{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T22:32:18Z","timestamp":1791844338469,"version":"4.3.4"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"7524","license":[{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T00:00:00Z","timestamp":1407888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2014,10,30]]},"DOI":"10.1038\/nature13612","type":"journal-article","created":{"date-parts":[[2014,8,12]],"date-time":"2014-08-12T06:12:23Z","timestamp":1407823943000},"page":"642-645","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":379,"title":["Enhanced neonatal Fc receptor function improves protection against primate SHIV infection"],"prefix":"10.1038","volume":"514","author":[{"given":"Sung-Youl","family":"Ko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amarendra","family":"Pegu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S.","family":"Rudicell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Gordon","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saran","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas D.","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Rath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John-Paul","family":"Todd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott R.","family":"Penzak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin O.","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha C.","family":"Nason","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley T.","family":"Haase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivas S.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Blumberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Mascola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary J.","family":"Nabel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,8,13]]},"reference":[{"key":"BFnature13612_CR1","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/nri2155","volume":"7","author":"DC Roopenian","year":"2007","unstructured":"Roopenian, D. C. & Akilesh, S. FcRn: the neonatal Fc receptor comes of age. Nature Rev. Immunol. 7, 715\u2013725 (2007)","journal-title":"Nature Rev. Immunol."},{"key":"BFnature13612_CR2","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0065-2776(09)03004-1","volume":"103","author":"ES Ward","year":"2009","unstructured":"Ward, E. S. & Ober, R. J. Multitasking by exploitation of intracellular transport functions: the many faces of FcRn. Adv. Immunol. 103, 77\u2013115 (2009)","journal-title":"Adv. Immunol."},{"key":"BFnature13612_CR3","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1126\/science.1187659","volume":"329","author":"X Wu","year":"2010","unstructured":"Wu, X. et al. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1. Science 329, 856\u2013861 (2010)","journal-title":"Science"},{"key":"BFnature13612_CR4","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature06106","volume":"449","author":"AJ Hessell","year":"2007","unstructured":"Hessell, A. J. et al. Fc receptor but not complement binding is important in antibody protection against HIV. Nature 449, 101\u2013104 (2007)","journal-title":"Nature"},{"key":"BFnature13612_CR5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1038\/nri2206","volume":"8","author":"F Nimmerjahn","year":"2008","unstructured":"Nimmerjahn, F. & Ravetch, J. V. Fc\u03b3 receptors as regulators of immune responses. Nature Rev. Immunol. 8, 34\u201347 (2008)","journal-title":"Nature Rev. Immunol."},{"key":"BFnature13612_CR6","doi-asserted-by":"publisher","first-page":"e1000433","DOI":"10.1371\/journal.ppat.1000433","volume":"5","author":"AJ Hessell","year":"2009","unstructured":"Hessell, A. J. et al. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Pathogens 5, e1000433 (2009)","journal-title":"PLoS Pathogens"},{"key":"BFnature13612_CR7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1126\/science.1178746","volume":"326","author":"LM Walker","year":"2009","unstructured":"Walker, L. M. et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science 326, 285\u2013289 (2009)","journal-title":"Science"},{"key":"BFnature13612_CR8","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1128\/JVI.01272-09","volume":"84","author":"AJ Hessell","year":"2010","unstructured":"Hessell, A. J. et al. Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian\u2013human immunodeficiency virus SHIVBa-L. J. Virol. 84, 1302\u20131313 (2010)","journal-title":"J. Virol."},{"key":"BFnature13612_CR9","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature10373","volume":"477","author":"LM Walker","year":"2011","unstructured":"Walker, L. M. et al. Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature 477, 466\u2013470 (2011)","journal-title":"Nature"},{"key":"BFnature13612_CR10","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/nature11544","volume":"491","author":"J Huang","year":"2012","unstructured":"Huang, J. et al. Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Nature 491, 406\u2013412 (2012)","journal-title":"Nature"},{"key":"BFnature13612_CR11","doi-asserted-by":"publisher","first-page":"18921","DOI":"10.1073\/pnas.1214785109","volume":"109","author":"B Moldt","year":"2012","unstructured":"Moldt, B. et al. Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo. Proc. Natl Acad. Sci. USA 109, 18921\u201318925 (2012)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13612_CR12","doi-asserted-by":"publisher","first-page":"9763","DOI":"10.1073\/pnas.0403235101","volume":"101","author":"AJ Bitonti","year":"2004","unstructured":"Bitonti, A. J. et al. Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway. Proc. Natl Acad. Sci. USA 101, 9763\u20139768 (2004)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13612_CR13","doi-asserted-by":"publisher","first-page":"23514","DOI":"10.1074\/jbc.M604292200","volume":"281","author":"WF Dall\u2019 Acqua","year":"2006","unstructured":"Dall\u2019 Acqua, W. F., Kiener, P. A. & Wu, H. Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn). J. Biol. Chem. 281, 23514\u201323524 (2006)","journal-title":"J. Biol. Chem."},{"key":"BFnature13612_CR14","doi-asserted-by":"publisher","first-page":"346","DOI":"10.4049\/jimmunol.176.1.346","volume":"176","author":"PR Hinton","year":"2006","unstructured":"Hinton, P. R. et al. An engineered human IgG1 antibody with longer serum half-life. J. Immunol. 176, 346\u2013356 (2006)","journal-title":"J. Immunol."},{"key":"BFnature13612_CR15","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1093\/intimm\/dxl110","volume":"18","author":"SB Petkova","year":"2006","unstructured":"Petkova, S. B. et al. Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int. Immunol. 18, 1759\u20131769 (2006)","journal-title":"Int. Immunol."},{"key":"BFnature13612_CR16","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/nbt.1601","volume":"28","author":"J Zalevsky","year":"2010","unstructured":"Zalevsky, J. et al. Enhanced antibody half-life improves in vivo activity. Nature Biotechnol. 28, 157\u2013159 (2010)","journal-title":"Nature Biotechnol."},{"key":"BFnature13612_CR17","doi-asserted-by":"publisher","first-page":"5171","DOI":"10.4049\/jimmunol.169.9.5171","volume":"169","author":"WF Dall\u2019 Acqua","year":"2002","unstructured":"Dall\u2019 Acqua, W. F. et al. Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences. J. Immunol. 169, 5171\u20135180 (2002)","journal-title":"J. Immunol."},{"key":"BFnature13612_CR18","doi-asserted-by":"publisher","first-page":"3528","DOI":"10.4049\/jimmunol.170.7.3528","volume":"170","author":"DC Roopenian","year":"2003","unstructured":"Roopenian, D. C. et al. The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG\u2013Fc-coupled drugs. J. Immunol. 170, 3528\u20133533 (2003)","journal-title":"J. Immunol."},{"key":"BFnature13612_CR19","doi-asserted-by":"publisher","first-page":"8672","DOI":"10.1128\/JVI.00287-12","volume":"86","author":"A Smalls-Mantey","year":"2012","unstructured":"Smalls-Mantey, A. et al. Antibody-dependent cellular cytotoxicity against primary HIV-infected CD4+ T cells is directly associated with the magnitude of surface IgG binding. J. Virol. 86, 8672\u20138680 (2012)","journal-title":"J. Virol."},{"key":"BFnature13612_CR20","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jim.2005.09.018","volume":"308","author":"VR G\u00f3mez-Rom\u00e1n","year":"2006","unstructured":"G\u00f3mez-Rom\u00e1n, V. R. et al. A simplified method for the rapid fluorometric assessment of antibody-dependent cell-mediated cytotoxicity. J. Immunol. Methods 308, 53\u201367 (2006)","journal-title":"J. Immunol. Methods"},{"key":"BFnature13612_CR21","doi-asserted-by":"publisher","first-page":"11604","DOI":"10.1128\/JVI.01361-13","volume":"87","author":"K Klein","year":"2013","unstructured":"Klein, K. et al. Neutralizing IgG at the portal of infection mediates protection against vaginal simian\/human immunodeficiency virus challenge. J. Virol. 87, 11604\u201311616 (2013)","journal-title":"J. Virol."},{"key":"BFnature13612_CR22","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nri3516","volume":"13","author":"PD Kwong","year":"2013","unstructured":"Kwong, P. D., Mascola, J. R. & Nabel, G. J. Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning. Nature Rev. Immunol. 13, 693\u2013701 (2013)","journal-title":"Nature Rev. Immunol."},{"key":"BFnature13612_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/infdis\/163.1.1","volume":"163","author":"IM Onorato","year":"1991","unstructured":"Onorato, I. M. et al. Mucosal immunity induced by enhance-potency inactivated and oral polio vaccines. J. Infect. Dis. 163, 1\u20136 (1991)","journal-title":"J. Infect. Dis."},{"key":"BFnature13612_CR24","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/0016-5085(90)91290-M","volume":"98","author":"P Sicinski","year":"1990","unstructured":"Sicinski, P. et al. Poliovirus type 1 enters the human host through intestinal M cells. Gastroenterology 98, 56\u201358 (1990)","journal-title":"Gastroenterology"},{"key":"BFnature13612_CR25","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.immuni.2004.05.007","volume":"20","author":"M Yoshida","year":"2004","unstructured":"Yoshida, M. et al. Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells. Immunity 20, 769\u2013783 (2004)","journal-title":"Immunity"},{"key":"BFnature13612_CR26","doi-asserted-by":"publisher","first-page":"7552","DOI":"10.1073\/pnas.0802203105","volume":"105","author":"BF Keele","year":"2008","unstructured":"Keele, B. F. et al. Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc. Natl Acad. Sci. USA 105, 7552\u20137557 (2008)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13612_CR27","doi-asserted-by":"publisher","first-page":"4388","DOI":"10.1073\/pnas.1012861108","volume":"108","author":"Z Li","year":"2011","unstructured":"Li, Z. et al. Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infection. Proc. Natl Acad. Sci. USA 108, 4388\u20134393 (2011)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13612_CR28","doi-asserted-by":"publisher","first-page":"6147","DOI":"10.1128\/AAC.01285-13","volume":"57","author":"GJ Robbie","year":"2013","unstructured":"Robbie, G. J. et al. A novel investigational Fc-modified humanized monoclonal antibody, motavizumab-YTE, has an extended half-life in healthy adults. Antimicrob. Agents Chemother. 57, 6147\u20136153 (2013)","journal-title":"Antimicrob. Agents Chemother."},{"key":"BFnature13612_CR29","doi-asserted-by":"publisher","first-page":"243ra88","DOI":"10.1126\/scitranslmed.3008992","volume":"6","author":"A Pegu","year":"2014","unstructured":"Pegu, A. et al. Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor. Sci. Transl. Med. 6, 243ra88 (2014)","journal-title":"Sci. Transl. Med."},{"key":"BFnature13612_CR30","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1073\/pnas.63.1.78","volume":"63","author":"GM Edelman","year":"1969","unstructured":"Edelman, G. M. et al. The covalent structure of an entire \u03b3G immunoglobulin molecule. Proc. Natl Acad. Sci. USA 63, 78\u201385 (1969)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13612_CR31","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1073\/pnas.89.2.638","volume":"89","author":"LN Gastinel","year":"1992","unstructured":"Gastinel, L. N., Simister, N. E. & Bjorkman, P. J. Expression and crystallization of a soluble and functional form of an Fc receptor related to class I histocompatibility molecules. Proc. Natl Acad. Sci. USA 89, 638\u2013642 (1992)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature13612_CR32","doi-asserted-by":"publisher","first-page":"10108","DOI":"10.1128\/JVI.79.16.10108-10125.2005","volume":"79","author":"M Li","year":"2005","unstructured":"Li, M. et al. Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies. J. Virol. 79, 10108\u201310125 (2005)","journal-title":"J. Virol."},{"key":"BFnature13612_CR33","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1016\/j.vaccine.2006.10.046","volume":"25","author":"Y Shu","year":"2007","unstructured":"Shu, Y. et al. Efficient protein boosting after plasmid DNA or recombinant adenovirus immunization with HIV-1 vaccine constructs. Vaccine 25, 1398\u20131408 (2007)","journal-title":"Vaccine"},{"key":"BFnature13612_CR34","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1128\/JVI.02108-09","volume":"84","author":"MS Seaman","year":"2010","unstructured":"Seaman, M. S. et al. Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies. J. Virol. 84, 1439\u20131452 (2010)","journal-title":"J. Virol."},{"key":"BFnature13612_CR35","doi-asserted-by":"publisher","first-page":"28038","DOI":"10.1074\/jbc.M202367200","volume":"277","author":"SM Claypool","year":"2002","unstructured":"Claypool, S. M., Dickinson, B. L., Yoshida, M., Lencer, W. I. & Blumberg, R. S. Functional reconstitution of human FcRn in Madin\u2013Darby canine kidney cells requires co-expressed human \u03b22-microglobulin. J. Biol. Chem. 277, 28038\u201328050 (2002)","journal-title":"J. Biol. Chem."},{"key":"BFnature13612_CR36","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1172\/JCI45157","volume":"121","author":"M Zeng","year":"2011","unstructured":"Zeng, M. et al. Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. J. Clin. Invest. 121, 998\u20131008 (2011)","journal-title":"J. Clin. Invest."},{"key":"BFnature13612_CR37","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.immuni.2013.11.003","volume":"39","author":"K Baker","year":"2013","unstructured":"Baker, K. et al. Neonatal Fc receptor expression in dendritic cells mediates protective immunity against colorectal cancer. Immunity 39, 1095\u20131107 (2013)","journal-title":"Immunity"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature13612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature13612","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature13612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:23:42Z","timestamp":1684419822000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature13612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,13]]},"references-count":37,"journal-issue":{"issue":"7524","published-print":{"date-parts":[[2014,10,30]]}},"alternative-id":["BFnature13612"],"URL":"https:\/\/doi.org\/10.1038\/nature13612","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,13]]},"assertion":[{"value":"6 March 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}