{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:20:36Z","timestamp":1791922836314,"version":"4.3.4"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"7614","license":[{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2016,7,11]],"date-time":"2016-07-11T00:00:00Z","timestamp":1468195200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2016,8,4]]},"DOI":"10.1038\/nature18642","type":"journal-article","created":{"date-parts":[[2016,7,12]],"date-time":"2016-07-12T11:08:10Z","timestamp":1468321690000},"page":"41-47","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":999,"title":["The genetic architecture of type 2 diabetes"],"prefix":"10.1038","volume":"536","author":[{"given":"Christian","family":"Fuchsberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Flannick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya M.","family":"Teslovich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anubha","family":"Mahajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineeta","family":"Agarwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle J.","family":"Gaulton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Fontanillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loukas","family":"Moutsianas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis J.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel A.","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R. B.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Blackwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil R.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. William","family":"Rayner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Cingolani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam E.","family":"Locke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Fernandez","family":"Tajes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Highland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josee","family":"Dupuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Chines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia M.","family":"Lindgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne U.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen R.","family":"Huyghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"van de Bunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"M\u00fcller-Nurasyid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Grarup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather M.","family":"Stringham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric R.","family":"Gamazon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Below","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Jin","family":"Go","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Stitzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorota","family":"Pasko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C. J.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tibor V.","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola L.","family":"Beer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron G.","family":"Day-Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasha","family":"Fingerlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momoko","family":"Horikoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iksoo","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Kamran","family":"Ikram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong-Jo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongkang","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Seok","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selyeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng-Han","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor J.","family":"Maxwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Nagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan P.","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Barzilai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin F.","family":"Voight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bok-Ghee","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher P.","family":"Jenkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teemu","family":"Kuulasmaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kuusisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa","family":"Manning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maggie C. Y.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholette D.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverley","family":"Balkau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Stan\u010d\u00e1kov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna E.","family":"Abboud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Boeing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vilmantas","family":"Giedraitis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorairaj","family":"Prabhakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omri","family":"Gottesman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Carey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoenix","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua D.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Neale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Butterworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna M. M.","family":"Howson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heung Man","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Heon","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Danesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent K. L.