{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:49:50Z","timestamp":1791298190836,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"7234","license":[{"start":{"date-parts":[[2009,1,11]],"date-time":"2009-01-11T00:00:00Z","timestamp":1231632000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1038\/nature07638","type":"journal-article","created":{"date-parts":[[2009,1,11]],"date-time":"2009-01-11T12:58:22Z","timestamp":1231678702000},"page":"97-101","source":"Crossref","is-referenced-by-count":776,"title":["Transcriptome sequencing to detect gene fusions in cancer"],"prefix":"10.1038","volume":"458","author":[{"given":"Christopher A.","family":"Maher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan","family":"Kumar-Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanker","family":"Kalyana-Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Sam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terrence","family":"Barrette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nallasivam","family":"Palanisamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arul M.","family":"Chinnaiyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,1,11]]},"reference":[{"key":"BFnature07638_CR1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/ng1335","volume":"36","author":"F Mitelman","year":"2004","unstructured":"Mitelman, F., Johansson, B. & Mertens, F. Fusion genes and rearranged genes as a linear function of chromosome aberrations in cancer. Nature Genet. 36, 331\u2013334 (2004)","journal-title":"Nature Genet."},{"key":"BFnature07638_CR2","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1126\/science.1117679","volume":"310","author":"SA Tomlins","year":"2005","unstructured":"Tomlins, S. A. et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310, 644\u2013648 (2005)","journal-title":"Science"},{"key":"BFnature07638_CR3","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/nature06024","volume":"448","author":"SA Tomlins","year":"2007","unstructured":"Tomlins, S. A. et al. Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature 448, 595\u2013599 (2007)","journal-title":"Nature"},{"key":"BFnature07638_CR4","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/nrc2402","volume":"8","author":"C Kumar-Sinha","year":"2008","unstructured":"Kumar-Sinha, C., Tomlins, S. A. & Chinnaiyan, A. M. Recurrent gene fusions in prostate cancer. Nature Rev. Cancer 8, 497\u2013511 (2008)","journal-title":"Nature Rev. Cancer"},{"key":"BFnature07638_CR5","doi-asserted-by":"publisher","first-page":"4971","DOI":"10.1158\/0008-5472.CAN-07-6158","volume":"68","author":"YL Choi","year":"2008","unstructured":"Choi, Y. L. et al. Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res. 68, 4971\u20134976 (2008)","journal-title":"Cancer Res."},{"key":"BFnature07638_CR6","doi-asserted-by":"publisher","first-page":"4275","DOI":"10.1158\/1078-0432.CCR-08-0168","volume":"14","author":"JP Koivunen","year":"2008","unstructured":"Koivunen, J. P. et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin. Cancer Res. 14, 4275\u20134283 (2008)","journal-title":"Clin. Cancer Res."},{"key":"BFnature07638_CR7","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1593\/neo.07878","volume":"10","author":"S Perner","year":"2008","unstructured":"Perner, S. et al. EML4-ALK fusion lung cancer: a rare acquired event. Neoplasia 10, 298\u2013302 (2008)","journal-title":"Neoplasia"},{"key":"BFnature07638_CR8","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.cell.2007.11.025","volume":"131","author":"K Rikova","year":"2007","unstructured":"Rikova, K. et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 131, 1190\u20131203 (2007)","journal-title":"Cell"},{"key":"BFnature07638_CR9","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/nature05945","volume":"448","author":"M Soda","year":"2007","unstructured":"Soda, M. et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448, 561\u2013566 (2007)","journal-title":"Nature"},{"key":"BFnature07638_CR10","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/35106108","volume":"1","author":"JD Rowley","year":"2001","unstructured":"Rowley, J. D. Chromosome translocations: dangerous liaisons revisited. Nature Rev. Cancer 1, 245\u2013250 (2001)","journal-title":"Nature Rev. Cancer"},{"key":"BFnature07638_CR11","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1056\/NEJMoa040938","volume":"350","author":"TJ Lynch","year":"2004","unstructured":"Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129\u2013239 (2004)","journal-title":"N. Engl. J. Med."