{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:01:21Z","timestamp":1791896481427,"version":"4.3.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7510","license":[{"start":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T00:00:00Z","timestamp":1404864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T00:00:00Z","timestamp":1404864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2014,7,24]]},"DOI":"10.1038\/nature13473","type":"journal-article","created":{"date-parts":[[2014,7,8]],"date-time":"2014-07-08T08:58:35Z","timestamp":1404809915000},"page":"483-487","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":474,"title":["Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles"],"prefix":"10.1038","volume":"511","author":[{"given":"Susanne","family":"Walz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Lorenzin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Morton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin E.","family":"Wiese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"von Eyss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffi","family":"Herold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Rycak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Dumay-Odelot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saadia","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Bartkuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Roels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"W\u00fcstefeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Teichmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Zender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Lin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Sansom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elmar","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Eilers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,9]]},"reference":[{"key":"BFnature13473_CR1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.cell.2012.08.033","volume":"151","author":"Z Nie","year":"2012","unstructured":"Nie, Z. et al. c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cells. Cell 151, 68\u201379 (2012)","journal-title":"Cell"},{"key":"BFnature13473_CR2","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cell.2012.08.026","volume":"151","author":"CY Lin","year":"2012","unstructured":"Lin, C. Y. et al. Transcriptional amplification in tumor cells with Elevated c-Myc. Cell 151, 56\u201367 (2012)","journal-title":"Cell"},{"key":"BFnature13473_CR3","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1016\/j.cell.2008.04.043","volume":"133","author":"X Chen","year":"2008","unstructured":"Chen, X. et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133, 1106\u20131117 (2008)","journal-title":"Cell"},{"key":"BFnature13473_CR4","doi-asserted-by":"publisher","first-page":"17834","DOI":"10.1073\/pnas.0604129103","volume":"103","author":"KI Zeller","year":"2006","unstructured":"Zeller, K. I. et al. Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc. Natl Acad. Sci. USA 103, 17834\u201317839 (2006)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13473_CR5","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1084\/jem.20111512","volume":"209","author":"D Horiuchi","year":"2012","unstructured":"Horiuchi, D. et al. MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J. Exp. Med. 209, 679\u2013696 (2012)","journal-title":"J. Exp. Med."},{"key":"BFnature13473_CR6","doi-asserted-by":"publisher","first-page":"3534","DOI":"10.1073\/pnas.0901230107","volume":"107","author":"JT Yustein","year":"2010","unstructured":"Yustein, J. T. et al. Induction of ectopic Myc target gene JAG2 augments hypoxic growth and tumorigenesis in a human B-cell model. Proc. Natl Acad. Sci. USA 107, 3534\u20133539 (2010)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13473_CR7","doi-asserted-by":"publisher","first-page":"19190","DOI":"10.1073\/pnas.1208215109","volume":"109","author":"LJ Valentijn","year":"2012","unstructured":"Valentijn, L. J. et al. Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification. Proc. Natl Acad. Sci. USA 109, 19190\u201319195 (2012)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13473_CR8","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.cell.2010.03.030","volume":"141","author":"PB Rahl","year":"2010","unstructured":"Rahl, P. B. et al. c-Myc regulates transcriptional pause release. Cell 141, 432\u2013445 (2010)","journal-title":"Cell"},{"key":"BFnature13473_CR9","doi-asserted-by":"publisher","first-page":"a014290","DOI":"10.1101\/cshperspect.a014290","volume":"3","author":"KE Wiese","year":"2013","unstructured":"Wiese, K. E. et al. The role of MIZ-1 in MYC-dependent tumorigenesis. Cold Spring Harb. Perspect. Med. 3, a014290 (2013)","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"BFnature13473_CR10","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0092-8674(92)90123-T","volume":"69","author":"GI