{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:14:09Z","timestamp":1792178049027,"version":"4.4.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"7493","license":[{"start":{"date-parts":[[2014,1,19]],"date-time":"2014-01-19T00:00:00Z","timestamp":1390089600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1038\/nature12910","type":"journal-article","created":{"date-parts":[[2014,1,20]],"date-time":"2014-01-20T06:42:34Z","timestamp":1390200154000},"page":"513-518","source":"Crossref","is-referenced-by-count":347,"title":["Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development"],"prefix":"10.1038","volume":"507","author":[{"given":"Xindong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuliang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza I.","family":"Nurieva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens G.","family":"van der Flier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Nakatsukasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sattva S.","family":"Neelapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Clevers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,19]]},"reference":[{"key":"BFnature12910_CR1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/imr.12040","volume":"252","author":"X Liu","year":"2013","unstructured":"Liu, X., Nurieva, R. I. & Dong, C. Transcriptional regulation of follicular T-helper (Tfh) cells. Immunol. Rev. 252, 139\u2013145 (2013)","journal-title":"Immunol. Rev."},{"key":"BFnature12910_CR2","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.immuni.2011.11.001","volume":"35","author":"CG Vinuesa","year":"2011","unstructured":"Vinuesa, C. G. & Cyster, J. G. How T cells earn the follicular rite of passage. Immunity 35, 671\u2013680 (2011)","journal-title":"Immunity"},{"key":"BFnature12910_CR3","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nature12058","volume":"496","author":"H Xu","year":"2013","unstructured":"Xu, H. et al. Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility. Nature 496, 523\u2013527 (2013)","journal-title":"Nature"},{"key":"BFnature12910_CR4","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1084\/jem.20120219","volume":"209","author":"X Liu","year":"2012","unstructured":"Liu, X. et al. Bcl6 expression specifies the T follicular helper cell program in vivo. J. Exp. Med. 209, 1841\u20131852 (2012)","journal-title":"J. Exp. Med."},{"key":"BFnature12910_CR5","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/j.cell.2009.01.031","volume":"136","author":"LG van der Flier","year":"2009","unstructured":"van der Flier, L. G. et al. Transcription factor achaete scute-like 2 controls intestinal stem cell fate. Cell 136, 903\u2013912 (2009)","journal-title":"Cell"},{"key":"BFnature12910_CR6","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev-immunol-031210-101400","volume":"29","author":"S Crotty","year":"2011","unstructured":"Crotty, S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29, 621\u2013663 (2011)","journal-title":"Annu. Rev. Immunol."},{"key":"BFnature12910_CR7","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1126\/science.1175870","volume":"325","author":"RJ Johnston","year":"2009","unstructured":"Johnston, R. J. et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325, 1006\u20131010 (2009)","journal-title":"Science"},{"key":"BFnature12910_CR8","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1126\/science.1176676","volume":"325","author":"RI Nurieva","year":"2009","unstructured":"Nurieva, R. I. et al. Bcl6 mediates the development of T follicular helper cells. Science 325, 1001\u20131005 (2009)","journal-title":"Science"},{"key":"BFnature12910_CR9","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.immuni.2009.07.002","volume":"31","author":"D Yu","year":"2009","unstructured":"Yu, D. et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31, 457\u2013468 (2009)","journal-title":"Immunity"},{"key":"BFnature12910_CR10","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1038\/ni.1690","volume":"10","author":"AT Bauquet","year":"2009","unstructured":"Bauquet, A. T. et al. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nature Immunol. 10, 167\u2013175 (2009)","journal-title":"Nature Immunol."},{"key":"BFnature12910_CR11","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1084\/jem.20091548","volume":"207","author":"BC Betz","year":"2010","unstructured":"Betz, B. C. et al. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J. Exp. Med. 207, 933\u2013942 (2010)","journal-title":"J. Exp. Med."},{"key":"BFnature12910_CR12","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1038\/ni.2037","volume":"12","author":"W Ise","year":"2011","unstructured":"Ise, W. et al. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nature Immunol. 12, 536\u2013543 (2011)","journal-title":"Nature Immunol."},{"key":"BFnature12910_CR13","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.immuni.2009.10.008","volume":"31","author":"H Kwon","year":"2009","unstructured":"Kwon, H. et al. Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity 31, 941\u2013952 (2009)","journal-title":"Immunity"},{"key":"BFnature12910_CR14","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1084\/jem.20111174","volume":"209","author":"RJ Johnston","year":"2012","unstructured":"Johnston, R. J., Choi, Y. S., Diamond, J. A., Yang, J. A. & Crotty, S. STAT5 is a potent negative regulator of TFH cell differentiation. J. Exp. Med. 209, 243\u2013250 (2012)","journal-title":"J. Exp. Med."},{"key":"BFnature12910_CR15","doi-asserted-by":"publisher","first-page":"11234","DOI":"10.1074\/jbc.M111.324046","volume":"287","author":"RI Nurieva","year":"2012","unstructured":"Nurieva, R. I. et al. STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function. J. Biol. Chem. 287, 11234\u201311239 (2012)","journal-title":"J. Biol. Chem."