{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:07:21Z","timestamp":1792724841864,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7328","license":[{"start":{"date-parts":[[2010,12,8]],"date-time":"2010-12-08T00:00:00Z","timestamp":1291766400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1038\/nature09588","type":"journal-article","created":{"date-parts":[[2010,12,8]],"date-time":"2010-12-08T11:11:09Z","timestamp":1291806669000},"page":"53-57","source":"Crossref","is-referenced-by-count":906,"title":["A selective role for dopamine in stimulus\u2013reward learning"],"prefix":"10.1038","volume":"469","author":[{"given":"Shelly B.","family":"Flagel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy J.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry E.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alayna","family":"Czuj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Willuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina A.","family":"Akers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M.","family":"Clinton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul E. M.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huda","family":"Akil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,12,8]]},"reference":[{"key":"BFnature09588_CR1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1146\/annurev.psych.56.091103.070229","volume":"57","author":"W Schultz","year":"2006","unstructured":"Schultz, W. Behavioral theories and the neurophysiology of reward. Annu. Rev. Psychol. 57, 87\u2013115 (2006)","journal-title":"Annu. Rev. Psychol."},{"key":"BFnature09588_CR2","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1038\/nrn1406","volume":"5","author":"RA Wise","year":"2004","unstructured":"Wise, R. A. Dopamine, learning and motivation. Nature Rev. Neurosci. 5, 483\u2013494 (2004)","journal-title":"Nature Rev. Neurosci."},{"key":"BFnature09588_CR3","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1038\/nn1923","volume":"10","author":"JJ Day","year":"2007","unstructured":"Day, J. J., Roitman, M. F., Wightman, R. M. & Carelli, R. M. Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens. Nature Neurosci. 10, 1020\u20131028 (2007)","journal-title":"Nature Neurosci."},{"key":"BFnature09588_CR4","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1126\/science.275.5306.1593","volume":"275","author":"W Schultz","year":"1997","unstructured":"Schultz, W., Dayan, P. & Montague, P. R. A neural substrate of prediction and reward. Science 275, 1593\u20131599 (1997)","journal-title":"Science"},{"key":"BFnature09588_CR5","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1523\/JNEUROSCI.16-05-01936.1996","volume":"16","author":"PR Montague","year":"1996","unstructured":"Montague, P. R., Dayan, P. & Sejnowski, T. J. A framework for mesencephalic dopamine systems based on predictive Hebbian learning. J. Neurosci. 16, 1936\u20131947 (1996)","journal-title":"J. Neurosci."},{"key":"BFnature09588_CR6","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/35083500","volume":"412","author":"P Waelti","year":"2001","unstructured":"Waelti, P., Dickinson, A. & Schultz, W. Dopamine responses comply with basic assumptions of formal learning theory. Nature 412, 43\u201348 (2001)","journal-title":"Nature"},{"key":"BFnature09588_CR7","first-page":"367","volume-title":"Neuroeconomics: Decision Making and the Brain","author":"BW Balleine","year":"2008","unstructured":"Balleine, B. W., Daw, N. D. & O\u2019Doherty, J. P. in Neuroeconomics: Decision Making and the Brain (eds Glimcher, P. W., Camerer, C. F., Fehr, E. & Poldrack, R. A.) 367\u2013389 (Academic Press, 2008)"},{"key":"BFnature09588_CR8","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s00213-006-0578-x","volume":"191","author":"KC Berridge","year":"2007","unstructured":"Berridge, K. C. The debate over dopamine\u2019s role in reward: the case for incentive salience. Psychopharmacology 191, 391\u2013431 (2007)","journal-title":"Psychopharmacology"},{"key":"BFnature09588_CR9","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/S0165-0173(98)00019-8","volume":"28","author":"KC Berridge","year":"1998","unstructured":"Berridge, K. C. & Robinson, T. E. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res. Brain Res. Rev. 28, 309\u2013369 (1998)","journal-title":"Brain Res. Brain Res. Rev."},{"key":"BFnature09588_CR10","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.coph.2008.12.014","volume":"9","author":"KC Berridge","year":"2009","unstructured":"Berridge, K. C., Robinson, T. E. & Aldridge, J. W. Dissecting components of reward: 'liking', 'wanting', and learning. Curr. Opin. Pharmacol. 9, 65\u201373 (2009)","journal-title":"Curr. Opin. Pharmacol."},{"key":"BFnature09588_CR11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.concog.2004.10.004","volume":"14","author":"J Panksepp","year":"2005","unstructured":"Panksepp, J. Affective consciousness: core emotional feelings in animals and humans. Conscious. Cogn. 14, 30\u201380 (2005)","journal-title":"Conscious. Cogn."