{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:28:09Z","timestamp":1791196089921,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"7438","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1038\/nature11924","type":"journal-article","created":{"date-parts":[[2013,2,19]],"date-time":"2013-02-19T10:23:19Z","timestamp":1361269399000},"page":"476-479","source":"Crossref","is-referenced-by-count":239,"title":["Adult somatic stem cells in the human parasite Schistosoma mansoni"],"prefix":"10.1038","volume":"494","author":[{"given":"James J.","family":"Collins III","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bramwell G.","family":"Lambrus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marla E.","family":"Tharp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harini","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip A.","family":"Newmark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,20]]},"reference":[{"key":"BFnature11924_CR1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0001-706X(00)00122-4","volume":"77","author":"L Chitsulo","year":"2000","unstructured":"Chitsulo, L., Engels, D., Montresor, A. & Savioli, L. The global status of schistosomiasis and its control. Acta Trop. 77, 41\u201351 (2000)","journal-title":"Acta Trop."},{"key":"BFnature11924_CR2","volume-title":"Schistosomes: Development, Reproduction, and Host Relations","author":"PF Basch","year":"1991","unstructured":"Basch, P. F. Schistosomes: Development, Reproduction, and Host Relations (Oxford Univ. Press, 1991)"},{"key":"BFnature11924_CR3","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1126\/science.1203983","volume":"332","author":"DE Wagner","year":"2011","unstructured":"Wagner, D. E., Wang, I. E. & Reddien, P. W. Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration. Science 332, 811\u2013816 (2011)","journal-title":"Science"},{"key":"BFnature11924_CR4","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/nrg759","volume":"3","author":"PA Newmark","year":"2002","unstructured":"Newmark, P. A. & S\u00e1nchez Alvarado, A. Not your father\u2019s planarian: a classic model enters the era of functional genomics. Nature Rev. Genet. 3, 210\u2013219 (2002)","journal-title":"Nature Rev. Genet."},{"key":"BFnature11924_CR5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1017\/S0031182009991727","volume":"137","author":"K Brehm","year":"2010","unstructured":"Brehm, K. Echinococcus multilocularis as an experimental model in stem cell research and molecular host-parasite interaction. Parasitology 137, 537\u2013555 (2010)","journal-title":"Parasitology"},{"key":"BFnature11924_CR6","doi-asserted-by":"crossref","first-page":"e1455","DOI":"10.1371\/journal.pntd.0001455","volume":"6","author":"AV Protasio","year":"2012","unstructured":"Protasio, A. V. et al. A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni. PLoS Negl. Trop. Dis. 6, e1455 (2012)","journal-title":"PLoS Negl. Trop. Dis."},{"key":"BFnature11924_CR7","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","volume":"460","author":"M Berriman","year":"2009","unstructured":"Berriman, M. et al. The genome of the blood fluke Schistosoma mansoni. Nature 460, 352\u2013358 (2009)","journal-title":"Nature"},{"key":"BFnature11924_CR8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1017\/S0031182000054731","volume":"88","author":"JE Den Hollander","year":"1984","unstructured":"Den Hollander, J. E. & Erasmus, D. A. Schistosoma mansoni: DNA synthesis in males and females from mixed and single-sex infections. Parasitology 88, 463\u2013476 (1984)","journal-title":"Parasitology"},{"key":"BFnature11924_CR9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2307\/3279273","volume":"62","author":"PM Nollen","year":"1976","unstructured":"Nollen, P. M., Floyd, R. D., Kolzow, R. G. & Deter, D. L. The timing of reproductive cell development and movement in Schistosoma mansoni, S.  japonicum, and S.  haematobium, using techniques of autoradiography and transplantation. J. Parasitol. 62, 227\u2013231 (1976)","journal-title":"J. Parasitol."},{"key":"BFnature11924_CR10","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1073\/pnas.0712168105","volume":"105","author":"A Salic","year":"2008","unstructured":"Salic, A. & Mitchison, T. J. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc. Natl Acad. Sci. USA 105, 2415\u20132420 (2008)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature11924_CR11","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1006\/dbio.2000.9645","volume":"220","author":"PA Newmark","year":"2000","unstructured":"Newmark, P. A. & S\u00e1nchez Alvarado, A. Bromodeoxyuridine specifically labels the regenerative stem cells of planarians. Dev. Biol. 220, 142\u2013153 (2000)","journal-title":"Dev. Biol."},{"key":"BFnature11924_CR12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ydbio.2011.05.669","volume":"356","author":"DJ Forsthoefel","year":"2011","unstructured":"Forsthoefel, D. J., Park, A. E. & Newmark, P. A. Stem cell-based growth, regeneration, and remodeling of the planarian intestine. Dev. Biol. 356, 445\u2013459 (2011)","journal-title":"Dev. Biol."