{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:01:38Z","timestamp":1791266498296,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"7355","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1038\/nature10199","type":"journal-article","created":{"date-parts":[[2011,7,12]],"date-time":"2011-07-12T06:41:04Z","timestamp":1310452864000},"page":"196-200","source":"Crossref","is-referenced-by-count":358,"title":["Functional regeneration of respiratory pathways after spinal cord injury"],"prefix":"10.1038","volume":"475","author":[{"given":"Warren J.","family":"Alilain","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin P.","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Silver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,7,13]]},"reference":[{"key":"BFnature10199_CR1","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/37776","volume":"390","author":"SJ Davies","year":"1997","unstructured":"Davies, S. J. et al. Regeneration of adult axons in white matter tracts of the central nervous system. Nature 390, 680\u2013683 (1997)","journal-title":"Nature"},{"key":"BFnature10199_CR2","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/416636a","volume":"416","author":"EJ Bradbury","year":"2002","unstructured":"Bradbury, E. J. et al. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 416, 636\u2013640 (2002)","journal-title":"Nature"},{"key":"BFnature10199_CR3","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/nrn1326","volume":"5","author":"J Silver","year":"2004","unstructured":"Silver, J. & Miller, J. H. Regeneration beyond the glial scar. Nature Rev. Neurosci. 5, 146\u2013156 (2004)","journal-title":"Nature Rev. Neurosci."},{"key":"BFnature10199_CR4","doi-asserted-by":"publisher","first-page":"4406","DOI":"10.1523\/JNEUROSCI.5467-05.2006","volume":"26","author":"JM Massey","year":"2006","unstructured":"Massey, J. M. et al. Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury. J. Neurosci. 26, 4406\u20134414 (2006)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR5","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1038\/nn.2377","volume":"12","author":"G Garc\u00eda-Alias","year":"2009","unstructured":"Garc\u00eda-Alias, G., Barkhuysen, S., Buckle, M. & Fawcett, J. W. Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation. Nature Neurosci. 12, 1145\u20131151 (2009)","journal-title":"Nature Neurosci."},{"key":"BFnature10199_CR6","doi-asserted-by":"publisher","first-page":"7761","DOI":"10.1523\/JNEUROSCI.4659-09.2010","volume":"30","author":"AS Hunanyan","year":"2010","unstructured":"Hunanyan, A. S. et al. Role of chondroitin sulfate proteoglycans in axonal conduction in mammalian spinal cord. J. Neurosci. 30, 7761\u20137769 (2010)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR7","doi-asserted-by":"publisher","first-page":"5843","DOI":"10.1523\/JNEUROSCI.0137-10.2010","volume":"30","author":"C Schachtrup","year":"2010","unstructured":"Schachtrup, C. et al. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-\u03b2 after vascular damage. J. Neurosci. 30, 5843\u20135854 (2010)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR8","doi-asserted-by":"publisher","first-page":"4550","DOI":"10.1523\/JNEUROSCI.5135-04.2005","volume":"25","author":"H Choi","year":"2005","unstructured":"Choi, H. et al. Respiratory abnormalities resulting from midcervical spinal cord injury and their reversal by serotonin 1A agonists in conscious rats. J. Neurosci. 25, 4550\u20134559 (2005)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR9","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1089\/neu.2005.22.203","volume":"22","author":"DD Fuller","year":"2005","unstructured":"Fuller, D. D. et al. Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors. J. Neurotrauma 22, 203\u2013213 (2005)","journal-title":"J. Neurotrauma"},{"key":"BFnature10199_CR10","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1523\/JNEUROSCI.0148-05.2005","volume":"25","author":"FJ Golder","year":"2005","unstructured":"Golder, F. J. & Mitchell, G. S. Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury. J. Neurosci. 25, 2925\u20132932 (2005)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR11","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1152\/japplphysiol.00847.2002","volume":"94","author":"HG Goshgarian","year":"2003","unstructured":"Goshgarian, H. G. The crossed phrenic phenomenon: a model for plasticity in the respiratory pathways following spinal cord injury. J. Appl. Physiol. 