{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T21:10:22Z","timestamp":1792444222314,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7293","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1038\/nature08901","type":"journal-article","created":{"date-parts":[[2010,3,3]],"date-time":"2010-03-03T13:21:02Z","timestamp":1267622462000},"page":"1362-1366","source":"Crossref","is-referenced-by-count":501,"title":["IL25 elicits a multipotent progenitor cell population that promotes TH2 cytokine responses"],"prefix":"10.1038","volume":"464","author":[{"given":"Steven A.","family":"Saenz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark C.","family":"Siracusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline G.","family":"Perrigoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean P.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F.","family":"Urban Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel E.","family":"Tocker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison L.","family":"Budelsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie A.","family":"Kleinschek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Kastelein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Kambayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinash","family":"Bhandoola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Artis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,4,1]]},"reference":[{"key":"BFnature08901_CR1","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/nri2199","volume":"7","author":"RM Anthony","year":"2007","unstructured":"Anthony, R. M., Rutitzky, L. I., Urban, J. F., Stadecker, M. J. & Gause, W. C. Protective immune mechanisms in helminth infection. Nature Rev. Immunol. 7, 975\u2013987 (2007)","journal-title":"Nature Rev. Immunol."},{"key":"BFnature08901_CR2","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/ni0802-715","volume":"3","author":"DT Umetsu","year":"2002","unstructured":"Umetsu, D. T., McIntire, J. J., Akbari, O., Macaubas, C. & DeKruyff, R. H. Asthma: an epidemic of dysregulated immunity. Nature Immunol. 3, 715\u2013720 (2002)","journal-title":"Nature Immunol."},{"key":"BFnature08901_CR3","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/ni805","volume":"3","author":"V Soumelis","year":"2002","unstructured":"Soumelis, V. et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nature Immunol. 3, 673\u2013680 (2002)","journal-title":"Nature Immunol."},{"key":"BFnature08901_CR4","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.immuni.2005.09.015","volume":"23","author":"J Schmitz","year":"2005","unstructured":"Schmitz, J. et al. IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity 23, 479\u2013490 (2005)","journal-title":"Immunity"},{"key":"BFnature08901_CR5","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S1074-7613(01)00243-6","volume":"15","author":"MM Fort","year":"2001","unstructured":"Fort, M. M. et al. IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo . Immunity 15, 985\u2013995 (2001)","journal-title":"Immunity"},{"key":"BFnature08901_CR6","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/nature05590","volume":"446","author":"C Zaph","year":"2007","unstructured":"Zaph, C. et al. Epithelial-cell-intrinsic IKK-\u03b2 expression regulates intestinal immune homeostasis. Nature 446, 552\u2013556 (2007)","journal-title":"Nature"},{"key":"BFnature08901_CR7","doi-asserted-by":"publisher","first-page":"2727","DOI":"10.1084\/jem.20080698","volume":"205","author":"A Terashima","year":"2008","unstructured":"Terashima, A. et al. A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity. J. Exp. Med. 205, 2727\u20132733 (2008)","journal-title":"J. Exp. Med."},{"key":"BFnature08901_CR8","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/ni1558","volume":"9","author":"CL Sokol","year":"2008","unstructured":"Sokol, C. L., Barton, G. M., Farr, A. G. & Medzhitov, R. A mechanism for the initiation of allergen-induced T helper type 2 responses. Nature Immunol. 9, 310\u2013318 (2008)","journal-title":"Nature Immunol."},{"key":"BFnature08901_CR9","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.4049\/jimmunol.174.2.1063","volume":"174","author":"A Gessner","year":"2005","unstructured":"Gessner, A., Mohrs, K. & Mohrs, M. Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production. J. Immunol. 174, 1063\u20131072 (2005)","journal-title":"J. Immunol."},{"key":"BFnature08901_CR10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1084\/jem.20040590","volume":"200","author":"B Min","year":"2004","unstructured":"Min, B. et al. Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite. J. Exp. Med. 200, 507\u2013517 (2004)","journal-title":"J. Exp. Med."},{"key":"BFnature08901_CR11","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1084\/jem.20052448","volume":"203","author":"D Voehringer","year":"2006","unstructured":"Voehringer, D., Reese, T. A., Huang, X., Shinkai, K. & Locksley, R. M. Type 2 immunity is controlled by IL-4\/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J. Exp. Med. 203, 1435\u20131446 (2006)","journal-title":"J. Exp. Med."},{"key":"BFnature08901_CR12","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1111\/j.1600-065X.2008.00713.x","volume":"226","author":"SA Saenz","year":"2008","unstructured":"Saenz, S. A., Taylor, B. C. & Artis, D. Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites. Immunol. Rev. 226, 172\u2013190 (2008)","journal-title":"Immunol. Rev."},{"key":"BFnature08901_CR13","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1093\/intimm\/dxn037","volume":"20","author":"Y Kondo","year":"2008","unstructured":"Kondo, Y. et al. Administration of IL-33 induces airway hyperresponsiveness and goblet cell hyperplasia in the lungs in the absence of adaptive immune system. Int. Immunol. 20, 791\u2013800 (2008)","journal-title":"Int. Immunol."},{"key":"BFnature08901_CR14","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1038\/ni.1740","volume":"10","author":"JG Perrigoue","year":"2009","unstructured":"Perrigoue, J. G. et al. MHC class II-dependent basophil-CD4+ T cell interactions promote TH2 cytokine-dependent immunity. Nature Immunol. 