{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T07:04:32Z","timestamp":1790492672410,"version":"4.1.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"7593","license":[{"start":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T00:00:00Z","timestamp":1455062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T00:00:00Z","timestamp":1455062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2016,3,10]]},"DOI":"10.1038\/nature16975","type":"journal-article","created":{"date-parts":[[2016,2,10]],"date-time":"2016-02-10T08:16:26Z","timestamp":1455092186000},"page":"241-244","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":222,"title":["A receptor heteromer mediates the male perception of female attractants in plants"],"prefix":"10.1038","volume":"531","author":[{"given":"Tong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Fei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Xia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Chun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Ju","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Cai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,10]]},"reference":[{"key":"BFnature16975_CR1","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1126\/science.1104954","volume":"307","author":"ML Marton","year":"2005","unstructured":"Marton, M. L., Cordts, S., Broadhvest, J. & Dresselhaus, T. Micropylar pollen tube guidance by egg apparatus 1 of maize. Science 307, 573\u2013576 (2005)","journal-title":"Science"},{"key":"BFnature16975_CR2","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nature07882","volume":"458","author":"S Okuda","year":"2009","unstructured":"Okuda, S. et al. Defensin-like polypeptide LUREs are pollen tube attractants secreted from synergid cells. Nature 458, 357\u2013361 (2009)","journal-title":"Nature"},{"key":"BFnature16975_CR3","doi-asserted-by":"publisher","first-page":"e1001449","DOI":"10.1371\/journal.pbio.1001449","volume":"10","author":"H Takeuchi","year":"2012","unstructured":"Takeuchi, H. & Higashiyama, T. A species-specific cluster of defensin-like genes encodes diffusible pollen tube attractants in Arabidopsis. PLoS Biol. 10, e1001449 (2012)","journal-title":"PLoS Biol."},{"key":"BFnature16975_CR4","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1104\/pp.112.211441","volume":"162","author":"AE Loraine","year":"2013","unstructured":"Loraine, A. E., McCormick, S., Estrada, A., Patel, K. & Qin, P. RNA-seq of Arabidopsis pollen uncovers novel transcription and alternative splicing. Plant Physiol. 162, 1092\u20131109 (2013)","journal-title":"Plant Physiol."},{"key":"BFnature16975_CR5","doi-asserted-by":"publisher","first-page":"e1000621","DOI":"10.1371\/journal.pgen.1000621","volume":"5","author":"Y Qin","year":"2009","unstructured":"Qin, Y. et al. Penetration of the stigma and style elicits a novel transcriptome in pollen tubes, pointing to genes critical for growth in a pistil. PLoS Genet. 5, e1000621 (2009)","journal-title":"PLoS Genet."},{"key":"BFnature16975_CR6","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1104\/pp.104.046367","volume":"136","author":"P Zimmermann","year":"2004","unstructured":"Zimmermann, P., Hirsch-Hoffmann, M., Hennig, L. & Gruissem, W. GENEVESTIGATOR. Arabidopsis microarraydatabase and analysis toolbox. Plant Physiol. 136, 2621\u20132632 (2004)","journal-title":"Plant Physiol."},{"key":"BFnature16975_CR7","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1104\/pp.108.126375","volume":"148","author":"Y Wang","year":"2008","unstructured":"Wang, Y. et al. Transcriptome analyses show changes in gene expression to accompany pollen germination and tube growth in Arabidopsis. Plant Physiol. 148, 1201\u20131211 (2008)","journal-title":"Plant Physiol."},{"key":"BFnature16975_CR8","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1046\/j.1365-313X.1994.06030321.x","volume":"6","author":"J Muschietti","year":"1994","unstructured":"Muschietti, J., Dircks, L., Vancanneyt, G. & McCormick, S. LAT52 protein is essential for tomato pollen development: pollen expressing antisense LAT52 RNA hydrates and germinates abnormally and cannot achieve fertilization. Plant J. 6, 321\u2013338 (1994)","journal-title":"Plant J."