{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:17:01Z","timestamp":1791397021895,"version":"4.3.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7292","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1038\/nature08963","type":"journal-article","created":{"date-parts":[[2010,4,20]],"date-time":"2010-04-20T10:40:22Z","timestamp":1271760022000},"page":"1192-1195","source":"Crossref","is-referenced-by-count":226,"title":["Listeria monocytogenes impairs SUMOylation for efficient infection"],"prefix":"10.1038","volume":"464","author":[{"given":"David","family":"Ribet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Hamon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Gouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Anne","family":"Nahori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Impens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Neyret-Kahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kris","family":"Gevaert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl","family":"Vandekerckhove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Dejean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Cossart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnature08963_CR1","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.chom.2008.07.009","volume":"4","author":"MA Hamon","year":"2008","unstructured":"Hamon, M. A. & Cossart, P. Histone modifications and chromatin remodeling during bacterial infections. Cell Host Microbe 4, 100\u2013109 (2008)","journal-title":"Cell Host Microbe"},{"key":"BFnature08963_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.chom.2007.02.003","volume":"1","author":"A Rytkonen","year":"2007","unstructured":"Rytkonen, A. & Holden, D. W. Bacterial interference of ubiquitination and deubiquitination. Cell Host Microbe 1, 13\u201322 (2007)","journal-title":"Cell Host Microbe"},{"key":"BFnature08963_CR3","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1038\/nrm2293","volume":"8","author":"R Geiss-Friedlander","year":"2007","unstructured":"Geiss-Friedlander, R. & Melchior, F. Concepts in sumoylation: a decade on. Nature Rev. Mol. Cell Biol. 8, 947\u2013956 (2007)","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"BFnature08963_CR4","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1016\/j.micinf.2008.07.043","volume":"10","author":"P Cossart","year":"2008","unstructured":"Cossart, P. & Toledo-Arana, A. Listeria monocytogenes, a unique model in infection biology: an overview. Microbes Infect. 10, 1041\u20131050 (2008)","journal-title":"Microbes Infect."},{"key":"BFnature08963_CR5","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/ncb1292","volume":"7","author":"E Veiga","year":"2005","unstructured":"Veiga, E. & Cossart, P. Listeria hijacks the clathrin-dependent endocytic machinery to invade mammalian cells. Nature Cell Biol. 7, 894\u2013900 (2005)","journal-title":"Nature Cell Biol."},{"key":"BFnature08963_CR6","doi-asserted-by":"publisher","first-page":"2208","DOI":"10.1111\/j.1462-5822.2008.01200.x","volume":"10","author":"M Bonazzi","year":"2008","unstructured":"Bonazzi, M., Veiga, E., Cerda, J. P. & Cossart, P. Successive post-translational modifications of E-cadherin are required for InlA-mediated internalisation of Listeria monocytogenes. Cell. Microbiol. 10, 2208\u20132222 (2008)","journal-title":"Cell. Microbiol."},{"key":"BFnature08963_CR7","doi-asserted-by":"publisher","first-page":"13467","DOI":"10.1073\/pnas.0702729104","volume":"104","author":"MA Hamon","year":"2007","unstructured":"Hamon, M. A. et al. Histone modifications induced by a family of bacterial toxins. Proc. Natl Acad. Sci. USA 104, 13467\u201313472 (2007)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature08963_CR8","doi-asserted-by":"publisher","first-page":"2298","DOI":"10.1074\/mcp.M600212-MCP200","volume":"5","author":"AC Vertegaal","year":"2006","unstructured":"Vertegaal, A. C. et al. Distinct and overlapping sets of SUMO-1 and SUMO-2 target proteins revealed by quantitative proteomics. Mol. Cell. Proteomics 5, 2298\u20132310 (2006)","journal-title":"Mol. Cell. Proteomics"},{"key":"BFnature08963_CR9","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/nature07958","volume":"458","author":"M Hochstrasser","year":"2009","unstructured":"Hochstrasser, M. Origin and function of ubiquitin-like proteins. Nature 458, 422\u2013429 (2009)","journal-title":"Nature"},{"key":"BFnature08963_CR10","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.devcel.2005.10.007","volume":"9","author":"K Nacerddine","year":"2005","unstructured":"Nacerddine, K. et al. The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. Dev. Cell 9, 769\u2013779 (2005)","journal-title":"Dev. Cell"},{"key":"BFnature08963_CR11","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.tcb.2007.08.002","volume":"17","author":"RT Hay","year":"2007","unstructured":"Hay, R. T. SUMO-specific proteases: a twist in the tail. Trends Cell Biol. 17, 370\u2013376 (2007)","journal-title":"Trends Cell Biol."