{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T21:05:50Z","timestamp":1793048750688,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"7425","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1038\/nature11618","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T09:10:02Z","timestamp":1353402602000},"page":"547-553","source":"Crossref","is-referenced-by-count":448,"title":["Hippocampal\u2013cortical interaction during periods of subcortical silence"],"prefix":"10.1038","volume":"491","author":[{"given":"N. K.","family":"Logothetis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Eschenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Augath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Steudel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. C.","family":"Evrard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Besserve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Oeltermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"BFnature11618_CR1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1037\/0033-295X.99.2.195","volume":"99","author":"LR Squire","year":"1992","unstructured":"Squire, L. R. Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans. Psychol. Rev. 99, 195\u2013231 (1992)","journal-title":"Psychol. Rev."},{"key":"BFnature11618_CR2","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1146\/annurev.psych.48.1.547","volume":"48","author":"H Eichenbaum","year":"1997","unstructured":"Eichenbaum, H. Declarative memory: insights from cognitive neurobiology. Annu. Rev. Psychol. 48, 547\u2013572 (1997)","journal-title":"Annu. Rev. Psychol."},{"key":"BFnature11618_CR3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/npp.2010.169","volume":"36","author":"L Nadel","year":"2011","unstructured":"Nadel, L. & Hardt, O. Update on memory systems and processes. Neuropsychopharmacology 36, 251\u2013273 (2011)","journal-title":"Neuropsychopharmacology"},{"key":"BFnature11618_CR4","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0306-4522(89)90423-5","volume":"31","author":"G Buzs\u00e1ki","year":"1989","unstructured":"Buzs\u00e1ki, G. Two-stage model of memory trace formation: a role for \u201cnoisy\u201d brain states. Neuroscience 31, 551\u2013570 (1989)","journal-title":"Neuroscience"},{"key":"BFnature11618_CR5","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/cercor\/6.2.81","volume":"6","author":"G Buzs\u00e1ki","year":"1996","unstructured":"Buzs\u00e1ki, G. The hippocampo\u2013neocortical dialogue. Cereb. Cortex 6, 81\u201392 (1996)","journal-title":"Cereb. Cortex"},{"key":"BFnature11618_CR6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(08)63064-2","volume":"121","author":"ME Hasselmo","year":"1999","unstructured":"Hasselmo, M. E. Neuromodulation and the hippocampus: memory function and dysfunction in a network simulation. Prog. Brain Res. 121, 3\u201318 (1999)","journal-title":"Prog. Brain Res."},{"key":"BFnature11618_CR7","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0079-6123(02)38076-2","volume":"138","author":"CMA Pennartz","year":"2002","unstructured":"Pennartz, C. M. A., Uylings, H. B. M., Barnes, C. A. & McNaughton, B. L. Memory reactivation and consolidation during sleep: from cellular mechanisms to human performance. Prog. Brain. Res. 138, 143\u2013166 (2002)","journal-title":"Prog. Brain. Res."},{"key":"BFnature11618_CR8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/35036213","volume":"1","author":"H Eichenbaum","year":"2000","unstructured":"Eichenbaum, H. A cortical-hippocampal system for declarative memory. Nature Rev. Neurosci. 1, 41\u201350 (2000)","journal-title":"Nature Rev. Neurosci."