Evan","year":"1992","unstructured":"Evan, G. I. et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69, 119\u2013128 (1992)","journal-title":"Cell"},{"key":"BFnature13473_CR11","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545\u201315550 (2005)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13473_CR12","doi-asserted-by":"publisher","first-page":"5216","DOI":"10.1128\/MCB.13.9.5216","volume":"13","author":"TK Blackwell","year":"1993","unstructured":"Blackwell, T. K. et al. Binding of Myc proteins to canonical and noncanonical DNA sequences. Mol. Cell. Biol. 13, 5216\u20135224 (1993)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature13473_CR13","doi-asserted-by":"publisher","first-page":"48562","DOI":"10.1074\/jbc.M109014200","volume":"276","author":"SR Eberhardy","year":"2001","unstructured":"Eberhardy, S. R. & Farnham, P. J. c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism. J. Biol. Chem. 276, 48562\u201348571 (2001)","journal-title":"J. Biol. Chem."},{"key":"BFnature13473_CR14","doi-asserted-by":"publisher","first-page":"40156","DOI":"10.1074\/jbc.M207441200","volume":"277","author":"SR Eberhardy","year":"2002","unstructured":"Eberhardy, S. R. & Farnham, P. J. Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J. Biol. Chem. 277, 40156\u201340162 (2002)","journal-title":"J. Biol. Chem."},{"key":"BFnature13473_CR15","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/ncb1434","volume":"8","author":"E Guccione","year":"2006","unstructured":"Guccione, E. et al. Myc-binding-site recognition in the human genome is determined by chromatin context. Nature Cell Biol. 8, 764\u2013770 (2006)","journal-title":"Nature Cell Biol."},{"key":"BFnature13473_CR16","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1038\/sj.emboj.7600279","volume":"23","author":"C Bouchard","year":"2004","unstructured":"Bouchard, C., Marquardt, J., Bras, A., Medema, R. H. & Eilers, M. Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins. EMBO J. 23, 2830\u20132840 (2004)","journal-title":"EMBO J."},{"key":"BFnature13473_CR17","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1101\/gad.200303.112","volume":"26","author":"JP Hsin","year":"2012","unstructured":"Hsin, J. P. & Manley, J. L. The RNA polymerase II CTD coordinates transcription and RNA processing. Genes Dev. 26, 2119\u20132137 (2012)","journal-title":"Genes Dev."},{"key":"BFnature13473_CR18","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1038\/ncomms3535","volume":"4","author":"E Wolf","year":"2013","unstructured":"Wolf, E. et al. Miz1 is required to maintain autophagic flux. Nature Commun. 4, 2535 (2013)","journal-title":"Nature Commun."},{"key":"BFnature13473_CR19","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/35070076","volume":"3","author":"P Staller","year":"2001","unstructured":"Staller, P. et al. Repression of p15INK4b expression by Myc through association with Miz-1. Nature Cell Biol. 3, 392\u2013399 (2001)","journal-title":"Nature Cell Biol."},{"key":"BFnature13473_CR20","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1158\/0008-5472.CAN-10-2627","volume":"71","author":"N Iraci","year":"2011","unstructured":"Iraci, N. et al. A SP1\/MIZ1\/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF. Cancer Res. 71, 404\u2013412 (2011)","journal-title":"Cancer Res."},{"key":"BFnature13473_CR21","doi-asserted-by":"publisher","first-page":"4510","DOI":"10.1073\/pnas.081074898","volume":"98","author":"AL Gartel","year":"2001","unstructured":"Gartel, A. L. et al. Myc represses the p21(WAF1\/CIP1) promoter and interacts with Sp1\/Sp3. Proc. Natl Acad. Sci. USA 98, 4510\u20134515 (2001)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13473_CR22","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/S1097-2765(02)00633-0","volume":"10","author":"S Herold","year":"2002","unstructured":"Herold, S. et al. Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol. Cell 10, 509\u2013521 (2002)","journal-title":"Mol. Cell"},{"key":"BFnature13473_CR23","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.immuni.2010.11.028","volume":"33","author":"C Kosan","year":"2010","unstructured":"Kosan, C. et al. Transcription factor Miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation. Immunity 33, 917\u2013928 (2010)","journal-title":"Immunity"},{"key":"BFnature13473_CR24","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1101\/gad.585710","volume":"24","author":"J van Riggelen","year":"2010","unstructured":"van Riggelen, J. et al. The interaction between Myc and Miz1 is required to antagonize TGF\u03b2-dependent autocrine signaling during lymphoma formation and maintenance. Genes Dev. 24, 1281\u20131294 (2010)","journal-title":"Genes Dev."