},{"key":"BFnature08963_CR12","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1007\/s00018-007-7137-4","volume":"64","author":"J Zhao","year":"2007","unstructured":"Zhao, J. Sumoylation regulates diverse biological processes. Cell. Mol. Life Sci. 64, 3017\u20133033 (2007)","journal-title":"Cell. Mol. Life Sci."},{"key":"BFnature08963_CR13","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.mib.2006.06.008","volume":"9","author":"R Boggio","year":"2006","unstructured":"Boggio, R. & Chiocca, S. Viruses and sumoylation: recent highlights. Curr. Opin. Microbiol. 9, 430\u2013436 (2006)","journal-title":"Curr. Opin. Microbiol."},{"key":"BFnature08963_CR14","doi-asserted-by":"publisher","first-page":"4873","DOI":"10.1002\/pmic.200800421","volume":"8","author":"K Gevaert","year":"2008","unstructured":"Gevaert, K. et al. Stable isotopic labeling in proteomics. Proteomics 8, 4873\u20134885 (2008)","journal-title":"Proteomics"},{"key":"BFnature08963_CR15","doi-asserted-by":"publisher","first-page":"6252","DOI":"10.1074\/jbc.275.9.6252","volume":"275","author":"H Saitoh","year":"2000","unstructured":"Saitoh, H. & Hinchey, J. Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2\/3. J. Biol. Chem. 275, 6252\u20136258 (2000)","journal-title":"J. Biol. Chem."},{"key":"BFnature08963_CR16","doi-asserted-by":"publisher","first-page":"ra24","DOI":"10.1126\/scisignal.2000282","volume":"2","author":"F Golebiowski","year":"2009","unstructured":"Golebiowski, F. et al. System-wide changes to SUMO modifications in response to heat shock. Sci. Signal. 2, ra24 (2009)","journal-title":"Sci. Signal."},{"key":"BFnature08963_CR17","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.micinf.2007.05.005","volume":"9","author":"P Schnupf","year":"2007","unstructured":"Schnupf, P. & Portnoy, D. A. Listeriolysin O: a phagosome-specific lysin. Microbes Infect. 9, 1176\u20131187 (2007)","journal-title":"Microbes Infect."},{"key":"BFnature08963_CR18","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1083\/jcb.135.6.1457","volume":"135","author":"MJ Matunis","year":"1996","unstructured":"Matunis, M. J., Coutavas, E. & Blobel, G. A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J. Cell Biol. 135, 1457\u20131470 (1996)","journal-title":"J. Cell Biol."},{"key":"BFnature08963_CR19","doi-asserted-by":"publisher","first-page":"4641","DOI":"10.1128\/IAI.59.12.4641-4646.1991","volume":"59","author":"F Nato","year":"1991","unstructured":"Nato, F. et al. Production and characterization of neutralizing and nonneutralizing monoclonal antibodies against listeriolysin O. Infect. Immun. 59, 4641\u20134646 (1991)","journal-title":"Infect. Immun."},{"key":"BFnature08963_CR20","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1111\/j.1365-2958.1990.tb00578.x","volume":"4","author":"E Michel","year":"1990","unstructured":"Michel, E., Reich, K. A., Favier, R., Berche, P. & Cossart, P. Attenuated mutants of the intracellular bacterium Listeria monocytogenes obtained by single amino acid substitutions in listeriolysin O. Mol. Microbiol. 4, 2167\u20132178 (1990)","journal-title":"Mol. Microbiol."},{"key":"BFnature08963_CR21","doi-asserted-by":"publisher","first-page":"11597","DOI":"10.1074\/jbc.M111039200","volume":"277","author":"EM Hotze","year":"2002","unstructured":"Hotze, E. M. et al. Monomer-monomer interactions drive the prepore to pore conversion of a beta-barrel-forming cholesterol-dependent cytolysin. J. Biol. Chem. 277, 11597\u201311605 (2002)","journal-title":"J. Biol. Chem."},{"key":"BFnature08963_CR22","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.molcel.2004.11.007","volume":"16","author":"R Boggio","year":"2004","unstructured":"Boggio, R., Colombo, R., Hay, R. T., Draetta, G. F. & Chiocca, S. A mechanism for inhibiting the SUMO pathway. Mol. Cell 16, 549\u2013561 (2004)","journal-title":"Mol. Cell"},{"key":"BFnature08963_CR23","doi-asserted-by":"publisher","first-page":"15376","DOI":"10.1074\/jbc.M700889200","volume":"282","author":"R Boggio","year":"2007","unstructured":"Boggio, R., Passafaro, A. & Chiocca, S. Targeting SUMO E1 to ubiquitin ligases: a viral strategy to counteract sumoylation. J. Biol. Chem. 282, 15376\u201315382 (2007)","journal-title":"J. Biol. Chem."