"XL Zhan","year":"2004","unstructured":"Zhan, X. L. et al. Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies. Neuron 43, 673\u2013686 (2004)","journal-title":"Neuron"},{"key":"BFnature06469_CR15","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/nn1652","volume":"9","author":"H Zhu","year":"2006","unstructured":"Zhu, H. et al. Dendritic patterning by Dscam and synaptic partner matching in the Drosophila antennal lobe. Nature Neurosci. 9, 349\u2013355 (2006)","journal-title":"Nature Neurosci."},{"key":"BFnature06469_CR16","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.cell.2006.03.034","volume":"125","author":"BE Chen","year":"2006","unstructured":"Chen, B. E. et al. The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila . Cell 125, 607\u2013620 (2006)","journal-title":"Cell"},{"key":"BFnature06469_CR17","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.tibs.2006.08.003","volume":"31","author":"SL Zipursky","year":"2006","unstructured":"Zipursky, S. L., Wojtowicz, W. M. & Hattori, D. Got diversity? Wiring the fly brain with Dscam. Trends Biochem. Sci. 31, 581\u2013588 (2006)","journal-title":"Trends Biochem. Sci."},{"key":"BFnature06469_CR18","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.neuron.2007.04.018","volume":"54","author":"T Kidd","year":"2007","unstructured":"Kidd, T. & Condron, B. Avoiding the SCAMs. Neuron 54, 350\u2013352 (2007)","journal-title":"Neuron"},{"key":"BFnature06469_CR19","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/nature05855","volume":"447","author":"SS Millard","year":"2007","unstructured":"Millard, S. S. et al. Dscam2 mediates axonal tiling in the Drosophila visual system. Nature 447, 720\u2013724 (2007)","journal-title":"Nature"},{"key":"BFnature06469_CR20","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0076-6879(04)92022-8","volume":"392","author":"Y Zeng","year":"2005","unstructured":"Zeng, Y., Cai, X. & Cullen, B. R. Use of RNA polymerase II to transcribe artificial microRNAs. Methods Enzymol. 392, 371\u2013380 (2005)","journal-title":"Methods Enzymol."},{"key":"BFnature06469_CR21","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/nmeth923","volume":"3","author":"K Chang","year":"2006","unstructured":"Chang, K., Elledge, S. J. & Hannon, G. J. Lessons from Nature: microRNA-based shRNA libraries. Nature Methods 3, 707\u2013714 (2006)","journal-title":"Nature Methods"},{"key":"BFnature06469_CR22","first-page":"107","volume":"50","author":"SH Hughes","year":"2004","unstructured":"Hughes, S. H. The RCAS vector system. Folia Biol. (Praha) 50, 107\u2013119 (2004)","journal-title":"Folia Biol. (Praha)"},{"key":"BFnature06469_CR23","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1002\/(SICI)1096-9861(19980622)396:1<20::AID-CNE3>3.0.CO;2-K","volume":"396","author":"JC Wohrn","year":"1998","unstructured":"Wohrn, J. C. et al. Cadherin expression in the retina and retinofugal pathways of the chicken embryo. J. Comp. Neurol. 396, 20\u201338 (1998)","journal-title":"J. Comp. Neurol."},{"key":"BFnature06469_CR24","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.mcn.2006.08.001","volume":"33","author":"M Yamagata","year":"2006","unstructured":"Yamagata, M. et al. Labeled lines in the retinotectal system: markers for retinorecipient sublaminae and the retinal ganglion cell subsets that innervate them. Mol. Cell. Neurosci. 33, 296\u2013310 (2006)","journal-title":"Mol. Cell. Neurosci."},{"key":"BFnature06469_CR25","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1007\/s004380100525","volume":"266","author":"X Li","year":"2001","unstructured":"Li, X. et al. The minimum internal and external sequence requirements for transposition of the eukaryotic transformation vector piggyBac. Mol. Genet. Genomics 266, 190\u2013198 (2001)","journal-title":"Mol. Genet. Genomics"},{"key":"BFnature06469_CR26","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.cell.2005.07.013","volume":"122","author":"S Ding","year":"2005","unstructured":"Ding, S. et al. Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. Cell 122, 473\u2013483 (2005)","journal-title":"Cell"},{"key":"BFnature06469_CR27","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.devcel.2004.09.006","volume":"7","author":"A Poliakov","year":"2004","unstructured":"Poliakov, A., Cotrina, M. & Wilkinson, D. G. Diverse roles of eph receptors and ephrins in the regulation of cell migration and tissue assembly. Dev. Cell 7, 465\u2013480 (2004)","journal-title":"Dev. Cell"},{"key":"BFnature06469_CR28","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1016\/S0092-8674(00)80804-1","volume":"97","author":"K Hong","year":"1999","unstructured":"Hong, K. et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97, 927\u2013941 (1999)","journal-title":"Cell"},{"key":"BFnature06469_CR29","doi-asserted-by":"crossref","unstructured":"Fuerst, P. G., Koizumi, A., Masland, R. H. & Burgess, R. W. Neurite arborization and mosaic spacing in the mouse retina require DSCAM. Nature doi: 10.1038\/nature06514 (this issue)","DOI":"10.1038\/nature06514"},{"key":"BFnature06469_CR30","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0959-4388(99)80010-5","volume":"9","author":"JR Sanes","year":"1999","unstructured":"Sanes, J. R. & Yamagata, M. Formation of lamina-specific synaptic connections. Curr. Opin. Neurobiol. 9, 79\u201387 (1999)","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnature06469_CR31","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1002\/cne.902600406","volume":"260","author":"AW Spira","year":"1987","unstructured":"Spira, A. W. et al. Localization of choline acetyltransferase-like immunoreactivity in the embryonic chick retina. J. Comp. Neurol. 260, 526\u2013538 (1987)","journal-title":"J. Comp. Neurol."},{"key":"BFnature06469_CR32","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/0896-6273(88)90127-4","volume":"1","author":"BA Barres","year":"1988","unstructured":"Barres, B. A. et al. Immunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panning. Neuron 1, 791\u2013803 (1988)","journal-title":"Neuron"},{"key":"BFnature06469_CR33","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0896-6273(91)90075-B","volume":"7","author":"H Inuzuka","year":"1991","unstructured":"Inuzuka, H., Miyatani, S. & Takeichi, M. R-cadherin: a novel Ca(2+)-dependent cell-cell adhesion molecule expressed in the retina. Neuron 7, 69\u201379 (1991)","journal-title":"Neuron"},{"key":"BFnature06469_CR34","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1111\/j.1471-4159.1986.tb13064.x","volume":"46","author":"CD Johnson","year":"1986","unstructured":"Johnson, C. D. & Epstein, M. L. Monoclonal antibodies and polyvalent antiserum to chicken choline acetyltransferase. J. Neurochem. 46, 968\u2013976 (1986)","journal-title":"J. Neurochem."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature06469","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature06469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature06469.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:12:30Z","timestamp":1684433550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature06469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":34,"journal-issue":{"issue":"7177","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["BFnature06469"],"URL":"https:\/\/doi.org\/10.1038\/nature06469","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}