{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:43:02Z","timestamp":1791420182204,"version":"4.3.3"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"7241","license":[{"start":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T00:00:00Z","timestamp":1236124800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1038\/nature07831","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T13:23:49Z","timestamp":1236173029000},"page":"1034-1038","source":"Crossref","is-referenced-by-count":553,"title":["Glycerol monolaurate prevents mucosal SIV transmission"],"prefix":"10.1038","volume":"458","author":[{"given":"Qingsheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob D.","family":"Estes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Schlievert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J.","family":"Brosnahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Southern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cavan S.","family":"Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marnie L.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Schultz-Darken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla R.","family":"Nephew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Pambuccian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Lifson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John V.","family":"Carlis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley T.","family":"Haase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,3,4]]},"reference":[{"key":"BFnature07831_CR1","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1038\/453289a","volume":"453","author":"AS Fauci","year":"2008","unstructured":"Fauci, A. S. 25 years of HIV. Nature 453, 289\u2013290 (2008)","journal-title":"Nature"},{"key":"BFnature07831_CR2","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/450325a","volume":"450","author":"H Ledford","year":"2007","unstructured":"Ledford, H. HIV vaccine may raise risk. Nature 450, 325 (2007)","journal-title":"Nature"},{"key":"BFnature07831_CR3","first-page":"12","volume":"446","author":"E Check","year":"2007","unstructured":"Check, E. Scientists rethink approach to HIV gels. Nature 446, 12 (2007)","journal-title":"Nature"},{"key":"BFnature07831_CR4","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1126\/science.319.5866.1026b","volume":"319","author":"J Cohen","year":"2008","unstructured":"Cohen, J. AIDS research. Microbicide fails to protect against HIV. Science 319, 1026\u20131027 (2008)","journal-title":"Science"},{"key":"BFnature07831_CR5","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1038\/nri1706","volume":"5","author":"AT Haase","year":"2005","unstructured":"Haase, A. T. Perils at mucosal front lines for HIV and SIV and their hosts. Nature Rev. Immunol. 5, 783\u2013792 (2005)","journal-title":"Nature Rev. Immunol."},{"key":"BFnature07831_CR6","doi-asserted-by":"publisher","first-page":"9217","DOI":"10.1128\/JVI.79.14.9217-9227.2005","volume":"79","author":"CJ Miller","year":"2005","unstructured":"Miller, C. J. et al. Propagation and dissemination of infection after vaginal transmission of SIV. J. Virol. 79, 9217\u20139227 (2005)","journal-title":"J. Virol."},{"key":"BFnature07831_CR7","first-page":"305","volume-title":"Cosmetic and Drug Preservation","author":"JJ Kabara","year":"1984","unstructured":"Kabara, J. J. in Cosmetic and Drug Preservation (eds Kabara, J. J. et al.) 305\u2013322 (Marcel Dekker, Inc, 1984)"},{"key":"BFnature07831_CR8","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1021\/bi051992u","volume":"45","author":"ML Peterson","year":"2006","unstructured":"Peterson, M. L. & Schlievert, P. M. Glycerol monolaurate inhibits the effects of Gram-positive select agents on eukaryotic cells. Biochemistry 45, 2387\u20132397 (2006)","journal-title":"Biochemistry"},{"key":"BFnature07831_CR9","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1038\/nature03513","volume":"434","author":"Q Li","year":"2005","unstructured":"Li, Q. et al. Peak SIV replication in resting memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 434, 1148\u20131152 (2005)","journal-title":"Nature"},{"key":"BFnature07831_CR10","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1038\/nature03501","volume":"434","author":"JJ Mattapallil","year":"2005","unstructured":"Mattapallil, J. J. et al. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 434, 1093\u20131097 (2005)","journal-title":"Nature"},{"key":"BFnature07831_CR11","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/ni1141","volume":"5","author":"M Colonna","year":"2004","unstructured":"Colonna, M., Trinchieri, G. & Liu, Y. J. Plasmacytoid dendritic cells in immunity. Nature Immunol. 5, 1219\u20131226 (2004)","journal-title":"Nature Immunol."},{"key":"BFnature07831_CR12","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1086\/500368","volume":"193","author":"JD Estes","year":"2006","unstructured":"Estes, J. D. et al. Premature induction of an immunosuppressive regulatory T cell response during acute simian immunodeficiency virus infection. J. Infect. Dis. 193, 703\u2013712 (2006)","journal-title":"J. Infect. Dis."},{"key":"BFnature07831_CR13","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1002\/jlb.66.2.252","volume":"66","author":"MC Dieu-Nosjean","year":"1999","unstructured":"Dieu-Nosjean, M. C., Vicari, A., Lebecque, S. & Caux, C. Regulation of dendritic cell trafficking: a process that involves the participation of selective chemokines. J. Leukoc. Biol. 66, 252\u2013262 (1999)","journal-title":"J. Leukoc. Biol."},{"key":"BFnature07831_CR14","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1128\/AAC.36.3.626","volume":"36","author":"PM Schlievert","year":"1992","unstructured":"Schlievert, P. M., Deringer, J. R., Kim, M. H., Projan, S. J. & Novick, R. P. Effect of glycerol monolaurate on bacterial growth and toxin production. Antimicrob. Agents Chemother. 