{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:43:10Z","timestamp":1791250990418,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7387","license":[{"start":{"date-parts":[[2012,1,29]],"date-time":"2012-01-29T00:00:00Z","timestamp":1327795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/nature10751","type":"journal-article","created":{"date-parts":[[2012,1,27]],"date-time":"2012-01-27T19:25:50Z","timestamp":1327692350000},"page":"108-112","source":"Crossref","is-referenced-by-count":165,"title":["Structural and functional conservation of key domains in InsP3 and ryanodine receptors"],"prefix":"10.1038","volume":"483","author":[{"given":"Min-Duk","family":"Seo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj","family":"Velamakanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Ishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Stathopulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Dale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Ames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiko","family":"Ikura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin W.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,1,29]]},"reference":[{"key":"BFnature10751_CR1","volume-title":"Structure and Function of Calcium Release Channels","author":"I Serysheva","year":"2010","unstructured":"Serysheva, I., ed. Structure and Function of Calcium Release Channels. (Academic Press, 2010)"},{"key":"BFnature10751_CR2","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/nature01268","volume":"420","author":"I Bosanac","year":"2002","unstructured":"Bosanac, I. et al. Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature 420, 696\u2013700 (2002)","journal-title":"Nature"},{"key":"BFnature10751_CR3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.molcel.2004.11.047","volume":"17","author":"I Bosanac","year":"2005","unstructured":"Bosanac, I. et al. Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor. Mol. Cell 17, 193\u2013203 (2005)","journal-title":"Mol. Cell"},{"key":"BFnature10751_CR4","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/nchembio.195","volume":"5","author":"AM Rossi","year":"2009","unstructured":"Rossi, A. M. et al. Synthetic partial agonists reveal key steps in IP3 receptor activation. Nature Chem. Biol. 5, 631\u2013639 (2009)","journal-title":"Nature Chem. Biol."},{"key":"BFnature10751_CR5","doi-asserted-by":"publisher","first-page":"16551","DOI":"10.1074\/jbc.M300646200","volume":"278","author":"K Uchida","year":"2003","unstructured":"Uchida, K., Miyauchi, H., Furuichi, T., Michikawa, T. & Mikoshiba, K. Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor. J. Biol. Chem. 278, 16551\u201316560 (2003)","journal-title":"J. Biol. Chem."},{"key":"BFnature10751_CR6","doi-asserted-by":"publisher","first-page":"24431","DOI":"10.1074\/jbc.M604190200","volume":"281","author":"ZT Schug","year":"2006","unstructured":"Schug, Z. T. & Joseph, S. K. The role of the S4\u2013S5 linker and C-terminal tail in inositol 1,4,5-trisphosphate receptor function. J. Biol. Chem. 281, 24431\u201324440 (2006)","journal-title":"J. Biol. Chem."},{"key":"BFnature10751_CR7","doi-asserted-by":"publisher","first-page":"36092","DOI":"10.1074\/jbc.M110.140160","volume":"285","author":"J Chan","year":"2010","unstructured":"Chan, J. et al. Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating. J. Biol. Chem. 285, 36092\u201336099 (2010)","journal-title":"J. Biol. Chem."},{"key":"BFnature10751_CR8","doi-asserted-by":"publisher","first-page":"36081","DOI":"10.1074\/jbc.M110.140129","volume":"285","author":"H Yamazaki","year":"2010","unstructured":"Yamazaki, H., Chan, J., Ikura, M., Michikawa, T. & Mikoshiba, K. Tyr-167\/Trp-168 in type1\/3 inositol 1,4,5-trisphosphate receptor mediates functional coupling between ligand binding and channel opening. J. Biol. Chem. 285, 36081\u201336091 (2010)","journal-title":"J. Biol. Chem."},{"key":"BFnature10751_CR9","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1038\/nature09471","volume":"468","author":"CC Tung","year":"2010","unstructured":"Tung, C. C., Lobo, P. A., Kimlicka, L. & Van Petegem, F. The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule. Nature 468, 585\u2013588 (2010)","journal-title":"Nature"},{"key":"BFnature10751_CR10","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.str.2011.05.003","volume":"19","author":"SJ Ludtke","year":"2011","unstructured":"Ludtke, S. J. et al. Flexible architecture of IP3R1 by cryo-EM. Structure 19, 1192\u20131199 (2011)","journal-title":"Structure"},{"key":"BFnature10751_CR11","doi-asserted-by":"publisher","first-page":"11040","DOI":"10.1073\/pnas.0905186106","volume":"106","author":"FJ Amador","year":"2009","unstructured":"Amador, F. J. et al. Crystal structure of type I ryanodine receptor amino-terminal \u03b2-trefoil domain reveals a disease-associated mutation \u201chot spot\u201d loop. Proc. Natl Acad. Sci. USA 106, 11040\u201311044 (2009)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature10751_CR12","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1016\/j.str.2009.08.016","volume":"17","author":"PA Lobo","year":"2009","unstructured":"Lobo, P. A. & Van Petegem, F. Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations. Structure 17, 1505\u20131514 (2009)","journal-title":"Structure"},{"key":"BFnature10751_CR13","doi-asserted-by":"publisher","first-page":"a004010","DOI":"10.1101\/cshperspect.a004010","volume":"2","author":"CW Taylor","year":"2010","unstructured":"Taylor, C. W. & Tovey, S. C. IP3 receptors: toward understanding their activation. Cold Spring Harb. Perspect. Biol. 2, a004010 (2010)","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"BFnature10751_CR14","doi-asserted-by":"publisher","first-page":"8093","DOI":"10.1074\/jbc.M806932200","volume":"284","author":"G Anyatonwu","year":"2009","unstructured":"Anyatonwu, G. & Joseph, S. K. Surface accessibility and conformational changes in the N-terminal domain of type I inositol trisphosphate receptors: studies using cysteine substitution mutagenesis. J. Biol. Chem. 284, 8093\u20138102 (2009)","journal-title":"J. Biol. Chem."},{"key":"BFnature10751_CR15","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1093\/cvr\/cvn303","volume":"81","author":"H Tateishi","year":"2009","unstructured":"Tateishi, H. et al. Defective domain-domain interactions within the ryanodine receptor as a critical cause of diastolic Ca2+ leak in failing hearts. Cardiovasc. Res. 81, 536\u2013545 (2009)","journal-title":"Cardiovasc. Res."},{"key":"BFnature10751_CR16","doi-asserted-by":"publisher","first-page":"1204","DOI":"10.1039\/b819328b","volume":"14","author":"KM Sureshan","year":"2009","unstructured":"Sureshan, K. M. et al. Activation of IP3 receptors by synthetic bisphosphate ligands. Chem. Commun. 14, 1204\u20131206 (2009)","journal-title":"Chem. Commun."},{"key":"BFnature10751_CR17","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/j.jmb.2007.08.057","volume":"373","author":"J Chan","year":"2007","unstructured":"Chan, J. et al. Ligand-induced conformational changes via flexible linkers in the amino-terminal region of the inositol 1,4,5-trisphosphate receptor. J. Mol. Biol. 373, 1269\u20131280 (2007)","journal-title":"J. Mol. Biol."},{"key":"BFnature10751_CR18","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/nature04709","volume":"440","author":"ML Mayer","year":"2006","unstructured":"Mayer, M. L. Glutamate receptors at atomic resolution. Nature 440, 456\u2013462 (2006)","journal-title":"Nature"},{"key":"BFnature10751_CR19","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1038\/nsmb.2112","volume":"18","author":"CC Lin","year":"2011","unstructured":"Lin, C. C., Baek, K. & Lu, Z. Apo and InsP3-bound crystal structures of the ligand-binding domain of an InsP3 receptor. Nature Struct. Mol. Biol. 18, 1172\u20131174 (2011)","journal-title":"Nature Struct. Mol. Biol."},{"key":"BFnature10751_CR20","doi-asserted-by":"publisher","first-page":"4272","DOI":"10.1021\/bi061557f","volume":"46","author":"T Hamada","year":"2007","unstructured":"Hamada, T., Bannister, M. L. & Ikemoto, N. Peptide probe study of the role of interaction between the cytoplasmic and transmembrane domains of the ryanodine receptor in the channel regulation mechanism. Biochemistry 46, 4272\u20134279 (2007)","journal-title":"Biochemistry"},{"key":"BFnature10751_CR21","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1085\/jgp.114.2.243","volume":"114","author":"J Ramos-Franco","year":"1999","unstructured":"Ramos-Franco, J., Galvan, D., Mignery, G. A. & Fill, M. Location of the permeation pathway in the recombinant type-1 inositol 1,4,5-trisphosphate receptor. J. Gen. Physiol. 114, 243\u2013250 (1999)","journal-title":"J. Gen. Physiol."},{"key":"BFnature10751_CR22","doi-asserted-by":"publisher","first-page":"e85","DOI":"10.1371\/journal.pbio.1000085","volume":"7","author":"M Sams\u00f3","year":"2009","unstructured":"Sams\u00f3, M., Feng, W., Pessah, I. N. & Allen, P. D. Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. PLoS Biol. 7, e85 (2009)","journal-title":"PLoS Biol."},{"key":"BFnature10751_CR23","doi-asserted-by":"publisher","first-page":"12755","DOI":"10.1074\/jbc.M609833200","volume":"282","author":"M Iwai","year":"2007","unstructured":"Iwai, M., Michikawa, T., Bosanac, I., Ikura, M. & Mikoshiba, K. Molecular basis of the isoform-specific ligand-binding affinity of inositol 1,4,5-trisphosphate receptors. J. Biol. Chem. 282, 12755\u201312764 (2007)","journal-title":"J. Biol. Chem."},{"key":"BFnature10751_CR24","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0026-895X(25)10918-8","volume":"37","author":"A Chu","year":"1990","unstructured":"Chu, A., Diaz-Munoz, M., Hawkes, M. J., Brush, K. & Hamilton, S. L. Ryanodine as a probe for the functional state of the skeletal muscle sarcoplasmic reticulum calcium release channel. Mol. Pharmacol. 37, 735\u2013741 (1990)","journal-title":"Mol. Pharmacol."},{"key":"BFnature10751_CR25","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/BF00812070","volume":"21","author":"FA Lai","year":"1989","unstructured":"Lai, F. A. & Meissner, G. The muscle ryanodine receptor and its intrinsic Ca2+ channel activity. J. Bioenerg. Biomembr. 