{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:17:11Z","timestamp":1791397031948,"version":"4.3.3"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"7610","license":[{"start":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:00:00Z","timestamp":1467158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T00:00:00Z","timestamp":1467158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2016,7,7]]},"DOI":"10.1038\/nature18317","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T11:36:11Z","timestamp":1467200171000},"page":"173-177","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":142,"title":["A core viral protein binds host nucleosomes to sequester immune danger signals"],"prefix":"10.1038","volume":"535","author":[{"given":"Daphne C.","family":"Avgousti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Kulej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha J.","family":"Pancholi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolina","family":"Sekulic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Petrescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalynn C.","family":"Molden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Blumenthal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Paris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emigdio D.","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philomena","family":"Ostapchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Hearing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Seeholzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Scott","family":"Worthen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben E.","family":"Black","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin A.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D.","family":"Weitzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,29]]},"reference":[{"key":"BFnature18317_CR1","first-page":"787","volume":"7","author":"NC Elde","year":"2009","unstructured":"Elde, N. C. & Malik, H. S. The evolutionary conundrum of pathogen mimicry. Nature Rev. Microbiol. 7, 787\u2013797 (2009)","journal-title":"Rev. Microbiol."},{"key":"BFnature18317_CR2","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1146\/annurev-immunol-031210-101303","volume":"32","author":"ST Smale","year":"2014","unstructured":"Smale, S. T., Tarakhovsky, A. & Natoli, G. Chromatin contributions to the regulation of innate immunity. Annu. Rev. Immunol. 32, 489\u2013511 (2014)","journal-title":"Annu. Rev. Immunol."},{"key":"BFnature18317_CR3","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1038\/267552a0","volume":"267","author":"MA Lischwe","year":"1977","unstructured":"Lischwe, M. A. & Sung, M. T. A histone-like protein from adenovirus chromatin. Nature 267, 552\u2013554 (1977)","journal-title":"Nature"},{"key":"BFnature18317_CR4","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1002\/j.1460-2075.1986.tb04406.x","volume":"5","author":"PK Chatterjee","year":"1986","unstructured":"Chatterjee, P. K., Vayda, M. E. & Flint, S. J. Adenoviral protein VII packages intracellular viral DNA throughout the early phase of infection. EMBO J. 5, 1633\u20131644 (1986)","journal-title":"EMBO J."},{"key":"BFnature18317_CR5","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1093\/nar\/11.2.441","volume":"11","author":"ME Vayda","year":"1983","unstructured":"Vayda, M. E., Rogers, A. E. & Flint, S. J. The structure of nucleoprotein cores released from adenovirions. Nucleic Acids Res. 11, 441\u2013460 (1983)","journal-title":"Nucleic Acids Res."},{"key":"BFnature18317_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mam.2014.05.001","volume":"40","author":"R Kang","year":"2014","unstructured":"Kang, R. et al. HMGB1 in health and disease. Mol. Aspects Med. 40, 1\u2013116 (2014)","journal-title":"Mol. Aspects Med."},{"key":"BFnature18317_CR7","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/nri1594","volume":"5","author":"MT Lotze","year":"2005","unstructured":"Lotze, M. T. & Tracey, K. J. High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal. Nature Rev. Immunol. 