},{"key":"BFnature08963_CR24","doi-asserted-by":"publisher","first-page":"3614","DOI":"10.1128\/IAI.71.6.3614-3618.2003","volume":"71","author":"S Dramsi","year":"2003","unstructured":"Dramsi, S. & Cossart, P. Listeriolysin O-mediated calcium influx potentiates entry of Listeria monocytogenes into the human Hep-2 epithelial cell line. Infect. Immun. 71, 3614\u20133618 (2003)","journal-title":"Infect. Immun."},{"key":"BFnature08963_CR25","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1128\/IAI.64.6.2359-2361.1996","volume":"64","author":"P Tang","year":"1996","unstructured":"Tang, P., Rosenshine, I., Cossart, P. & Finlay, B. B. Listeriolysin O activates mitogen-activated protein kinase in eucaryotic cells. Infect. Immun. 64, 2359\u20132361 (1996)","journal-title":"Infect. Immun."},{"key":"BFnature08963_CR26","doi-asserted-by":"publisher","first-page":"31043","DOI":"10.1074\/jbc.C300112200","volume":"278","author":"X Lin","year":"2003","unstructured":"Lin, X., Liang, M., Liang, Y. Y., Brunicardi, F. C. & Feng, X. H. SUMO-1\/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4. J. Biol. Chem. 278, 31043\u201331048 (2003)","journal-title":"J. Biol. Chem."},{"key":"BFnature08963_CR27","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1038\/ncb1728","volume":"10","author":"JS Kang","year":"2008","unstructured":"Kang, J. S., Saunier, E. F., Akhurst, R. J. & Derynck, R. The type I TGF-beta receptor is covalently modified and regulated by sumoylation. Nature Cell Biol. 10, 654\u2013664 (2008)","journal-title":"Nature Cell Biol."},{"key":"BFnature08963_CR28","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S0966-842X(99)01498-5","volume":"7","author":"DR Fitzpatrick","year":"1999","unstructured":"Fitzpatrick, D. R. & Bielefeldt-Ohmann, H. Transforming growth factor beta in infectious disease: always there for the host and the pathogen. Trends Microbiol. 7, 232\u2013236 (1999)","journal-title":"Trends Microbiol."},{"key":"BFnature08963_CR29","doi-asserted-by":"publisher","first-page":"3901","DOI":"10.1128\/IAI.64.9.3901-3904.1996","volume":"64","author":"A Nakane","year":"1996","unstructured":"Nakane, A. et al. Transforming growth factor beta is protective in host resistance against Listeria monocytogenes infection in mice. Infect. Immun. 64, 3901\u20133904 (1996)","journal-title":"Infect. Immun."},{"key":"BFnature08963_CR30","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1083\/jcb.200201081","volume":"156","author":"IJ Glomski","year":"2002","unstructured":"Glomski, I. J., Gedde, M. M., Tsang, A. W., Swanson, J. A. & Portnoy, D. A. The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells. J. Cell Biol. 156, 1029\u20131038 (2002)","journal-title":"J. Cell Biol."},{"key":"BFnature08963_CR31","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/j.1365-2958.1995.tb02297.x","volume":"16","author":"S Dramsi","year":"1995","unstructured":"Dramsi, S. et al. Entry of Listeria monocytogenes into hepatocytes requires expression of inIB, a surface protein of the internalin multigene family. Mol. Microbiol. 16, 251\u2013261 (1995)","journal-title":"Mol. Microbiol."},{"key":"BFnature08963_CR32","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.molcel.2006.05.016","volume":"22","author":"O Bischof","year":"2006","unstructured":"Bischof, O. et al. The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis. Mol. Cell 22, 783\u2013794 (2006)","journal-title":"Mol. Cell"}],"updated-by":[{"DOI":"10.1038\/s41586-020-2154-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T00:00:00Z","timestamp":1586995200000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature08963.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature08963","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature08963.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:33:00Z","timestamp":1684420380000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature08963"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":32,"journal-issue":{"issue":"7292","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["BFnature08963"],"URL":"https:\/\/doi.org\/10.1038\/nature08963","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.3013969.793485403","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.3013969.2775061","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.3013969.2833062","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.3013969.2815054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.3013969.2693069","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}