{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:55:28Z","timestamp":1792684528193,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7450","license":[{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T00:00:00Z","timestamp":1367971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2013,5,23]]},"DOI":"10.1038\/nature12110","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T11:15:57Z","timestamp":1367925357000},"page":"494-497","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":280,"title":["Immune surveillance by CD8\u03b1\u03b1+ skin-resident T\u2009cells in human herpes virus infection"],"prefix":"10.1038","volume":"497","author":[{"given":"Jia","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khamsone","family":"Phasouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela S.","family":"Kask","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Klock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Diem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Koelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Wald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harlan","family":"Robins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Corey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,8]]},"reference":[{"key":"BFnature12110_CR1","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1084\/jem.20061792","volume":"204","author":"J Zhu","year":"2007","unstructured":"Zhu, J. et al. Virus-specific CD8+ T cells accumulate near sensory nerve endings in genital skin during subclinical HSV-2 reactivation. J. Exp. Med. 204, 595\u2013603 (2007)","journal-title":"J. Exp. Med."},{"key":"BFnature12110_CR2","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1038\/nm.2006","volume":"15","author":"J Zhu","year":"2009","unstructured":"Zhu, J. et al. Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition. Nature Med. 15, 886\u2013892 (2009)","journal-title":"Nature Med."},{"key":"BFnature12110_CR3","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1056\/NEJM199509213331205","volume":"333","author":"A Wald","year":"1995","unstructured":"Wald, A., Zeh, J., Selke, S., Ashley, R. L. & Corey, L. Virologic characteristics of subclinical and symptomatic genital herpes infections. N. Engl. J. Med. 333, 770\u2013775 (1995)","journal-title":"N. Engl. J. Med."},{"key":"BFnature12110_CR4","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1056\/NEJM200003233421203","volume":"342","author":"A Wald","year":"2000","unstructured":"Wald, A. et al. Reactivation of genital herpes simplex virus type 2 infection in asymptomatic seropositive persons. N. Engl. J. Med. 342, 844\u2013850 (2000)","journal-title":"N. Engl. J. Med."},{"key":"BFnature12110_CR5","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1086\/591913","volume":"198","author":"KE Mark","year":"2008","unstructured":"Mark, K. E. et al. Rapidly cleared episodes of herpes simplex virus reactivation in immunocompetent adults. J. Infect. Dis. 198, 1141\u20131149 (2008)","journal-title":"J. Infect. Dis."},{"key":"BFnature12110_CR6","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/ni1101-997","volume":"2","author":"A Hayday","year":"2001","unstructured":"Hayday, A., Theodoridis, E., Ramsburg, E. & Shires, J. Intraepithelial lymphocytes: exploring the Third Way in immunology. Nature Immunol. 2, 997\u20131003 (2001)","journal-title":"Nature Immunol."},{"key":"BFnature12110_CR7","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1038\/ni.2106","volume":"12","author":"Y Huang","year":"2011","unstructured":"Huang, Y. et al. Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule. Nature Immunol. 12, 1086\u20131095 (2011)","journal-title":"Nature Immunol."},{"key":"BFnature12110_CR8","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/nature02284","volume":"427","author":"M Matloubian","year":"2004","unstructured":"Matloubian, M. et al. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1. Nature 427, 355\u2013360 (2004)","journal-title":"Nature"},{"key":"BFnature12110_CR9","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1038\/ni1240","volume":"6","author":"SK Bromley","year":"2005","unstructured":"Bromley, S. K., Thomas, S. Y. & Luster, A. D. Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics. Nature Immunol. 6, 895\u2013901 (2005)","journal-title":"Nature Immunol."},{"key":"BFnature12110_CR10","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/ni1238","volume":"6","author":"GF Debes","year":"2005","unstructured":"Debes, G. F. et al. Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues. Nature Immunol. 