{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:53:21Z","timestamp":1791410001932,"version":"4.3.3"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7229","license":[{"start":{"date-parts":[[2008,12,7]],"date-time":"2008-12-07T00:00:00Z","timestamp":1228608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1038\/nature07568","type":"journal-article","created":{"date-parts":[[2008,12,7]],"date-time":"2008-12-07T13:05:38Z","timestamp":1228655138000},"page":"594-598","source":"Crossref","is-referenced-by-count":195,"title":["Enterotoxigenic Escherichia coli EtpA mediates adhesion between flagella and host cells"],"prefix":"10.1038","volume":"457","author":[{"given":"Koushik","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Hilliard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiwen","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite M.","family":"Ostmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Fleckenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,12,7]]},"reference":[{"key":"BFnature07568_CR1","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1128\/IAI.73.1.18-29.2005","volume":"73","author":"AG Torres","year":"2005","unstructured":"Torres, A. G., Zhou, X. & Kaper, J. B. Adherence of diarrheagenic Escherichia coli strains to epithelial cells. Infect. Immun. 73, 18\u201329 (2005)","journal-title":"Infect. Immun."},{"key":"BFnature07568_CR2","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1111\/j.1462-5822.2006.00736.x","volume":"8","author":"FC Dorsey","year":"2006","unstructured":"Dorsey, F. C., Fischer, J. F. & Fleckenstein, J. M. Directed delivery of heat-labile enterotoxin by enterotoxigenic Escherichia coli . Cell. Microbiol. 8, 1516\u20131527 (2006)","journal-title":"Cell. Microbiol."},{"key":"BFnature07568_CR3","unstructured":"World Health Organization. Future directions for research on enterotoxigenic Escherichia coli vaccines for developing countries. Wkly Epidemiol. Rec. 81, 97\u2013104 (2006)"},{"key":"BFnature07568_CR4","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1128\/CMR.18.3.465-483.2005","volume":"18","author":"F Qadri","year":"2005","unstructured":"Qadri, F. et al. Enterotoxigenic Escherichia coli in developing countries: epidemiology, microbiology, clinical features, treatment, and prevention. Clin. Microbiol. Rev. 18, 465\u2013483 (2005)","journal-title":"Clin. Microbiol. Rev."},{"key":"BFnature07568_CR5","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1046\/j.1365-2958.2001.02278.x","volume":"40","author":"F Jacob-Dubuisson","year":"2001","unstructured":"Jacob-Dubuisson, F., Locht, C. & Antoine, R. Two-partner secretion in Gram-negative bacteria: a thrifty, specific pathway for large virulence proteins. Mol. Microbiol. 40, 306\u2013313 (2001)","journal-title":"Mol. Microbiol."},{"key":"BFnature07568_CR6","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1128\/IAI.74.4.2245-2258.2006","volume":"74","author":"JM Fleckenstein","year":"2006","unstructured":"Fleckenstein, J. M. et al. Identification of a two-partner secretion locus of enterotoxigenic Escherichia coli . Infect. Immun. 74, 2245\u20132258 (2006)","journal-title":"Infect. Immun."},{"key":"BFnature07568_CR7","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nature01830","volume":"424","author":"K Yonekura","year":"2003","unstructured":"Yonekura, K., Maki-Yonekura, S. & Namba, K. Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy. Nature 424, 643\u2013650 (2003)","journal-title":"Nature"},{"key":"BFnature07568_CR8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1128\/IAI.12.3.656-667.1975","volume":"12","author":"DG Evans","year":"1975","unstructured":"Evans, D. G. et al. Plasmid-controlled colonization factor associated with virulence in Escherichia coli enterotoxigenic for humans. Infect. Immun. 12, 656\u2013667 (1975)","journal-title":"Infect. Immun."},{"key":"BFnature07568_CR9","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1016\/0966-842X(96)10068-8","volume":"4","author":"W Gaastra","year":"1996","unstructured":"Gaastra, W. & Svennerholm, A. M. Colonization factors of human enterotoxigenic Escherichia coli (ETEC). Trends Microbiol. 