},{"key":"BFnature07638_CR12","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1056\/NEJM200103153441101","volume":"344","author":"DJ Slamon","year":"2001","unstructured":"Slamon, D. J. et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344, 783\u2013792 (2001)","journal-title":"N. Engl. J. Med."},{"key":"BFnature07638_CR13","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1056\/NEJMoa020461","volume":"347","author":"GD Demetri","year":"2002","unstructured":"Demetri, G. D. et al. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N. Engl. J. Med. 347, 472\u2013480 (2002)","journal-title":"N. Engl. J. Med."},{"key":"BFnature07638_CR14","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1056\/NEJMoa062867","volume":"355","author":"BJ Druker","year":"2006","unstructured":"Druker, B. J. et al. Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia. N. Engl. J. Med. 355, 2408\u20132417 (2006)","journal-title":"N. Engl. J. Med."},{"key":"BFnature07638_CR15","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nrc1299","volume":"4","author":"PA Futreal","year":"2004","unstructured":"Futreal, P. A. et al. A census of human cancer genes. Nature Rev. Cancer 4, 177\u2013183 (2004)","journal-title":"Nature Rev. Cancer"},{"key":"BFnature07638_CR16","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/315550a0","volume":"315","author":"E Shtivelman","year":"1985","unstructured":"Shtivelman, E., Lifshitz, B., Gale, R. P. & Canaani, E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature 315, 550\u2013554 (1985)","journal-title":"Nature"},{"key":"BFnature07638_CR17","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.molcel.2005.03.018","volume":"18","author":"T Takahara","year":"2005","unstructured":"Takahara, T., Tasic, B., Maniatis, T., Akanuma, H. & Yanagisawa, S. Delay in synthesis of the 3\u2032 splice site promotes trans-splicing of the preceding 5\u2032 splice site. Mol. Cell 18, 245\u2013251 (2005)","journal-title":"Mol. Cell"},{"key":"BFnature07638_CR18","doi-asserted-by":"publisher","first-page":"16561","DOI":"10.1074\/jbc.M009609200","volume":"276","author":"D Communi","year":"2001","unstructured":"Communi, D., Suarez-Huerta, N., Dussossoy, D., Savi, P. & Boeynaems, J. M. Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. J. Biol. Chem. 276, 16561\u201316566 (2001)","journal-title":"J. Biol. Chem."},{"key":"BFnature07638_CR19","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1002\/pros.20499","volume":"66","author":"M Gleave","year":"2006","unstructured":"Gleave, M. et al. The effects of the dual 5\u03b1-reductase inhibitor dutasteride on localized prostate cancer \u2013 results from a 4-month pre-radical prostatectomy study. Prostate 66, 1674\u20131685 (2006)","journal-title":"Prostate"},{"key":"BFnature07638_CR20","doi-asserted-by":"publisher","first-page":"7629","DOI":"10.1158\/0008-5472.CAN-08-2014","volume":"68","author":"B Han","year":"2008","unstructured":"Han, B. et al. A fluorescence in situ hybridization screen for E26 transformation-specific aberrations: identification of DDX5\u2013ETV4 fusion protein in prostate cancer. Cancer Res. 68, 7629\u20137637 (2008)","journal-title":"Cancer Res."},{"key":"BFnature07638_CR21","doi-asserted-by":"publisher","first-page":"2883","DOI":"10.1056\/NEJM200412303512724","volume":"351","author":"TD Barber","year":"2004","unstructured":"Barber, T. D., Vogelstein, B., Kinzler, K. W. & Velculescu, V. E. Somatic mutations of EGFR in colorectal cancers and glioblastomas. N. Engl. J. Med. 351, 2883 (2004)","journal-title":"N. Engl. J. Med."},{"key":"BFnature07638_CR22","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1038\/35057192","volume":"409","author":"VG Cheung","year":"2001","unstructured":"Cheung, V. G. et al. Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature 409, 953\u2013958 (2001)","journal-title":"Nature"},{"key":"BFnature07638_CR23","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1038\/nature05610","volume":"446","author":"C Greenman","year":"2007","unstructured":"Greenman, C. et al. Patterns of somatic mutation in human cancer genomes. Nature 446, 153\u2013158 (2007)","journal-title":"Nature"},{"key":"BFnature07638_CR24","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/ng1571","volume":"37","author":"P Stephens","year":"2005","unstructured":"Stephens, P. et al. A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nature Genet. 37, 590\u2013592 (2005)","journal-title":"Nature Genet."},{"key":"BFnature07638_CR25","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0168-9525(99)01937-X","volume":"16","author":"RL Strausberg","year":"2000","unstructured":"Strausberg, R. L., Buetow, K. H., Emmert-Buck, M. R. & Klausner, R. D. The cancer genome anatomy project: building an annotated gene index. Trends Genet. 16, 103\u2013106 (2000)","journal-title":"Trends Genet."},{"key":"BFnature07638_CR26","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1038\/nature06358","volume":"450","author":"BA Weir","year":"2007","unstructured":"Weir, B. A. et al. Characterizing the cancer genome in lung adenocarcinoma. Nature 450, 893\u2013898 (2007)","journal-title":"Nature"},{"key":"BFnature07638_CR27","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1126\/science.1145720","volume":"318","author":"LD Wood","year":"2007","unstructured":"Wood, L. D. et al. The genomic landscapes of human breast and colorectal cancers. Science 318, 1108\u20131113 (2007)","journal-title":"Science"},{"key":"BFnature07638_CR28","first-page":"163","volume":"15","author":"S Korenchuk","year":"2001","unstructured":"Korenchuk, S. et al. VCaP, a cell-based model system of human prostate cancer. In Vivo 15, 163\u2013168 (2001)","journal-title":"In Vivo"},{"key":"BFnature07638_CR29","first-page":"1038","volume":"6","author":"MA Rubin","year":"2000","unstructured":"Rubin, M. A. et al. Rapid (\u2018warm\u2019) autopsy study for procurement of metastatic prostate cancer. Clin. Cancer Res. 6, 1038\u20131045 (2000)","journal-title":"Clin. Cancer Res."},{"key":"BFnature07638_CR30","doi-asserted-by":"publisher","first-page":"D493","DOI":"10.1093\/nar\/gkh103","volume":"32","author":"D Karolchik","year":"2004","unstructured":"Karolchik, D. et al. The UCSC Table Browser data retrieval tool. Nucleic Acids Res. 32 (Database issue). D493\u2013D496 (2004)","journal-title":"Nucleic Acids Res."},{"key":"BFnature07638_CR31","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S1570-8667(03)00065-0","volume":"2","author":"MI Abouelhoda","year":"2004","unstructured":"Abouelhoda, M. I., Kurtz, S. & Ohlebusch, E. Replacing suffix trees with enhanced suffix arrays. J. Discrete Algorithms 2, 53\u201386 (2004)","journal-title":"J. Discrete Algorithms"},{"key":"BFnature07638_CR32","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1101\/gr.229202","volume":"12","author":"WJ Kent","year":"2002","unstructured":"Kent, W. J. BLAT \u2013 the BLAST-like alignment tool. Genome Res. 12, 656\u2013664 (2002)","journal-title":"Genome Res."},{"key":"BFnature07638_CR33","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/gb-2002-3-7-research0034","volume":"3","author":"J Vandesompele","year":"2002","unstructured":"Vandesompele, J. et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3, 34\u201350 (2002)","journal-title":"Genome Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature07638.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature07638","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature07638.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:21:21Z","timestamp":1684419681000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature07638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1,11]]},"references-count":33,"journal-issue":{"issue":"7234","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["BFnature07638"],"URL":"https:\/\/doi.org\/10.1038\/nature07638","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1158903.620157","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,1,11]]}}}