5, 331\u2013342 (2005)","journal-title":"Rev. Immunol."},{"key":"BFnature18317_CR8","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.tim.2010.07.003","volume":"18","author":"K Paschos","year":"2010","unstructured":"Paschos, K. & Allday, M. J. Epigenetic reprogramming of host genes in viral and microbial pathogenesis. Trends Microbiol. 18, 439\u2013447 (2010)","journal-title":"Trends Microbiol."},{"key":"BFnature18317_CR9","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature10892","volume":"483","author":"I Marazzi","year":"2012","unstructured":"Marazzi, I. et al. Suppression of the antiviral response by an influenza histone mimic. Nature 483, 428\u2013433 (2012)","journal-title":"Nature"},{"key":"BFnature18317_CR10","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nrg2539","volume":"10","author":"R Ferrari","year":"2009","unstructured":"Ferrari, R., Berk, A. J. & Kurdistani, S. K. Viral manipulation of the host epigenome for oncogenic transformation. Nature Rev. Genet. 10, 290\u2013294 (2009)","journal-title":"Nature Rev. Genet."},{"key":"BFnature18317_CR11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.virol.2012.09.023","volume":"435","author":"DM Knipe","year":"2013","unstructured":"Knipe, D. M. et al. Snapshots: chromatin control of viral infection. Virology 435, 141\u2013156 (2013)","journal-title":"Virology"},{"key":"BFnature18317_CR12","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.chom.2014.10.004","volume":"16","author":"R Ferrari","year":"2014","unstructured":"Ferrari, R. et al. Adenovirus small E1A employs the lysine acetylases p300\/CBP and tumor suppressor Rb to repress select host genes and promote productive virus infection. Cell Host Microbe 16, 663\u2013676 (2014)","journal-title":"Cell Host Microbe"},{"key":"BFnature18317_CR13","doi-asserted-by":"publisher","first-page":"29471","DOI":"10.1074\/jbc.M304545200","volume":"278","author":"SM Wykes","year":"2003","unstructured":"Wykes, S. M. & Krawetz, S. A. The structural organization of sperm chromatin. J. Biol. Chem. 278, 29471\u201329477 (2003)","journal-title":"J. Biol. Chem."},{"key":"BFnature18317_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/B978-0-12-391940-3.00001-9","volume":"512","author":"S Lin","year":"2012","unstructured":"Lin, S. & Garcia, B. A. Examining histone posttranslational modification patterns by high-resolution mass spectrometry. Methods Enzymol. 512, 3\u201328 (2012)","journal-title":"Methods Enzymol."},{"key":"BFnature18317_CR15","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/nprot.2007.202","volume":"2","author":"D Shechter","year":"2007","unstructured":"Shechter, D., Dormann, H. L., Allis, C. D. & Hake, S. B. Extraction, purification and analysis of histones. Nature Protocols 2, 1445\u20131457 (2007)","journal-title":"Nature Protocols"},{"key":"BFnature18317_CR16","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/978-1-61779-477-3_25","volume":"833","author":"SS Teves","year":"2012","unstructured":"Teves, S. S. & Henikoff, S. Salt fractionation of nucleosomes for genome-wide profiling. Methods Mol. Biol. 833, 421\u2013432 (2012)","journal-title":"Methods Mol. Biol."},{"key":"BFnature18317_CR17","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1126\/science.1259308","volume":"348","author":"SJ Falk","year":"2015","unstructured":"Falk, S. J. et al. Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere. Science 348, 699\u2013703 (2015)","journal-title":"Science"},{"key":"BFnature18317_CR18","doi-asserted-by":"publisher","first-page":"19122","DOI":"10.1038\/srep19122","volume":"6","author":"AE White","year":"2016","unstructured":"White, A. E., Hieb, A. R. & Luger, K. A quantitative investigation of linker histone interactions with nucleosomes and chromatin. Sci. Rep. 6, 19122 (2016)","journal-title":"Sci. Rep."