{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T02:55:32Z","timestamp":1792205732535,"version":"4.4.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"7337","license":[{"start":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T00:00:00Z","timestamp":1297209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1038\/nature09855","type":"journal-article","created":{"date-parts":[[2011,2,9]],"date-time":"2011-02-09T11:15:16Z","timestamp":1297250116000},"page":"230-234","source":"Crossref","is-referenced-by-count":591,"title":["Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome"],"prefix":"10.1038","volume":"471","author":[{"given":"Masayuki","family":"Yazawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca M.","family":"Pasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Hallmayer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo E.","family":"Dolmetsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,2,9]]},"reference":[{"key":"BFnature09855_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-199601000-00001","volume":"75","author":"MT Keating","year":"1996","unstructured":"Keating, M. T. The long QT syndrome. A review of recent molecular genetic and physiologic discoveries. Medicine 75, 1\u20135 (1996)","journal-title":"Medicine"},{"key":"BFnature09855_CR2","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1056\/NEJMra000650","volume":"345","author":"HV Huikuri","year":"2001","unstructured":"Huikuri, H. V., Castellanos, A. & Myerburg, R. J. Sudden death due to cardiac arrhythmias. N. Engl. J. Med. 345, 1473\u20131482 (2001)","journal-title":"N. Engl. J. Med."},{"key":"BFnature09855_CR3","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0378-4274(01)00510-0","volume":"127","author":"I Paakkari","year":"2002","unstructured":"Paakkari, I. Cardiotoxicity of new antihistamines and cisapride. Toxicol. Lett. 127, 279\u2013284 (2002)","journal-title":"Toxicol. Lett."},{"key":"BFnature09855_CR4","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.cell.2004.09.011","volume":"119","author":"I Splawski","year":"2004","unstructured":"Splawski, I. et al. CaV1.2 Ca2+ channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 119, 19\u201331 (2004)","journal-title":"Cell"},{"key":"BFnature09855_CR5","doi-asserted-by":"publisher","first-page":"8089","DOI":"10.1073\/pnas.0502506102","volume":"102","author":"I Splawski","year":"2005","unstructured":"Splawski, I. et al. Severe arrhythmia disorder caused by cardiac L-type Ca2+ channel mutations. Proc. Natl Acad. Sci. USA 102, 8089\u20138096 (2005)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09855_CR6","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1038\/sj.bjp.0707414","volume":"152","author":"V Yarotskyy","year":"2007","unstructured":"Yarotskyy, V. & Elmslie, K. S. Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (CaV1.2) Ca2+ channels. Br. J. Pharmacol. 152, 386\u2013395 (2007)","journal-title":"Br. J. Pharmacol."},{"key":"BFnature09855_CR7","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1113\/jphysiol.2008.161737","volume":"587","author":"V Yarotskyy","year":"2009","unstructured":"Yarotskyy, V., Gao, G., Peterson, B. Z. & Elmslie, K. S. The Timothy syndrome mutation of cardiac CaV1.2 (L-type) channels: multiple altered gating mechanisms and pharmacological restoration of inactivation. J. Physiol. (Lond.) 587, 551\u2013565 (2009)","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnature09855_CR8","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1074\/jbc.M109.076448","volume":"285","author":"V Yarotskyy","year":"2010","unstructured":"Yarotskyy, V. et al. Roscovitine binds to novel L-channel (CaV1.2) sites that separately affect activation and inactivation. J. Biol. Chem. 285, 43\u201353 (2010)","journal-title":"J. Biol. Chem."},{"key":"BFnature09855_CR9","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1172\/JCI25539","volume":"115","author":"DM Roden","year":"2005","unstructured":"Roden, D. M. & Viswanathan, P. C. Genetics of acquired long QT syndrome. J. Clin. Invest. 115, 2025\u20132032 (2005)","journal-title":"J. Clin. Invest."},{"key":"BFnature09855_CR10","doi-asserted-by":"publisher","first-page":"20990","DOI":"10.1073\/pnas.0710527105","volume":"104","author":"L Chen","year":"2007","unstructured":"Chen, L. et al. Mutation of an A-kinase-anchoring protein causes long-QT syndrome. Proc. Natl Acad. Sci. USA 104, 20990\u201320995 (2007)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09855_CR11","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1056\/NEJMcp0706513","volume":"358","author":"DM Roden","year":"2008","unstructured":"Roden, D. M. Clinical practice. Long-QT syndrome. N. Engl. J. Med. 358, 169\u2013176 (2008)","journal-title":"N. Engl. J. Med."},{"key":"BFnature09855_CR12","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1056\/NEJMoa0908679","volume":"363","author":"A Moretti","year":"2010","unstructured":"Moretti, A. et al. Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N. Engl. J. Med. 363, 1397\u20131409 (2010)","journal-title":"N. Engl. J. Med."},{"key":"BFnature09855_CR13","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1146\/annurev.ph.46.030184.002353","volume":"46","author":"H Reuter","year":"1984","unstructured":"Reuter, H. Ion channels in cardiac cell membranes. Annu. Rev. Physiol. 