{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:08:28Z","timestamp":1791317308813,"version":"4.3.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7632","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2016,12,8]]},"DOI":"10.1038\/nature20583","type":"journal-article","created":{"date-parts":[[2016,11,8]],"date-time":"2016-11-08T11:28:04Z","timestamp":1478604484000},"page":"284-287","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":276,"title":["Ad26\/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys"],"prefix":"10.1038","volume":"540","author":[{"given":"Erica N.","family":"Borducchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn E.","family":"Stephenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Abbink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ng\u2019ang\u2019a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph P.","family":"Nkolola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Brinkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Peter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jetton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Mondesir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanell","family":"Mojta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abishek","family":"Chandrashekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Molloy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Alter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Gerold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison L.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria G.","family":"Pau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanneke","family":"Schuitemaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hesselgesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romas","family":"Geleziunas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merlin L.","family":"Robb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson L.","family":"Michael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan H.","family":"Barouch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"key":"BFnature20583_CR1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1126\/science.1255512","volume":"345","author":"DH Barouch","year":"2014","unstructured":"Barouch, D. H. & Deeks, S. G. Immunologic strategies for HIV-1 remission and eradication. Science 345, 169\u2013174 (2014)","journal-title":"Science"},{"key":"BFnature20583_CR2","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1038\/nm.4108","volume":"22","author":"SG Deeks","year":"2016","unstructured":"Deeks, S. G. et al. International AIDS Society global scientific strategy: towards an HIV cure 2016. Nat. Med. 22, 839\u2013850 (2016)","journal-title":"Nat. Med."},{"key":"BFnature20583_CR3","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.cell.2013.09.061","volume":"155","author":"DH Barouch","year":"2013","unstructured":"Barouch, D. H. et al. Protective efficacy of a global HIV-1 mosaic vaccine against heterologous SHIV challenges in rhesus monkeys. Cell 155, 531\u2013539 (2013)","journal-title":"Cell"},{"key":"BFnature20583_CR4","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nature10766","volume":"482","author":"DH Barouch","year":"2012","unstructured":"Barouch, D. H. et al. Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys. Nature 482, 89\u201393 (2012)","journal-title":"Nature"},{"key":"BFnature20583_CR5","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1126\/science.278.5341.1295","volume":"278","author":"D Finzi","year":"1997","unstructured":"Finzi, D. et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278, 1295\u20131300 (1997)","journal-title":"Science"},{"key":"BFnature20583_CR6","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1128\/JVI.77.3.1659-1665.2003","volume":"77","author":"D Persaud","year":"2003","unstructured":"Persaud, D., Zhou, Y., Siliciano, J. M. & Siliciano, R. F. Latency in human immunodeficiency virus type 1 infection: no easy answers. J. Virol. 77, 1659\u20131665 (2003)","journal-title":"J. Virol."},{"key":"BFnature20583_CR7","doi-asserted-by":"publisher","first-page":"13193","DOI":"10.1073\/pnas.94.24.13193","volume":"94","author":"TW Chun","year":"1997","unstructured":"Chun, T. W. et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl Acad. Sci. USA 94, 13193\u201313197 (1997)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature20583_CR8","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.cell.2013.09.020","volume":"155","author":"YC Ho","year":"2013","unstructured":"Ho, Y. C. et al. Replication-competent noninduced proviruses in the latent reservoir increase barrier to HIV-1 cure. Cell 155, 540\u2013551 (2013)","journal-title":"Cell"},{"key":"BFnature20583_CR9","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1038\/8394","volume":"5","author":"D Finzi","year":"1999","unstructured":"Finzi, D. et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nat. Med. 5, 512\u2013517 (1999)","journal-title":"Nat. Med."