},{"key":"BFnature11924_CR13","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF00026179","volume":"84","author":"J Bagu\u00f1\u00e1","year":"1981","unstructured":"Bagu\u00f1\u00e1, J. & Romero, R. Quantitative analysis of cell types during growth, degrowth and regeneration in the planarians Dugesia mediterranea and Dugesia tigrina. Hydrobiologia 84, 181\u2013194 (1981)","journal-title":"Hydrobiologia"},{"key":"BFnature11924_CR14","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.stem.2012.01.016","volume":"10","author":"DE Wagner","year":"2012","unstructured":"Wagner, D. E., Ho, J. J. & Reddien, P. W. Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis. Cell Stem Cell 10, 299\u2013311 (2012)","journal-title":"Cell Stem Cell"},{"key":"BFnature11924_CR15","doi-asserted-by":"crossref","first-page":"R19","DOI":"10.1186\/gb-2012-13-3-r19","volume":"13","author":"J Solana","year":"2012","unstructured":"Solana, J. et al. Defining the molecular profile of planarian pluripotent stem cells using a combinatorial RNAseq, RNA interference and irradiation approach. Genome Biol. 13, R19 (2012)","journal-title":"Genome Biol."},{"key":"BFnature11924_CR16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.stem.2008.07.002","volume":"3","author":"GT Eisenhoffer","year":"2008","unstructured":"Eisenhoffer, G. T., Kang, H. & S\u00e1nchez Alvarado, A. Molecular analysis of stem cells and their descendants during cell turnover and regeneration in the planarian Schmidtea mediterranea. Cell Stem Cell 3, 327\u2013339 (2008)","journal-title":"Cell Stem Cell"},{"key":"BFnature11924_CR17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.pt.2004.03.004","volume":"20","author":"CR Caffrey","year":"2004","unstructured":"Caffrey, C. R., McKerrow, J. H., Salter, J. P. & Sajid, M. Blood \u2018n\u2019 guts: an update on schistosome digestive peptidases. Trends Parasitol. 20, 241\u2013248 (2004)","journal-title":"Trends Parasitol."},{"key":"BFnature11924_CR18","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1038\/emboj.2012.110","volume":"31","author":"P \u00d6nal","year":"2012","unstructured":"\u00d6nal, P. et al. Gene expression of pluripotency determinants is conserved between mammalian and planarian stem cells. EMBO J. 31, 2755\u20132769 (2012)","journal-title":"EMBO J."},{"key":"BFnature11924_CR19","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1002\/stem.1144","volume":"30","author":"RM Labb\u00e9","year":"2012","unstructured":"Labb\u00e9, R. M. et al. A comparative transcriptomic analysis reveals conserved features of stem cell pluripotency in planarians and mammals. Stem Cells 30, 1734\u20131745 (2012)","journal-title":"Stem Cells"},{"key":"BFnature11924_CR20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1242\/dev.044297","volume":"137","author":"BJ Pearson","year":"2010","unstructured":"Pearson, B. J. & S\u00e1nchez Alvarado, A. A planarian p53 homolog regulates proliferation and self-renewal in adult stem cell lineages. Development 137, 213\u2013221 (2010)","journal-title":"Development"},{"key":"BFnature11924_CR21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1440-169X.2002.00634.x","volume":"44","author":"K Ogawa","year":"2002","unstructured":"Ogawa, K. et al. Planarian fibroblast growth factor receptor homologs expressed in stem cells and cephalic ganglions. Dev. Growth Differ. 44, 191\u2013204 (2002)","journal-title":"Dev. Growth Differ."},{"key":"BFnature11924_CR22","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ydbio.2010.02.037","volume":"341","author":"L Rouhana","year":"2010","unstructured":"Rouhana, L., Shibata, N., Nishimura, O. & Agata, K. Different requirements for conserved post-transcriptional regulators in planarian regeneration and stem cell maintenance. Dev. Biol. 341, 429\u2013443 (2010)","journal-title":"Dev. Biol."},{"key":"BFnature11924_CR23","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1194037","volume":"329","author":"C Juliano","year":"2010","unstructured":"Juliano, C. & Wessel, G. Versatile germline genes. Science 329, 640\u2013641 (2010)","journal-title":"Science"},{"key":"BFnature11924_CR24","doi-asserted-by":"crossref","first-page":"e1686","DOI":"10.1371\/journal.pntd.0001686","volume":"6","author":"DE Skinner","year":"2012","unstructured":"Skinner, D. E. et al. Vasa-like DEAD-box RNA helicases of Schistosoma mansoni. PLoS Negl Trop Dis 6, e1686 (2012)","journal-title":"PLoS Negl Trop Dis"},{"key":"BFnature11924_CR25","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1242\/dev.050146","volume":"137","author":"F Lanner","year":"2010","unstructured":"Lanner, F. & Rossant, J. The role of FGF\/Erk signaling in pluripotent cells. Development 137, 3351\u20133360 (2010)","journal-title":"Development"},{"key":"BFnature11924_CR26","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1126\/science.1064462","volume":"294","author":"SJ Davies","year":"2001","unstructured":"Davies, S. J. et al. Modulation of blood fluke development in the liver by hepatic CD4+ lymphocytes. Science 294, 1358\u20131361 (2001)","journal-title":"Science"},{"key":"BFnature11924_CR27","first-page":"653","volume":"71","author":"AE Severinghaus","year":"1928","unstructured":"Severinghaus, A. E. Sex studies on Schistosoma japonicum. Q. J. Microsc. Sci. 71, 653\u2013702 (1928)","journal-title":"Q. J. Microsc. Sci."