{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:28:49Z","timestamp":1791332929536,"version":"4.3.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7207","license":[{"start":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T00:00:00Z","timestamp":1216166400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2008,8]]},"DOI":"10.1038\/nature07171","type":"journal-article","created":{"date-parts":[[2008,7,17]],"date-time":"2008-07-17T13:38:13Z","timestamp":1216301893000},"page":"1019-1022","source":"Crossref","is-referenced-by-count":125,"title":["Molecular basis of the copulatory plug polymorphism in Caenorhabditis elegans"],"prefix":"10.1038","volume":"454","author":[{"given":"Michael F.","family":"Palopoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew V.","family":"Rockman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aye","family":"TinMaung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camden","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Curwen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Aduna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Laurita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Kruglyak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,7,16]]},"reference":[{"key":"BFnature07171_CR1","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/genetics\/146.1.149","volume":"146","author":"J Hodgkin","year":"1997","unstructured":"Hodgkin, J. & Doniach, T. Natural variation and copulatory plug formation in Caenorhabditis elegans . Genetics 146, 149?164 (1997)","journal-title":"Genetics"},{"key":"BFnature07171_CR2","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1006\/anbe.1994.1221","volume":"48","author":"DM Barker","year":"1994","unstructured":"Barker, D. M. Copulatory plugs and paternity assurance in the nematode Caenorhabditis elegans . Anim. Behav. 48, 147?156 (1994)","journal-title":"Anim. Behav."},{"key":"BFnature07171_CR3","doi-asserted-by":"publisher","first-page":"9003","DOI":"10.1073\/pnas.0403094101","volume":"101","author":"K Kiontke","year":"2004","unstructured":"Kiontke, K. et al. Caenorhabditis phylogeny predicts convergence of hermaphroditism and extensive intron loss. Proc. Natl Acad. Sci. USA 101, 9003?9008 (2004)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature07171_CR4","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1101\/gr.2639304","volume":"14","author":"S Cho","year":"2004","unstructured":"Cho, S., Jin, S. W., Cohen, A. & Ellis, R. E. A phylogeny of Caenorhabditis reveals frequent loss of introns during nematode evolution. Genome Res. 14, 1207?1220 (2004)","journal-title":"Genome Res."},{"key":"BFnature07171_CR5","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.cub.2005.06.022","volume":"15","author":"A Barriere","year":"2005","unstructured":"Barriere, A. & Felix, M. A. High local genetic diversity and low outcrossing rate in Caenorhabditis elegans natural populations. Curr. Biol. 15, 1176?1184 (2005)","journal-title":"Curr. Biol."},{"key":"BFnature07171_CR6","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1534\/genetics.106.067223","volume":"176","author":"A Barriere","year":"2007","unstructured":"Barriere, A. & Felix, M. A. Temporal dynamics and linkage disequilibrium in natural Caenorhabditis elegans populations. Genetics 176, 999?1011 (2007)","journal-title":"Genetics"},{"key":"BFnature07171_CR7","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1016\/j.cub.2005.08.034","volume":"15","author":"A Sivasundar","year":"2005","unstructured":"Sivasundar, A. & Hey, J. Sampling from natural populations with RNAi reveals high outcrossing and population structure in Caenorhabditis elegans . Curr. Biol. 15, 1598?1602 (2005)","journal-title":"Curr. Biol."},{"key":"BFnature07171_CR8","volume-title":"WormBook","author":"A Barriere","year":"2005","unstructured":"Barriere, A. & Felix, M. A. Natural variation and population genetics of Caenorhabditis elegans . WormBook 10.1895\/wormbook.1.43.1 (2005); \u3008 http:\/\/www.wormbook.org \u3009"},{"key":"BFnature07171_CR9","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1093\/oxfordjournals.molbev.a026400","volume":"17","author":"JL Desseyn","year":"2000","unstructured":"Desseyn, J. L., Aubert, J. P., Porchet, N. & Laine, A. Evolution of the large secreted gel-forming mucins. Mol. Biol. Evol. 17, 1175?1184 (2000)","journal-title":"Mol. Biol. Evol."