{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:03:09Z","timestamp":1792296189023,"version":"4.4.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"7389","license":[{"start":{"date-parts":[[2012,3,1]],"date-time":"2012-03-01T00:00:00Z","timestamp":1330560000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1038\/nature10879","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T12:24:24Z","timestamp":1331036664000},"page":"336-340","source":"Crossref","is-referenced-by-count":2755,"title":["Phase transitions in the assembly of multivalent signalling proteins"],"prefix":"10.1038","volume":"483","author":[{"given":"Pilong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudeep","family":"Banjade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Chun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Llaguno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javoris V.","family":"Hollingsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman F.","family":"Banani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu-Xing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Tracy","family":"Nixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,3,7]]},"reference":[{"key":"BFnature10879_CR1","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1038\/nature04662","volume":"440","author":"N Jones","year":"2006","unstructured":"Jones, N. et al. Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes. Nature 440, 818\u2013823 (2006)","journal-title":"Nature"},{"key":"BFnature10879_CR2","volume-title":"Principles of Polymer Chemistry","author":"PJ Flory","year":"1953","unstructured":"Flory, P. J. Principles of Polymer Chemistry (Cornell Univ. Press, 1953)"},{"key":"BFnature10879_CR3","doi-asserted-by":"publisher","first-page":"3696","DOI":"10.1021\/j100216a005","volume":"86","author":"RJ Cohen","year":"1982","unstructured":"Cohen, R. J. & Benedek, G. B. Equilibrium and kinetic theory of polymerization and the sol-gel transition. J. Phys. Chem. 86, 3696\u20133714 (1982)","journal-title":"J. Phys. Chem."},{"key":"BFnature10879_CR4","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/pi.852","volume":"51","author":"J-M Lehn","year":"2002","unstructured":"Lehn, J.-M. Supramolecular polymer chemistry\u2014scope and perspectives. Polym. Int. 51, 825\u2013839 (2002)","journal-title":"Polym. Int."},{"key":"BFnature10879_CR5","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511975691","volume-title":"Polymer Physics: Applications to Molecular Association and Thermoreversible Gelation","author":"F Tanaka","year":"2011","unstructured":"Tanaka, F. Polymer Physics: Applications to Molecular Association and Thermoreversible Gelation (Cambridge Univ. Press, 2011)"},{"key":"BFnature10879_CR6","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1021\/ma970616h","volume":"31","author":"AN Semenov","year":"1998","unstructured":"Semenov, A. N. & Rubinstein, M. Thermoreversible gelation in solutions of associative polymers. 1. Statics. Macromolecules 31, 1373\u20131385 (1998)","journal-title":"Macromolecules"},{"key":"BFnature10879_CR7","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/S0959-440X(02)00364-0","volume":"12","author":"CF Brewer","year":"2002","unstructured":"Brewer, C. F., Miceli, M. C. & Baum, L. G. Clusters, bundles, arrays and lattices: novel mechanisms for lectin\u2013saccharide-mediated cellular interactions. Curr. Opin. Struct. Biol. 12, 616\u2013623 (2002)","journal-title":"Curr. Opin. Struct. Biol."},{"key":"BFnature10879_CR8","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1126\/science.1083653","volume":"300","author":"T Pawson","year":"2003","unstructured":"Pawson, T. & Nash, P. Assembly of cell regulatory systems through protein interaction domains. Science 300, 445\u2013452 (2003)","journal-title":"Science"},{"key":"BFnature10879_CR9","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nrm2178","volume":"8","author":"BM Lunde","year":"2007","unstructured":"Lunde, B. M., Moore, C. & Varani, G. RNA-binding proteins: modular design for efficient function. Nature Rev. Mol. Cell Biol. 8, 479\u2013490 (2007)","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"BFnature10879_CR10","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nrm2298","volume":"8","author":"AJ Ruthenburg","year":"2007","unstructured":"Ruthenburg, A. J., Li, H., Patel, D. J. & Allis, C. D. Multivalent engagement of chromatin modifications by linked binding modules. Nature Rev. Mol. Cell Biol. 8, 983\u2013994 (2007)","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"BFnature10879_CR11","doi-asserted-by":"publisher","first-page":"5715","DOI":"10.1021\/ja01142a045","volume":"74","author":"R Goldberg","year":"1952","unstructured":"Goldberg, R. A theory of antibody\u2013antigen reactions. I. Theory for reactions of multivalent antigen with bivalent and univalent antibody. J. Am. Chem. Soc. 74, 5715\u20135725 (1952)","journal-title":"J. Am. Chem. Soc."