},{"key":"BFnature09588_CR12","volume-title":"Sign-Tracking: The Stimulus-Reinforcer Relation and Directed Action","author":"E Hearst","year":"1974","unstructured":"Hearst, E. & Jenkins, H. Sign-Tracking: The Stimulus-Reinforcer Relation and Directed Action (Monograph of the Psychonomic Society, 1974)"},{"key":"BFnature09588_CR13","first-page":"67","volume-title":"Operant-Pavlovian Interactions","author":"R Boakes","year":"1977","unstructured":"Boakes, R. in Operant-Pavlovian Interactions (eds Davis, H. & Hurwitz, H. M. B.) 67\u201397 (Erlbaum, 1977)"},{"key":"BFnature09588_CR14","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.biopsych.2008.09.006","volume":"65","author":"TE Robinson","year":"2009","unstructured":"Robinson, T. E. & Flagel, S. B. Dissociating the predictive and incentive motivational properties of reward-related cues through the study of individual differences. Biol. Psychiat. 65, 869\u2013873 (2009)","journal-title":"Biol. Psychiat."},{"key":"BFnature09588_CR15","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1007\/s10519-006-9058-7","volume":"36","author":"JD Stead","year":"2006","unstructured":"Stead, J. D. et al. Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors. Behav. Genet. 36, 697\u2013712 (2006)","journal-title":"Behav. Genet."},{"key":"BFnature09588_CR16","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/npp.2009.142","volume":"35","author":"SB Flagel","year":"2010","unstructured":"Flagel, S. B. et al. An animal model of genetic vulnerability to behavioral disinhibition and responsiveness to reward-related cues: implications for addiction. Neuropsychopharmacology 35, 388\u2013400 (2010)","journal-title":"Neuropsychopharmacology"},{"key":"BFnature09588_CR17","first-page":"223","volume-title":"Psychology of Learning and Motivation","author":"KC Berridge","year":"2001","unstructured":"Berridge, K. C. in Psychology of Learning and Motivation (ed. Medin, D. L.) 223\u2013278 (Academic Press, 2001)"},{"key":"BFnature09588_CR18","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/S0149-7634(02)00007-6","volume":"26","author":"RN Cardinal","year":"2002","unstructured":"Cardinal, R. N., Parkinson, J. A., Hall, J. & Everitt, B. J. Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex. Neurosci. Biobehav. Rev. 26, 321\u2013352 (2002)","journal-title":"Neurosci. Biobehav. Rev."},{"key":"BFnature09588_CR19","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/j.1749-6632.1999.tb09262.x","volume":"877","author":"AE Kelley","year":"1999","unstructured":"Kelley, A. E. Functional specificity of ventral striatal compartments in appetitive behaviors. Ann. NY Acad. Sci. 877, 71\u201390 (1999)","journal-title":"Ann. NY Acad. Sci."},{"key":"BFnature09588_CR20","doi-asserted-by":"publisher","first-page":"6189","DOI":"10.1073\/pnas.0502080102","volume":"102","author":"JW Dalley","year":"2005","unstructured":"Dalley, J. W. et al. Time-limited modulation of appetitive Pavlovian memory by D1 and NMDA receptors in the nucleus accumbens. Proc. Natl Acad. Sci. USA 102, 6189\u20136194 (2005)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09588_CR21","doi-asserted-by":"publisher","first-page":"9471","DOI":"10.1523\/JNEUROSCI.21-23-09471.2001","volume":"21","author":"P Di Ciano","year":"2001","unstructured":"Di Ciano, P., Cardinal, R. N., Cowell, R. A., Little, S. J. & Everitt, B. J. Differential involvement of NMDA, AMPA\/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior. J. Neurosci. 21, 9471\u20139477 (2001)","journal-title":"J. Neurosci."},{"key":"BFnature09588_CR22","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0166-4328(02)00291-7","volume":"137","author":"JA Parkinson","year":"2002","unstructured":"Parkinson, J. A. et al. Nucleus accumbens dopamine depletion impairs both acquisition and performance of appetitive Pavlovian approach behaviour: implications for mesoaccumbens dopamine function. Behav. Brain Res. 137, 149\u2013163 (2002)","journal-title":"Behav. Brain Res."},{"key":"BFnature09588_CR23","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1523\/JNEUROSCI.19-06-02401.1999","volume":"19","author":"JA Parkinson","year":"1999","unstructured":"Parkinson, J. A., Olmstead, M. C., Burns, L. H., Robbins, T. W. & Everitt, B. J. Dissociation in effects of lesions of the nucleus accumbens core and shell on appetitive pavlovian approach behavior and the potentiation of conditioned reinforcement and locomotor activity by D-amphetamine. J. Neurosci. 19, 2401\u20132411 (1999)","journal-title":"J. Neurosci."},{"key":"BFnature09588_CR24","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/nmeth.1412","volume":"7","author":"JJ Clark","year":"2010","unstructured":"Clark, J. J. et al. Chronic microsensors for longitudinal, subsecond dopamine detection in behaving animals. Nature Methods 7, 126\u2013129 (2010)","journal-title":"Nature Methods"},{"key":"BFnature09588_CR25","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/0165-0173(93)90013-P","volume":"18","author":"TE Robinson","year":"1993","unstructured":"Robinson, T. E. & Berridge, K. C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res. Brain Res. Rev. 18, 247\u2013291 (1993)","journal-title":"Brain Res. Brain Res. Rev."