{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:47:32Z","timestamp":1790484452035,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7303","license":[{"start":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T00:00:00Z","timestamp":1277251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1038\/nature09137","type":"journal-article","created":{"date-parts":[[2010,6,23]],"date-time":"2010-06-23T18:32:11Z","timestamp":1277317931000},"page":"234-237","source":"Crossref","is-referenced-by-count":145,"title":["Loss of fish actinotrichia proteins and the fin-to-limb transition"],"prefix":"10.1038","volume":"466","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purva","family":"Wagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Guay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Sanchez-Pulido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaja K.","family":"Padhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Korzh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Andrade-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Andr\u00e9e","family":"Akimenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,23]]},"reference":[{"key":"BFnature09137_CR1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0925-4773(98)00176-2","volume":"79","author":"H Grandel","year":"1998","unstructured":"Grandel, H. & Schulte-Merker, S. The development of the paired fins in the zebrafish (Danio rerio). Mech. Dev. 79, 99\u2013120 (1998)","journal-title":"Mech. Dev."},{"key":"BFnature09137_CR2","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1111\/j.1440-169X.2007.00942.x","volume":"49","author":"N Mercader","year":"2007","unstructured":"Mercader, N. Early steps of paired fin development in zebrafish compared with tetrapod limb development. Dev. Growth Differ. 49, 421\u2013437 (2007)","journal-title":"Dev. Growth Differ."},{"key":"BFnature09137_CR3","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1242\/dev.126.5.883","volume":"126","author":"S Pizette","year":"1999","unstructured":"Pizette, S. & Niswander, L. BMPs negatively regulate structure and function of the limb apical ectodermal ridge. Development 126, 883\u2013894 (1999)","journal-title":"Development"},{"key":"BFnature09137_CR4","first-page":"145","volume":"87","author":"PJ Dane","year":"1985","unstructured":"Dane, P. J. & Tucker, J. B. Modulation of epidermal cell shaping and extracellular matrix during caudal fin morphogenesis in the zebrafish Brachydanio rerio. J. Embryol. Exp. Morphol. 87, 145\u2013161 (1985)","journal-title":"J. Embryol. Exp. Morphol."},{"key":"BFnature09137_CR5","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/ar.1092040408","volume":"204","author":"A Wood","year":"1982","unstructured":"Wood, A. Early pectoral fin development and morphogenesis of the apical ectodermal ridge in the killifish, Aphysosemion scheeli. Anat. Rec. 204, 349\u2013356 (1982)","journal-title":"Anat. Rec."},{"key":"BFnature09137_CR6","first-page":"79","volume":"63","author":"J Bouvet","year":"1974","unstructured":"Bouvet, J. Diff\u00e9renciation et ultrastructure du squelette distal de la nageoire pectorale chez la truite indig\u00e8ne (Salmo Trutta Fario L.). I. Diff\u00e9renciation et ultrastructure des actinotriches. Arch. Anat. Microsc. Morphol. Exp. 63, 79\u201396 (1974)","journal-title":"Arch. Anat. Microsc. Morphol. Exp."},{"key":"BFnature09137_CR7","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/jmor.1051510304","volume":"151","author":"J G\u00e9raudie","year":"1977","unstructured":"G\u00e9raudie, J. Initiation of the actinotrichial development in the early fin bud of the fish, Salmo. J. Morphol. 151, 353\u2013361 (1977)","journal-title":"J. Morphol."},{"key":"BFnature09137_CR8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1242\/jcs.66.1.205","volume":"66","author":"A Wood","year":"1984","unstructured":"Wood, A. & Thorogood, P. An analysis of in vitro cell migration during teleost fin morphogenesis. J. Cell Sci. 66, 205\u2013222 (1984)","journal-title":"J. Cell Sci."},{"key":"BFnature09137_CR9","first-page":"105","volume":"130","author":"H Garrault","year":"1936","unstructured":"Garrault, H. D\u00e9veloppement des fibres d\u2019\u00e9lastoidine (actinotrichia) chez les salmonides. Arch. Anat. Microsc. 130, 105\u2013137 (1936)","journal-title":"Arch. Anat. Microsc."},{"key":"BFnature09137_CR10","first-page":"286","volume":"6","author":"CF Krukenberg","year":"1885","unstructured":"Krukenberg, C. F. Ueber die chemische Beschaffenheit der sog. Hornf\u00e4den von Mustelus und \u00fcber die Zusammensetzung der keratin\u00f6sen H\u00fcllen um den Eiern von Scyllium stellate. Mitt. Zool. Stat. Neapel 6, 286\u2013296 (1885)","journal-title":"Mitt. Zool. Stat. Neapel"},{"key":"BFnature09137_CR11","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/bj0620621","volume":"62","author":"M Damodaran","year":"1956","unstructured":"Damodaran, M., Sivaraman, C. & Dhavalikar, R. S. Amino acid composition of elastoidin. Biochem. J. 62, 621\u2013625 (1956)","journal-title":"Biochem. J."