},{"key":"BFnature10879_CR12","doi-asserted-by":"publisher","first-page":"8640","DOI":"10.1074\/jbc.M412827200","volume":"280","author":"TK Dam","year":"2005","unstructured":"Dam, T. K. et al. Thermodynamic, kinetic, and electron microscopy studies of concanavalin A and Dioclea grandiflora lectin cross-linked with synthetic divalent carbohydrates. J. Biol. Chem. 280, 8640\u20138646 (2005)","journal-title":"J. Biol. Chem."},{"key":"BFnature10879_CR13","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1002\/cbic.200800550","volume":"10","author":"C Sisu","year":"2009","unstructured":"Sisu, C. et al. The influence of ligand valency on aggregation mechanisms for inhibiting bacterial toxins. Chembiochem 10, 329\u2013337 (2009)","journal-title":"Chembiochem"},{"key":"BFnature10879_CR14","doi-asserted-by":"publisher","first-page":"ra76","DOI":"10.1126\/scisignal.2000546","volume":"2","author":"J Jin","year":"2009","unstructured":"Jin, J. et al. Eukaryotic protein domains as functional units of cellular evolution. Sci. Signal. 2, ra76 (2009)","journal-title":"Sci. Signal."},{"key":"BFnature10879_CR15","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0301-4622(98)00208-7","volume":"75","author":"N Asherie","year":"1998","unstructured":"Asherie, N. et al. Oligomerization and phase separation in globular protein solutions. Biophys. Chem. 75, 213\u2013227 (1998)","journal-title":"Biophys. Chem."},{"key":"BFnature10879_CR16","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/pol.1952.120090106","volume":"9","author":"WH Stockmayer","year":"1952","unstructured":"Stockmayer, W. H. Molecular distribution in condensation polymers. J. Polym. Sci. 9, 69\u201371 (1952)","journal-title":"J. Polym. Sci."},{"key":"BFnature10879_CR17","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/pj.2010.59","volume":"42","author":"J Li","year":"2010","unstructured":"Li, J., Ngai, T. & Wu, C. The slow relaxation mode: from solutions to gel networks. Polym. J. 42, 609\u2013625 (2010)","journal-title":"Polym. J."},{"key":"BFnature10879_CR18","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s00397-006-0149-4","volume":"46","author":"A Semenov","year":"2007","unstructured":"Semenov, A., Charlot, A., Auzely-Velty, R. & Rinaudo, M. Rheological properties of binary associating polymers. Rheol. Acta 46, 541\u2013568 (2007)","journal-title":"Rheol. Acta"},{"key":"BFnature10879_CR19","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1128\/MCB.01770-07","volume":"28","author":"IM Blasutig","year":"2008","unstructured":"Blasutig, I. M. et al. Phosphorylated YDXV motifs and Nck SH2\/SH3 adaptors act cooperatively to induce actin reorganization. Mol. Cell. Biol. 28, 2035\u20132046 (2008)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature10879_CR20","doi-asserted-by":"publisher","first-page":"26448","DOI":"10.1074\/jbc.M103856200","volume":"276","author":"R Rohatgi","year":"2001","unstructured":"Rohatgi, R., Nollau, P., Ho, H. Y., Kirschner, M. W. & Mayer, B. J. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP\u2013Arp2\/3 pathway. J. Biol. Chem. 276, 26448\u201326452 (2001)","journal-title":"J. Biol. Chem."},{"key":"BFnature10879_CR21","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.molcel.2008.10.012","volume":"32","author":"SB Padrick","year":"2008","unstructured":"Padrick, S. B. et al. Hierarchical regulation of WASP\/WAVE proteins. Mol. Cell 32, 426\u2013438 (2008)","journal-title":"Mol. Cell"},{"key":"BFnature10879_CR22","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1146\/annurev.biochem.77.060407.135452","volume":"79","author":"SB Padrick","year":"2010","unstructured":"Padrick, S. B. & Rosen, M. K. Physical mechanisms of signal integration by WASP family proteins. Annu. Rev. Biochem. 79, 707\u2013735 (2010)","journal-title":"Annu. Rev. Biochem."},{"key":"BFnature10879_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1478-811X-7-1","volume":"7","author":"M Lettau","year":"2009","unstructured":"Lettau, M., Pieper, J. & Janssen, O. Nck adaptor proteins: functional versatility in T cells. Cell Commun. Signal. 7, 1 (2009)","journal-title":"Cell Commun. Signal."},{"key":"BFnature10879_CR24","doi-asserted-by":"publisher","first-page":"3635","DOI":"10.1093\/nar\/gkg584","volume":"31","author":"JC Obenauer","year":"2003","unstructured":"Obenauer, J. C., Cantley, L. C. & Yaffe, M. B. Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Res. 31, 3635\u20133641 (2003)","journal-title":"Nucleic Acids Res."},{"key":"BFnature10879_CR25","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.devcel.2009.10.017","volume":"17","author":"AG Matera","year":"2009","unstructured":"Matera, A. G., Izaguire-Sierra, M., Praveen, K. & Rajendra, T. K. Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly? Dev. Cell 17, 639\u2013647 (2009)","journal-title":"Dev. Cell"},{"key":"BFnature10879_CR26","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.molcel.2009.11.020","volume":"36","author":"JR Buchan","year":"2009","unstructured":"Buchan, J. R. & Parker, R. Eukaryotic stress granules: the ins and outs of translation. Mol. Cell 36, 932\u2013941 (2009)","journal-title":"Mol. Cell"},{"key":"BFnature10879_CR27","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.molcel.2007.02.011","volume":"25","author":"R Parker","year":"2007","unstructured":"Parker, R. & Sheth, U. P bodies and the control of mRNA translation and degradation. Mol. Cell 25, 635\u2013646 (2007)","journal-title":"Mol. Cell"},{"key":"BFnature10879_CR28","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ceb.2006.03.005","volume":"18","author":"AG Matera","year":"2006","unstructured":"Matera, A. G. & Shpargel, K. B. Pumping RNA: nuclear bodybuilding along the RNP pipeline. Curr. Opin. Cell Biol. 18, 317\u2013324 (2006)","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFnature10879_CR29","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/nrm2277","volume":"8","author":"R Bernardi","year":"2007","unstructured":"Bernardi, R. & Pandolfi, P. P. Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nature Rev. Mol. Cell Biol. 8, 1006\u20131016 (2007)","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"BFnature10879_CR30","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1126\/science.1172046","volume":"324","author":"CP Brangwynne","year":"2009","unstructured":"Brangwynne, C. P. et al. Germline P granules are liquid droplets that localize by controlled dissolution\/condensation. Science 324, 1729\u20131732 (2009)","journal-title":"Science"},{"key":"BFnature10879_CR31","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.str.2007.02.007","volume":"15","author":"B Chen","year":"2007","unstructured":"Chen, B. et al. ATP ground- and transition states of bacterial enhancer binding AAA+ ATPases support complex formation with their target protein, \u03c354. Structure 15, 429\u2013440 (2007)","journal-title":"Structure"},{"key":"BFnature10879_CR32","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1107\/S0021889892001663","volume":"25","author":"DI Svergun","year":"1992","unstructured":"Svergun, D. I. Determination of the regularization parameter in indirect-transform methods using perceptual criteria. J. Appl. Crystallogr. 25, 495\u2013503 (1992)","journal-title":"J. Appl. Crystallogr."},{"key":"BFnature10879_CR33","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1107\/S0021889809043076","volume":"43","author":"H Fischer","year":"2010","unstructured":"Fischer, H., Neto, M. O., Napolitano, H. B., Polikarpov, I. & Craievich, A. F. Determination of the molecular weight of proteins in solution from a single small-angle X-ray scattering measurement on a relative scale. J. Appl. Crystallogr. 43, 101\u2013109 (2010)","journal-title":"J. Appl. Crystallogr."},{"key":"BFnature10879_CR34","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0010-4655(82)90174-6","volume":"27","author":"SW Provencher","year":"1982","unstructured":"Provencher, S. W. CONTIN: a general purpose constrained regularization program for inverting noisy linear algebraic and integral equations. Comput. Phys. Commun. 27, 229\u2013242 (1982)","journal-title":"Comput. Phys. Commun."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature10879.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature10879","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature10879.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:58:50Z","timestamp":1684418330000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature10879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":34,"journal-issue":{"issue":"7389","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["BFnature10879"],"URL":"https:\/\/doi.org\/10.1038\/nature10879","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717960640.793489908","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717960640.793463709","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717960640.793464158","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717960640.793471102","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}