},{"key":"BFnature11618_CR9","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1126\/science.1589772","volume":"256","author":"G Buzs\u00e1ki","year":"1992","unstructured":"Buzs\u00e1ki, G., Horvath, Z., Urioste, R., Hetke, J. & Wise, K. High-frequency network oscillation in the hippocampus. Science 256, 1025\u20131027 (1992)","journal-title":"Science"},{"key":"BFnature11618_CR10","first-page":"114","volume-title":"The Hippocampus as a Cognitive Map","author":"J O'Keefe","year":"1978","unstructured":"O'Keefe, J. & Nadel, L. The Hippocampus as a Cognitive Map 114\u2013152 (Oxford Univ. Press, 1978)"},{"key":"BFnature11618_CR11","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1152\/jn.00401.2007","volume":"98","author":"WE Skaggs","year":"2007","unstructured":"Skaggs, W. E. et al. EEG sharp waves and sparse ensemble unit activity in the macaque hippocampus. J. Neurophysiol. 98, 898\u2013910 (2007)","journal-title":"J. Neurophysiol."},{"key":"BFnature11618_CR12","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1093\/brain\/awn103","volume":"131","author":"N Axmacher","year":"2008","unstructured":"Axmacher, N., Elger, C. E. & Fell, J. Ripples in the medial temporal lobe are relevant for human memory consolidation. Brain 131, 1806\u20131817 (2008)","journal-title":"Brain"},{"key":"BFnature11618_CR13","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1523\/JNEUROSCI.15-01-00030.1995","volume":"15","author":"A Ylinen","year":"1995","unstructured":"Ylinen, A. et al. Sharp wave-associated high-frequency oscillation (200\u2009Hz) in the intact hippocampus: network and intracellular mechanisms. J. Neurosci. 15, 30\u201346 (1995)","journal-title":"J. Neurosci."},{"key":"BFnature11618_CR14","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.conb.2011.02.005","volume":"21","author":"G Girardeau","year":"2011","unstructured":"Girardeau, G. & Zugaro, M. Hippocampal ripples and memory consolidation. Curr. Opin. Neurobiol. 21, 452\u2013459 (2011)","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnature11618_CR15","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.8036517","volume":"265","author":"MA Wilson","year":"1994","unstructured":"Wilson, M. A. & McNaughton, B. L. Reactivation of hippocampal ensemble memories during sleep. Science 265, 676\u2013679 (1994)","journal-title":"Science"},{"key":"BFnature11618_CR16","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1523\/JNEUROSCI.19-10-04090.1999","volume":"19","author":"HS Kudrimoti","year":"1999","unstructured":"Kudrimoti, H. S., Barnes, C. A. & McNaughton, B. L. Reactivation of hippocampal cell assemblies: effects of behavioral state, experience, and EEG dynamics. J. Neurosci. 19, 4090\u20134101 (1999)","journal-title":"J. Neurosci."},{"key":"BFnature11618_CR17","doi-asserted-by":"crossref","first-page":"9497","DOI":"10.1523\/JNEUROSCI.19-21-09497.1999","volume":"19","author":"Z N\u00e1dasdy","year":"1999","unstructured":"N\u00e1dasdy, Z., Hirase, H., Czurko, A., Csicsvari, J. & Buzsaki, G. Replay and time compression of recurring spike sequences in the hippocampus. J. Neurosci. 19, 9497\u20139507 (1999)","journal-title":"J. Neurosci."},{"key":"BFnature11618_CR18","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1126\/science.271.5257.1870","volume":"271","author":"WE Skaggs","year":"1996","unstructured":"Skaggs, W. E. & McNaughton, B. L. Replay of neuronal firing sequences in rat hippocampus during sleep following spatial experience. Science 271, 1870\u20131873 (1996)","journal-title":"Science"},{"key":"BFnature11618_CR19","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1101\/lm.726008","volume":"15","author":"O Eschenko","year":"2008","unstructured":"Eschenko, O., Ramadan, W., Molle, M., Born, J. & Sara, S. J. Sustained increase in hippocampal sharp-wave ripple activity during slow-wave sleep after learning. Learn. Mem. 15, 222\u2013228 (2008)","journal-title":"Learn. Mem."},{"key":"BFnature11618_CR20","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nn2037","volume":"11","author":"J O'Neill","year":"2008","unstructured":"O'Neill, J., Senior, T. J., Allen, K., Huxter, J. R. & Csicsvari, J. Reactivation of experience-dependent cell assembly patterns in the hippocampus. Nature Neurosci. 