4, 444\u2013452 (1996)","journal-title":"Trends Microbiol."},{"key":"BFnature07568_CR10","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1586\/14760584.7.6.795","volume":"7","author":"AM Svennerholm","year":"2008","unstructured":"Svennerholm, A. M. & Tobias, J. Vaccines against enterotoxigenic Escherichia coli . Expert Rev. Vaccines 7, 795\u2013804 (2008)","journal-title":"Expert Rev. Vaccines"},{"key":"BFnature07568_CR11","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1046\/j.1365-2958.2002.02899.x","volume":"44","author":"JA Giron","year":"2002","unstructured":"Giron, J. A. et al. The flagella of enteropathogenic Escherichia coli mediate adherence to epithelial cells. Mol. Microbiol. 44, 361\u2013379 (2002)","journal-title":"Mol. Microbiol."},{"key":"BFnature07568_CR12","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1128\/CMR.10.4.569","volume":"10","author":"MK Wolf","year":"1997","unstructured":"Wolf, M. K. Occurrence, distribution, and associations of O and H serogroups, colonization factor antigens, and toxins of enterotoxigenic Escherichia coli . Clin. Microbiol. Rev. 10, 569\u2013584 (1997)","journal-title":"Clin. Microbiol. Rev."},{"key":"BFnature07568_CR13","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1126\/science.290.5499.2148","volume":"290","author":"K Yonekura","year":"2000","unstructured":"Yonekura, K. et al. The bacterial flagellar cap as the rotary promoter of flagellin self-assembly. Science 290, 2148\u20132152 (2000)","journal-title":"Science"},{"key":"BFnature07568_CR14","first-page":"37","volume-title":"Protein\u2013Protein Interactions: A Molecular Cloning Manual","author":"V Sudakin","year":"2005","unstructured":"Sudakin, V. in Protein\u2013Protein Interactions: A Molecular Cloning Manual 2nd edn, Vol. 1 (eds Golemis, E. & Adams, P. D.) Ch. 3 37\u201354 (Cold Spring Harbor Laboratory Press, 2005)"},{"key":"BFnature07568_CR15","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul, S. F. et al. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 3389\u20133402 (1997)","journal-title":"Nucleic Acids Res."},{"key":"BFnature07568_CR16","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1046\/j.1365-2958.1999.01639.x","volume":"34","author":"K Komoriya","year":"1999","unstructured":"Komoriya, K. et al. Flagellar proteins and type III-exported virulence factors are the predominant proteins secreted into the culture media of Salmonella typhimurium . Mol. Microbiol. 34, 767\u2013779 (1999)","journal-title":"Mol. Microbiol."},{"key":"BFnature07568_CR17","doi-asserted-by":"publisher","first-page":"2556","DOI":"10.1126\/science.1066397","volume":"294","author":"Q Jin","year":"2001","unstructured":"Jin, Q. & He, S. Y. Role of the Hrp pilus in type III protein secretion in Pseudomonas syringae . Science 294, 2556\u20132558 (2001)","journal-title":"Science"},{"key":"BFnature07568_CR18","doi-asserted-by":"publisher","first-page":"15528","DOI":"10.1073\/pnas.2534343100","volume":"100","author":"S Maki-Yonekura","year":"2003","unstructured":"Maki-Yonekura, S., Yonekura, K. & Namba, K. Domain movements of HAP2 in the cap-filament complex formation and growth process of the bacterial flagellum. Proc. Natl Acad. Sci. USA 100, 15528\u201315533 (2003)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature07568_CR19","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/0076-6879(91)08030-L","volume":"208","author":"SP Goff","year":"1991","unstructured":"Goff, S. P. & Prasad, V. R. Linker insertion mutagenesis as probe of structure\u2013function relationships. Methods Enzymol. 208, 586\u2013603 (1991)","journal-title":"Methods Enzymol."},{"key":"BFnature07568_CR20","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1128\/IAI.01304-07","volume":"76","author":"K Roy","year":"2008","unstructured":"Roy, K. et al. The EtpA exoprotein of enterotoxigenic Escherichia coli promotes intestinal colonization and is a protective antigen in an experimental model of murine infection. Infect. Immun. 