},{"key":"BFnature09137_CR12","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1093\/oxfordjournals.jbchem.a128487","volume":"60","author":"S Kimura","year":"1966","unstructured":"Kimura, S. & Kubota, M. Studies on elastoidin I. Some chemical and physical properties of elastoidin and its components. J. Biochem. 60, 615\u2013621 (1966)","journal-title":"J. Biochem."},{"key":"BFnature09137_CR13","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0305-0491(86)90081-7","volume":"84","author":"S Kimura","year":"1986","unstructured":"Kimura, S., Uematsu, Y. & Miyauchi, Y. Shark (Prionace glauca) elastoidin: characterization of its collagen as [alpha 1(E)]3 homotrimers. Comp. Biochem. Physiol. B 84, 305\u2013308 (1986)","journal-title":"Comp. Biochem. Physiol. B"},{"key":"BFnature09137_CR14","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1002\/dvdy.20153","volume":"231","author":"BK Padhi","year":"2004","unstructured":"Padhi, B. K. et al. Screen for genes differentially expressed during regeneration of the zebrafish caudal fin. Dev. Dyn. 231, 527\u2013541 (2004)","journal-title":"Dev. Dyn."},{"key":"BFnature09137_CR15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S0006-8993(99)01909-5","volume":"848","author":"NG Seidah","year":"1999","unstructured":"Seidah, N. G. & Chretien, M. Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides. Brain Res. 848, 45\u201362 (1999)","journal-title":"Brain Res."},{"key":"BFnature09137_CR16","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1006\/jsbi.2001.4392","volume":"134","author":"MA Andrade","year":"2001","unstructured":"Andrade, M. A., Perez-Iratxeta, C. & Ponting, C. P. Protein repeats: structures, functions, and evolution. J. Struct. Biol. 134, 117\u2013131 (2001)","journal-title":"J. Struct. Biol."},{"key":"BFnature09137_CR17","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/978-1-4684-7636-1_38","volume-title":"Biology of Invertebrate and Lower Vertebrate Collagens","author":"J G\u00e9raudie","year":"1985","unstructured":"G\u00e9raudie, J. in Biology of Invertebrate and Lower Vertebrate Collagens (eds Bairati, A. & Garrone, R.) 451\u2013455 (Plenum, 1985)"},{"key":"BFnature09137_CR18","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1002\/dvdy.21274","volume":"236","author":"M Nishidate","year":"2007","unstructured":"Nishidate, M., Nakatani, Y., Kudo, A. & Kawakami, A. Identification of novel markers expressed during fin regeneration by microarray analysis in medaka fish. Dev. Dynamics 236, 2685\u20132693 (2007)","journal-title":"Dev. Dynamics"},{"key":"BFnature09137_CR19","doi-asserted-by":"publisher","first-page":"e101","DOI":"10.1371\/journal.pbio.0050101","volume":"5","author":"B Venkatesh","year":"2007","unstructured":"Venkatesh, B. et al. Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii). PLoS Biol. 5, e101 (2007)","journal-title":"PLoS Biol."},{"key":"BFnature09137_CR20","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1101\/gad.12.11.1571","volume":"12","author":"GR Martin","year":"1998","unstructured":"Martin, G. R. The roles of FGFs in the early development of vertebrate limbs. Genes Dev. 12, 1571\u20131586 (1998)","journal-title":"Genes Dev."},{"key":"BFnature09137_CR21","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.ydbio.2008.06.032","volume":"322","author":"D Ahn","year":"2008","unstructured":"Ahn, D. & Ho, R. K. Tri-phasic expression of posterior Hox genes during development of pectoral fins in zebrafish: implications for the evolution of vertebrate paired appendages. Dev. Biol. 322, 220\u2013233 (2008)","journal-title":"Dev. Biol."},{"key":"BFnature09137_CR22","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/375678a0","volume":"375","author":"P Sordino","year":"1995","unstructured":"Sordino, P., van der Hoeven, F. & Duboule, D. Hox gene expression in teleost fins and the origin of vertebrate digits. Nature 375, 678\u2013681 (1995)","journal-title":"Nature"},{"key":"BFnature09137_CR23","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.devcel.2009.02.005","volume":"16","author":"J Mao","year":"2009","unstructured":"Mao, J., McGlinn, E., Huang, P., Tabin, C. J. & McMahon, A. P. Fgf-dependent Etv4\/5 activity is required for posterior restriction of Sonic hedgehog and promoting outgrowth of the vertebrate limb. Dev. Cell 16, 600\u2013606 (2009)","journal-title":"Dev. Cell"},{"key":"BFnature09137_CR24","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.devcel.2009.02.008","volume":"16","author":"Z Zhang","year":"2009","unstructured":"Zhang, Z., Verheyden, J. M., Hassel, J. A. & Sun, X. FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds. Dev. Cell 16, 607\u2013613 (2009)","journal-title":"Dev. Cell"},{"key":"BFnature09137_CR25","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S0925-4773(97)00656-4","volume":"62","author":"D B\u00fcscher","year":"1997","unstructured":"B\u00fcscher, D., Bosse, B., Heymer, J. & Ruther, U. Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech. Dev. 62, 175\u2013182 (1997)","journal-title":"Mech. Dev."},{"key":"BFnature09137_CR26","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.ydbio.2007.03.517","volume":"306","author":"J Zakany","year":"2007","unstructured":"Zakany, J., Zacchetti, G. & Duboule, D. Interactions between HOXD and Gli3 genes control the limb apical ectodermal ridge via Fgf10. Dev. Biol. 306, 883\u2013893 (2007)","journal-title":"Dev. Biol."},{"key":"BFnature09137_CR27","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1086\/425183","volume":"77","author":"JA Long","year":"2004","unstructured":"Long, J. A. & Gordon, M. S. The greatest step in vertebrate history: a paleobiological review of the fish-tetrapod transition. Physiol. Biochem. Zool. 77, 700\u2013719 (2004)","journal-title":"Physiol. Biochem. Zool."},{"key":"BFnature09137_CR28","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ng0393-241","volume":"3","author":"CC Hui","year":"1993","unstructured":"Hui, C. C. & Joyner, A. L. A mouse model of Greig cephalopolysyndactyly syndrome: the extra-toesJ mutation contains an intragenic deletion of the Gli3 gene. Nature Genet. 3, 241\u2013246 (1993)","journal-title":"Nature Genet."},{"key":"BFnature09137_CR29","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1002\/dvdy.21417","volume":"237","author":"A Smith","year":"2008","unstructured":"Smith, A. et al. Gene expression analysis on sections of zebrafish regenerating fins reveals limitations in the whole-mount in situ hybridization method. Dev. Dyn. 237, 417\u2013425 (2008)","journal-title":"Dev. Dyn."},{"key":"BFnature09137_CR30","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1471-213X-6-5","volume":"6","author":"BG Choo","year":"2006","unstructured":"Choo, B. G. et al. Zebrafish transgenic enhancer TRAP line database (ZETRAP). BMC Dev. Biol. 6, 5 (2006)","journal-title":"BMC Dev. Biol."},{"key":"BFnature09137_CR31","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nprot.2007.514","volume":"3","author":"C Thisse","year":"2008","unstructured":"Thisse, C. & Thisse, B. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nature Protocols 3, 59\u201369 (2008)","journal-title":"Nature Protocols"},{"key":"BFnature09137_CR32","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/j.ydbio.2004.10.003","volume":"277","author":"OV Tyurina","year":"2005","unstructured":"Tyurina, O. V. et al. Zebrafish Gli3 functions as both an activator and a repressor in Hedgehog signaling. Dev. Biol. 277, 537\u2013556 (2005)","journal-title":"Dev. Biol."},{"key":"BFnature09137_CR33","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1242\/jcs.112.5.749","volume":"112","author":"C Lang","year":"1999","unstructured":"Lang, C. et al. Molecular characterization and developmentally regulated expression of Xenopus lamina-associated polypeptide 2 (XLAP2). J. Cell Sci. 112, 749\u2013759 (1999)","journal-title":"J. Cell Sci."},{"key":"BFnature09137_CR34","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1002\/dvdy.20630","volume":"235","author":"R Thummel","year":"2006","unstructured":"Thummel, R. et al. Inhibition of zebrafish fin regeneration using in vivo electroporation of morpholinos against fgfr1 and msxb. Dev. Dyn. 235, 336\u2013346 (2006)","journal-title":"Dev. Dyn."},{"key":"BFnature09137_CR35","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1002\/dvdy.20619","volume":"235","author":"F Avaron","year":"2006","unstructured":"Avaron, F., Hoffman, L., Guay, D. & Akimenko, M. A. Characterization of two new zebrafish members of the hedgehog family: atypical expression of a zebrafish indian hedgehog gene in skeletal elements of both endochondral and dermal origins. Dev. Dyn. 235, 478\u2013489 (2006)","journal-title":"Dev. Dyn."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature09137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature09137","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature09137.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:34:26Z","timestamp":1684434866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature09137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,23]]},"references-count":35,"journal-issue":{"issue":"7303","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["BFnature09137"],"URL":"https:\/\/doi.org\/10.1038\/nature09137","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,23]]}}}