11, 209\u2013215 (2008)","journal-title":"Nature Neurosci."},{"key":"BFnature11618_CR21","doi-asserted-by":"crossref","first-page":"e6697","DOI":"10.1371\/journal.pone.0006697","volume":"4","author":"W Ramadan","year":"2009","unstructured":"Ramadan, W., Eschenko, O. & Sara, S. J. Hippocampal sharp wave\/ripples during sleep for consolidation of associative memory. PloS ONE 4, e6697 (2009)","journal-title":"PloS ONE"},{"key":"BFnature11618_CR22","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/nn.2384","volume":"12","author":"G Girardeau","year":"2009","unstructured":"Girardeau, G., Benchenane, K., Wiener, S. I., Buzsaki, G. & Zugaro, M. B. Selective suppression of hippocampal ripples impairs spatial memory. Nature Neurosci. 12, 1222\u20131223 (2009)","journal-title":"Nature Neurosci."},{"key":"BFnature11618_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hipo.20707","volume":"20","author":"V Ego-Stengel","year":"2010","unstructured":"Ego-Stengel, V. & Wilson, M. A. Disruption of ripple-associated hippocampal activity during rest impairs spatial learning in the rat. Hippocampus 20, 1\u201310 (2010)","journal-title":"Hippocampus"},{"key":"BFnature11618_CR24","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S0896-6273(00)80629-7","volume":"21","author":"AG Siapas","year":"1998","unstructured":"Siapas, A. G. & Wilson, M. A. Coordinated interactions between hippocampal ripples and cortical spindles during slow-wave sleep. Neuron 21, 1123\u20131128 (1998)","journal-title":"Neuron"},{"key":"BFnature11618_CR25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.neuron.2009.01.011","volume":"61","author":"CM Wierzynski","year":"2009","unstructured":"Wierzynski, C. M., Lubenov, E. V., Gu, M. & Siapas, A. G. State-dependent spike-timing relationships between hippocampal and prefrontal circuits during sleep. Neuron 61, 587\u2013596 (2009)","journal-title":"Neuron"},{"key":"BFnature11618_CR26","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.neuron.2006.10.023","volume":"52","author":"Y Isomura","year":"2006","unstructured":"Isomura, Y. et al. Integration and segregation of activity in entorhinal\u2013hippocampal subregions by neocortical slow oscillations. Neuron 52, 871\u2013882 (2006)","journal-title":"Neuron"},{"key":"BFnature11618_CR27","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1073\/pnas.0437938100","volume":"100","author":"A Sirota","year":"2003","unstructured":"Sirota, A., Csicsvari, J., Buhl, D. & Buzsaki, G. Communication between neocortex and hippocampus during sleep in rodents. Proc. Natl Acad. Sci. USA 100, 2065\u20132069 (2003)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature11618_CR28","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.1523\/JNEUROSCI.13-08-03252.1993","volume":"13","author":"M Steriade","year":"1993","unstructured":"Steriade, M., Nunez, A. & Amzica, F. A novel slow ( 1\u2009Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components. J. Neurosci. 13, 3252\u20133265 (1993)","journal-title":"J. Neurosci."},{"key":"BFnature11618_CR29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev.neuro.20.1.185","volume":"20","author":"DA McCormick","year":"1997","unstructured":"McCormick, D. A. & Bal, T. Sleep and arousal\u2014thalamocortical mechanisms. Annu. Rev. Neurosci. 20, 185\u2013215 (1997)","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnature11618_CR30","doi-asserted-by":"crossref","first-page":"10941","DOI":"10.1523\/JNEUROSCI.22-24-10941.2002","volume":"22","author":"M M\u00f6lle","year":"2002","unstructured":"M\u00f6lle, M., Marshall, L., Gais, S. & Born, J. Grouping of spindle activity during slow oscillations in human non-rapid eye movement sleep. J. Neurosci. 22, 10941\u201310947 (2002)","journal-title":"J. Neurosci."