},{"key":"BFnature13473_CR25","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.ccr.2005.04.023","volume":"7","author":"SR Hingorani","year":"2005","unstructured":"Hingorani, S. R. et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7, 469\u2013483 (2005)","journal-title":"Cancer Cell"},{"key":"BFnature13473_CR26","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/S1074-7613(01)00088-7","volume":"14","author":"IM de Alboran","year":"2001","unstructured":"de Alboran, I. M. et al. Analysis of c-Myc function in normal cells via conditional gene-targeted mutation. Immunity 14, 45\u201355 (2001)","journal-title":"Immunity"},{"key":"BFnature13473_CR27","doi-asserted-by":"publisher","first-page":"11382","DOI":"10.1073\/pnas.93.21.11382","volume":"93","author":"L Naldini","year":"1996","unstructured":"Naldini, L., Blomer, U., Gage, F. H., Trono, D. & Verma, I. M. Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc. Natl Acad. Sci. USA 93, 11382\u201311388 (1996)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13473_CR28","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1128\/MCB.17.5.2529","volume":"17","author":"KE Boyd","year":"1997","unstructured":"Boyd, K. E. & Farnham, P. J. Myc versus USF: discrimination at the cad gene is determined by core promoter elements. Mol. Cell. Biol. 17, 2529\u20132537 (1997)","journal-title":"Mol. Cell. Biol."},{"key":"BFnature13473_CR29","doi-asserted-by":"crossref","first-page":"11.7.1","DOI":"10.1002\/0471250953.bi1107s32","volume":"32","author":"B Langmead","year":"2010","unstructured":"Langmead, B. Aligning short sequencing reads with Bowtie. Curr. Protoc. Bioinformatics 32, 11.7.1\u201311.7.14 (2010)","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"BFnature13473_CR30","doi-asserted-by":"publisher","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang, Y. et al. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9, R137 (2008)","journal-title":"Genome Biol."},{"key":"BFnature13473_CR31","doi-asserted-by":"publisher","first-page":"2730","DOI":"10.1093\/bioinformatics\/btp472","volume":"25","author":"JW Nicol","year":"2009","unstructured":"Nicol, J. W., Helt, G. A., Blanchard, S. G., Jr, Raja, A. & Loraine, A. E. The Integrated Genome Browser: free software for distribution and exploration of genome-scale datasets. Bioinformatics 25, 2730\u20132731 (2009)","journal-title":"Bioinformatics"},{"key":"BFnature13473_CR32","doi-asserted-by":"publisher","first-page":"e35","DOI":"10.1093\/nar\/gkq1287","volume":"39","author":"T Ye","year":"2011","unstructured":"Ye, T. et al. seqMINER: an integrated ChIP-seq data interpretation platform. Nucleic Acids Res. 39, e35 (2011)","journal-title":"Nucleic Acids Res."},{"key":"BFnature13473_CR33","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"AR Quinlan","year":"2010","unstructured":"Quinlan, A. R. & Hall, I. M. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 26, 841\u2013842 (2010)","journal-title":"Bioinformatics"},{"key":"BFnature13473_CR34","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics 26, 139\u2013140 (2010)","journal-title":"Bioinformatics"},{"key":"BFnature13473_CR35","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang da","year":"2009","unstructured":"Huang da, W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nature Protocols 4, 44\u201357 (2009)","journal-title":"Nature Protocols"},{"key":"BFnature13473_CR36","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1093\/bioinformatics\/btr189","volume":"27","author":"P Machanick","year":"2011","unstructured":"Machanick, P. & Bailey, T. L. MEME-ChIP: motif analysis of large DNA datasets. Bioinformatics 27, 1696\u20131697 (2011)","journal-title":"Bioinformatics"},{"key":"BFnature13473_CR37","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/nsmb.1806","volume":"17","author":"A Barski","year":"2010","unstructured":"Barski, A. et al. Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes. Nature Struct. Mol. Biol. 17, 629\u2013634 (2010)","journal-title":"Nature Struct. Mol. Biol."},{"key":"BFnature13473_CR38","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/ncb1224","volume":"7","author":"C Grandori","year":"2005","unstructured":"Grandori, C. et al. c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. Nature Cell Biol. 7, 311\u2013318 (2005)","journal-title":"Nature Cell Biol."}],"updated-by":[{"DOI":"10.1038\/nature14054","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2014,12,17]],"date-time":"2014-12-17T00:00:00Z","timestamp":1418774400000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature13473.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature13473","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature13473.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:22:20Z","timestamp":1684419740000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature13473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,9]]},"references-count":38,"journal-issue":{"issue":"7510","published-print":{"date-parts":[[2014,7,24]]}},"alternative-id":["BFnature13473"],"URL":"https:\/\/doi.org\/10.1038\/nature13473","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.718499010.793498606","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,9]]},"assertion":[{"value":"7 September 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}