},{"key":"BFnature09588_CR26","doi-asserted-by":"publisher","first-page":"12220","DOI":"10.1523\/JNEUROSCI.2499-09.2009","volume":"29","author":"AJ Tindell","year":"2009","unstructured":"Tindell, A. J., Smith, K. S., Berridge, K. C. & Aldridge, J. W. Dynamic computation of incentive salience: \"wanting\" what was never \"liked\". J. Neurosci. 29, 12220\u201312228 (2009)","journal-title":"J. Neurosci."},{"key":"BFnature09588_CR27","doi-asserted-by":"publisher","first-page":"e1000437","DOI":"10.1371\/journal.pcbi.1000437","volume":"5","author":"J Zhang","year":"2009","unstructured":"Zhang, J., Berridge, K. C., Tindell, A. J., Smith, K. S. & Aldridge, J. W. A neural computational model of incentive salience. PLOS Comput. Biol. 5, e1000437 (2009)","journal-title":"PLOS Comput. Biol."},{"key":"BFnature09588_CR28","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bbr.2010.07.022","volume":"216","author":"JS Beckmann","year":"2011","unstructured":"Beckmann, J. S., Marusich, J. A., Gipson, C. D. & Bardo, M. T. Novelty seeking, incentive salience and acquisition of cocaine self-administration in the rat. Behav. Brain Res. 216, 159\u2013165 (2011)","journal-title":"Behav. Brain Res."},{"key":"BFnature09588_CR29","doi-asserted-by":"publisher","first-page":"8122","DOI":"10.1523\/JNEUROSCI.20-21-08122.2000","volume":"20","author":"CL Wyvell","year":"2000","unstructured":"Wyvell, C. L. & Berridge, K. C. Intra-accumbens amphetamine increases the conditioned incentive salience of sucrose reward: enhancement of reward \"wanting\" without enhanced \"liking\" or response reinforcement. J. Neurosci. 20, 8122\u20138130 (2000)","journal-title":"J. Neurosci."},{"key":"BFnature09588_CR30","doi-asserted-by":"publisher","first-page":"7831","DOI":"10.1523\/JNEUROSCI.21-19-07831.2001","volume":"21","author":"CL Wyvell","year":"2001","unstructured":"Wyvell, C. L. & Berridge, K. C. Incentive sensitization by previous amphetamine exposure: increased cue-triggered \"wanting\" for sucrose reward. J. Neurosci. 21, 7831\u20137840 (2001)","journal-title":"J. Neurosci."},{"key":"BFnature09588_CR31","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1007\/s002130050728","volume":"139","author":"A Tomie","year":"1998","unstructured":"Tomie, A., Aguado, A. S., Pohorecky, L. A. & Benjamin, D. Ethanol induces impulsive-like responding in a delay-of-reward operant choice procedure: impulsivity predicts autoshaping. Psychopharmacology 139, 376\u2013382 (1998)","journal-title":"Psychopharmacology"},{"key":"BFnature09588_CR32","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1126\/science.1165598","volume":"324","author":"WJ Kuo","year":"2009","unstructured":"Kuo, W. J., Sjostrom, T., Chen, Y. P., Wang, Y. H. & Huang, C. Y. Intuition and deliberation: two systems for strategizing in the brain. Science 324, 519\u2013522 (2009)","journal-title":"Science"},{"key":"BFnature09588_CR33","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1016\/j.yhbeh.2007.03.009","volume":"51","author":"SM Clinton","year":"2007","unstructured":"Clinton, S. M, et al. Individual differences in novelty-seeking and emotional reactivity correlate with variation in maternal behavior. Horm. Behav. 51, 655\u2013664 (2007)","journal-title":"Horm. Behav."},{"key":"BFnature09588_CR34","volume-title":"Linear Mixed Models for Longitudinal Data","author":"G Verbeke","year":"2000","unstructured":"Verbeke, G. &. Molenberghs, G. Linear Mixed Models for Longitudinal Data (Springer, 2000)"},{"key":"BFnature09588_CR35","doi-asserted-by":"publisher","first-page":"5697","DOI":"10.1021\/ac0491509","volume":"76","author":"ML Heien","year":"2004","unstructured":"Heien, M. L. Johnson, M. A. & Wightman, R. M. Resolving neurotransmitters detected by fast-scan cyclic voltammetry. Anal. Chem. 76, 5697\u20135704 (2004)","journal-title":"Anal. Chem."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature09588.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature09588","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature09588.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:48:39Z","timestamp":1684417719000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature09588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,8]]},"references-count":35,"journal-issue":{"issue":"7328","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["BFnature09588"],"URL":"https:\/\/doi.org\/10.1038\/nature09588","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.7085958.9417054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.7085958.13277055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.7085958.7585054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.7085958.14866277","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.7085958.7991054","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.7085958.14574055","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.7085958.9814056","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.7085958.7308056","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12,8]]}}}