},{"key":"BFnature11618_CR31","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1212\/WNL.49.4.952","volume":"49","author":"F Amzica","year":"1997","unstructured":"Amzica, F. & Steriade, M. The K-complex: its slow ( 1-Hz) rhythmicity and relation to delta waves. Neurology 49, 952\u2013959 (1997)","journal-title":"Neurology"},{"key":"BFnature11618_CR32","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1101\/lm.73504","volume":"11","author":"FP Battaglia","year":"2004","unstructured":"Battaglia, F. P., Sutherland, G. R. & McNaughton, B. L. Hippocampal sharp wave bursts coincide with neocortical \u201cup-state\u201d transitions. Learn. Mem. 11, 697\u2013704 (2004)","journal-title":"Learn. Mem."},{"key":"BFnature11618_CR33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1152\/jn.00014.2006","volume":"96","author":"M M\u00f6lle","year":"2006","unstructured":"M\u00f6lle, M., Yeshenko, O., Marshall, L., Sara, S. J. & Born, J. Hippocampal sharp wave-ripples linked to slow oscillations in rat slow-wave sleep. J. Neurophysiol. 96, 62\u201370 (2006)","journal-title":"J. Neurophysiol."},{"key":"BFnature11618_CR34","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1093\/brain\/awm146","volume":"130","author":"Z Clemens","year":"2007","unstructured":"Clemens, Z. et al. Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans. Brain 130, 2868\u20132878 (2007)","journal-title":"Brain"},{"key":"BFnature11618_CR35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.brainresrev.2006.01.007","volume":"52","author":"N Axmacher","year":"2006","unstructured":"Axmacher, N., Mormann, F., Fernandez, G., Elger, C. E. & Fell, J. Memory formation by neuronal synchronization. Brain Res. Rev. 52, 170\u2013182 (2006)","journal-title":"Brain Res. Rev."},{"key":"BFnature11618_CR36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/15622971003637637","volume":"11","author":"J Born","year":"2010","unstructured":"Born, J. Slow-wave sleep and the consolidation of long-term memory. World J. Biol. Psychiatry 11, 16\u201321 (2010)","journal-title":"World J. Biol. Psychiatry"},{"key":"BFnature11618_CR37","doi-asserted-by":"crossref","first-page":"d878","DOI":"10.2741\/1043","volume":"8","author":"M Steriade","year":"2003","unstructured":"Steriade, M. The corticothalamic system in sleep. Front. Biosci. 8, d878\u2013d899 (2003)","journal-title":"Front. Biosci."},{"key":"BFnature11618_CR38","doi-asserted-by":"crossref","first-page":"8605","DOI":"10.1523\/JNEUROSCI.0294-11.2011","volume":"31","author":"D Sullivan","year":"2011","unstructured":"Sullivan, D. et al. Relationships between hippocampal sharp waves, ripples, and fast gamma oscillation: influence of dentate and entorhinal cortical activity. J. Neurosci. 31, 8605\u20138616 (2011)","journal-title":"J. Neurosci."},{"key":"BFnature11618_CR39","volume-title":"The Rhesus Monkey Brain in Stereotactic Coordinates","author":"G Paxinos","year":"2008","unstructured":"Paxinos, G., Huang, X. F., Petrides, M. & Toga, A. W. The Rhesus Monkey Brain in Stereotactic Coordinates (Elsevier, 2008)"},{"key":"BFnature11618_CR40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nn1675","volume":"9","author":"A Shmuel","year":"2006","unstructured":"Shmuel, A., Augath, M. A., Oeltermann, A. & Logothetis, N. K. Negative functional MRI response correlates with decreases in neuronal activity in monkey visual area V1. Nature Neurosci. 9, 569\u2013577 (2006)","journal-title":"Nature Neurosci."},{"key":"BFnature11618_CR41","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/nn.2631","volume":"13","author":"NK Logothetis","year":"2010","unstructured":"Logothetis, N. K. et al. The effects of electrical microstimulation on cortical signal propagation. Nature Neurosci. 13, 1283\u20131291 (2010)","journal-title":"Nature Neurosci."