},{"key":"BFnature18317_CR19","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","volume":"128","author":"T Kouzarides","year":"2007","unstructured":"Kouzarides, T. Chromatin modifications and their function. Cell 128, 693\u2013705 (2007)","journal-title":"Cell"},{"key":"BFnature18317_CR20","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1128\/jvi.35.3.637-643.1980","volume":"35","author":"MJ Fedor","year":"1980","unstructured":"Fedor, M. J. & Daniell, E. Acetylation of histone-like proteins of adenovirus type 5. J. Virol. 35, 637\u2013643 (1980)","journal-title":"J. Virol."},{"key":"BFnature18317_CR21","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1038\/srep01812","volume":"3","author":"CM Robinson","year":"2013","unstructured":"Robinson, C. M. et al. Molecular evolution of human adenoviruses. Sci. Rep. 3, 1812 (2013)","journal-title":"Sci. Rep."},{"key":"BFnature18317_CR22","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1021\/bi051248+","volume":"45","author":"B Gyurcsik","year":"2006","unstructured":"Gyurcsik, B., Haruki, H., Takahashi, T., Mihara, H. & Nagata, K. Binding modes of the precursor of adenovirus major core protein VII to DNA and template activating factor I: implication for the mechanism of remodeling of the adenovirus chromatin. Biochemistry 45, 303\u2013313 (2006)","journal-title":"Biochemistry"},{"key":"BFnature18317_CR23","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1128\/JVI.80.2.794-801.2006","volume":"80","author":"H Haruki","year":"2006","unstructured":"Haruki, H., Okuwaki, M., Miyagishi, M., Taira, K. & Nagata, K. Involvement of template-activating factor I\/SET in transcription of adenovirus early genes as a positive-acting factor. J. Virol. 80, 794\u2013801 (2006)","journal-title":"J. Virol."},{"key":"BFnature18317_CR24","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/nature00858","volume":"418","author":"P Scaffidi","year":"2002","unstructured":"Scaffidi, P., Misteli, T. & Bianchi, M. E. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418, 191\u2013195 (2002)","journal-title":"Nature"},{"key":"BFnature18317_CR25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bbaexp.2005.03.002","volume":"1729","author":"N Sapojnikova","year":"2005","unstructured":"Sapojnikova, N. et al. Biochemical observation of the rapid mobility of nuclear HMGB1. Biochim. Biophys. Acta 1729, 57\u201363 (2005)","journal-title":"Biochim. Biophys. Acta"},{"key":"BFnature18317_CR26","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1038\/nature11290","volume":"488","author":"B Lu","year":"2012","unstructured":"Lu, B. et al. Novel role of PKR in inflammasome activation and HMGB1 release. Nature 488, 670\u2013674 (2012)","journal-title":"Nature"},{"key":"BFnature18317_CR27","first-page":"767","volume":"5","author":"CJ Koziol-White","year":"2011","unstructured":"Koziol-White, C. J., Damera, G. & Panettieri, R. A. Jr. Targeting airway smooth muscle in airways diseases: an old concept with new twists. Expert Rev. Respir. Med. 5, 767\u2013777 (2011)","journal-title":"Respir. Med."},{"key":"BFnature18317_CR28","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1164\/rccm.200402-188OC","volume":"170","author":"H Ueno","year":"2004","unstructured":"Ueno, H. et al. Contributions of high mobility group box protein in experimental and clinical acute lung injury. Am. J. Respir. Crit. Care Med. 170, 1310\u20131316 (2004)","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"BFnature18317_CR29","doi-asserted-by":"publisher","first-page":"6459","DOI":"10.1128\/JVI.78.12.6459-6468.2004","volume":"78","author":"JS Johnson","year":"2004","unstructured":"Johnson, J. S. et al. Adenovirus protein VII condenses DNA, represses transcription, and associates with transcriptional activator E1A. J. Virol. 78, 6459\u20136468 (2004)","journal-title":"J. Virol."},{"key":"BFnature18317_CR30","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1128\/JVI.02540-10","volume":"85","author":"KA Karen","year":"2011","unstructured":"Karen, K. A. & Hearing, P. Adenovirus core protein VII protects the viral genome from a DNA damage response at early times after infection. J. Virol. 85, 4135\u20134142 (2011)","journal-title":"J. Virol."