10, 697\u2013705 (2009)","journal-title":"Nature Immunol."},{"key":"BFnature08901_CR15","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nature08636","volume":"463","author":"K Moro","year":"2009","unstructured":"Moro, K. et al. Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells. Nature 463, 540\u2013544 (2009)","journal-title":"Nature"},{"key":"BFnature08901_CR16","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1084\/jem.20051615","volume":"203","author":"PG Fallon","year":"2006","unstructured":"Fallon, P. G. et al. Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion. J. Exp. Med. 203, 1105\u20131116 (2006)","journal-title":"J. Exp. Med."},{"key":"BFnature08901_CR17","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1016\/j.immuni.2006.04.008","volume":"24","author":"Y Nagai","year":"2006","unstructured":"Nagai, Y. et al. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 24, 801\u2013812 (2006)","journal-title":"Immunity"},{"key":"BFnature08901_CR18","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.cell.2007.09.047","volume":"131","author":"S Massberg","year":"2007","unstructured":"Massberg, S. et al. Immunosurveillance by hematopoietic progenitor cells trafficking through blood, lymph, and peripheral tissues. Cell 131, 994\u20131008 (2007)","journal-title":"Cell"},{"key":"BFnature08901_CR19","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S1074-7613(01)00186-8","volume":"15","author":"M Mohrs","year":"2001","unstructured":"Mohrs, M., Shinkai, K., Mohrs, K. & Locksley, R. M. Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 15, 303\u2013311 (2001)","journal-title":"Immunity"},{"key":"BFnature08901_CR20","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1017\/S001667230002098X","volume":"39","author":"MF Lyon","year":"1982","unstructured":"Lyon, M. F. & Glenister, P. H. A new allele sash (Wsh) at the W-locus and a spontaneous recessive lethal in mice. Genet. Res. 39, 315\u2013322 (1982)","journal-title":"Genet. Res."},{"key":"BFnature08901_CR21","doi-asserted-by":"publisher","first-page":"443","DOI":"10.4049\/jimmunol.169.1.443","volume":"169","author":"SD Hurst","year":"2002","unstructured":"Hurst, S. D. et al. New IL-17 family members promote Th1 or Th2 responses in the lung: in vivo function of the novel cytokine IL-25. J. Immunol. 169, 443\u2013453 (2002)","journal-title":"J. Immunol."},{"key":"BFnature08901_CR22","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1084\/jem.20051496","volume":"203","author":"AM Owyang","year":"2006","unstructured":"Owyang, A. M. et al. Interleukin 25 regulates type 2 cytokine-dependent immunity and limits chronic inflammation in the gastrointestinal tract. J. Exp. Med. 203, 843\u2013849 (2006)","journal-title":"J. Exp. Med."},{"key":"BFnature08901_CR23","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/35102167","volume":"414","author":"T Reya","year":"2001","unstructured":"Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature 414, 105\u2013111 (2001)","journal-title":"Nature"},{"key":"BFnature08901_CR24","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1016\/j.cell.2008.10.048","volume":"135","author":"A Wilson","year":"2008","unstructured":"Wilson, A. et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135, 1118\u20131129 (2008)","journal-title":"Cell"},{"key":"BFnature08901_CR25","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1182\/blood.V19.6.702.702","volume":"19","author":"JW Goodman","year":"1962","unstructured":"Goodman, J. W. & Hodgson, G. S. Evidence for stem cells in the peripheral blood of mice. Blood 19, 702\u2013714 (1962)","journal-title":"Blood"},{"key":"BFnature08901_CR26","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1126\/science.1064081","volume":"294","author":"DE Wright","year":"2001","unstructured":"Wright, D. E., Wagers, A. J., Gulati, A. P., Johnson, F. L. & Weissman, I. L. Physiological migration of hematopoietic stem and progenitor cells. Science 294, 1933\u20131936 (2001)","journal-title":"Science"},{"key":"BFnature08901_CR27","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1002\/hep.510260122","volume":"26","author":"JE Cardier","year":"1997","unstructured":"Cardier, J. E. & Barbera-Guillem, E. Extramedullary hematopoiesis in the adult mouse liver is associated with specific hepatic sinusoidal endothelial cells. Hepatology 26, 165\u2013175 (1997)","journal-title":"Hepatology"},{"key":"BFnature08901_CR28","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1073\/pnas.032438799","volume":"99","author":"SL McKinney-Freeman","year":"2002","unstructured":"McKinney-Freeman, S. L. et al. Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proc. Natl Acad. Sci. USA 99, 1341\u20131346 (2002)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature08901_CR29","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1126\/science.8066449","volume":"265","author":"T Nakano","year":"1994","unstructured":"Nakano, T., Kodama, H. & Honjo, T. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science 265, 1098\u20131101 (1994)","journal-title":"Science"},{"key":"BFnature08901_CR30","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/nature06840","volume":"452","author":"JJ Bell","year":"2008","unstructured":"Bell, J. J. & Bhandoola, A. The earliest thymic progenitors for T cells possess myeloid lineage potential. Nature 452, 764\u2013767 (2008)","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature08901.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature08901","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature08901.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:32:26Z","timestamp":1684420346000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature08901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":30,"journal-issue":{"issue":"7293","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["BFnature08901"],"URL":"https:\/\/doi.org\/10.1038\/nature08901","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.2428956.2063054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.2428956.2895065","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}