},{"key":"BFnature11618_CR42","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1152\/jn.00048.2006","volume":"96","author":"JL Vincent","year":"2006","unstructured":"Vincent, J. L. et al. Coherent spontaneous activity identifies a hippocampal\u2013parietal mnemonic network. J. Neurophysiol. 96, 3517\u20133531 (2006)","journal-title":"J. Neurophysiol."},{"key":"BFnature11618_CR43","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0028-3932(02)00157-4","volume":"41","author":"RA Poldrack","year":"2003","unstructured":"Poldrack, R. A. & Packard, M. G. Competition among multiple memory systems: converging evidence from animal and human brain studies. Neuropsychologia 41, 245\u2013251 (2003)","journal-title":"Neuropsychologia"},{"key":"BFnature11618_CR44","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/hipo.10024","volume":"12","author":"JP Schroeder","year":"2002","unstructured":"Schroeder, J. P., Wingard, J. C. & Packard, M. G. Post-training reversible inactivation of hippocampus reveals interference between memory systems. Hippocampus 12, 280\u2013284 (2002)","journal-title":"Hippocampus"},{"key":"BFnature11618_CR45","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1101\/lm.1625310","volume":"17","author":"AM Oliveira","year":"2010","unstructured":"Oliveira, A. M., Hawk, J. D., Abel, T. & Havekes, R. Post-training reversible inactivation of the hippocampus enhances novel object recognition memory. Learn. Mem. 17, 155\u2013160 (2010)","journal-title":"Learn. Mem."},{"key":"BFnature11618_CR46","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.nlm.2004.05.003","volume":"82","author":"RA Poldrack","year":"2004","unstructured":"Poldrack, R. A. & Rodriguez, P. How do memory systems interact? Evidence from human classification learning. Neurobiol. Learn. Mem. 82, 324\u2013332 (2004)","journal-title":"Neurobiol. Learn. Mem."},{"key":"BFnature11618_CR47","first-page":"305","volume":"55","author":"J Mouret","year":"1963","unstructured":"Mouret, J., Jeannero, M. & Jouvet, M. L\u2032activit\u00e9 \u00e9lectrique du systeme visuel au cours de la phase paradoxale du sommeil chez le chat. J. Physiol. (Paris). 55, 305\u2013306 (1963)","journal-title":"J. Physiol. (Paris)"},{"key":"BFnature11618_CR48","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1523\/JNEUROSCI.5594-05.2006","volume":"26","author":"T Wolansky","year":"2006","unstructured":"Wolansky, T., Clement, E. A., Peters, S. R., Palczak, M. A. & Dickson, C. T. Hippocampal slow oscillation: a novel EEG state and its coordination with ongoing neocortical activity. J. Neurosci. 26, 6213\u20136229 (2006)","journal-title":"J. Neurosci."},{"key":"BFnature11618_CR49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2007.12.018","volume":"189","author":"N Axmacher","year":"2008","unstructured":"Axmacher, N., Elger, C. E. & Fell, J. Memory formation by refinement of neural representations: the inhibition hypothesis. Behav. Brain Res. 189, 1\u20138 (2008)","journal-title":"Behav. Brain Res."},{"key":"BFnature11618_CR50","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/nature06976","volume":"453","author":"NK Logothetis","year":"2008","unstructured":"Logothetis, N. K. What we can do and what we cannot do with fMRI. Nature 453, 869\u2013878 (2008)","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature11618.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature11618","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature11618.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T11:22:13Z","timestamp":1714562533000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature11618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":50,"journal-issue":{"issue":"7425","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["BFnature11618"],"URL":"https:\/\/doi.org\/10.1038\/nature11618","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717976769.793477673","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717976769.793470550","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}