},{"key":"BFnature07171_CR10","doi-asserted-by":"publisher","first-page":"31751","DOI":"10.1074\/jbc.274.45.31751","volume":"274","author":"J Perez-Vilar","year":"1999","unstructured":"Perez-Vilar, J. & Hill, R. L. The structure and assembly of secreted mucins. J. Biol. Chem. 274, 31751?31754 (1999)","journal-title":"J. Biol. Chem."},{"key":"BFnature07171_CR11","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1093\/glycob\/cwh066","volume":"14","author":"T Lang","year":"2004","unstructured":"Lang, T., Alexandersson, M., Hansson, G. C. & Samuelsson, T. Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu rubripes . Glycobiology 14, 521?527 (2004)","journal-title":"Glycobiology"},{"key":"BFnature07171_CR12","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1093\/glycob\/cwh151","volume":"15","author":"K Julenius","year":"2005","unstructured":"Julenius, K., Molgaard, A., Gupta, R. & Brunak, S. Prediction, conservation analysis, and structural characterization of mammalian mucin-type O-glycosylation sites. Glycobiology 15, 153?164 (2005)","journal-title":"Glycobiology"},{"key":"BFnature07171_CR13","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.jmb.2004.05.028","volume":"340","author":"JD Bendtsen","year":"2004","unstructured":"Bendtsen, J. D., Nielsen, H., von Heijne, G. & Brunak, S. Improved prediction of signal peptides: SignalP 3.0. J. Mol. Biol. 340, 783?795 (2004)","journal-title":"J. Mol. Biol."},{"key":"BFnature07171_CR14","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/299111a0","volume":"299","author":"G Dover","year":"1982","unstructured":"Dover, G. Molecular drive: A cohesive mode of species evolution. Nature 299, 111?117 (1982)","journal-title":"Nature"},{"key":"BFnature07171_CR15","doi-asserted-by":"crossref","first-page":"8518","DOI":"10.1016\/S0021-9258(19)40790-4","volume":"250","author":"R Lotan","year":"1975","unstructured":"Lotan, R., Skutelsky, E., Danon, D. & Sharon, N. The purification, composition, and specificity of the anti-T lectin from peanut (Arachis hypogaea). J. Biol. Chem. 250, 8518?8523 (1975)","journal-title":"J. Biol. Chem."},{"key":"BFnature07171_CR16","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/S0021-9258(18)93649-5","volume":"243","author":"DM Carlson","year":"1968","unstructured":"Carlson, D. M. Structures and immunochemical properties of oligosaccharides isolated from pig submaxillary mucins. J. Biol. Chem. 243, 616?626 (1968)","journal-title":"J. Biol. Chem."},{"key":"BFnature07171_CR17","volume-title":"WormAtlas","author":"R Lints","year":"2005","unstructured":"Lints, R. & Hall, D. H. Handbook of C. elegans male anatomy. WormAtlas \u3008 http:\/\/www.wormatlas.org\/handbook\/contents.htm \u3009 (2005)"},{"key":"BFnature07171_CR18","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1101\/gr.196201","volume":"11","author":"EW Ganko","year":"2001","unstructured":"Ganko, E. W., Fielman, K. T. & McDonald, J. F. Evolutionary history of Cer elements and their impact on the C. elegans genome. Genome Res. 11, 2066?2074 (2001)","journal-title":"Genome Res."},{"key":"BFnature07171_CR19","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1073\/pnas.92.2.599","volume":"92","author":"RJ Britten","year":"1995","unstructured":"Britten, R. J. Active gypsy\/Ty3 retrotransposons or retroviruses in Caenorhabditis elegans . Proc. Natl Acad. Sci. USA 92, 599?601 (1995)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature07171_CR20","first-page":"386","volume":"401","author":"MM Barr","year":"1999","unstructured":"Barr, M. M. & Sternberg, P. W. A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans . Nature 401, 386?389 (1999)","journal-title":"Nature"},{"key":"BFnature07171_CR21","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.cub.2004.12.073","volume":"15","author":"EM Peden","year":"2005","unstructured":"Peden, E. M. & Barr, M. M. The KLP-6 kinesin is required for male mating behaviors and polycystin localization in Caenorhabditis elegans . Curr. Biol. 15, 394?404 (2005)","journal-title":"Curr. Biol."