{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T13:58:49Z","timestamp":1792504729729,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7342","license":[{"start":{"date-parts":[[2011,3,23]],"date-time":"2011-03-23T00:00:00Z","timestamp":1300838400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1038\/nature09975","type":"journal-article","created":{"date-parts":[[2011,3,27]],"date-time":"2011-03-27T12:57:47Z","timestamp":1301230667000},"page":"186-190","source":"Crossref","is-referenced-by-count":285,"title":["Loss-of-function mutations in sodium channel Nav1.7 cause anosmia"],"prefix":"10.1038","volume":"472","author":[{"given":"Jan","family":"Weiss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Pyrski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Jacobi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Bufe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivienne","family":"Willnecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Schick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Zizzari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Gossage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Greer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trese","family":"Leinders-Zufall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Geoffrey","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Zufall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,3,23]]},"reference":[{"key":"BFnature09975_CR1","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.tig.2009.02.002","volume":"25","author":"Y Hasin-Brumshtein","year":"2009","unstructured":"Hasin-Brumshtein, Y., Lancet, D. & Olender, T. Human olfaction: from genomic variation to phenotypic diversity. Trends Genet. 25, 178\u2013184 (2009)","journal-title":"Trends Genet."},{"key":"BFnature09975_CR2","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/chemse\/bjl032","volume":"32","author":"E Feldmesser","year":"2007","unstructured":"Feldmesser, E. et al. Mutations in olfactory signal transduction genes are not a major cause of human congenital general anosmia. Chem. Senses 32, 21\u201330 (2007)","journal-title":"Chem. Senses"},{"key":"BFnature09975_CR3","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.conb.2008.09.020","volume":"18","author":"A Keller","year":"2008","unstructured":"Keller, A. & Vosshall, L. B. Better smelling through genetics: mammalian odor perception. Curr. Opin. Neurobiol. 18, 364\u2013369 (2008)","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnature09975_CR4","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1146\/annurev.physiol.63.1.871","volume":"63","author":"AL Goldin","year":"2001","unstructured":"Goldin, A. L. Resurgence of sodium channel research. Annu. Rev. Physiol. 63, 871\u2013894 (2001)","journal-title":"Annu. Rev. Physiol."},{"key":"BFnature09975_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1124\/pr.57.4.4","volume":"57","author":"WA Catterall","year":"2005","unstructured":"Catterall, W. A., Goldin, A. L. & Waxman, S. G. International Union of Pharmacology. XLVII. Nomenclature and structure\u2013function relationships of voltage-gated sodium channels. Pharmacol. Rev. 57, 397\u2013409 (2005)","journal-title":"Pharmacol. Rev."},{"key":"BFnature09975_CR6","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1038\/nature05413","volume":"444","author":"JJ Cox","year":"2006","unstructured":"Cox, J. J. et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature 444, 894\u2013898 (2006)","journal-title":"Nature"},{"key":"BFnature09975_CR7","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1111\/j.1399-0004.2007.00790.x","volume":"71","author":"YP Goldberg","year":"2007","unstructured":"Goldberg, Y. P. et al. Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. Clin. Genet. 71, 311\u2013319 (2007)","journal-title":"Clin. Genet."},{"key":"BFnature09975_CR8","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/hmg\/ddm160","volume":"16","author":"S Ahmad","year":"2007","unstructured":"Ahmad, S. et al. A stop codon mutation in SCN9A causes lack of pain sensation. Hum. Mol. Genet. 16, 2114\u20132121 (2007)","journal-title":"Hum. Mol. Genet."},{"key":"BFnature09975_CR9","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.tins.2007.08.004","volume":"30","author":"SD Dib-Hajj","year":"2007","unstructured":"Dib-Hajj, S. D., Cummins, T. R., Black, J. A. & Waxman, S. G. From genes to pain: Nav1.7 and human pain disorders. Trends Neurosci. 30, 555\u2013563 (2007)","journal-title":"Trends Neurosci."},{"issue":"1","key":"BFnature09975_CR10","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.pain.2009.06.025","volume":"145","author":"K. B. Nilsen","year":"2009","unstructured":"Nilsen, K. B. et al. Corrigendum to \u201cTwo novel SCN9A mutations causing insensitivity to pain.\u201d Pain . 145, 264 (2009)","journal-title":"Pain"},{"key":"BFnature09975_CR11","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1146\/annurev.physiol.70.113006.100608","volume":"71","author":"SD Munger","year":"2009","unstructured":"Munger, S. D., Leinders-Zufall, T. & Zufall, F. Subsystem organization of the mammalian sense of smell. Annu. Rev. Physiol. 