94, 795\u2013810 (2003)","journal-title":"J. Appl. Physiol."},{"key":"BFnature10199_CR12","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1006\/exnr.1999.7240","volume":"160","author":"SD Hadley","year":"1999","unstructured":"Hadley, S. D., Walker, P. D. & Goshgarian, H. G. Effects of the serotonin synthesis inhibitor p-CPA on the expression of the crossed phrenic phenomenon 4 h following C2 spinal cord hemisection. Exp. Neurol. 160, 479\u2013488 (1999)","journal-title":"Exp. Neurol."},{"key":"BFnature10199_CR13","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1523\/JNEUROSCI.4729-07.2008","volume":"28","author":"MR Hodges","year":"2008","unstructured":"Hodges, M. R. et al. Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons. J. Neurosci. 28, 2495\u20132505 (2008)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR14","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1126\/science.6171034","volume":"214","author":"S David","year":"1981","unstructured":"David, S. & Aguayo, A. J. Axonal elongation into peripheral nervous system \u2018bridges\u2019 after central nervous system injury in adult rats. Science 214, 931\u2013933 (1981)","journal-title":"Science"},{"key":"BFnature10199_CR15","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/0006-8993(85)90780-2","volume":"340","author":"M Munz","year":"1985","unstructured":"Munz, M. et al. Functional activity of rat brainstem neurons regenerating axons along peripheral nerve grafts. Brain Res. 340, 115\u2013125 (1985)","journal-title":"Brain Res."},{"key":"BFnature10199_CR16","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/0006-8993(88)91341-8","volume":"438","author":"P Gauthier","year":"1988","unstructured":"Gauthier, P. & Rasminsky, M. Activity of medullary respiratory neurons regenerating axons into peripheral nerve grafts in the adult rat. Brain Res. 438, 225\u2013236 (1988)","journal-title":"Brain Res."},{"key":"BFnature10199_CR17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/jnr.10379","volume":"70","author":"P Gauthier","year":"2002","unstructured":"Gauthier, P. et al. Functional reconnections established by central respiratory neurons regenerating axons into a nerve graft bridging the respiratory centers to the cervical spinal cord. J. Neurosci. Res. 70, 65\u201381 (2002)","journal-title":"J. Neurosci. Res."},{"key":"BFnature10199_CR18","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1523\/JNEUROSCI.3562-04.2005","volume":"25","author":"K Fouad","year":"2005","unstructured":"Fouad, K. et al. Combining Schwann cell bridges and olfactory-ensheathing glia grafts with chondroitinase promotes locomotor recovery after complete transection of the spinal cord. J. Neurosci. 25, 1169\u20131178 (2005)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR19","doi-asserted-by":"publisher","first-page":"7405","DOI":"10.1523\/JNEUROSCI.1166-06.2006","volume":"26","author":"JD Houle","year":"2006","unstructured":"Houle, J. D. et al. Combining an autologous peripheral nervous system \u2018bridge\u2019 and matrix modification by chondroitinase allows robust, functional regeneration beyond a hemisection lesion of the adult rat spinal cord. J. Neurosci. 26, 7405\u20137415 (2006)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR20","doi-asserted-by":"publisher","first-page":"11057","DOI":"10.1073\/pnas.0604613103","volume":"103","author":"LJ Yang","year":"2006","unstructured":"Yang, L. J. et al. Sialidase enhances spinal axon outgrowth in vivo . Proc. Natl Acad. Sci. USA 103, 11057\u201311062 (2006)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature10199_CR21","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1523\/JNEUROSCI.23-04-01424.2003","volume":"23","author":"L Zhou","year":"2003","unstructured":"Zhou, L., Baumgartner, B. J., Hill-Felberg, S. J., McGowen, L. R. & Shine, H. D. Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord. J. Neurosci. 23, 1424\u20131431 (2003)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR22","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/nn.2365","volume":"12","author":"LT Alto","year":"2009","unstructured":"Alto, L. T. et al. Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. Nature Neurosci. 12, 1106\u20131113 (2009)","journal-title":"Nature Neurosci."