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danish","family":"Saleheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing Yee","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia H. T.","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzma","family":"Afzal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rector","family":"Arya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tin","family":"Aung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Yu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Palli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne E.","family":"Curran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Rybin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidya S.","family":"Farook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon P.","family":"Fowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry I.","family":"Freedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Griswold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Esten","family":"Hale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiea-Chuen","family":"Khor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Lehne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doroth\u00e9e","family":"Thuillier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei Yen","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne T.","family":"van der Schouw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon K.","family":"Musani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobha","family":"Puppala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William R.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efc","family":"Yengo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian-Tsung","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman A.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farook","family":"Thameem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tien Yin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e5l Rasmus","family":"Nj\u00f8lstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Mangino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori L.","family":"Bonnycastle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schwarzmayr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Fadista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela L.","family":"Surdulescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Herder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J.","family":"Groves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wieland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jette","family":"Bork-Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Brandslund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cramer","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heikki A.","family":"Koistinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex S. F.","family":"Doney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Kinnunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00f5nu","family":"Esko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Farmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa","family":"Hakaste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Hodgkiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina","family":"Kravic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeriya","family":"Lyssenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Hollensted","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit E.","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claes","family":"Ladenvall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanne Marie","family":"Justesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemari","family":"K\u00e4r\u00e4j\u00e4m\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kriebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Rathmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lannfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Lauritzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narisu","family":"Narisu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Linneberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olle","family":"Melander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Milani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Neville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marju","family":"Orho-Melander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olov","family":"Rolandsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Swift","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders H.","family":"Rosengren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Stirrups","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelin","family":"Mihailov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Blancher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio O.","family":"Carneiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Maguire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Poplin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Shakir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Fennell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"DePristo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hrab\u00e9 de Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panos","family":"Deloukas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette P.","family":"Gjesing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goo","family":"Jun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacquelyn","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Onofrio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Thorand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Meisinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank B.