{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:58:18Z","timestamp":1791215898278,"version":"4.1.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"7544","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1038\/nature14373","type":"journal-article","created":{"date-parts":[[2015,3,19]],"date-time":"2015-03-19T15:03:11Z","timestamp":1426777391000},"page":"416-417","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A big-hearted molecule"],"prefix":"10.1038","volume":"519","author":[{"given":"Michaela","family":"Kuhn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,3,18]]},"reference":[{"key":"BFnature14373_CR1","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1038\/nature14332","volume":"519","author":"DI Lee","year":"2015","unstructured":"Lee, D. I. et al. Nature 519, 472\u2013476 (2015).","journal-title":"Nature"},{"key":"BFnature14373_CR2","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1161\/01.RES.0000094745.28948.4D","volume":"93","author":"M Kuhn","year":"2003","unstructured":"Kuhn, M. Circ. Res. 93, 700\u2013709 (2003).","journal-title":"Circ. Res."},{"key":"BFnature14373_CR3","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nrd4228","volume":"13","author":"DH Maurice","year":"2014","unstructured":"Maurice, D. H. et al. Nature Rev. Drug Discov. 13, 290\u2013314 (2014).","journal-title":"Nature Rev. Drug Discov."},{"key":"BFnature14373_CR4","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1093\/eurheartj\/ehr445","volume":"34","author":"S Frantz","year":"2013","unstructured":"Frantz, S. et al. Eur. Heart J. 34, 1233\u20131244 (2013).","journal-title":"Eur. Heart J."},{"key":"BFnature14373_CR5","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1038\/nature10405","volume":"478","author":"GB Ehret","year":"2011","unstructured":"Ehret, G. B. et al. Nature 478, 103\u2013109 (2011).","journal-title":"Nature"},{"key":"BFnature14373_CR6","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1172\/JCI17061","volume":"111","author":"R Holtwick","year":"2003","unstructured":"Holtwick, R. et al. J. Clin. Invest. 111, 1399\u20131407 (2003).","journal-title":"J. Clin. Invest."},{"key":"BFnature14373_CR7","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1038\/nm1175","volume":"11","author":"E Takimoto","year":"2005","unstructured":"Takimoto, E. et al. Nature Med. 11, 214\u2013222 (2005).","journal-title":"Nature Med."},{"key":"BFnature14373_CR8","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1161\/CIRCULATIONAHA.110.983866","volume":"124","author":"M Guazzi","year":"2011","unstructured":"Guazzi, M., Vicenzi, M., Arena, R. & Guazzi, M. D. Circulation 124, 164\u2013174 (2011).","journal-title":"Circulation"},{"key":"BFnature14373_CR9","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1001\/jama.2013.2024","volume":"309","author":"MM Redfield","year":"2013","unstructured":"Redfield, M. M. et al. J. Am. Med. Assoc. 309, 1268\u20131277 (2013).","journal-title":"J. Am. Med. Assoc."},{"key":"BFnature14373_CR10","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1056\/NEJMoa1409077","volume":"371","author":"JJV McMurray","year":"2014","unstructured":"McMurray, J. J. V. et al. N. Engl. J. Med. 371, 993\u20131004 (2014).","journal-title":"N. Engl. J. Med."},{"key":"BFnature14373_CR11","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1139\/y11-048","volume":"89","author":"R Zakeri","year":"2011","unstructured":"Zakeri, R. & Burnett, J. C. Can. J. Physiol. Pharmacol. 89, 593\u2013601 (2011).","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"BFnature14373_CR12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ijcard.2014.10.087","volume":"178","author":"J Ampadu","year":"2015","unstructured":"Ampadu, J. & Morley, J. E. Int. J. Cardiol. 178, 12\u201323 (2015).","journal-title":"Int. J. Cardiol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature14373.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature14373","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature14373.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:30:43Z","timestamp":1684434643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature14373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":12,"journal-issue":{"issue":"7544","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["BFnature14373"],"URL":"https:\/\/doi.org\/10.1038\/nature14373","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"18 March 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}