},{"key":"BFnature10199_CR23","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1038\/nn.2603","volume":"13","author":"K Liu","year":"2010","unstructured":"Liu, K. et al. PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nature Neurosci. 13, 1075\u20131081 (2010)","journal-title":"Nature Neurosci."},{"key":"BFnature10199_CR24","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1460-9568.2004.03837.x","volume":"21","author":"LT McPhail","year":"2005","unstructured":"McPhail, L. T., Plunet, W. T., Das, P. & Ramer, M. S. The astrocytic barrier to axonal regeneration at the dorsal root entry zone is induced by rhizotomy. Eur. J. Neurosci. 21, 267\u2013270 (2005)","journal-title":"Eur. J. Neurosci."},{"key":"BFnature10199_CR25","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1152\/japplphysiol.00599.2002","volume":"94","author":"F Hayashi","year":"2003","unstructured":"Hayashi, F., Hinrichsen, C. F. & McCrimmon, D. R. Short-term plasticity of descending synaptic input to phrenic motoneurons in rats. J. Appl. Physiol. 94, 1421\u20131430 (2003)","journal-title":"J. Appl. Physiol."},{"key":"BFnature10199_CR26","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1002\/cne.21864","volume":"511","author":"MA Lane","year":"2008","unstructured":"Lane, M. A. et al. Cervical prephrenic interneurons in the normal and lesioned spinal cord of the adult rat. J. Comp. Neurol. 511, 692\u2013709 (2008)","journal-title":"J. Comp. Neurol."},{"key":"BFnature10199_CR27","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nrn1327","volume":"5","author":"GG Turrigiano","year":"2004","unstructured":"Turrigiano, G. G. & Nelson, S. B. Homeostatic plasticity in the developing nervous system. Nature Rev. Neurosci. 5, 97\u2013107 (2004)","journal-title":"Nature Rev. Neurosci."},{"key":"BFnature10199_CR28","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1006\/exnr.1996.0114","volume":"140","author":"KD Nantwi","year":"1996","unstructured":"Nantwi, K. D., El-Bohy, A. & Goshgarian, H. G. Actions of systemic theophylline on hemidiaphragmatic recovery in rats following cervical spinal cord hemisection. Exp. Neurol. 140, 53\u201359 (1996)","journal-title":"Exp. Neurol."},{"key":"BFnature10199_CR29","doi-asserted-by":"publisher","first-page":"2993","DOI":"10.1523\/JNEUROSCI.23-07-02993.2003","volume":"23","author":"DD Fuller","year":"2003","unstructured":"Fuller, D. D., Johnson, S. M., Olson, E. B., Jr & Mitchell, G. S. Synaptic pathways to phrenic motoneurons are enhanced by chronic intermittent hypoxia after cervical spinal cord injury. J. Neurosci. 23, 2993\u20133000 (2003)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR30","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.1523\/JNEUROSCI.23-10-04182.2003","volume":"23","author":"YD Teng","year":"2003","unstructured":"Teng, Y. D. et al. Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats. J. Neurosci. 23, 4182\u20134189 (2003)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR31","doi-asserted-by":"publisher","first-page":"11862","DOI":"10.1523\/JNEUROSCI.3378-08.2008","volume":"28","author":"WJ Alilain","year":"2008","unstructured":"Alilain, W. J. et al. Light-induced rescue of breathing after spinal cord injury. J. Neurosci. 28, 11862\u201311870 (2008)","journal-title":"J. Neurosci."},{"key":"BFnature10199_CR32","doi-asserted-by":"crossref","unstructured":"Houle, J. D. et al. Combining peripheral nerve grafting and matrix modulation to repair the injured rat spinal cord. J. Vis. Exp. 10.3791\/1324 (2009)","DOI":"10.3791\/1324"},{"key":"BFnature10199_CR33","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"1998","unstructured":"Paxinos, G. & Watson, C. The Rat Brain in Stereotaxic Coordinates (Academic, 1998)"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature10199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature10199","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature10199.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:53:12Z","timestamp":1684417992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature10199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":33,"journal-issue":{"issue":"7355","published-print":{"date-parts":[[2011,7]]}},"alternative-id":["BFnature10199"],"URL":"https:\/\/doi.org\/10.1038\/nature10199","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13357164.14726498","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.13357164.793498906","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}