{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:53:24Z","timestamp":1791158004883,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7237","license":[{"start":{"date-parts":[[2009,2,8]],"date-time":"2009-02-08T00:00:00Z","timestamp":1234051200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1038\/nature07687","type":"journal-article","created":{"date-parts":[[2009,2,10]],"date-time":"2009-02-10T05:23:42Z","timestamp":1234243422000},"page":"519-523","source":"Crossref","is-referenced-by-count":143,"title":["Dynamic expression of epidermal caspase 8 simulates a wound healing response"],"prefix":"10.1038","volume":"458","author":[{"given":"Pedro","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai-Jen","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Ch\u2019en","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Jamora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,2,8]]},"reference":[{"key":"BFnature07687_CR1","doi-asserted-by":"publisher","first-page":"11830","DOI":"10.1073\/pnas.1734203100","volume":"100","author":"L Alonso","year":"2003","unstructured":"Alonso, L. & Fuchs, E. Stem cells of the skin epithelium. Proc. Natl Acad. Sci. USA 100 (Suppl. 1). 11830\u201311835 (2003)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature07687_CR2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1038\/sj.jid.5700008","volume":"126","author":"D Raj","year":"2006","unstructured":"Raj, D., Brash, D. E. & Grossman, D. Keratinocyte apoptosis in epidermal development and disease. J. Invest. Dermatol. 126, 243\u2013257 (2006)","journal-title":"J. Invest. Dermatol."},{"key":"BFnature07687_CR3","doi-asserted-by":"publisher","first-page":"8551","DOI":"10.1073\/pnas.96.15.8551","volume":"96","author":"V Vasioukhin","year":"1999","unstructured":"Vasioukhin, V., Degenstein, L., Wise, B. & Fuchs, E. The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin. Proc. Natl Acad. Sci. USA 96, 8551\u20138556 (1999)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature07687_CR4","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.4049\/jimmunol.175.6.3469","volume":"175","author":"DR Beisner","year":"2005","unstructured":"Beisner, D. R., Ch\u2019en, I. L., Kolla, R. V., Hoffmann, A. & Hedrick, S. M. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. J. Immunol. 175, 3469\u20133473 (2005)","journal-title":"J. Immunol."},{"key":"BFnature07687_CR5","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/nm1328","volume":"11","author":"M Ito","year":"2005","unstructured":"Ito, M. et al. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nature Med. 11, 1351\u20131354 (2005)","journal-title":"Nature Med."},{"key":"BFnature07687_CR6","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.devcel.2005.11.003","volume":"9","author":"V Levy","year":"2005","unstructured":"Levy, V., Lindon, C., Harfe, B. D. & Morgan, B. A. Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev. Cell 9, 855\u2013861 (2005)","journal-title":"Dev. Cell"},{"key":"BFnature07687_CR7","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1038\/sj.jid.5700376","volume":"126","author":"G Cotsarelis","year":"2006","unstructured":"Cotsarelis, G. Epithelial stem cells: a folliculocentric view. J. Invest. Dermatol. 126, 1459\u20131468 (2006)","journal-title":"J. Invest. Dermatol."},{"key":"BFnature07687_CR8","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.tcb.2005.09.002","volume":"15","author":"P Martin","year":"2005","unstructured":"Martin, P. & Leibovich, S. J. Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 15, 599\u2013607 (2005)","journal-title":"Trends Cell Biol."},{"key":"BFnature07687_CR9","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/j.1600-065X.2006.00483.x","volume":"215","author":"J Jameson","year":"2007","unstructured":"Jameson, J. & Havran, W. L. Skin \u03b3\u03b4 T-cell functions in homeostasis and wound healing. Immunol. Rev. 215, 114\u2013122 (2007)","journal-title":"Immunol. Rev."},{"key":"BFnature07687_CR10","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1016\/j.bbrc.2007.03.082","volume":"356","author":"M Ichinohe","year":"2007","unstructured":"Ichinohe, M. et al. Lack of phospholipase C-\u03b41 induces skin inflammation. Biochem. Biophys. Res. Commun. 