},{"key":"BFnature07171_CR22","volume-title":"WormBook","author":"MM Barr","year":"2006","unstructured":"Barr, M. M. & Garcia, L. R. Male mating behavior. WormBook 10.1895\/wormbook.1.78.1 (2006); \u3008 http:\/\/www.wormbook.org \u3009."},{"key":"BFnature07171_CR23","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.27468","volume-title":"The Genetical Theory of Natural Selection","author":"RA Fisher","year":"1930","unstructured":"Fisher, R. A. The Genetical Theory of Natural Selection (Oxford Univ. Press, 1930)"},{"key":"BFnature07171_CR24","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1111\/j.0014-3820.2000.tb00544.x","volume":"54","author":"DL Stern","year":"2000","unstructured":"Stern, D. L. Evolutionary developmental biology and the problem of variation. Evolution 54, 1079?1091 (2000)","journal-title":"Evolution"},{"key":"BFnature07171_CR25","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1101\/gad.1012602","volume":"16","author":"R Lints","year":"2002","unstructured":"Lints, R. & Emmons, S. W. Regulation of sex-specific differentiation and mating behavior in C. elegans by a new member of the DM domain transcription factor family. Genes Dev. 16, 2390?2402 (2002)","journal-title":"Genes Dev."},{"key":"BFnature07171_CR26","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/genetics\/160.3.983","volume":"160","author":"JR Chasnov","year":"2002","unstructured":"Chasnov, J. R. & Chow, K. L. Why are there males in the hermaphroditic species Caenorhabditis elegans? Genetics 160, 983?994 (2002)","journal-title":"Genetics"},{"key":"BFnature07171_CR27","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/molbev\/msh267","volume":"22","author":"AD Cutter","year":"2005","unstructured":"Cutter, A. D. & Ward, S. Sexual and temporal dynamics of molecular evolution in C. elegans development. Mol. Biol. Evol. 22, 178?188 (2005)","journal-title":"Mol. Biol. Evol."},{"key":"BFnature07171_CR28","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/genetics\/160.3.975","volume":"160","author":"AD Stewart","year":"2002","unstructured":"Stewart, A. D. & Phillips, P. C. Selection and maintenance of androdioecy in Caenorhabditis elegans . Genetics 160, 975?982 (2002)","journal-title":"Genetics"},{"key":"BFnature07171_CR29","volume-title":"The Nematode","author":"JE Sulston","year":"1988","unstructured":"Sulston, J. E. & Hodgkin, J. in The Nematode Caenorhabditis elegans (Cold Spring Harbor Press, 1988)"},{"key":"BFnature07171_CR30","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1101\/gr.926603","volume":"13","author":"M Brudno","year":"2003","unstructured":"Brudno, M. et al. LAGAN and Multi-LAGAN: Efficient tools for large-scale multiple alignment of genomic DNA. Genome Res. 13, 721?731 (2003)","journal-title":"Genome Res."},{"key":"BFnature07171_CR31","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S1046-2023(03)00050-1","volume":"30","author":"RS Kamath","year":"2003","unstructured":"Kamath, R. S. & Ahringer, J. Genome-wide RNAi screening in Caenorhabditis elegans . Methods 30, 313?321 (2003)","journal-title":"Methods"},{"key":"BFnature07171_CR32","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1016\/S0960-9822(02)01110-7","volume":"12","author":"M Tijsterman","year":"2002","unstructured":"Tijsterman, M., Okihara, K. L., Thijssen, K. & Plasterk, R. H. PPW-1, a PAZ\/PIWI protein required for efficient germline RNAi, is defective in a natural isolate of C. elegans . Curr. Biol. 12, 1535?1540 (2002)","journal-title":"Curr. Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature07171.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature07171","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature07171.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:17:37Z","timestamp":1684419457000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature07171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,16]]},"references-count":32,"journal-issue":{"issue":"7207","published-print":{"date-parts":[[2008,8]]}},"alternative-id":["BFnature07171"],"URL":"https:\/\/doi.org\/10.1038\/nature07171","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1117867.573966","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1117867.572957","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,16]]}}}