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Isomaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Karpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelia","family":"Huth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"O\u2019Rahilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin N. A.","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluf","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Rauramaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Tuomilehto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veikko","family":"Salomaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Christine","family":"Syv\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard N.","family":"Bergman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwaipayan","family":"Bharadwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin P.","family":"Bottinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Shin","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giriraj R.","family":"Chandak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana C. N.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Seng","family":"Chia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Daly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shah B.","family":"Ebrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Langenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen A.","family":"Jablonski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna M.","family":"Lehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald C. W.","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni I.","family":"Pollin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjinder","family":"Sandhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Tandon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Froguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00eas","family":"Barroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yik Ying","family":"Teo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Zeggini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth J. F.","family":"Loos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerrin S.","family":"Small","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janina S.","family":"Ried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph A.","family":"DeFronzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Grallert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Glaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Metspalu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Wareham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Banks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Ingelsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Kyung","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Illig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W.","family":"Franks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Trakalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Prokopenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reedik","family":"M\u00e4gi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yossi","family":"Farjoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine R.","family":"Owen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Gloyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Strauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiinamaija","family":"Tuomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaspal Singh","family":"Kooner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taesung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Hattersley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald W.","family":"Bowden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis S.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Atzmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Spector","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markku","family":"Laakso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim M.","family":"Strom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme I.","family":"Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Blangero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindranath","family":"Duggirala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Shyong","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilean","family":"McVean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig L.","family":"Hanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Seielstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy M.","family":"Frayling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James B.","family":"Meigs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Sladek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric S.","family":"Lander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey","family":"Gabriel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00ebl P.","family":"Burtt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Mohlke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Meitinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Groop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goncalo","family":"Abecasis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose C.","family":"Florez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Min","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Boehnke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Altshuler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark I.","family":"McCarthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,11]]},"reference":[{"key":"BFnature18642_CR1","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1017\/thg.2015.83","volume":"18","author":"G Willemsen","year":"2015","unstructured":"Willemsen, G. et al. The concordance and heritability of type 2 diabetes in 34,166 twin pairs from international twin registers: the discordant twin (DISCOTWIN) consortium. Twin Res. Hum. Genet. 18, 762\u2013771 (2015)","journal-title":"Twin Res. Hum. Genet."