71, 115\u2013140 (2009)","journal-title":"Annu. Rev. Physiol."},{"key":"BFnature09975_CR12","doi-asserted-by":"publisher","first-page":"12706","DOI":"10.1073\/pnas.0404915101","volume":"101","author":"MA Nassar","year":"2004","unstructured":"Nassar, M. A. et al. Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain. Proc. Natl Acad. Sci. USA 101, 12706\u201312711 (2004)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09975_CR13","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/nature02433","volume":"428","author":"J Li","year":"2004","unstructured":"Li, J., Ishii, T., Feinstein, P. & Mombaerts, P. Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. Nature 428, 393\u2013399 (2004)","journal-title":"Nature"},{"key":"BFnature09975_CR14","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1002\/j.1460-2075.1995.tb07091.x","volume":"14","author":"N Klugbauer","year":"1995","unstructured":"Klugbauer, N., Lacinova, L., Flockerzi, V. & Hofmann, F. Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. EMBO J. 14, 1084\u20131090 (1995)","journal-title":"EMBO J."},{"key":"BFnature09975_CR15","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1002\/cne.21484","volume":"504","author":"A Morinville","year":"2007","unstructured":"Morinville, A. et al. Distribution of the voltage-gated sodium channel Nav1.7 in the rat: expression in the autonomic and endocrine systems. J. Comp. Neurol. 504, 680\u2013689 (2007)","journal-title":"J. Comp. Neurol."},{"key":"BFnature09975_CR16","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/cne.902850207","volume":"285","author":"H Baker","year":"1989","unstructured":"Baker, H., Grillo, M. & Margolis, F. L. Biochemical and immunocytochemical characterization of olfactory marker protein in the rodent central nervous system. J. Comp. Neurol. 285, 246\u2013261 (1989)","journal-title":"J. Comp. Neurol."},{"key":"BFnature09975_CR17","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0896-6273(00)80435-3","volume":"20","author":"L Belluscio","year":"1998","unstructured":"Belluscio, L., Gold, G. H., Nemes, A. & Axel, R. Mice deficient in Golf are anosmic. Neuron 20, 69\u201381 (1998)","journal-title":"Neuron"},{"key":"BFnature09975_CR18","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0092-8674(01)00262-8","volume":"104","author":"H Zhao","year":"2001","unstructured":"Zhao, H. & Reed, R. R. X inactivation of the OCNC1 channel gene reveals a role for activity-dependent competition in the olfactory system. Cell 104, 651\u2013660 (2001)","journal-title":"Cell"},{"key":"BFnature09975_CR19","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1523\/JNEUROSCI.4939-05.2006","volume":"26","author":"M Spehr","year":"2006","unstructured":"Spehr, M. et al. Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands. J. Neurosci. 26, 1961\u20131970 (2006)","journal-title":"J. Neurosci."},{"key":"BFnature09975_CR20","doi-asserted-by":"publisher","first-page":"14507","DOI":"10.1073\/pnas.0704965104","volume":"104","author":"T Leinders-Zufall","year":"2007","unstructured":"Leinders-Zufall, T. et al. Contribution of the receptor guanylyl cyclase GC-D to chemosensory function in the olfactory epithelium. Proc. Natl Acad. Sci. USA 104, 14507\u201314512 (2007)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09975_CR21","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1126\/science.1063224","volume":"294","author":"SD Munger","year":"2001","unstructured":"Munger, S. D. et al. Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation. Science 294, 2172\u20132175 (2001)","journal-title":"Science"},{"key":"BFnature09975_CR22","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/acprof:oso\/9780195159561.001.1","volume-title":"The Synaptic Organization of the Brain","author":"GM Shepherd","year":"2004","unstructured":"Shepherd, G. M., Chen, W. R. & Greer, C. A. in The Synaptic Organization of the Brain (ed. Shepherd, G. M. ) 165\u2013216 (Oxford Univ. Press, 2004)"},{"key":"BFnature09975_CR23","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.semcdb.2006.04.007","volume":"17","author":"M Wachowiak","year":"2006","unstructured":"Wachowiak, M. & Shipley, M. T. Coding and synaptic processing of sensory information in the glomerular layer of the olfactory bulb. Semin. Cell Dev. Biol. 17, 411\u2013423 (2006)","journal-title":"Semin. Cell Dev. Biol."},{"key":"BFnature09975_CR24","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/0361-9230(95)02042-X","volume":"39","author":"WT Nickell","year":"1996","unstructured":"Nickell, W. T., Shipley, M. T. & Behbehani, M. M. Orthodromic synaptic activation of rat olfactory bulb mitral cells in isolated slices. Brain Res. Bull. 39, 57\u201362 (1996)","journal-title":"Brain Res. Bull."},{"key":"BFnature09975_CR25","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1111\/j.1460-9568.2007.05400.x","volume":"25","author":"MM Gabellec","year":"2007","unstructured":"Gabellec, M. M., Panzanelli, P., Sassoe-Pognetto, M. & Lledo, P. M. Synapse-specific localization of vesicular glutamate transporters in the rat olfactory bulb. Eur. J. Neurosci. 25, 1373\u20131383 (2007)","journal-title":"Eur. J. Neurosci."