46, 473\u2013484 (1984)","journal-title":"Annu. Rev. Physiol."},{"key":"BFnature09855_CR14","doi-asserted-by":"publisher","first-page":"8101","DOI":"10.1073\/pnas.93.15.8101","volume":"93","author":"BE Flucher","year":"1996","unstructured":"Flucher, B. E. & Franzini-Armstrong, C. Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle. Proc. Natl Acad. Sci. USA 93, 8101\u20138106 (1996)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09855_CR15","doi-asserted-by":"publisher","first-page":"39193","DOI":"10.1074\/jbc.M006467200","volume":"275","author":"C Seisenberger","year":"2000","unstructured":"Seisenberger, C. et al. Functional embryonic cardiomyocytes after disruption of the L-type \u03b11C (Cav1.2) Ca2+ channel gene in the mouse. J. Biol. Chem. 275, 39193\u201339199 (2000)","journal-title":"J. Biol. Chem."},{"key":"BFnature09855_CR16","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1093\/emboj\/17.12.3309","volume":"17","author":"H Takeshima","year":"1998","unstructured":"Takeshima, H. et al. Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2. EMBO J. 17, 3309\u20133316 (1998)","journal-title":"EMBO J."},{"key":"BFnature09855_CR17","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/nature05928","volume":"448","author":"M Yazawa","year":"2007","unstructured":"Yazawa, M. et al. TRIC channels are essential for Ca2+ handling in intracellular stores. Nature 448, 78\u201382 (2007)","journal-title":"Nature"},{"key":"BFnature09855_CR18","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1073\/pnas.0710501105","volume":"105","author":"CF Barrett","year":"2008","unstructured":"Barrett, C. F. & Tsien, R. W. The Timothy syndrome mutation differentially affects voltage- and calcium-dependent inactivation of CaV1.2 L-type Ca2+ channels. Proc. Natl Acad. Sci. USA 105, 2157\u20132162 (2008)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09855_CR19","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.1161\/CIRCULATIONAHA.108.788067","volume":"118","author":"WH Thiel","year":"2008","unstructured":"Thiel, W. H. et al. Proarrhythmic defects in Timothy syndrome require calmodulin kinase II. Circulation 118, 2225\u20132234 (2008)","journal-title":"Circulation"},{"key":"BFnature09855_CR20","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi, K. et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131, 861\u2013872 (2007)","journal-title":"Cell"},{"key":"BFnature09855_CR21","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1126\/science.1151526","volume":"318","author":"J Yu","year":"2007","unstructured":"Yu, J. et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 318, 1917\u20131920 (2007)","journal-title":"Science"},{"key":"BFnature09855_CR22","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1126\/science.1154884","volume":"321","author":"T Aoi","year":"2008","unstructured":"Aoi, T. et al. Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science 321, 699\u2013702 (2008)","journal-title":"Science"},{"key":"BFnature09855_CR23","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1161\/01.RES.0000080317.92718.99","volume":"93","author":"JQ He","year":"2003","unstructured":"He, J. Q., Ma, Y., Lee, Y., Thomson, J. A. & Kamp, T. J. Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ. Res. 93, 32\u201339 (2003)","journal-title":"Circ. Res."},{"key":"BFnature09855_CR24","first-page":"e30","volume":"104","author":"J Zhang","year":"2009","unstructured":"Zhang, J. et al. Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ. Res. 104, e30\u2013e41 (2009)","journal-title":"Circ. Res."},{"key":"BFnature09855_CR25","first-page":"2246","volume":"118","author":"M Brunner","year":"2008","unstructured":"Brunner, M. et al. Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome. J. Clin. Invest. 118, 2246\u20132259 (2008)","journal-title":"J. Clin. Invest."},{"key":"BFnature09855_CR26","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/j.1432-1033.1997.t01-2-00527.x","volume":"243","author":"L Meijer","year":"1997","unstructured":"Meijer, L. et al. Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 243, 527\u2013536 (1997)","journal-title":"Eur. J. Biochem."},{"key":"BFnature09855_CR27","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1002\/stem.95","volume":"27","author":"TH Tran","year":"2009","unstructured":"Tran, T. H. et al. Wnt3a-induced mesoderm formation and cardiomyogenesis in human embryonic stem cells. Stem Cells 27, 1869\u20131878 (2009)","journal-title":"Stem Cells"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature09855.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature09855","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature09855.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:50:51Z","timestamp":1684417851000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature09855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,9]]},"references-count":27,"journal-issue":{"issue":"7337","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["BFnature09855"],"URL":"https:\/\/doi.org\/10.1038\/nature09855","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.10459956.11296055","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,9]]}}}