356, 912\u2013918 (2007)","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFnature07687_CR11","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.cell.2005.11.043","volume":"124","author":"M Perez-Moreno","year":"2006","unstructured":"Perez-Moreno, M. et al. p120-catenin mediates inflammatory responses in the skin. Cell 124, 631\u2013644 (2006)","journal-title":"Cell"},{"key":"BFnature07687_CR12","doi-asserted-by":"publisher","first-page":"19798","DOI":"10.1074\/jbc.M300513200","volume":"278","author":"RM Hobbs","year":"2003","unstructured":"Hobbs, R. M. & Watt, F. M. Regulation of interleukin-1\u03b1 expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease. J. Biol. Chem. 278, 19798\u201319807 (2003)","journal-title":"J. Biol. Chem."},{"key":"BFnature07687_CR13","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/j.0022-202X.2004.23225.x","volume":"123","author":"RM Hobbs","year":"2004","unstructured":"Hobbs, R. M., Silva-Vargas, V., Groves, R. & Watt, F. M. Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions. J. Invest. Dermatol. 123, 503\u2013515 (2004)","journal-title":"J. Invest. Dermatol."},{"key":"BFnature07687_CR14","doi-asserted-by":"publisher","first-page":"5697","DOI":"10.4049\/jimmunol.170.11.5697","volume":"170","author":"JE Murphy","year":"2003","unstructured":"Murphy, J. E., Morales, R. E., Scott, J. & Kupper, T. S. IL-1\u03b1, innate immunity, and skin carcinogenesis: the effect of constitutive expression of IL-1\u03b1 in epidermis on chemical carcinogenesis. J. Immunol. 170, 5697\u20135703 (2003)","journal-title":"J. Immunol."},{"key":"BFnature07687_CR15","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0962-8924(01)01955-9","volume":"11","author":"S Werner","year":"2001","unstructured":"Werner, S. & Smola, H. Paracrine regulation of keratinocyte proliferation and differentiation. Trends Cell Biol. 11, 143\u2013146 (2001)","journal-title":"Trends Cell Biol."},{"key":"BFnature07687_CR16","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.4049\/jimmunol.136.9.3317","volume":"136","author":"C Hauser","year":"1986","unstructured":"Hauser, C., Saurat, J. H., Schmitt, A., Jaunin, F. & Dayer, J. M. Interleukin 1 is present in normal human epidermis. J. Immunol. 136, 3317\u20133323 (1986)","journal-title":"J. Immunol."},{"key":"BFnature07687_CR17","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1083\/jcb.149.5.999","volume":"149","author":"CK Kaufman","year":"2000","unstructured":"Kaufman, C. K. & Fuchs, E. It\u2019s got you covered. NF-\u03baB in the epidermis. J. Cell Biol. 149, 999\u20131004 (2000)","journal-title":"J. Cell Biol."},{"key":"BFnature07687_CR18","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1046\/j.1523-1747.2000.00917.x","volume":"114","author":"JE Murphy","year":"2000","unstructured":"Murphy, J. E., Robert, C. & Kupper, T. S. Interleukin-1 and cutaneous inflammation: a crucial link between innate and acquired immunity. J. Invest. Dermatol. 114, 602\u2013608 (2000)","journal-title":"J. Invest. Dermatol."},{"key":"BFnature07687_CR19","doi-asserted-by":"publisher","first-page":"997","DOI":"10.4049\/jimmunol.165.2.997","volume":"165","author":"K Yamanaka","year":"2000","unstructured":"Yamanaka, K. et al. Skin-specific caspase-1-transgenic mice show cutaneous apoptosis and pre-endotoxin shock condition with a high serum level of IL-18. J. Immunol. 165, 997\u20131003 (2000)","journal-title":"J. Immunol."},{"key":"BFnature07687_CR20","doi-asserted-by":"publisher","first-page":"11874","DOI":"10.1073\/pnas.92.25.11874","volume":"92","author":"RW Groves","year":"1995","unstructured":"Groves, R. W., Mizutani, H., Kieffer, J. D. & Kupper, T. S. Inflammatory skin disease in transgenic mice that express high levels of interleukin 1\u03b1 in basal epidermis. Proc. Natl Acad. Sci. USA 92, 11874\u201311878 (1995)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature07687_CR21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.tcb.2007.10.004","volume":"18","author":"B Faustin","year":"2008","unstructured":"Faustin, B. & Reed, J. C. Sunburned skin activates inflammasomes. Trends Cell Biol. 18, 4\u20138 (2008)","journal-title":"Trends Cell Biol."