36, 626\u2013632 (1992)","journal-title":"Antimicrob. Agents Chemother."},{"key":"BFnature07831_CR15","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1089\/aid.2005.21.228","volume":"21","author":"R Narimatsu","year":"2005","unstructured":"Narimatsu, R., Wolday, D. & Patterson, B. K. IL-8 increases transmission of HIV type 1 in cervical explant tissue. AIDS Res. Hum. Retroviruses 21, 228\u2013233 (2005)","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"BFnature07831_CR16","doi-asserted-by":"publisher","first-page":"4448","DOI":"10.1128\/AAC.00989-08","volume":"52","author":"PM Schlievert","year":"2008","unstructured":"Schlievert, P. M. et al. Glycerol monolaurate does not alter rhesus macaque (Macaca mulatta) vaginal lactobacilli and is safe for chronic use. Antimicrob. Agents Chemother. 52, 4448\u20134454 (2008)","journal-title":"Antimicrob. Agents Chemother."},{"key":"BFnature07831_CR17","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1128\/IAI.73.1.476-484.2005","volume":"73","author":"MA Crane-Godreau","year":"2005","unstructured":"Crane-Godreau, M. A. & Wira, C. R. CCL20\/macrophage inflammatory protein 3\u03b1 and tumor necrosis factor \u03b1 production by primary uterine epithelial cells in response to treatment with lipopolysaccharide or Pam3Cys. Infect. Immun. 73, 476\u2013484 (2005)","journal-title":"Infect. Immun."},{"key":"BFnature07831_CR18","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1111\/j.0105-2896.2005.00287.x","volume":"206","author":"CR Wira","year":"2005","unstructured":"Wira, C. R., Fahey, J. V., Sentman, C. L., Pioli, P. A. & Shen, L. Innate and adaptive immunity in female genital tract: cellular responses and interactions. Immunol. Rev. 206, 306\u2013335 (2005)","journal-title":"Immunol. Rev."},{"key":"BFnature07831_CR19","doi-asserted-by":"publisher","first-page":"14355","DOI":"10.1128\/JVI.79.22.14355-14370.2005","volume":"79","author":"Y Wang","year":"2005","unstructured":"Wang, Y. et al. The Toll-like receptor 7 (TLR7) agonist, imiquimod, and the TLR9 agonist, CpG ODN, induce antiviral cytokines and chemokines but do not prevent vaginal transmission of simian immunodeficiency virus when applied intravaginally to rhesus macaques. J. Virol. 79, 14355\u201314370 (2005)","journal-title":"J. Virol."},{"key":"BFnature07831_CR20","doi-asserted-by":"publisher","first-page":"e351","DOI":"10.1371\/journal.pmed.0030351","volume":"3","author":"PJ Klasse","year":"2006","unstructured":"Klasse, P. J., Shattock, R. J. & Moore, J. P. Which topical microbicides for blocking HIV-1 transmission will work in the real world? PLoS Med. 3, e351 (2006)","journal-title":"PLoS Med."},{"key":"BFnature07831_CR21","doi-asserted-by":"publisher","first-page":"14048","DOI":"10.1128\/JVI.78.24.14048-14052.2004","volume":"78","author":"Z-M Ma","year":"2004","unstructured":"Ma, Z.-M., Abel, K., Rourke, T., Wang, Y. & Miller, C. J. A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low-dose intravaginal simian immunodeficiency virus inoculations. J. Virol. 78, 14048\u201314052 (2004)","journal-title":"J. Virol."},{"key":"BFnature07831_CR22","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1089\/108729102760330263","volume":"16","author":"R Johnston","year":"2002","unstructured":"Johnston, R. Microbicides 2002: an update. AIDS Patient Care STDS 16, 419\u2013430 (2002)","journal-title":"AIDS Patient Care STDS"},{"key":"BFnature07831_CR23","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nrmicro729","volume":"1","author":"RJ Shattock","year":"2003","unstructured":"Shattock, R. J. & Moore, J. P. Inhibiting sexual transmission of HIV-1 infection. Nature Rev. Microbiol. 1, 25\u201334 (2003)","journal-title":"Nature Rev. Microbiol."},{"key":"BFnature07831_CR24","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/j.1600-0684.2005.00128.x","volume":"34","author":"AN Cline","year":"2005","unstructured":"Cline, A. N., Bess, J. W., Piatak, M. & Lifson, J. D. Highly sensitive SIV plasma viral load assay: practical considerations, realistic performance expectations, and application to reverse engineering of vaccines for AIDS. J. Med. Primatol. 34, 303\u2013312 (2005)","journal-title":"J. Med. Primatol."},{"key":"BFnature07831_CR25","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1128\/IAI.73.4.2164-2174.2005","volume":"73","author":"ML Peterson","year":"2005","unstructured":"Peterson, M. L. et al. The innate immune system is activated by stimulation of vaginal epithelial cells with Staphylococcus aureus and toxic shock syndrome toxin 1. Infect. Immun. 73, 2164\u20132174 (2005)","journal-title":"Infect. Immun."},{"key":"BFnature07831_CR26","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1086\/381396","volume":"189","author":"Q Li","year":"2004","unstructured":"Li, Q. et al. Functional genomic analysis of the response of HIV-1 infected lymphatic tissue to antiretroviral therapy. J. Infect. Dis. 189, 572\u2013582 (2004)","journal-title":"J. Infect. Dis."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature07831.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature07831","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature07831.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:22:36Z","timestamp":1684419756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature07831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,4]]},"references-count":26,"journal-issue":{"issue":"7241","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["BFnature07831"],"URL":"https:\/\/doi.org\/10.1038\/nature07831","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1157442.623126","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1157442.617601","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1157442.619213","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1157442.617948","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1157442.618416","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3,4]]}}}