},{"key":"BFnature18642_CR2","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/ng.2383","volume":"44","author":"AP Morris","year":"2012","unstructured":"Morris, A. P. et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat. Genet. 44, 981\u2013990 (2012)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR3","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1038\/ng.2897","volume":"46","author":"A Mahajan","year":"2014","unstructured":"Mahajan, A. et al. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat. Genet. 46, 234\u2013244 (2014)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR4","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/ng.609","volume":"42","author":"BF Voight","year":"2010","unstructured":"Voight, B. F. et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat. Genet. 42, 579\u2013589 (2010)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR5","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1038\/ng.921","volume":"43","author":"JS Kooner","year":"2011","unstructured":"Kooner, J. S. et al. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat. Genet. 43, 984\u2013989 (2011)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/ng.1019","volume":"44","author":"YS Cho","year":"2011","unstructured":"Cho, Y. S. et al. Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat. Genet. 44, 67\u201372 (2011)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR7","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/ng.2882","volume":"46","author":"V Steinthorsdottir","year":"2014","unstructured":"Steinthorsdottir, V. et al. Identification of low-frequency and rare sequence variants associated with elevated or reduced risk of type 2 diabetes. Nat. Genet. 46, 294\u2013298 (2014)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR8","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1007\/s00125-013-2874-4","volume":"56","author":"RC Ma","year":"2013","unstructured":"Ma, R. C. et al. Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4 . Diabetologia 56, 1291\u20131305 (2013)","journal-title":"Diabetologia"},{"key":"BFnature18642_CR9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/ng.2507","volume":"45","author":"JR Huyghe","year":"2013","unstructured":"Huyghe, J. R. et al. Exome array analysis identifies new loci and low-frequency variants influencing insulin processing and secretion. Nat. Genet. 45, 197\u2013201 (2013)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR10","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/ng.3437","volume":"47","author":"KJ Gaulton","year":"2015","unstructured":"Gaulton, K. J. et al. Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat. Genet. 47, 1415\u20131425 (2015)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR11","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nature08494","volume":"461","author":"TA Manolio","year":"2009","unstructured":"Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747\u2013753 (2009)","journal-title":"Nature"},{"key":"BFnature18642_CR12","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.ajhg.2013.11.005","volume":"93","author":"KE Lohmueller","year":"2013","unstructured":"Lohmueller, K. E. et al. Whole-exome sequencing of 2,000 Danish individuals and the role of rare coding variants in type 2 diabetes. Am. J. Hum. Genet. 93, 1072\u20131086 (2013)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature18642_CR13","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s00125-012-2756-1","volume":"56","author":"A Albrechtsen","year":"2013","unstructured":"Albrechtsen, A. et al. Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia 56, 298\u2013310 (2013)","journal-title":"Diabetologia"},{"key":"BFnature18642_CR14","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.cell.2013.10.058","volume":"156","author":"M Claussnitzer","year":"2014","unstructured":"Claussnitzer, M. et al. Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms. Cell 156, 343\u2013358 (2014)","journal-title":"Cell"},{"key":"BFnature18642_CR15","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.ajhg.2013.05.010","volume":"93","author":"S Lee","year":"2013","unstructured":"Lee, S., Teslovich, T. M., Boehnke, M. & Lin, X. General framework for meta-analysis of rare variants in sequencing association studies. Am. J. Hum. Genet. 93, 42\u201353 (2013)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature18642_CR16","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/ng.548","volume":"42","author":"HM Kang","year":"2010","unstructured":"Kang, H. M. et al. Variance component model to account for sample structure in genome-wide association studies. Nat. Genet. 42, 348\u2013354 (2010)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR17","doi-asserted-by":"publisher","first-page":"2591","DOI":"10.1101\/gad.269003","volume":"17","author":"P Collombat","year":"2003","unstructured":"Collombat, P. et al. Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev. 17, 2591\u20132603 (2003)","journal-title":"Genes Dev."},{"key":"BFnature18642_CR18","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.jdiacomp.2012.03.025","volume":"26","author":"S Kooptiwut","year":"2012","unstructured":"Kooptiwut, S. et al. Defective PAX4 R192H transcriptional repressor activities associated with maturity onset diabetes of the young and early onset-age of type 2 diabetes. J. Diabetes Complications 26, 343\u2013347 (2012)","journal-title":"J. Diabetes Complications"},{"key":"BFnature18642_CR19","doi-asserted-by":"publisher","first-page":"2272","DOI":"10.1007\/s00125-011-2182-9","volume":"54","author":"C Langenberg","year":"2011","unstructured":"Langenberg, C. et al. Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. Diabetologia 54, 2272\u20132282 (2011)","journal-title":"Diabetologia"},{"key":"BFnature18642_CR20","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/embor.2012.183","volume":"14","author":"A Oppelt","year":"2013","unstructured":"Oppelt, A. et al. Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep. 14, 57\u201364 (2013)","journal-title":"EMBO Rep."},{"key":"BFnature18642_CR21","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/ng.2901","volume":"46","author":"J Kozlitina","year":"2014","unstructured":"Kozlitina, J. et al. Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat. Genet. 46, 352\u2013356 (2014)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR22","doi-asserted-by":"publisher","first-page":"8913","DOI":"10.1073\/pnas.1323785111","volume":"111","author":"H Mahdessian","year":"2014","unstructured":"Mahdessian, H. et al. TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. Proc. Natl Acad. Sci. USA 111, 8913\u20138918 (2014)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature18642_CR23","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1006\/geno.1997.5001","volume":"45","author":"A Thiagalingam","year":"1997","unstructured":"Thiagalingam, A., Lengauer, C., Baylin, S. B. & Nelkin, B. D. RREB1, a ras responsive element binding protein, maps to human chromosome 6p25. Genomics 45, 630\u2013632 (1997)","journal-title":"Genomics"},{"key":"BFnature18642_CR24","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/ncpendmet0778","volume":"4","author":"R Murphy","year":"2008","unstructured":"Murphy, R., Ellard, S. & Hattersley, A. T. Clinical implications of a molecular genetic classification of monogenic \u03b2-cell diabetes. Nat. Clin. Pract. Endocrinol. Metab. 4, 200\u2013213 (2008)","journal-title":"Nat. Clin. Pract. Endocrinol. Metab."},{"key":"BFnature18642_CR25","doi-asserted-by":"publisher","first-page":"e1000294","DOI":"10.1371\/journal.pbio.1000294","volume":"8","author":"SP Dickson","year":"2010","unstructured":"Dickson, S. P., Wang, K., Krantz, I., Hakonarson, H. & Goldstein, D. B. Rare variants create synthetic genome-wide associations. PLoS Biol. 8, e1000294 (2010)","journal-title":"PLoS Biol."},{"key":"BFnature18642_CR26","doi-asserted-by":"publisher","first-page":"e1000580","DOI":"10.1371\/journal.pbio.1000580","volume":"9","author":"CA Anderson","year":"2011","unstructured":"Anderson, C. A., Soranzo, N., Zeggini, E. & Barrett, J. C. Synthetic associations are unlikely to account for many common disease genome-wide association signals. PLoS Biol. 9, e1000580 (2011)","journal-title":"PLoS Biol."},{"key":"BFnature18642_CR27","doi-asserted-by":"publisher","first-page":"e1000579","DOI":"10.1371\/journal.pbio.1000579","volume":"9","author":"NR Wray","year":"2011","unstructured":"Wray, N. R., Purcell, S. M. & Visscher, P. M. Synthetic associations created by rare variants do not explain most GWAS results. PLoS Biol. 9, e1000579 (2011)","journal-title":"PLoS Biol."},{"key":"BFnature18642_CR28","doi-asserted-by":"publisher","first-page":"e1001363","DOI":"10.1371\/journal.pgen.1001363","volume":"7","author":"X Sim","year":"2011","unstructured":"Sim, X. et al. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. PLoS Genet. 7, e1001363 (2011)","journal-title":"PLoS Genet."},{"key":"BFnature18642_CR29","doi-asserted-by":"publisher","first-page":"e1001008","DOI":"10.1371\/journal.pbio.1001008","volume":"9","author":"DB Goldstein","year":"2011","unstructured":"Goldstein, D. B. The importance of synthetic associations will only be resolved empirically. PLoS Biol. 9, e1001008 (2011)","journal-title":"PLoS Biol."},{"key":"BFnature18642_CR30","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1086\/519024","volume":"81","author":"J Wakefield","year":"2007","unstructured":"Wakefield, J. A Bayesian measure of the probability of false discovery in genetic epidemiology studies. Am. J. Hum. Genet. 81, 208\u2013227 (2007)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature18642_CR31","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1038\/ng.2435","volume":"44","author":"JB Maller","year":"2012","unstructured":"Maller, J. B. et al. Bayesian refinement of association signals for 14 loci in 3 common diseases. Nat. Genet. 44, 1294\u20131301 (2012)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR32","doi-asserted-by":"crossref","unstructured":"ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature 489, 57\u201374 (2012)","DOI":"10.1038\/nature11247"},{"key":"BFnature18642_CR33","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.cell.2010.09.006","volume":"143","author":"TS Mikkelsen","year":"2010","unstructured":"Mikkelsen, T. S. et al. Comparative epigenomic analysis of murine and human adipogenesis. Cell 143, 156\u2013169 (2010)","journal-title":"Cell"},{"key":"BFnature18642_CR34","doi-asserted-by":"publisher","first-page":"17921","DOI":"10.1073\/pnas.1317023110","volume":"110","author":"SC Parker","year":"2013","unstructured":"Parker, S. C. et al. Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc. Natl Acad. Sci. USA 110, 17921\u201317926 (2013)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature18642_CR35","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/ng.2870","volume":"46","author":"L Pasquali","year":"2014","unstructured":"Pasquali, L. et al. Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants. Nat. Genet. 46, 136\u2013143 (2014)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR36","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1038\/ng.530","volume":"42","author":"KJ Gaulton","year":"2010","unstructured":"Gaulton, K. J. et al. A map of open chromatin in human pancreatic islets. Nat. Genet. 42, 255\u2013259 (2010)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR37","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1126\/science.1222794","volume":"337","author":"MT Maurano","year":"2012","unstructured":"Maurano, M. T. et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 337, 1190\u20131195 (2012)","journal-title":"Science"},{"key":"BFnature18642_CR38","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.ajhg.2014.03.004","volume":"94","author":"JK Pickrell","year":"2014","unstructured":"Pickrell, J. K. Joint analysis of functional genomic data and genome-wide association studies of 18 human traits. Am. J. Hum. Genet. 