21, 227\u2013246 (1989)","journal-title":"J. Bioenerg. Biomembr."},{"key":"BFnature10751_CR26","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1242\/jcs.064071","volume":"123","author":"Z Liu","year":"2010","unstructured":"Liu, Z. et al. Dynamic, inter-subunit interactions between the N-terminal and central mutation regions of cardiac ryanodine receptor. J. Cell Sci. 123, 1775\u20131784 (2010)","journal-title":"J. Cell Sci."},{"key":"BFnature10751_CR27","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1091\/mbc.e03-09-0688","volume":"15","author":"CH George","year":"2004","unstructured":"George, C. H. et al. Ryanodine receptor regulation by intramolecular interactions between cytoplasmic and transmembrane domains. Mol. Biol. Cell 15, 2627\u20132638 (2004)","journal-title":"Mol. Biol. Cell"},{"key":"BFnature10751_CR28","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","volume":"276","author":"Z Otwinowski","year":"1997","unstructured":"Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307\u2013326 (1997)","journal-title":"Methods Enzymol."},{"key":"BFnature10751_CR29","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1107\/S0021889807021206","volume":"40","author":"AJ McCoy","year":"2007","unstructured":"McCoy, A. J. et al. Phaser crystallographic software. J. Appl. Crystallogr. 40, 658\u2013674 (2007)","journal-title":"J. Appl. Crystallogr."},{"key":"BFnature10751_CR30","doi-asserted-by":"crossref","first-page":"13472","DOI":"10.1016\/S0021-9258(18)77371-7","volume":"265","author":"K Otsu","year":"1990","unstructured":"Otsu, K. et al. Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum. J. Biol. Chem. 265, 13472\u201313483 (1990)","journal-title":"J. Biol. Chem."},{"key":"BFnature10751_CR31","doi-asserted-by":"publisher","first-page":"12979","DOI":"10.1074\/jbc.M109.096016","volume":"285","author":"SC Tovey","year":"2010","unstructured":"Tovey, S. C. et al. Regulation of inositol 1,4,5-trisphosphate receptors by cAMP independent of cAMP-dependent protein kinase. J. Biol. Chem. 285, 12979\u201312989 (2010)","journal-title":"J. Biol. Chem."},{"key":"BFnature10751_CR32","volume-title":"Pharmacologic Analysis of Drug\u2013Receptor Interactions","author":"TP Kenakin","year":"1997","unstructured":"Kenakin, T. P. Pharmacologic Analysis of Drug\u2013Receptor Interactions 3rd edn (Lippincott, Williams & Wilkins, 1997)"},{"key":"BFnature10751_CR33","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1107\/S0907444996012255","volume":"53","author":"GN Murshudov","year":"1997","unstructured":"Murshudov, G. N., Vagin, A. A. & Dodson, E. J. Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr. D 53, 240\u2013255 (1997)","journal-title":"Acta Crystallogr. D"},{"key":"BFnature10751_CR34","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"P Emsley","year":"2004","unstructured":"Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D 60, 2126\u20132132 (2004)","journal-title":"Acta Crystallogr. D"},{"key":"BFnature10751_CR35","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/S0021-9258(19)39968-5","volume":"265","author":"F Zorzato","year":"1990","unstructured":"Zorzato, F. et al. Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum. J. Biol. Chem. 265, 2244\u20132256 (1990)","journal-title":"J. Biol. Chem."},{"key":"BFnature10751_CR36","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nprot.2006.40","volume":"1","author":"SC Tovey","year":"2006","unstructured":"Tovey, S. C., Sun, Y. & Taylor, C. W. Rapid functional assays of intracellular Ca2+ channels. Nature Protocols 1, 259\u2013263 (2006)","journal-title":"Nature Protocols"},{"key":"BFnature10751_CR37","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","volume":"25","author":"EF Pettersen","year":"2004","unstructured":"Pettersen, E. F. et al. UCSF Chimera\u2014a visualization system for exploratory research and analysis. J. Comput. Chem. 25, 1605\u20131612 (2004)","journal-title":"J. Comput. Chem."},{"key":"BFnature10751_CR38","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1006\/jsbi.1998.4080","volume":"125","author":"W Wriggers","year":"1999","unstructured":"Wriggers, W., Milligan, R. A. & McCammon, J. A. Situs: a package for docking crystal structures into low-resolution maps from electron microscopy. J. Struct. Biol. 125, 185\u2013195 (1999)","journal-title":"J. Struct. Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature10751.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature10751","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature10751.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T09:39:42Z","timestamp":1742377182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature10751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,29]]},"references-count":38,"journal-issue":{"issue":"7387","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["BFnature10751"],"URL":"https:\/\/doi.org\/10.1038\/nature10751","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,29]]}}}