6, 889\u2013894 (2005)","journal-title":"Nature Immunol."},{"key":"BFnature12110_CR11","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.4049\/jimmunol.174.5.2485","volume":"174","author":"H Chi","year":"2005","unstructured":"Chi, H. & Flavell, R. A. Cutting edge: regulation of T cell trafficking and primary immune responses by sphingosine 1-phosphate receptor 1. J. Immunol. 174, 2485\u20132488 (2005)","journal-title":"J. Immunol."},{"key":"BFnature12110_CR12","doi-asserted-by":"publisher","first-page":"10587","DOI":"10.1128\/JVI.01237-12","volume":"86","author":"T Peng","year":"2012","unstructured":"Peng, T. et al. An effector phenotype of CD8+ T cells at the junction epithelium during clinical quiescence of herpes simplex virus 2 infection. J. Virol. 86, 10587\u201310596 (2012)","journal-title":"J. Virol."},{"key":"BFnature12110_CR13","doi-asserted-by":"publisher","first-page":"18973","DOI":"10.1073\/pnas.1006614107","volume":"107","author":"JT Schiffer","year":"2010","unstructured":"Schiffer, J. T. et al. Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes. Proc. Natl Acad. Sci. USA 107, 18973\u201318978 (2010)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature12110_CR14","doi-asserted-by":"publisher","first-page":"7ra16","DOI":"10.1126\/scitranslmed.3000193","volume":"1","author":"JT Schiffer","year":"2009","unstructured":"Schiffer, J. T. et al. Frequent release of low amounts of herpes simplex virus from neurons: results of a mathematical model. Sci. Transl Med. 1, 7ra16 (2009)","journal-title":"Sci. Transl Med."},{"key":"BFnature12110_CR15","doi-asserted-by":"publisher","first-page":"4099","DOI":"10.1182\/blood-2009-04-217604","volume":"114","author":"HS Robins","year":"2009","unstructured":"Robins, H. S. et al. Comprehensive assessment of T-cell receptor \u03b2-chain diversity in \u03b1\u03b2 T cells. Blood 114, 4099\u20134107 (2009)","journal-title":"Blood"},{"key":"BFnature12110_CR16","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1084\/jem.189.12.1907","volume":"189","author":"F Tilloy","year":"1999","unstructured":"Tilloy, F. et al. An invariant T cell receptor \u03b1 chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted \u03b1\u03b2 T cell subpopulation in mammals. J. Exp. Med. 189, 1907\u20131921 (1999)","journal-title":"J. Exp. Med."},{"key":"BFnature12110_CR17","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.it.2011.02.005","volume":"32","author":"L Le Bourhis","year":"2011","unstructured":"Le Bourhis, L. et al. Mucosal-associated invariant T cells: unconventional development and function. Trends Immunol. 32, 212\u2013218 (2011)","journal-title":"Trends Immunol."},{"key":"BFnature12110_CR18","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1172\/JCI60556","volume":"122","author":"L Jing","year":"2012","unstructured":"Jing, L. et al. Cross-presentation and genome-wide screening reveal candidate T cells antigens for a herpes simplex virus type 1 vaccine. J. Clin. Invest. 122, 654\u2013673 (2012)","journal-title":"J. Clin. Invest."},{"key":"BFnature12110_CR19","doi-asserted-by":"publisher","first-page":"117ra7","DOI":"10.1126\/scitranslmed.3003008","volume":"4","author":"RA Clark","year":"2012","unstructured":"Clark, R. A. et al. Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Sci. Transl. Med. 4, 117ra7 (2012)","journal-title":"Sci. Transl. Med."},{"key":"BFnature12110_CR20","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1038\/ni.1718","volume":"10","author":"T Gebhardt","year":"2009","unstructured":"Gebhardt, T. et al. Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus. Nature Immunol. 10, 524\u2013530 (2009)","journal-title":"Nature Immunol."},{"key":"BFnature12110_CR21","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1038\/nature10339","volume":"477","author":"T Gebhardt","year":"2011","unstructured":"Gebhardt, T. et al. Different patterns of peripheral migration by memory CD4+ and CD8+ T cells. Nature 477, 216\u2013219 (2011)","journal-title":"Nature"},{"key":"BFnature12110_CR22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nature10851","volume":"483","author":"X Jiang","year":"2012","unstructured":"Jiang, X. et al. Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity. Nature 483, 227\u2013231 (2012)","journal-title":"Nature"},{"key":"BFnature12110_CR23","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1016\/S1074-7613(03)00112-2","volume":"18","author":"KM Khanna","year":"2003","unstructured":"Khanna, K. M., Bonneau, R. H., Kinchington, P. R. & Hendricks, R. L. Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. Immunity 18, 593\u2013603 (2003)","journal-title":"Immunity"},{"key":"BFnature12110_CR24","doi-asserted-by":"publisher","first-page":"e16245","DOI":"10.1371\/journal.pone.0016245","volume":"6","author":"R Purwar","year":"2011","unstructured":"Purwar, R. et al. Resident memory T cells (TRM) are abundant in human lung: diversity, function, and antigen specificity. PLoS ONE 6, e16245 (2011)","journal-title":"PLoS ONE"},{"key":"BFnature12110_CR25","doi-asserted-by":"publisher","first-page":"17872","DOI":"10.1073\/pnas.1010201107","volume":"107","author":"LM Wakim","year":"2010","unstructured":"Wakim, L. M., Woodward-Davis, A. & Bevan, M. J. Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence. Proc. Natl Acad. Sci. USA 107, 17872\u201317879 (2010)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature12110_CR26","doi-asserted-by":"publisher","first-page":"6123","DOI":"10.4049\/jimmunol.175.9.6123","volume":"175","author":"L Trautmann","year":"2005","unstructured":"Trautmann, L. et al. Selection of T cell clones expressing high-affinity public TCRs within human cytomegalovirus-specific CD8 T cell responses. J. Immunol. 175, 6123\u20136132 (2005)","journal-title":"J. Immunol."},{"key":"BFnature12110_CR27","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1172\/JCI111678","volume":"75","author":"AL Cunningham","year":"1985","unstructured":"Cunningham, A. L., Turner, R. R., Miller, A. C., Para, M. F. & Merigan, T. C. Evolution of recurrent herpes simplex lesions. An immunohistologic study. J. Clin. Invest. 75, 226\u2013233 (1985)","journal-title":"J. Clin. Invest."},{"key":"BFnature12110_CR28","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/nature08511","volume":"462","author":"Y Nakanishi","year":"2009","unstructured":"Nakanishi, Y., Lu, B., Gerard, C. & Iwasaki, A. CD8+ T lymphocyte mobilization to virus-infected tissue requires CD4+ T-cell help. Nature 462, 510\u2013513 (2009)","journal-title":"Nature"},{"key":"BFnature12110_CR29","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1128\/JCM.01405-06","volume":"45","author":"AS Magaret","year":"2007","unstructured":"Magaret, A. S., Wald, A., Huang, M. L., Selke, S. & Corey, L. Optimizing PCR positivity criterion for detection of herpes simplex virus DNA on skin and mucosa. J. Clin. Microbiol. 45, 1618\u20131620 (2007)","journal-title":"J. Clin. Microbiol."},{"key":"BFnature12110_CR30","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1126\/science.1352912","volume":"257","author":"SR Riddell","year":"1992","unstructured":"Riddell, S. R. et al. Restoration of viral immunity in immunodeficient humans by the adoptive transfer of T cell clones. Science 257, 238\u2013241 (1992)","journal-title":"Science"}],"updated-by":[{"DOI":"10.1038\/nature12324","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T00:00:00Z","timestamp":1370995200000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature12110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature12110","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature12110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:10:51Z","timestamp":1684419051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature12110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,8]]},"references-count":30,"journal-issue":{"issue":"7450","published-print":{"date-parts":[[2013,5,23]]}},"alternative-id":["BFnature12110"],"URL":"https:\/\/doi.org\/10.1038\/nature12110","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718012687.793477202","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,8]]},"assertion":[{"value":"5 January 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2013","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Nature 497, 494\u2013497 (2013); doi:10.1038\/nature12110 In Fig. 2a of our Letter, the label \u2018CXCR7\u2019 should be \u2018CXCR6\u2019, and the label \u2018CXCR8\u2019 should be \u2018CXCR7\u2019. This error has been corrected in the HTML and PDF versions of the paper.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"L.C. is on the scientific advisory board for, and hold stock (<1% of company) in, Immune Design Corp. H.R. is a co-founder of Adaptive Biotechnologies, owns stock and intellectual property of this company, and consults for the company. A.W. has received research support from NIH, Genocea Biosciences, Agenus, and Gilead Sciences, and has been a consultant to Aicuris GmbH. D.M.K. is a consultant for Agenus and EISAI. C.J. is conducting research with AiCuris GmbH, which is developing treatment for HSV.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}