},{"key":"BFnature07687_CR22","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.cub.2007.05.074","volume":"17","author":"L Feldmeyer","year":"2007","unstructured":"Feldmeyer, L. et al. The inflammasome mediates UVB-induced activation and secretion of interleukin-1\u03b2 by keratinocytes. Curr. Biol. 17, 1140\u20131145 (2007)","journal-title":"Curr. Biol."},{"key":"BFnature07687_CR23","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1038\/sj.jid.5700922","volume":"127","author":"C Johansen","year":"2007","unstructured":"Johansen, C., Moeller, K., Kragballe, K. & Iversen, L. The activity of caspase-1 is increased in lesional psoriatic epidermis. J. Invest. Dermatol. 127, 2857\u20132864 (2007)","journal-title":"J. Invest. Dermatol."},{"key":"BFnature07687_CR24","doi-asserted-by":"publisher","first-page":"487","DOI":"10.2337\/diabetes.55.02.06.db05-1201","volume":"55","author":"HA Al-Mashat","year":"2006","unstructured":"Al-Mashat, H. A. et al. Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing. Diabetes 55, 487\u2013495 (2006)","journal-title":"Diabetes"},{"key":"BFnature07687_CR25","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/nature01063","volume":"419","author":"HJ Chun","year":"2002","unstructured":"Chun, H. J. et al. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 419, 395\u2013399 (2002)","journal-title":"Nature"},{"key":"BFnature07687_CR26","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.gene.2004.05.002","volume":"338","author":"JP Anderson","year":"2004","unstructured":"Anderson, J. P. et al. Structural, expression, and evolutionary analysis of mouse CIAS1. Gene 338, 25\u201334 (2004)","journal-title":"Gene"},{"key":"BFnature07687_CR27","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1016\/S0021-9258(18)38163-8","volume":"266","author":"D Hohl","year":"1991","unstructured":"Hohl, D. et al. Characterization of human loricrin. Structure and function of a new class of epidermal cell envelope proteins. J. Biol. Chem. 266, 6626\u20136636 (1991)","journal-title":"J. Biol. Chem."},{"key":"BFnature07687_CR28","doi-asserted-by":"publisher","first-page":"4189","DOI":"10.4049\/jimmunol.175.7.4189","volume":"175","author":"RN Aravalli","year":"2005","unstructured":"Aravalli, R. N., Hu, S., Rowen, T. N., Palmquist, J. M. & Lokensgard, J. R. Cutting edge: TLR2-mediated proinflammatory cytokine and chemokine production by microglial cells in response to herpes simplex virus. J. Immunol. 175, 4189\u20134193 (2005)","journal-title":"J. Immunol."},{"key":"BFnature07687_CR29","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.1073\/pnas.0510422103","volume":"103","author":"A Kobielak","year":"2006","unstructured":"Kobielak, A. & Fuchs, E. Links between \u03b1-catenin, NF-\u03baB, and squamous cell carcinoma in skin. Proc. Natl Acad. Sci. USA 103, 2322\u20132327 (2006)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature07687_CR30","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1083\/jcb.200711082","volume":"181","author":"J Li","year":"2008","unstructured":"Li, J., Yin, H. L. & Yuan, J. Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. J. Cell Biol. 181, 321\u2013333 (2008)","journal-title":"J. Cell Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature07687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature07687","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature07687.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T19:11:34Z","timestamp":1684869094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature07687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,8]]},"references-count":30,"journal-issue":{"issue":"7237","published-print":{"date-parts":[[2009,3]]}},"alternative-id":["BFnature07687"],"URL":"https:\/\/doi.org\/10.1038\/nature07687","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1160132.620421","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,8]]}}}