76, 2106\u20132112 (2008)","journal-title":"Infect. Immun."},{"key":"BFnature07568_CR21","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1046\/j.1365-2958.1997.4281787.x","volume":"24","author":"KM Ottemann","year":"1997","unstructured":"Ottemann, K. M. & Miller, J. F. Roles for motility in bacterial\u2013host interactions. Mol. Microbiol. 24, 1109\u20131117 (1997)","journal-title":"Mol. Microbiol."},{"key":"BFnature07568_CR22","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1086\/589862","volume":"47","author":"SA Plotkin","year":"2008","unstructured":"Plotkin, S. A. Vaccines: correlates of vaccine-induced immunity. Clin. Infect. Dis. 47, 401\u2013409 (2008)","journal-title":"Clin. Infect. Dis."},{"key":"BFnature07568_CR23","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.jmb.2007.10.067","volume":"376","author":"XQ Mu","year":"2008","unstructured":"Mu, X. Q., Savarino, S. J. & Bullitt, E. The three-dimensional structure of CFA\/I adhesion pili: traveler\u2019s diarrhea bacteria hang on by a spring. J. Mol. Biol. 376, 614\u2013620 (2008)","journal-title":"J. Mol. Biol."},{"key":"BFnature07568_CR24","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/j.1365-2958.2006.05236.x","volume":"61","author":"AZ Buscher","year":"2006","unstructured":"Buscher, A. Z. et al. Surface anchoring of a bacterial adhesin secreted by the two-partner secretion pathway. Mol. Microbiol. 61, 470\u2013483 (2006)","journal-title":"Mol. Microbiol."},{"key":"BFnature07568_CR25","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1038\/ni1011","volume":"4","author":"KD Smith","year":"2003","unstructured":"Smith, K. D. et al. Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Nature Immunol. 4, 1247\u20131253 (2003)","journal-title":"Nature Immunol."},{"key":"BFnature07568_CR26","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1128\/IAI.74.2.869-875.2006","volume":"74","author":"KP Allen","year":"2006","unstructured":"Allen, K. P., Randolph, M. M. & Fleckenstein, J. M. Importance of heat-labile enterotoxin in colonization of the adult mouse small intestine by human enterotoxigenic Escherichia coli strains. Infect. Immun. 74, 869\u2013875 (2006)","journal-title":"Infect. Immun."},{"key":"BFnature07568_CR27","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1021\/pr060472y","volume":"6","author":"ED Cummings","year":"2007","unstructured":"Cummings, E. D. et al. High-throughput proteomics processing of proteins in polyacrylamide in a multiwell format. J. Proteome Res. 6, 1603\u20131608 (2007)","journal-title":"J. Proteome Res."},{"key":"BFnature07568_CR28","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1021\/ac991363o","volume":"72","author":"W Zhang","year":"2000","unstructured":"Zhang, W. & Chait, B. T. ProFound: an expert system for protein identification using mass spectrometric peptide mapping information. Anal. Chem. 72, 2482\u20132489 (2000)","journal-title":"Anal. Chem."},{"key":"BFnature07568_CR29","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1038\/35074106","volume":"410","author":"F Hayashi","year":"2001","unstructured":"Hayashi, F. et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410, 1099\u20131103 (2001)","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature07568.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature07568","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature07568.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:20:50Z","timestamp":1684419650000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature07568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,7]]},"references-count":29,"journal-issue":{"issue":"7229","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["BFnature07568"],"URL":"https:\/\/doi.org\/10.1038\/nature07568","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1147316.605123","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1147316.604471","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,7]]}}}