94, 559\u2013573 (2014)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature18642_CR39","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1469-1809.1965.tb00500.x","volume":"29","author":"DS Falconer","year":"1965","unstructured":"Falconer, D. S. The inheritance of liability to certain diseases, estimated from the incidence among relatives. Ann. Hum. Genet. 29, 51\u201376 (1965)","journal-title":"Ann. Hum. Genet."},{"key":"BFnature18642_CR40","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1038\/ng.2804","volume":"45","author":"V Agarwala","year":"2013","unstructured":"Agarwala, V., Flannick, J. & Sunyaev, S., GoT2D Consortium & Altshuler, D. Evaluating empirical bounds on complex disease genetic architecture. Nat. Genet. 45, 1418\u20131427 (2013)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR41","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.cell.2010.03.032","volume":"141","author":"J McClellan","year":"2010","unstructured":"McClellan, J. & King, M. C. Genetic heterogeneity in human disease. Cell 141, 210\u2013217 (2010)","journal-title":"Cell"},{"key":"BFnature18642_CR42","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1038\/ng.608","volume":"42","author":"J Yang","year":"2010","unstructured":"Yang, J. et al. Common SNPs explain a large proportion of the heritability for human height. Nat. Genet. 42, 565\u2013569 (2010)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR43","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/ng.2915","volume":"46","author":"J Flannick","year":"2014","unstructured":"Flannick, J. et al. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nat. Genet. 46, 357\u2013363 (2014)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR44","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1038\/ng.1053","volume":"44","author":"A Bonnefond","year":"2012","unstructured":"Bonnefond, A. et al. Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat. Genet. 44, 297\u2013301 (2012)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR45","doi-asserted-by":"crossref","unstructured":"Sigma Type 2 Diabetes Consortium et al. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature 506, 97\u2013101 (2014)","DOI":"10.1038\/nature12828"},{"key":"BFnature18642_CR46","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1038\/nature13425","volume":"512","author":"I Moltke","year":"2014","unstructured":"Moltke, I. et al. A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes. Nature 512, 190\u2013193 (2014)","journal-title":"Nature"},{"key":"BFnature18642_CR47","unstructured":"Sigma Type 2 Diabetes Consortium et al. Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. JAMA 311, 2305\u20132314 (2014)"},{"key":"BFnature18642_CR48","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1126\/science.1246981","volume":"343","author":"T Wang","year":"2014","unstructured":"Wang, T., Wei, J. J., Sabatini, D. M. & Lander, E. S. Genetic screens in human cells using the CRISPR-Cas9 system. Science 343, 80\u201384 (2014)","journal-title":"Science"},{"key":"BFnature18642_CR49","doi-asserted-by":"publisher","first-page":"13127","DOI":"10.1073\/pnas.1410428111","volume":"111","author":"AR Majithia","year":"2014","unstructured":"Majithia, A. R. et al. Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes. Proc. Natl Acad. Sci. USA 111, 13127\u201313132 (2014)","journal-title":"diabetes. Proc. Natl Acad. Sci. USA"},{"key":"BFnature18642_CR50","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/gepi.20572","volume":"35","author":"LT Guey","year":"2011","unstructured":"Guey, L. T. et al. Power in the phenotypic extremes: a simulation study of power in discovery and replication of rare variants. Genet. Epidemiol. 35, 236\u2013246 (2011)","journal-title":"Genet. Epidemiol."},{"key":"BFnature18642_CR51","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754\u20131760 (2009)","journal-title":"Bioinformatics"},{"key":"BFnature18642_CR52","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/ng.806","volume":"43","author":"MA DePristo","year":"2011","unstructured":"DePristo, M. A. et al. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat. Genet. 43, 491\u2013498 (2011)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR53","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","volume":"20","author":"A McKenna","year":"2010","unstructured":"McKenna, A. et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 1297\u20131303 (2010)","journal-title":"Genome Res."},{"key":"BFnature18642_CR54","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.ajhg.2012.09.004","volume":"91","author":"G Jun","year":"2012","unstructured":"Jun, G. et al. Detecting and estimating contamination of human DNA samples in sequencing and array-based genotype data. Am. J. Hum. Genet. 91, 839\u2013848 (2012)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature18642_CR55","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature11632","volume":"491","author":"GR Abecasis","year":"2012","unstructured":"Abecasis, G. R. et al. An integrated map of genetic variation from 1,092 human genomes. Nature 491, 56\u201365 (2012)","journal-title":"Nature"},{"key":"BFnature18642_CR56","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1038\/ng.768","volume":"43","author":"RE Handsaker","year":"2011","unstructured":"Handsaker, R. E., Korn, J. M., Nemesh, J. & McCarroll, S. A. Discovery and genotyping of genome structural polymorphism by sequencing on a population scale. Nat. Genet. 43, 269\u2013276 (2011)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR57","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1086\/521987","volume":"81","author":"SR Browning","year":"2007","unstructured":"Browning, S. R. & Browning, B. L. Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering. Am. J. Hum. Genet. 81, 1084\u20131097 (2007)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature18642_CR58","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1101\/gr.117259.110","volume":"21","author":"Y Li","year":"2011","unstructured":"Li, Y., Sidore, C., Kang, H. M., Boehnke, M. & Abecasis, G. R. Low-coverage sequencing: implications for design of complex trait association studies. Genome Res. 21, 940\u2013951 (2011)","journal-title":"Genome Res."},{"key":"BFnature18642_CR59","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.ajhg.2008.06.005","volume":"83","author":"AL Price","year":"2008","unstructured":"Price, A. L. et al. Long-range LD can confound genome scans in admixed populations. Am. J. Hum. Genet. 83, 132\u2013135, author reply 135\u2013139 (2008)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature18642_CR60","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/978-1-60327-367-1_19","volume":"628","author":"ME Weale","year":"2010","unstructured":"Weale, M. E. Quality control for genome-wide association studies. Methods Mol. Biol. 628, 341\u2013372 (2010)","journal-title":"Methods Mol. Biol."},{"key":"BFnature18642_CR61","doi-asserted-by":"crossref","unstructured":"Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447, 661\u2013678 (2007)","DOI":"10.1038\/nature05911"},{"key":"BFnature18642_CR62","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"AL Price","year":"2006","unstructured":"Price, A. L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904\u2013909 (2006)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR63","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1093\/bioinformatics\/btu704","volume":"31","author":"C Fuchsberger","year":"2015","unstructured":"Fuchsberger, C., Abecasis, G. R. & Hinds, D. A. minimac2: faster genotype imputation. Bioinformatics 31, 782\u2013784 (2015)","journal-title":"Bioinformatics"},{"key":"BFnature18642_CR64","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/biomet\/80.1.27","volume":"80","author":"D Firth","year":"1993","unstructured":"Firth, D. Bias reduction of maximum-likelihood-estimates. Biometrika 80, 27\u201338 (1993)","journal-title":"Biometrika"},{"key":"BFnature18642_CR65","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/gepi.21742","volume":"37","author":"C Ma","year":"2013","unstructured":"Ma, C., Blackwell, T., Boehnke, M. & Scott, L. J. Recommended joint and meta-analysis strategies for case-control association testing of single low-count variants. Genet. Epidemiol. 37, 539\u2013550 (2013)","journal-title":"Genet. Epidemiol."},{"key":"BFnature18642_CR66","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1002\/gepi.20630","volume":"35","author":"AP Morris","year":"2011","unstructured":"Morris, A. P. Transethnic meta-analysis of genomewide association studies. Genet. Epidemiol. 35, 809\u2013822 (2011)","journal-title":"Genet. Epidemiol."},{"key":"BFnature18642_CR67","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/nrg3002","volume":"12","author":"MF Seldin","year":"2011","unstructured":"Seldin, M. F., Pasaniuc, B. & Price, A. L. New approaches to disease mapping in admixed populations. Nat. Rev. Genet. 12, 523\u2013528 (2011)","journal-title":"Nat. Rev. Genet."},{"key":"BFnature18642_CR68","doi-asserted-by":"publisher","first-page":"e1000519","DOI":"10.1371\/journal.pgen.1000519","volume":"5","author":"AL Price","year":"2009","unstructured":"Price, A. L. et al. Sensitive detection of chromosomal segments of distinct ancestry in admixed populations. PLoS Genet. 5, e1000519 (2009)","journal-title":"PLoS Genet."},{"key":"BFnature18642_CR69","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/gepi.21692","volume":"37","author":"C Churchhouse","year":"2013","unstructured":"Churchhouse, C. & Marchini, J. Multiway admixture deconvolution using phased or unphased ancestral panels. Genet. Epidemiol. 37, 1\u201312 (2013)","journal-title":"Genet. Epidemiol."},{"key":"BFnature18642_CR70","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nature12975","volume":"506","author":"SM Purcell","year":"2014","unstructured":"Purcell, S. M. et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature 506, 185\u2013190 (2014)","journal-title":"Nature"},{"key":"BFnature18642_CR71","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1093\/biostatistics\/kxs014","volume":"13","author":"S Lee","year":"2012","unstructured":"Lee, S., Wu, M. C. & Lin, X. Optimal tests for rare variant effects in sequencing association studies. Biostatistics 13, 762\u2013775 (2012)","journal-title":"Biostatistics"},{"key":"BFnature18642_CR72","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/ng2088","volume":"39","author":"J Marchini","year":"2007","unstructured":"Marchini, J., Howie, B., Myers, S., McVean, G. & Donnelly, P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet. 39, 906\u2013913 (2007)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR73","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","volume":"55","author":"B Devlin","year":"1999","unstructured":"Devlin, B. & Roeder, K. Genomic control for association studies. Biometrics 55, 997\u20131004 (1999)","journal-title":"Biometrics"},{"key":"BFnature18642_CR74","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer, C. J., Li, Y. & Abecasis, G. R. METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190\u20132191 (2010)","journal-title":"Bioinformatics"},{"key":"BFnature18642_CR75","doi-asserted-by":"publisher","first-page":"9362","DOI":"10.1073\/pnas.0903103106","volume":"106","author":"LA Hindorff","year":"2009","unstructured":"Hindorff, L. A. et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl Acad. Sci. USA 106, 9362\u20139367 (2009)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature18642_CR76","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1038\/ng.237","volume":"40","author":"JM Korn","year":"2008","unstructured":"Korn, J. M. et al. Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs. Nat. Genet. 40, 1253\u20131260 (2008)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR77","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2307\/2531435","volume":"46","author":"WR Rice","year":"1990","unstructured":"Rice, W. R. A consensus combined P-value test and the family-wide significance of component tests. Biometrics 46, 303\u2013308 (1990)","journal-title":"Biometrics"},{"key":"BFnature18642_CR78","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/ng.2213","volume":"44","author":"J Yang","year":"2012","unstructured":"Yang, J. et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nat. Genet. 44, 369\u2013375 (2012)","journal-title":"Nat. Genet."},{"key":"BFnature18642_CR79","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ajhg.2010.11.011","volume":"88","author":"J Yang","year":"2011","unstructured":"Yang, J., Lee, S. H., Goddard, M. E. & Visscher, P. M. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76\u201382 (2011)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature18642_CR80","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1101\/gr.135350.111","volume":"22","author":"J Harrow","year":"2012","unstructured":"Harrow, J. et al. GENCODE: the reference human genome annotation for The ENCODE Project. Genome Res. 22, 1760\u20131774 (2012)","journal-title":"Genome Res."},{"key":"BFnature18642_CR81","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/nbt.1662","volume":"28","author":"J Ernst","year":"2010","unstructured":"Ernst, J. & Kellis, M. Discovery and characterization of chromatin states for systematic annotation of the human genome. Nat. Biotechnol. 28, 817\u2013825 (2010)","journal-title":"Nat. Biotechnol."},{"key":"BFnature18642_CR82","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545\u201315550 (2005)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature18642_CR83","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nbt1295","volume":"25","author":"K Lage","year":"2007","unstructured":"Lage, K. et al. A human phenome\u2013interactome network of protein complexes implicated in genetic disorders. Nat. Biotechnol. 25, 309\u2013316 (2007)","journal-title":"Nat. Biotechnol."},{"key":"BFnature18642_CR84","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1038\/nmeth.1938","volume":"9","author":"T Nepusz","year":"2012","unstructured":"Nepusz, T., Yu, H. & Paccanaro, A. Detecting overlapping protein complexes in protein\u2013protein interaction networks. Nat. Methods 9, 471\u2013472 (2012)","journal-title":"Nat. Methods"},{"key":"BFnature18642_CR85","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1093\/bioinformatics\/btq615","volume":"27","author":"P Jia","year":"2011","unstructured":"Jia, P., Zheng, S., Long, J., Zheng, W. & Zhao, Z. dmGWAS: dense module searching for genome-wide association studies in protein\u2013protein interaction networks. Bioinformatics 27, 95\u2013102 (2011)","journal-title":"Bioinformatics"},{"key":"BFnature18642_CR86","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1093\/bioinformatics\/btn317","volume":"24","author":"BW Lambert","year":"2008","unstructured":"Lambert, B. W., Terwilliger, J. D. & Weiss, K. M. ForSim: a tool for exploring the genetic architecture of complex traits with controlled truth. Bioinformatics 24, 1821\u20131822 (2008)","journal-title":"Bioinformatics"},{"key":"BFnature18642_CR87","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1073\/pnas.0906182107","volume":"107","author":"A Eyre-Walker","year":"2010","unstructured":"Eyre-Walker, A. Evolution in health and medicine Sackler colloquium: Genetic architecture of a complex trait and its implications for fitness and genome-wide association studies. Proc. Natl Acad. Sci. USA 107 (Suppl 1), 1752\u20131756 (2010)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature18642_CR88","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1056\/NEJMoa0801869","volume":"359","author":"V Lyssenko","year":"2008","unstructured":"Lyssenko, V. et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N. Engl. J. Med. 359, 2220\u20132232 (2008)","journal-title":"N. Engl. J. Med."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nature18642.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nature18642","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nature18642.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T01:57:24Z","timestamp":1718675844000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature18642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,11]]},"references-count":88,"journal-issue":{"issue":"7614","published-print":{"date-parts":[[2016,8,4]]}},"alternative-id":["BFnature18642"],"URL":"https:\/\/doi.org\/10.1038\/nature18642","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726494254.793520814","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,11]]},"assertion":[{"value":"20 May 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"R.A.D. has been a member of advisory boards for Astra Zeneca, Novo Nordisk, Janssen, Lexicon and Boehringer-Ingelheim; received research support from Bristol Myers Squibb, Boehringer- Ingelheim, Takeda and Astra Zeneca; and is a member of speakers\u2019 bureaus for Novo-Nordisk and Astra Zeneca. J.C.F. has received consulting honoraria from Pfizer and PanGenX. M.I.M. has received consulting and advisory board honoraria from Pfizer, Lilly, and NovoNordisk. G.M. and P.D. are co-founders of Genomics PLC, which provides genome analytics. D.A. is an employee of and holds equity in Vertex Pharmaceuticals.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}