},{"key":"BFnature20583_CR10","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1038\/44755","volume":"401","author":"TW Chun","year":"1999","unstructured":"Chun, T. W., Davey, R. T., Jr, Engel, D., Lane, H. C. & Fauci, A. S. Re-emergence of HIV after stopping therapy. Nature 401, 874\u2013875 (1999)","journal-title":"Nature"},{"key":"BFnature20583_CR11","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.immuni.2012.01.014","volume":"36","author":"L Shan","year":"2012","unstructured":"Shan, L. et al. Stimulation of HIV-1-specific cytolytic T lymphocytes facilitates elimination of latent viral reservoir after virus reactivation. Immunity 36, 491\u2013501 (2012)","journal-title":"Immunity"},{"key":"BFnature20583_CR12","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1038\/nature14053","volume":"517","author":"K Deng","year":"2015","unstructured":"Deng, K. et al. Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations. Nature 517, 381\u2013385 (2015)","journal-title":"Nature"},{"key":"BFnature20583_CR13","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nature07469","volume":"457","author":"J Liu","year":"2009","unstructured":"Liu, J. et al. Immune control of an SIV challenge by a T-cell-based vaccine in rhesus monkeys. Nature 457, 87\u201391 (2009)","journal-title":"Nature"},{"key":"BFnature20583_CR14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1038\/nature13594","volume":"512","author":"JB Whitney","year":"2014","unstructured":"Whitney, J. B. et al. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature 512, 74\u201377 (2014)","journal-title":"Nature"},{"key":"BFnature20583_CR15","doi-asserted-by":"publisher","first-page":"4654","DOI":"10.1128\/JVI.02696-06","volume":"81","author":"P Abbink","year":"2007","unstructured":"Abbink, P. et al. Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D. J. Virol. 81, 4654\u20134663 (2007)","journal-title":"J. Virol."},{"key":"BFnature20583_CR16","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/ni1118","volume":"5","author":"T Kawai","year":"2004","unstructured":"Kawai, T. et al. Interferon-\u03b1 induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat. Immunol. 5, 1061\u20131068 (2004)","journal-title":"Nat. Immunol."},{"key":"BFnature20583_CR17","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/ni758","volume":"3","author":"H Hemmi","year":"2002","unstructured":"Hemmi, H. et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3, 196\u2013200 (2002)","journal-title":"Nat. Immunol."},{"key":"BFnature20583_CR18","doi-asserted-by":"publisher","first-page":"319","DOI":"10.7326\/M14-1027","volume":"161","author":"TJ Henrich","year":"2014","unstructured":"Henrich, T. J. et al. Antiretroviral-free HIV-1 remission and viral rebound after allogeneic stem cell transplantation: report of 2 cases. Ann. Intern. Med. 161, 319\u2013327 (2014)","journal-title":"Ann. Intern. Med."},{"key":"BFnature20583_CR19","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1056\/NEJMoa1302976","volume":"369","author":"D Persaud","year":"2013","unstructured":"Persaud, D. et al. Absence of detectable HIV-1 viremia after treatment cessation in an infant. N. Engl. J. Med. 369, 1828\u20131835 (2013)","journal-title":"N. Engl. J. Med."},{"key":"BFnature20583_CR20","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/nm.4113","volume":"22","author":"R Banga","year":"2016","unstructured":"Banga, R. et al. PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals. Nat. Med. 22, 754\u2013761 (2016)","journal-title":"Nat. Med."},{"key":"BFnature20583_CR21","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1038\/80481","volume":"6","author":"Z Hel","year":"2000","unstructured":"Hel, Z. et al. Viremia control following antiretroviral treatment and therapeutic immunization during primary SIV251 infection of macaques. Nat. Med. 6, 1140\u20131146 (2000)","journal-title":"Nat. Med."},{"key":"BFnature20583_CR22","doi-asserted-by":"publisher","first-page":"e10555","DOI":"10.1371\/journal.pone.0010555","volume":"5","author":"ES Rosenberg","year":"2010","unstructured":"Rosenberg, E. S. et al. Safety and immunogenicity of therapeutic DNA vaccination in individuals treated with antiretroviral therapy during acute\/early HIV-1 infection. PLoS One 5, e10555 (2010)","journal-title":"PLoS One"},{"key":"BFnature20583_CR23","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1093\/infdis\/jiq143","volume":"203","author":"JZ Li","year":"2011","unstructured":"Li, J. Z. et al. Factors associated with viral rebound in HIV-1-infected individuals enrolled in a therapeutic HIV-1 gag vaccine trial. J. Infect. Dis. 203, 976\u2013983 (2011)","journal-title":"J. Infect. Dis."},{"key":"BFnature20583_CR24","doi-asserted-by":"publisher","first-page":"10406","DOI":"10.1128\/JVI.01155-10","volume":"84","author":"J Liu","year":"2010","unstructured":"Liu, J. et al. Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys. J. Virol. 84, 10406\u201310412 (2010)","journal-title":"J. Virol."},{"key":"BFnature20583_CR25","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.jtbi.2009.04.010","volume":"259","author":"D Burg","year":"2009","unstructured":"Burg, D., Rong, L., Neumann, A. U. & Dahari, H. Mathematical modeling of viral kinetics under immune control during primary HIV-1 infection. J. Theor. Biol. 259, 751\u2013759 (2009)","journal-title":"J. Theor. Biol."},{"key":"BFnature20583_CR26","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1098\/rstb.2000.0570","volume":"355","author":"D Wodarz","year":"2000","unstructured":"Wodarz, D. et al. A new theory of cytotoxic T-lymphocyte memory: implications for HIV treatment. Philos. Trans. R. Soc. B Biol. Sci. 355, 329\u2013343 (2000)","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"BFnature20583_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0025-5564(01)00072-4","volume":"173","author":"T Luzyanina","year":"2001","unstructured":"Luzyanina, T., Engelborghs, K., Ehl, S., Klenerman, P. & Bocharov, G. Low level viral persistence after infection with LCMV: a quantitative insight through numerical bifurcation analysis. Math. Biosci. 173, 1\u201323 (2001)","journal-title":"Math. Biosci."},{"key":"BFnature20583_CR28","doi-asserted-by":"publisher","first-page":"e1000103","DOI":"10.1371\/journal.pcbi.1000103","volume":"4","author":"CL Althaus","year":"2008","unstructured":"Althaus, C. L. & De Boer, R. J. Dynamics of immune escape during HIV\/SIV infection. PLOS Comput. Biol. 4, e1000103 (2008)","journal-title":"PLOS Comput. Biol."},{"key":"BFnature20583_CR29","doi-asserted-by":"publisher","first-page":"e1002200","DOI":"10.1371\/journal.pcbi.1002200","volume":"7","author":"M Elemans","year":"2011","unstructured":"Elemans, M. et al. Why don\u2019t CD8+ T cells reduce the lifespan of SIV-infected cells in vivo? PLOS Comput. Biol. 7, e1002200 (2011)","journal-title":"PLOS Comput. Biol."},{"key":"BFnature20583_CR30","doi-asserted-by":"crossref","unstructured":"Gadhamsetty, S., Coorens, T. & Boer, R. J. de. Notwithstanding circumstantial alibis, cytotoxic T cells can be major killers of HIV-1 infected cells. J. Virol. 306\u2013316 (2016)","DOI":"10.1128\/JVI.00306-16"},{"key":"BFnature20583_CR31","doi-asserted-by":"publisher","first-page":"19079","DOI":"10.1073\/pnas.0707449104","volume":"104","author":"HY Chen","year":"2007","unstructured":"Chen, H. Y., Di Mascio, M., Perelson, A. S., Ho, D. D. & Zhang, L. Determination of virus burst size in vivo using a single-cycle SIV in rhesus macaques. Proc. Natl Acad. Sci. USA 104, 19079\u201319084 (2007)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature20583_CR32","doi-asserted-by":"publisher","first-page":"e1000906","DOI":"10.1371\/journal.pcbi.1000906","volume":"6","author":"RJ De Boer","year":"2010","unstructured":"De Boer, R. J., Ribeiro, R. M. & Perelson, A. S. Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues. PLOS Comput. Biol. 6, e1000906 (2010)","journal-title":"PLOS Comput. Biol."},{"key":"BFnature20583_CR33","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1016\/S0140-6736(99)02035-8","volume":"354","author":"B Ramratnam","year":"1999","unstructured":"Ramratnam, B. et al. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet 354, 1782\u20131785 (1999)","journal-title":"Lancet"},{"key":"BFnature20583_CR34","unstructured":"Chivers, C. MHadaptive: General Markov Chain Monte Carlo for Bayesian Inference using adaptive Metropolis-Hastings sampling. https:\/\/cran.r-project.org\/web\/packages\/MHadaptive\/MHadaptive.pdf (2012)"},{"key":"BFnature20583_CR35","unstructured":"Soetaert, K., Petzoldt, T. & Setzer, R. W. deSolve: Solvers for Initial Value Problems of Differential Equations (ODE, DAE, DDE). https:\/\/cran.r-project.org\/web\/packages\/deSolve\/vignettes\/deSolve.pdf (2016)"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nature20583.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nature20583","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nature20583.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T14:14:00Z","timestamp":1684851240000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature20583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,9]]},"references-count":35,"journal-issue":{"issue":"7632","published-print":{"date-parts":[[2016,12,8]]}},"alternative-id":["BFnature20583"],"URL":"https:\/\/doi.org\/10.1038\/nature20583","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.726972002.793541814","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.726972002.793526493","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,9]]},"assertion":[{"value":"3 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"M.G.P. and H.S. are employees of Janssen Infectious Diseases and Vaccines. J.H. and R.G. are employees of Gilead Sciences.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}