},{"key":"BFnature11924_CR28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1017\/S0031182000053920","volume":"94","author":"MK Shaw","year":"1987","unstructured":"Shaw, M. K. & Erasmus, D. A. Schistosoma mansoni: structural damage and tegumental repair after in vivo treatment with praziquantel. Parasitology 94, 243\u2013254 (1987)","journal-title":"Parasitology"},{"key":"BFnature11924_CR29","doi-asserted-by":"crossref","first-page":"e1000509","DOI":"10.1371\/journal.pbio.1000509","volume":"8","author":"JJ Collins III","year":"2010","unstructured":"Collins, J. J., III et al. Genome-wide analyses reveal a role for peptide hormones in planarian germline development. PLoS Biol. 8, e1000509 (2010)","journal-title":"PLoS Biol."},{"key":"BFnature11924_CR30","doi-asserted-by":"crossref","first-page":"e1009","DOI":"10.1371\/journal.pntd.0001009","volume":"5","author":"JJ Collins III","year":"2011","unstructured":"Collins, J. J., III, King, R. S., Cogswell, A., Williams, D. L. & Newmark, P. A. An atlas for Schistosoma mansoni organs and life-cycle stages using cell type-specific markers and confocal microscopy. PLoS Negl. Trop. Dis. 5, e1009 (2011)","journal-title":"PLoS Negl. Trop. Dis."},{"key":"BFnature11924_CR31","doi-asserted-by":"crossref","unstructured":"Lewis, F. Schistosomiasis. Curr. Protoc. Immunol. Ch. 19, Unit 19 11. (2001)","DOI":"10.1146\/annurev.immunol.19.1.497"},{"key":"BFnature11924_CR32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.2307\/3280632","volume":"67","author":"PF Basch","year":"1981","unstructured":"Basch, P. F. Cultivation of Schistosoma mansoni in vitro. I. Establishment of cultures from cercariae and development until pairing. J. Parasitol. 67, 179\u2013185 (1981)","journal-title":"J. Parasitol."},{"key":"BFnature11924_CR33","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.molbiopara.2011.03.001","volume":"178","author":"AA Cogswell","year":"2011","unstructured":"Cogswell, A. A., Collins, J. J., III, Newmark, P. A. & Williams, D. L. Whole mount in situ hybridization methodology for Schistosoma mansoni. Mol. Biochem. Parasitol. 178, 46\u201350 (2011)","journal-title":"Mol. Biochem. Parasitol."},{"key":"BFnature11924_CR34","doi-asserted-by":"crossref","first-page":"20404","DOI":"10.1073\/pnas.1101126108","volume":"108","author":"AB Neef","year":"2011","unstructured":"Neef, A. B. & Luedtke, N. W. Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides. Proc. Natl Acad. Sci. USA 108, 20404\u201320409 (2011)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature11924_CR35","first-page":"36","volume":"11","author":"MD Abramoff","year":"2004","unstructured":"Abramoff, M. D., Magelhaes, P. J. & Ram, S. J. Image processing with ImageJ. Biophotonics Int. 11, 36\u201342 (2004)","journal-title":"Biophotonics Int."},{"key":"BFnature11924_CR36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/bioinformatics\/btl567","volume":"23","author":"S Falcon","year":"2007","unstructured":"Falcon, S. & Gentleman, R. Using GOstats to test gene lists for GO term association. Bioinformatics 23, 257\u2013258 (2007)","journal-title":"Bioinformatics"},{"key":"BFnature11924_CR37","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0020-7519(03)00030-4","volume":"33","author":"PJ Skelly","year":"2003","unstructured":"Skelly, P. J., Da\u2019dara, A. & Harn, D. A. Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference. Int. J. Parasitol. 33, 363\u2013369 (2003)","journal-title":"Int. J. Parasitol."},{"key":"BFnature11924_CR38","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0166-6851(03)00078-1","volume":"128","author":"JP Boyle","year":"2003","unstructured":"Boyle, J. P., Wu, X. J., Shoemaker, C. B. & Yoshino, T. P. Using RNA interference to manipulate endogenous gene expression in Schistosoma mansoni sporocysts. Mol. Biochem. Parasitol. 128, 205\u2013215 (2003)","journal-title":"Mol. Biochem. Parasitol."},{"key":"BFnature11924_CR39","doi-asserted-by":"crossref","first-page":"e850","DOI":"10.1371\/journal.pntd.0000850","volume":"4","author":"S \u0160tefani\u0107","year":"2010","unstructured":"\u0160tefani\u0107, S. et al. RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening. PLoS Negl. Trop. Dis. 4, e850 (2010)","journal-title":"PLoS Negl. Trop. Dis."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature11924.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature11924","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature11924.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:08:50Z","timestamp":1684418930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature11924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":39,"journal-issue":{"issue":"7438","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["BFnature11924"],"URL":"https:\/\/doi.org\/10.1038\/nature11924","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.717980872.793472067","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.717980872.793476389","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2]]}}}