},{"key":"BFnature12910_CR16","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1038\/nm.1982","volume":"15","author":"L Gattinoni","year":"2009","unstructured":"Gattinoni, L. et al. Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells. Nature Med. 15, 808\u2013813 (2009)","journal-title":"Nature Med."},{"key":"BFnature12910_CR17","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/j.immuni.2012.02.012","volume":"36","author":"A Ballesteros-Tato","year":"2012","unstructured":"Ballesteros-Tato, A. et al. Interleukin-2 inhibits germinal center formation by limiting T follicular helper cell differentiation. Immunity 36, 847\u2013856 (2012)","journal-title":"Immunity"},{"key":"BFnature12910_CR18","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1084\/jem.20102065","volume":"208","author":"SK Lee","year":"2011","unstructured":"Lee, S. K. et al. B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells. J. Exp. Med. 208, 1377\u20131388 (2011)","journal-title":"J. Exp. Med."},{"key":"BFnature12910_CR19","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1038\/ni1100","volume":"5","author":"CD Allen","year":"2004","unstructured":"Allen, C. D. et al. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nature Immunol. 5, 943\u2013952 (2004)","journal-title":"Nature Immunol."},{"key":"BFnature12910_CR20","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/nm.2426","volume":"17","author":"Y Chung","year":"2011","unstructured":"Chung, Y. et al. Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nature Med. 17, 983\u2013988 (2011)","journal-title":"Nature Med."},{"key":"BFnature12910_CR21","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/ni.2182","volume":"13","author":"HE Liang","year":"2012","unstructured":"Liang, H. E. et al. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nature Immunol. 13, 58\u201366 (2012)","journal-title":"Nature Immunol."},{"key":"BFnature12910_CR22","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1038\/ni.2086","volume":"12","author":"M Miyazaki","year":"2011","unstructured":"Miyazaki, M. et al. The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells. Nature Immunol. 12, 992\u20131001 (2011)","journal-title":"Nature Immunol."},{"key":"BFnature12910_CR23","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/0092-8674(89)90434-0","volume":"58","author":"C Murre","year":"1989","unstructured":"Murre, C. et al. Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58, 537\u2013544 (1989)","journal-title":"Cell"},{"key":"BFnature12910_CR24","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1189\/jlb.0909639","volume":"87","author":"Y Hiramatsu","year":"2010","unstructured":"Hiramatsu, Y. et al. c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-\u03b2 inhibits c-Maf-induced IL-21 production in CD4+ T cells. J. Leukoc. Biol. 87, 703\u2013712 (2010)","journal-title":"J. Leukoc. Biol."},{"key":"BFnature12910_CR25","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.cell.2012.09.016","volume":"151","author":"M Ciofani","year":"2012","unstructured":"Ciofani, M. et al. A validated regulatory network for Th17 cell specification. Cell 151, 289\u2013303 (2012)","journal-title":"Cell"},{"key":"BFnature12910_CR26","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1084\/jem.20112256","volume":"209","author":"JK Yoo","year":"2012","unstructured":"Yoo, J. K., Fish, E. N. & Braciale, T. J. LAPCs promote follicular helper T cell differentiation of Ag-primed CD4+ T cells during respiratory virus infection. J. Exp. Med. 209, 1853\u20131867 (2012)","journal-title":"J. Exp. Med."},{"key":"BFnature12910_CR27","doi-asserted-by":"publisher","first-page":"30815","DOI":"10.1074\/jbc.M109.052472","volume":"284","author":"Y Zhang","year":"2009","unstructured":"Zhang, Y. et al. MKP-1 is necessary for T cell activation and function. J. Biol. Chem. 284, 30815\u201330824 (2009)","journal-title":"J. Biol. Chem."},{"key":"BFnature12910_CR28","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.immuni.2008.12.009","volume":"30","author":"G Wei","year":"2009","unstructured":"Wei, G. et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30, 155\u2013167 (2009)","journal-title":"Immunity"},{"key":"BFnature12910_CR29","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/ni.1965","volume":"12","author":"T Maruyama","year":"2011","unstructured":"Maruyama, T. et al. Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3. Nature Immunol. 12, 86\u201395 (2011)","journal-title":"Nature Immunol."},{"key":"BFnature12910_CR30","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/nature07345","volume":"455","author":"H Qi","year":"2008","unstructured":"Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L. & Germain, R. N. SAP-controlled T\u2013B cell interactions underlie germinal centre formation. Nature 455, 764\u2013769 (2008)","journal-title":"Nature"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature12910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature12910","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature12910.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:18:14Z","timestamp":1684419494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature12910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,19]]},"references-count":30,"journal-issue":{"issue":"7493","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["BFnature12910"],"URL":"https:\/\/doi.org\/10.1038\/nature12910","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718252257.793493792","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.718252257.793491016","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,19]]}}}