},{"key":"BFnature16975_CR9","doi-asserted-by":"publisher","first-page":"3288","DOI":"10.1105\/tpc.111.088914","volume":"23","author":"HJ Li","year":"2011","unstructured":"Li, H. J. et al. POD1 regulates pollen tube guidance in response to micropylar female signaling and acts in early embryo patterning in Arabidopsis. Plant Cell 23, 3288\u20133302 (2011)","journal-title":"Plant Cell"},{"key":"BFnature16975_CR10","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/j.1365-313X.2005.02609.x","volume":"45","author":"MA Jones","year":"2006","unstructured":"Jones, M. A., Raymond, M. J. & Smirnoff, N. Analysis of the root-hair morphogenesis transcriptome reveals the molecular identity of six genes with roles in root-hair development in Arabidopsis. Plant J. 45, 83\u2013100 (2006)","journal-title":"Plant J."},{"key":"BFnature16975_CR11","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.cub.2007.05.049","volume":"17","author":"K Fisher","year":"2007","unstructured":"Fisher, K. & Turner, S. PXY, a receptor-like kinase essential for maintaining polarity during plant vascular-tissue development. Curr. Biol. 17, 1061\u20131066 (2007)","journal-title":"Curr. Biol."},{"key":"BFnature16975_CR12","doi-asserted-by":"publisher","first-page":"15208","DOI":"10.1073\/pnas.0808444105","volume":"105","author":"Y Hirakawa","year":"2008","unstructured":"Hirakawa, Y. et al. Non-cell-autonomous control of vascular stem cell fate by a CLE peptide\/receptor system. Proc. Natl Acad. Sci. USA 105, 15208\u201315213 (2008)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature16975_CR13","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.plaphy.2008.06.011","volume":"46","author":"J Sels","year":"2008","unstructured":"Sels, J., Mathys, J., De Coninck, B. M., Cammue, B. P. & De Bolle, M. F. Plant pathogenesis-related (PR) proteins: a focus on PR peptides. Plant Physiol. Biochem. 46, 941\u2013950 (2008)","journal-title":"Plant Physiol. Biochem."},{"key":"BFnature16975_CR14","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1093\/mp\/sss103","volume":"6","author":"F Chang","year":"2013","unstructured":"Chang, F., Gu, Y., Ma, H. & Yang, Z. AtPRK2 promotes ROP1 activation via RopGEFs in the control of polarized pollen tube growth. Mol. Plant 6, 1187\u20131201 (2013)","journal-title":"Mol. Plant"},{"key":"BFnature16975_CR15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1038\/nature14561","volume":"522","author":"JS Lee","year":"2015","unstructured":"Lee, J. S. et al. Competitive binding of antagonistic peptides fine-tunes stomatal patterning. Nature 522, 439\u2013443 (2015)","journal-title":"Nature"},{"key":"BFnature16975_CR16","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0092-8674(02)00812-7","volume":"110","author":"J Li","year":"2002","unstructured":"Li, J. et al. BAK1, an Arabidopsis LRR receptor-like protein kinase, interacts with BRI1 and modulates brassinosteroid signaling. Cell 110, 213\u2013222 (2002)","journal-title":"Cell"},{"key":"BFnature16975_CR17","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1126\/science.1242468","volume":"341","author":"J Santiago","year":"2013","unstructured":"Santiago, J., Henzler, C. & Hothorn, M. Molecular mechanism for plant steroid receptor activation by somatic embryogenesis co-receptor kinases. Science 341, 889\u2013892 (2013)","journal-title":"Science"},{"key":"BFnature16975_CR18","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1126\/science.1243825","volume":"342","author":"Y Sun","year":"2013","unstructured":"Sun, Y. et al. Structural basis for flg22-induced activation of the Arabidopsis FLS2\u2013BAK1 immune complex. Science 342, 624\u2013628, (2013)","journal-title":"Science"},{"key":"BFnature16975_CR19","doi-asserted-by":"publisher","first-page":"3503","DOI":"10.1093\/jxb\/erm226","volume":"58","author":"E Castells","year":"2007","unstructured":"Castells, E. & Casacuberta, J. M. Signalling through kinase-defective domains: the prevalence of atypical receptor-like kinases in plants. J. Exp. Bot. 58, 3503\u20133511 (2007)","journal-title":"J. Exp. Bot."},{"key":"BFnature16975_CR20","doi-asserted-by":"publisher","first-page":"6030","DOI":"10.1038\/ncomms7030","volume":"6","author":"LY Chen","year":"2015","unstructured":"Chen, L. Y. et al. The Arabidopsis alkaline ceramidase TOD1 is a key turgor pressure regulator in plant cells. Nature Commun . 