},{"key":"BFnature18317_CR31","doi-asserted-by":"publisher","first-page":"12799","DOI":"10.1073\/pnas.1103532108","volume":"108","author":"P Khandelia","year":"2011","unstructured":"Khandelia, P., Yap, K. & Makeyev, E. V. Streamlined platform for short hairpin RNA interference and transgenesis in cultured mammalian cells. Proc. Natl Acad. Sci. USA 108, 12799\u201312804 (2011)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature18317_CR32","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/ng0596-54","volume":"13","author":"KF Kozarsky","year":"1996","unstructured":"Kozarsky, K. F., Jooss, K., Donahee, M., Strauss, J. F., III & Wilson, J. M. Effective treatment of familial hypercholesterolaemia in the mouse model using adenovirus-mediated transfer of the VLDL receptor gene. Nature Genet. 13, 54\u201362 (1996)","journal-title":"Nature Genet."},{"key":"BFnature18317_CR33","doi-asserted-by":"publisher","first-page":"1887","DOI":"10.1128\/JVI.02134-10","volume":"85","author":"NI Orazio","year":"2011","unstructured":"Orazio, N. I., Naeger, C. M., Karlseder, J. & Weitzman, M. D. The adenovirus E1b55K\/E4orf6 complex induces degradation of the Bloom helicase during infection. J. Virol. 85, 1887\u20131892 (2011)","journal-title":"J. Virol."},{"key":"BFnature18317_CR34","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.virol.2006.03.042","volume":"351","author":"LP Le","year":"2006","unstructured":"Le, L. P. et al. Core labeling of adenovirus with EGFP. Virology 351, 291\u2013302 (2006)","journal-title":"Virology"},{"key":"BFnature18317_CR35","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/0042-6822(83)90274-X","volume":"128","author":"NC Reich","year":"1983","unstructured":"Reich, N. C., Sarnow, P., Duprey, E. & Levine, A. J. Monoclonal antibodies which recognize native and denatured forms of the adenovirus DNA-binding protein. Virology 128, 480\u2013484 (1983)","journal-title":"Virology"},{"key":"BFnature18317_CR36","doi-asserted-by":"publisher","first-page":"e1002084","DOI":"10.1371\/journal.ppat.1002084","volume":"7","author":"CE Lilley","year":"2011","unstructured":"Lilley, C. E., Chaurushiya, M. S., Boutell, C., Everett, R. D. & Weitzman, M. D. The intrinsic antiviral defense to incoming HSV-1 genomes includes specific DNA repair proteins and is counteracted by the viral protein ICP0. PLoS Pathog. 7, e1002084 (2011)","journal-title":"PLoS Pathog."},{"key":"BFnature18317_CR37","first-page":"e50318","volume":"73","author":"S Das","year":"2013","unstructured":"Das, S., MacDonald, K., Chang, H.-Y. S. & Mitzner, W. A simple method of mouse lung intubation. J. Vis. Exp . 73, e50318 (2013)","journal-title":"J. Vis. Exp"},{"key":"BFnature18317_CR38","doi-asserted-by":"publisher","first-page":"7247","DOI":"10.1128\/IAI.72.12.7247-7256.2004","volume":"72","author":"S Jeyaseelan","year":"2004","unstructured":"Jeyaseelan, S., Chu, H. W., Young, S. K. & Worthen, G. S. Transcriptional profiling of lipopolysaccharide-induced acute lung injury. Infect. Immun. 72, 7247\u20137256 (2004)","journal-title":"Infect. Immun."},{"key":"BFnature18317_CR39","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.4049\/jimmunol.164.4.2151","volume":"164","author":"JA Nick","year":"2000","unstructured":"Nick, J. A. et al. Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation. J. Immunol. 164, 2151\u20132159 (2000)","journal-title":"J. Immunol."},{"key":"BFnature18317_CR40","first-page":"1","volume":"Unit 21","author":"K Zaret","year":"2005","unstructured":"Zaret, K. Micrococcal nuclease analysis of chromatin structure. Curr. Protoc. Mol. Biol. Chapter 21, Unit 21.1 (2005)","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"BFnature18317_CR41","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0003-2697(84)90782-6","volume":"138","author":"D Wessel","year":"1984","unstructured":"Wessel, D. & Fl\u00fcgge, U. I. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal. Biochem. 138, 141\u2013143 (1984)","journal-title":"Anal. Biochem."},{"key":"BFnature18317_CR42","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nbt.1511","volume":"26","author":"J Cox","year":"2008","unstructured":"Cox, J. & Mann, M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nature Biotechnol. 