{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:46:30Z","timestamp":1791942390728,"version":"4.3.4"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"7599","license":[{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,3,23]],"date-time":"2016-03-23T00:00:00Z","timestamp":1458691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2016,4,21]]},"DOI":"10.1038\/nature17631","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T13:46:46Z","timestamp":1458654406000},"page":"394-397","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":503,"title":["NOD1 and NOD2 signalling links ER stress with inflammation"],"prefix":"10.1038","volume":"532","author":[{"given":"A. Marijke","family":"Keestra-Gounder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana X.","family":"Byndloss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N\u00fabia","family":"Seyffert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briana M.","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ch\u00e1vez-Arroyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April Y.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Cevallos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oanh H.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor R.","family":"Tiffany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten F.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Kerrinnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Resmi","family":"Ravindran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Luciw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"McSorley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas J.","family":"B\u00e4umler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e M.","family":"Tsolis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,3,23]]},"reference":[{"key":"BFnature17631_CR1","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1016\/j.cell.2008.07.021","volume":"134","author":"A Kaser","year":"2008","unstructured":"Kaser, A. et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134, 743\u2013756 (2008)","journal-title":"Cell"},{"key":"BFnature17631_CR2","first-page":"25","volume":"7","author":"J Montane","year":"2014","unstructured":"Montane, J., Cadavez, L. & Novials, A. Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes. Diabetes Metab. Syndr. Obes. 7, 25\u201334, (2014)","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"BFnature17631_CR3","doi-asserted-by":"crossref","unstructured":"Celli, J. & Tsolis, R. M. Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes? Nature Rev. Microbiol. (2014)","DOI":"10.1038\/nrmicro3393"},{"key":"BFnature17631_CR4","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1126\/science.287.5453.664","volume":"287","author":"F Urano","year":"2000","unstructured":"Urano, F. et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287, 664\u2013666 (2000)","journal-title":"Science"},{"key":"BFnature17631_CR5","doi-asserted-by":"publisher","first-page":"e00418","DOI":"10.1128\/mBio.00418-12","volume":"4","author":"MF de Jong","year":"2013","unstructured":"de Jong, M. F. et al. Sensing of bacterial type IV secretion via the unfolded protein response. MBio 4, e00418\u201312 (2013)","journal-title":"MBio"},{"key":"BFnature17631_CR6","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1248\/bpb.26.931","volume":"26","author":"M Kaneko","year":"2003","unstructured":"Kaneko, M., Niinuma, Y. & Nomura, Y. Activation signal of nuclear factor-\u03baB in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2. Biol. Pharm. Bull. 26, 931\u2013935 (2003)","journal-title":"Biol. Pharm. Bull."},{"key":"BFnature17631_CR7","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/ni.2378","volume":"13","author":"M Schneider","year":"2012","unstructured":"Schneider, M. et al. The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-\u03baB. Nature Immunol. 13, 823\u2013831 (2012)","journal-title":"Nature Immunol."},{"key":"BFnature17631_CR8","doi-asserted-by":"publisher","first-page":"16968","DOI":"10.1074\/jbc.273.27.16968","volume":"273","author":"JV McCarthy","year":"1998","unstructured":"McCarthy, J. V., Ni, J. & Dixit, V. M. RIP2 is a novel NF-\u03baB-activating and cell death-inducing kinase. J. Biol. Chem. 273, 16968\u201316975 (1998)","journal-title":"J. Biol. Chem."},{"key":"BFnature17631_CR9","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1242\/jcs.01641","volume":"118","author":"L Li","year":"2005","unstructured":"Li, L. et al. TRIP6 is a RIP2-associated common signaling component of multiple NF-\u03baB activation pathways. J. Cell Sci. 118, 555\u2013563 (2005)","journal-title":"J. Cell Sci."},{"key":"BFnature17631_CR10","doi-asserted-by":"crossref","first-page":"17067","DOI":"10.1016\/S0021-9258(19)47340-7","volume":"266","author":"J Lytton","year":"1991","unstructured":"Lytton, J., Westlin, M. & Hanley, M. R. Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J. Biol. Chem. 266, 17067\u201317071 (1991)","journal-title":"J. Biol. Chem."},{"key":"BFnature17631_CR11","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/415092a","volume":"415","author":"M Calfon","year":"2002","unstructured":"Calfon, M. et al. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature 415, 92\u201396 (2002)","journal-title":"Nature"},{"key":"BFnature17631_CR12","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.cell.2014.07.002","volume":"158","author":"R Ghosh","year":"2014","unstructured":"Ghosh, R. et al. Allosteric inhibition of the IRE1\u03b1 RNase preserves cell viability and function during endoplasmic reticulum stress. Cell 158, 534\u2013548 (2014)","journal-title":"Cell"},{"key":"BFnature17631_CR13","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1182\/blood-2010-08-303099","volume":"117","author":"I Papandreou","year":"2011","unstructured":"Papandreou, I. et al. Identification of an Ire1\u03b1 endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma. Blood 117, 1311\u20131314 (2011)","journal-title":"Blood"},{"key":"BFnature17631_CR14","doi-asserted-by":"publisher","first-page":"1993","DOI":"10.1158\/0008-5472.CAN-12-3109","volume":"73","author":"C Atkins","year":"2013","unstructured":"Atkins, C. et al. Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res. 73, 1993\u20132002 (2013)","journal-title":"Cancer Res."},{"key":"BFnature17631_CR15","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/nrmicro2012","volume":"6","author":"RM Tsolis","year":"2008","unstructured":"Tsolis, R. M., Young, G. M., Solnick, J. V. & Baumler, A. J. From bench to bedside: stealth of enteroinvasive pathogens. Nature Rev. Microbiol. 6, 883\u2013892 (2008)","journal-title":"Nature Rev. Microbiol."},{"key":"BFnature17631_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1111\/j.1600-065X.2010.00982.x","volume":"240","author":"A Martirosyan","year":"2011","unstructured":"Martirosyan, A., Moreno, E. & Gorvel, J. P. An evolutionary strategy for a stealthy intracellular Brucella pathogen. Immunol. Rev. 240, 211\u2013234 (2011)","journal-title":"Immunol. Rev."},{"key":"BFnature17631_CR17","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1111\/j.1462-5822.2007.00922.x","volume":"9","author":"CM Roux","year":"2007","unstructured":"Roux, C. M. et al. Brucella requires a functional type IV secretion system to elicit innate immune responses in mice. Cell. Microbiol. 9, 1851\u20131869 (2007)","journal-title":"Cell. Microbiol."},{"key":"BFnature17631_CR18","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1111\/j.1365-2958.2008.06487.x","volume":"70","author":"MF de Jong","year":"2008","unstructured":"de Jong, M. F., Sun, Y. H., den Hartigh, A. B., van Dijl, J. M. & Tsolis, R. M. Identification of VceA and VceC, two members of the VjbR regulon that are translocated into macrophages by the Brucella type IV secretion system. Mol. Microbiol. 70, 1378\u20131396 (2008)","journal-title":"Mol. Microbiol."},{"key":"BFnature17631_CR19","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/1471-2180-5-22","volume":"5","author":"S Kim","year":"2005","unstructured":"Kim, S. et al. Interferon-\u03b3 promotes abortion due to Brucella infection in pregnant mice. BMC Microbiol. 5, 22 (2005)","journal-title":"BMC Microbiol."},{"key":"BFnature17631_CR20","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1111\/cmi.12455","volume":"17","author":"I Derre","year":"2015","unstructured":"Derre, I. Chlamydiae interaction with the endoplasmic reticulum: contact, function and consequences. Cell. Microbiol. 17, 959\u2013966 (2015)","journal-title":"Cell. Microbiol."},{"key":"BFnature17631_CR21","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/ni.1782","volume":"10","author":"A Sabbah","year":"2009","unstructured":"Sabbah, A. et al. Activation of innate immune antiviral responses by Nod2. Nature Immunol. 10, 1073\u20131080 (2009)","journal-title":"Nature Immunol."},{"key":"BFnature17631_CR22","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1165\/rcmb.2010-0460OC","volume":"46","author":"EC Roberson","year":"2012","unstructured":"Roberson, E. C. et al. Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-\u03b2 release in lung epithelial cells. Am. J. Respir. Cell Mol. Biol. 46, 573\u2013581 (2012)","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"BFnature17631_CR23","first-page":"Unit 11A.1","volume":"Chapter 11","author":"MA Scidmore","year":"2005","unstructured":"Scidmore, M. A. Cultivation and laboratory maintenance of Chlamydia trachomatis . Curr. Protoc. Microbiol. Chapter 11, Unit 11A.1, (2005)","journal-title":"Curr. Protoc. Microbiol."},{"key":"BFnature17631_CR24","first-page":"e00266","volume":"2","author":"AM Keestra","year":"2011","unstructured":"Keestra, A. M. et al. A Salmonella virulence factor activates the NOD1\/NOD2 signaling pathway. MBio 2, e00266\u201311 (2011)","journal-title":"MBio"},{"key":"BFnature17631_CR25","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nature12025","volume":"496","author":"AM Keestra","year":"2013","unstructured":"Keestra, A. M. et al. Manipulation of small Rho GTPases is a pathogen-induced process detected by NOD1. Nature 496, 233\u2013237 (2013)","journal-title":"Nature"},{"key":"BFnature17631_CR26","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1126\/science.7544915","volume":"269","author":"M Rothe","year":"1995","unstructured":"Rothe, M., Sarma, V., Dixit, V. M. & Goeddel, D. V. TRAF2-mediated activation of NF-\u03ba B by TNF receptor 2 and CD40. Science 269, 1424\u20131427 (1995)","journal-title":"Science"},{"key":"BFnature17631_CR27","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1128\/IAI.01896-06","volume":"75","author":"HG Rolan","year":"2007","unstructured":"Rolan, H. G. & Tsolis, R. M. Mice lacking components of adaptive immunity show increased Brucella abortus virB mutant colonization. Infect. Immun. 75, 2965\u20132973 (2007)","journal-title":"Infect. Immun."},{"key":"BFnature17631_CR28","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1128\/IAI.00203-08","volume":"76","author":"HG Rolan","year":"2008","unstructured":"Rolan, H. G. & Tsolis, R. M. Inactivation of the type IV secretion system reduces the Th1 polarization of the immune response to Brucella abortus infection. Infect. Immun. 76, 3207\u20133213 (2008)","journal-title":"Infect. Immun."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature17631.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature17631","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature17631.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T13:51:25Z","timestamp":1684417885000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature17631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,23]]},"references-count":28,"journal-issue":{"issue":"7599","published-print":{"date-parts":[[2016,4,21]]}},"alternative-id":["BFnature17631"],"URL":"https:\/\/doi.org\/10.1038\/nature17631","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,23]]},"assertion":[{"value":"10 April 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 March 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}