},{"key":"BFnature09975_CR26","doi-asserted-by":"publisher","first-page":"15613","DOI":"10.1073\/pnas.1007931107","volume":"107","author":"MB Richard","year":"2010","unstructured":"Richard, M. B., Taylor, S. R. & Greer, C. A. Age-induced disruption of selective olfactory bulb synaptic circuits. Proc. Natl Acad. Sci. USA 107, 15613\u201315618 (2010)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature09975_CR27","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/S0896-6273(04)00224-7","volume":"42","author":"CR Yu","year":"2004","unstructured":"Yu, C. R. et al. Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map. Neuron 42, 553\u2013566 (2004)","journal-title":"Neuron"},{"key":"BFnature09975_CR28","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1523\/JNEUROSCI.19-04-01359.1999","volume":"19","author":"AC Puche","year":"1999","unstructured":"Puche, A. C. & Shipley, M. T. Odor-induced, activity-dependent transneuronal gene induction in vitro: mediation by NMDA receptors. J. Neurosci. 19, 1359\u20131370 (1999)","journal-title":"J. Neurosci."},{"key":"BFnature09975_CR29","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/(SICI)1096-9861(19960527)369:2<264::AID-CNE7>3.0.CO;2-1","volume":"369","author":"JY Cho","year":"1996","unstructured":"Cho, J. Y., Min, N., Franzen, L. & Baker, H. Rapid down-regulation of tyrosine hydroxylase expression in the olfactory bulb of naris-occluded adult rats. J. Comp. Neurol. 369, 264\u2013276 (1996)","journal-title":"J. Comp. Neurol."},{"key":"BFnature09975_CR30","doi-asserted-by":"publisher","first-page":"9313","DOI":"10.1523\/JNEUROSCI.19-21-09313.1999","volume":"19","author":"H Baker","year":"1999","unstructured":"Baker, H. et al. Targeted deletion of a cyclic nucleotide-gated channel subunit (OCNC1): biochemical and morphological consequences in adult mice. J. Neurosci. 19, 9313\u20139321 (1999)","journal-title":"J. Neurosci."},{"key":"BFnature09975_CR31","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/nature06281","volume":"450","author":"K Kobayakawa","year":"2007","unstructured":"Kobayakawa, K. et al. Innate versus learned odour processing in the mouse olfactory bulb. Nature 450, 503\u2013508 (2007)","journal-title":"Nature"},{"key":"BFnature09975_CR32","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1523\/JNEUROSCI.4622-09.2010","volume":"30","author":"DW Wesson","year":"2010","unstructured":"Wesson, D. W., Levy, E., Nixon, R. A. & Wilson, D. A. Olfactory dysfunction correlates with amyloid-\u03b2 burden in an Alzheimer's disease mouse model. J. Neurosci. 30, 505\u2013514 (2010)","journal-title":"J. Neurosci."},{"key":"BFnature09975_CR33","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1016\/j.neuron.2010.07.003","volume":"67","author":"H Sakano","year":"2010","unstructured":"Sakano, H. Neural map formation in the mouse olfactory system. Neuron 67, 530\u2013542 (2010)","journal-title":"Neuron"},{"key":"BFnature09975_CR34","doi-asserted-by":"publisher","first-page":"944","DOI":"10.1002\/cne.21290","volume":"501","author":"M Pyrski","year":"2007","unstructured":"Pyrski, M. et al. Sodium\/calcium exchanger expression in the mouse and rat olfactory systems. J. Comp. Neurol. 501, 944\u2013958 (2007)","journal-title":"J. Comp. Neurol."},{"key":"BFnature09975_CR35","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/cne.10182","volume":"446","author":"WW Au","year":"2002","unstructured":"Au, W. W., Treloar, H. B. & Greer, C. A. Sublaminar organization of the mouse olfactory bulb nerve layer. J. Comp. Neurol. 446, 68\u201380 (2002)","journal-title":"J. Comp. Neurol."},{"key":"BFnature09975_CR36","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.1152\/jn.00642.2007","volume":"98","author":"K Ukhanov","year":"2007","unstructured":"Ukhanov, K., Leinders-Zufall, T. & Zufall, F. Patch-clamp analysis of gene-targeted vomeronasal neurons expressing a defined V1r or V2r receptor: ionic mechanisms underlying persistent firing. J. Neurophysiol. 98, 2357\u20132369 (2007)","journal-title":"J. Neurophysiol."},{"key":"BFnature09975_CR37","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1016\/j.cell.2010.03.037","volume":"141","author":"F Papes","year":"2010","unstructured":"Papes, F., Logan, D. W. & Stowers, L. The vomeronasal organ mediates interspecies defensive behaviors through detection of protein pheromone homologs. Cell 141, 692\u2013703 (2010)","journal-title":"Cell"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature09975.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature09975","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature09975.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:51:45Z","timestamp":1684417905000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature09975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3,23]]},"references-count":37,"journal-issue":{"issue":"7342","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["BFnature09975"],"URL":"https:\/\/doi.org\/10.1038\/nature09975","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.10139956.10914054","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3,23]]}}}