6, 6030 (2015)","journal-title":"Nature Commun"},{"key":"BFnature16975_CR21","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.1105\/tpc.15.00370","volume":"27","author":"HJ Li","year":"2015","unstructured":"Li, H. J. et al. Arabidopsis CBP1 is a novel regulator of transcription initiation in central cell-mediated pollen tube guidance. Plant Cell 27, 2880\u20132893 (2015)","journal-title":"Plant Cell"},{"key":"BFnature16975_CR22","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1105\/tpc.107.053967","volume":"19","author":"YH Chen","year":"2007","unstructured":"Chen, Y. H. et al. The central cell plays a critical role in pollen tube guidance in Arabidopsis. Plant Cell 19, 3563\u20133577 (2007)","journal-title":"Plant Cell"},{"key":"BFnature16975_CR23","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S0092-8674(00)80357-8","volume":"90","author":"J Li","year":"1997","unstructured":"Li, J. & Chory, J. A putative leucine-rich repeat receptor kinase involved in brassinosteroid signal transduction. Cell 90, 929\u2013938 (1997)","journal-title":"Cell"},{"key":"BFnature16975_CR24","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1046\/j.1365-313x.1998.00343.x","volume":"16","author":"SJ Clough","year":"1998","unstructured":"Clough, S. J. & Bent, A. F. Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana. Plant J. 16, 735\u2013743 (1998)","journal-title":"Plant J."},{"key":"BFnature16975_CR25","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1038\/nprot.2007.199","volume":"2","author":"SD Yoo","year":"2007","unstructured":"Yoo, S. D., Cho, Y. H. & Sheen, J. Arabidopsis mesophyll protoplasts: a versatile cell system for transient gene expression analysis. Nature Protocols 2, 1565\u20131572 (2007)","journal-title":"Nature Protocols"},{"key":"BFnature16975_CR26","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/j.1365-313X.2004.02219.x","volume":"40","author":"M Walter","year":"2004","unstructured":"Walter, M. et al. Visualization of protein interactions in living plant cells using bimolecular fluorescence complementation. Plant J. 40, 428\u2013438 (2004)","journal-title":"Plant J."},{"key":"BFnature16975_CR27","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/nature14300","volume":"521","author":"K Palikaras","year":"2015","unstructured":"Palikaras, K., Lionaki, E. & Tavernarakis, N. Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature 521, 525\u2013528 (2015)","journal-title":"Nature"},{"key":"BFnature16975_CR28","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1038\/nprot.2006.185","volume":"1","author":"TE Thingholm","year":"2006","unstructured":"Thingholm, T. E., Jorgensen, T. J., Jensen, O. N. & Larsen, M. R. Highly selective enrichment of phosphorylated peptides using titanium dioxide. Nature Protocols 1, 1929\u20131935 (2006)","journal-title":"Nature Protocols"},{"key":"BFnature16975_CR29","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nmeth.3283","volume":"12","author":"S Lu","year":"2015","unstructured":"Lu, S. et al. Mapping native disulfide bonds at a proteome scale. Nature Methods 12, 329\u2013331 (2015)","journal-title":"Nature Methods"}],"updated-by":[{"DOI":"10.1038\/nature17985","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T00:00:00Z","timestamp":1462924800000}}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature16975.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature16975","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature16975.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:49:58Z","timestamp":1684417798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature16975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,10]]},"references-count":29,"journal-issue":{"issue":"7593","published-print":{"date-parts":[[2016,3,10]]}},"alternative-id":["BFnature16975"],"URL":"https:\/\/doi.org\/10.1038\/nature16975","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726135520.793516533","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726135520.793515405","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,10]]},"assertion":[{"value":"9 November 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}