{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:44:29Z","timestamp":1791344669091,"version":"4.3.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7392","license":[{"start":{"date-parts":[[2012,3,7]],"date-time":"2012-03-07T00:00:00Z","timestamp":1331078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1038\/nature10956","type":"journal-article","created":{"date-parts":[[2012,3,6]],"date-time":"2012-03-06T12:24:24Z","timestamp":1331036664000},"page":"115-119","source":"Crossref","is-referenced-by-count":352,"title":["The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier\u2013Gorlin syndrome"],"prefix":"10.1038","volume":"484","author":[{"given":"Alex J.","family":"Kuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikui","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peggie","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Ishibe-Murakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayumi","family":"Yamazoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinshaw J.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Or","family":"Gozani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,3,7]]},"reference":[{"key":"BFnature10956_CR1","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1038\/nsmb1338","volume":"14","author":"SD Taverna","year":"2007","unstructured":"Taverna, S. D., Li, H., Ruthenburg, A. J., Allis, C. D. & Patel, D. J. How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nature Struct. Mol. Biol. 14, 1025\u20131040 (2007)","journal-title":"Nature Struct. Mol. Biol."},{"key":"BFnature10956_CR2","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/gb-2009-10-3-214","volume":"10","author":"BP Duncker","year":"2009","unstructured":"Duncker, B. P., Chesnokov, I. N. & McConkey, B. J. The origin recognition complex protein family. Genome Biol. 10, 214 (2009)","journal-title":"Genome Biol."},{"key":"BFnature10956_CR3","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/ng.775","volume":"43","author":"LS Bicknell","year":"2011","unstructured":"Bicknell, L. S. et al. Mutations in the pre-replication complex cause Meier-Gorlin syndrome. Nature Genet. 43, 356\u2013359 (2011)","journal-title":"Nature Genet."},{"key":"BFnature10956_CR4","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/ng.776","volume":"43","author":"LS Bicknell","year":"2011","unstructured":"Bicknell, L. S. et al. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nature Genet. 43, 350\u2013355 (2011)","journal-title":"Nature Genet."},{"key":"BFnature10956_CR5","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1101\/gad.169037","volume":"25","author":"A Klingseisen","year":"2011","unstructured":"Klingseisen, A. & Jackson, A. P. Mechanisms and pathways of growth failure in primordial dwarfism. Genes Dev. 25, 2011\u20132024 (2011)","journal-title":"Genes Dev."},{"key":"BFnature10956_CR6","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","volume":"128","author":"T Kouzarides","year":"2007","unstructured":"Kouzarides, T. Chromatin modifications and their function. Cell 128, 693\u2013705 (2007)","journal-title":"Cell"},{"key":"BFnature10956_CR7","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0014-5793(99)00132-5","volume":"446","author":"I Callebaut","year":"1999","unstructured":"Callebaut, I., Courvalin, J. C. & Mornon, J. P. The BAH (bromo-adjacent homology) domain: a link between DNA methylation, replication and transcriptional regulation. FEBS Lett. 446, 189\u2013193 (1999)","journal-title":"FEBS Lett."},{"key":"BFnature10956_CR8","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.molcel.2007.12.004","volume":"28","author":"M Onishi","year":"2007","unstructured":"Onishi, M., Liou, G. G., Buchberger, J. R., Walz, T. & Moazed, D. Role of the conserved Sir3-BAH domain in nucleosome binding and silent chromatin assembly. Mol. Cell 28, 1015\u20131028 (2007)","journal-title":"Mol. Cell"},{"key":"BFnature10956_CR9","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1128\/MCB.01682-08","volume":"29","author":"V Sampath","year":"2009","unstructured":"Sampath, V. et al. Mutational analysis of the Sir3 BAH domain reveals multiple points of interaction with nucleosomes. Mol. Cell. Biol. 29, 2532\u20132545 (2009)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature10956_CR10","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1126\/science.1210915","volume":"334","author":"KJ Armache","year":"2011","unstructured":"Armache, K. J., Garlick, J. D., Canzio, D., Narlikar, G. J. & Kingston, R. E. Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0\u2009\u00c5 resolution. Science 334, 977\u2013982 (2011)","journal-title":"Science"},{"key":"BFnature10956_CR11","doi-asserted-by":"publisher","first-page":"e6789","DOI":"10.1371\/journal.pone.0006789","volume":"4","author":"DJ Bua","year":"2009","unstructured":"Bua, D. J. et al. Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. PLoS ONE 4, e6789 (2009)","journal-title":"PLoS ONE"},{"key":"BFnature10956_CR12","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/0092-8674(95)90096-9","volume":"83","author":"SP Bell","year":"1995","unstructured":"Bell, S. P., Mitchell, J., Leber, J., Kobayashi, R. & Stillman, B. The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing. Cell 83, 563\u2013568 (1995)","journal-title":"Cell"},{"key":"BFnature10956_CR13","doi-asserted-by":"publisher","first-page":"552","DOI":"10.4161\/epi.6.5.15082","volume":"6","author":"ES Dorn","year":"2011","unstructured":"Dorn, E. S. & Cook, J. G. Nucleosomes in the neighborhood: new roles for chromatin modifications in replication origin control. Epigenetics 6, 552\u2013559 (2011)","journal-title":"Epigenetics"},{"key":"BFnature10956_CR14","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1146\/annurev.biochem.71.110601.135425","volume":"71","author":"SP Bell","year":"2002","unstructured":"Bell, S. P. & Dutta, A. DNA replication in eukaryotic cells. Annu. Rev. Biochem. 71, 333\u2013374 (2002)","journal-title":"Annu. Rev. Biochem."},{"key":"BFnature10956_CR15","doi-asserted-by":"publisher","first-page":"4600","DOI":"10.1093\/emboj\/cdf468","volume":"21","author":"Z Zhang","year":"2002","unstructured":"Zhang, Z., Hayashi, M. K., Merkel, O., Stillman, B. & Xu, R. M. Structure and function of the BAH-containing domain of Orc1p in epigenetic silencing. EMBO J. 21, 4600\u20134611 (2002)","journal-title":"EMBO J."},{"key":"BFnature10956_CR16","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1016\/j.cell.2006.10.043","volume":"127","author":"MV Botuyan","year":"2006","unstructured":"Botuyan, M. V. et al. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127, 1361\u20131373 (2006)","journal-title":"Cell"},{"key":"BFnature10956_CR17","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.molcel.2007.10.023","volume":"28","author":"H Li","year":"2007","unstructured":"Li, H. et al. Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. Mol. Cell 28, 677\u2013691 (2007)","journal-title":"Mol. Cell"},{"key":"BFnature10956_CR18","doi-asserted-by":"publisher","first-page":"2048","DOI":"10.1101\/gad.476008","volume":"22","author":"G Schotta","year":"2008","unstructured":"Schotta, G. et al. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev. 22, 2048\u20132061 (2008)","journal-title":"Genes Dev."},{"key":"BFnature10956_CR19","doi-asserted-by":"publisher","first-page":"5372","DOI":"10.1038\/sj.emboj.7601396","volume":"25","author":"K Noguchi","year":"2006","unstructured":"Noguchi, K., Vassilev, A., Ghosh, S., Yates, J. L. & DePamphilis, M. L. The BAH domain facilitates the ability of human Orc1 protein to activate replication origins in vivo. EMBO J. 25, 5372\u20135382 (2006)","journal-title":"EMBO J."},{"key":"BFnature10956_CR20","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/ncb2113","volume":"12","author":"M Tardat","year":"2010","unstructured":"Tardat, M. et al. The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells. Nature Cell Biol. 12, 1086\u20131093 (2010)","journal-title":"Nature Cell Biol."},{"key":"BFnature10956_CR21","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1083\/jcb.200706179","volume":"179","author":"M Tardat","year":"2007","unstructured":"Tardat, M., Murr, R., Herceg, Z., Sardet, C. & Julien, E. PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase. J. Cell Biol. 179, 1413\u20131426 (2007)","journal-title":"J. Cell Biol."},{"key":"BFnature10956_CR22","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1101\/gad.1674108","volume":"22","author":"B Miotto","year":"2008","unstructured":"Miotto, B. & Struhl, K. HBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1. Genes Dev. 22, 2633\u20132638 (2008)","journal-title":"Genes Dev."},{"key":"BFnature10956_CR23","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/366588a0","volume":"366","author":"D Kitsberg","year":"1993","unstructured":"Kitsberg, D., Selig, S., Keshet, I. & Cedar, H. Replication structure of the human \u03b2-globin gene domain. Nature 366, 588\u2013590 (1993)","journal-title":"Nature"},{"key":"BFnature10956_CR24","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/ng.777","volume":"43","author":"DL Guernsey","year":"2011","unstructured":"Guernsey, D. L. et al. Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. Nature Genet. 43, 360\u2013364 (2011)","journal-title":"Nature Genet."},{"key":"BFnature10956_CR25","doi-asserted-by":"publisher","first-page":"e1499","DOI":"10.1371\/journal.pone.0001499","volume":"3","author":"XJ Sun","year":"2008","unstructured":"Sun, X. J. et al. Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. PLoS ONE 3, e1499 (2008)","journal-title":"PLoS ONE"},{"key":"BFnature10956_CR26","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/nsmb.1988","volume":"18","author":"C Costas","year":"2011","unstructured":"Costas, C. et al. Genome-wide mapping of Arabidopsis thaliana origins of DNA replication and their associated epigenetic marks. Nature Struct. Mol. Biol. 18, 395\u2013400 (2011)","journal-title":"Nature Struct. Mol. Biol."},{"key":"BFnature10956_CR27","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.molcel.2009.12.012","volume":"37","author":"B Miotto","year":"2010","unstructured":"Miotto, B. & Struhl, K. HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin. Mol. Cell 37, 57\u201366 (2010)","journal-title":"Mol. Cell"},{"key":"BFnature10956_CR28","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nature09290","volume":"466","author":"Y Jacob","year":"2010","unstructured":"Jacob, Y. et al. Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases. Nature 466, 987\u2013991 (2010)","journal-title":"Nature"},{"key":"BFnature10956_CR29","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.tcb.2011.04.006","volume":"21","author":"J Brustel","year":"2011","unstructured":"Brustel, J., Tardat, M., Kirsh, O., Grimaud, C. & Julien, E. Coupling mitosis to DNA replication: the emerging role of the histone H4-lysine 20 methyltransferase PR-Set7. Trends Cell Biol. 21, 452\u2013460 (2011)","journal-title":"Trends Cell Biol."},{"key":"BFnature10956_CR30","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1128\/MCB.01768-08","volume":"29","author":"H Oda","year":"2009","unstructured":"Oda, H. et al. Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development. Mol. Cell. Biol. 29, 2278\u20132295 (2009)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature10956_CR31","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/nature04835","volume":"442","author":"X Shi","year":"2006","unstructured":"Shi, X. et al. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature 442, 96\u201399 (2006)","journal-title":"Nature"},{"key":"BFnature10956_CR32","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/nature06431","volume":"450","author":"AG Matthews","year":"2007","unstructured":"Matthews, A. G. et al. RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature 450, 1106\u20131110 (2007)","journal-title":"Nature"},{"key":"BFnature10956_CR33","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1107\/S0907444902016657","volume":"58","author":"PD Adams","year":"2002","unstructured":"Adams, P. D. et al. PHENIX: building new software for automated crystallographic structure determination. Acta Crystallogr. D 58, 1948\u20131954 (2002)","journal-title":"Acta Crystallogr. D"},{"key":"BFnature10956_CR34","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1107\/S0907444904019158","volume":"60","author":"P Emsley","year":"2004","unstructured":"Emsley, P. & Cowtan, K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D 60, 2126\u20132132 (2004)","journal-title":"Acta Crystallogr. D"},{"key":"BFnature10956_CR35","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1107\/S0021889807021206","volume":"40","author":"AJ McCoy","year":"2007","unstructured":"McCoy, A. J. et al. Phaser crystallographic software. J. Appl. Cryst. 40, 658\u2013674 (2007)","journal-title":"J. Appl. Cryst."},{"key":"BFnature10956_CR36","doi-asserted-by":"publisher","first-page":"8602","DOI":"10.1128\/MCB.20.22.8602-8612.2000","volume":"20","author":"J Mendez","year":"2000","unstructured":"Mendez, J. & Stillman, B. Chromatin association of human origin recognition complex, Cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol. Cell. Biol. 20, 8602\u20138612 (2000)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature10956_CR37","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.molcel.2011.08.042","volume":"44","author":"AJ Kuo","year":"2011","unstructured":"Kuo, A. J. et al. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol. Cell 44, 609\u2013620 (2011)","journal-title":"Mol. Cell"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature10956.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature10956","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature10956.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:59:31Z","timestamp":1684418371000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature10956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,7]]},"references-count":37,"journal-issue":{"issue":"7392","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["BFnature10956"],"URL":"https:\/\/doi.org\/10.1038\/nature10956","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.14266033.15778165","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,7]]}}}