26, 1367\u20131372 (2008)","journal-title":"Nature Biotechnol."},{"key":"BFnature18317_CR43","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature10098","volume":"473","author":"B Schwanh\u00e4usser","year":"2011","unstructured":"Schwanh\u00e4usser, B. et al. Global quantification of mammalian gene expression control. Nature 473, 337\u2013342 (2011)","journal-title":"Nature"},{"key":"BFnature18317_CR44","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.ymeth.2003.10.024","volume":"33","author":"Y Tanaka","year":"2004","unstructured":"Tanaka, Y. et al. Expression and purification of recombinant human histones. Methods 33, 3\u201311 (2004)","journal-title":"Methods"},{"key":"BFnature18317_CR45","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1006\/jmbi.1997.1235","volume":"272","author":"K Luger","year":"1997","unstructured":"Luger, K., Rechsteiner, T. J., Flaus, A. J., Waye, M. M. & Richmond, T. J. Characterization of nucleosome core particles containing histone proteins made in bacteria. J. Mol. Biol. 272, 301\u2013311 (1997)","journal-title":"J. Mol. Biol."},{"key":"BFnature18317_CR46","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/nsmb.2562","volume":"20","author":"D Hasson","year":"2013","unstructured":"Hasson, D. et al. The octamer is the major form of CENP-A nucleosomes at human centromeres. Nature Struct. Mol. Biol . 20, 687\u2013695 (2013)","journal-title":"Nature Struct. Mol. Biol"},{"key":"BFnature18317_CR47","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/nature09323","volume":"467","author":"N Sekulic","year":"2010","unstructured":"Sekulic, N., Bassett, E. A., Rogers, D. J. & Black, B. E. The structure of (CENP-A\u2013H4)2 reveals physical features that mark centromeres. Nature 467, 347\u2013351 (2010)","journal-title":"Nature"},{"key":"BFnature18317_CR48","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.ymeth.2015.06.008","volume":"90","author":"K Kulej","year":"2015","unstructured":"Kulej, K., Avgousti, D. C., Weitzman, M. D. & Garcia, B. A. Characterization of histone post-translational modifications during virus infection using mass spectrometry-based proteomics. Methods 90, 8\u201320 (2015)","journal-title":"Methods"},{"key":"BFnature18317_CR49","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.jaci.2008.07.040","volume":"122","author":"PR Cooper","year":"2008","unstructured":"Cooper, P. R. & Panettieri, R. A. Jr. Steroids completely reverse albuterol-induced \u03b22-adrenergic receptor tolerance in human small airways. J. Allergy Clin. Immunol. 122, 734\u2013740 (2008)","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFnature18317_CR50","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1126\/science.1068539","volume":"296","author":"DA Zacharias","year":"2002","unstructured":"Zacharias, D. A., Violin, J. D., Newton, A. C. & Tsien, R. Y. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296, 913\u2013916 (2002)","journal-title":"Science"},{"key":"BFnature18317_CR51","doi-asserted-by":"publisher","first-page":"11655","DOI":"10.1038\/srep11655","volume":"5","author":"D Blumenthal","year":"2015","unstructured":"Blumenthal, D., Goldstien, L., Edidin, M. & Gheber, L. A. Universal approach to FRAP analysis of arbitrary bleaching patterns. Sci. Rep. 5, 11655 (2015)","journal-title":"Sci. Rep."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature18317.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature18317","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature18317.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T17:52:53Z","timestamp":1684432373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature18317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,29]]},"references-count":51,"journal-issue":{"issue":"7610","published-print":{"date-parts":[[2016,7,7]]}},"alternative-id":["BFnature18317"],"URL":"https:\/\/doi.org\/10.1038\/nature18317","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,29]]},"assertion":[{"value":"10 March 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}