{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:43:42Z","timestamp":1791877422009,"version":"4.3.4"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"7674","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1038\/nature24017","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T12:33:59Z","timestamp":1506429239000},"page":"109-113","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Retrograde semaphorin\u2013plexin signalling drives homeostatic synaptic plasticity"],"prefix":"10.1038","volume":"550","author":[{"given":"Brian O.","family":"Orr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D.","family":"Fetter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme W.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"BFnature24017_CR1","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.neuron.2013.09.044","volume":"80","author":"GW Davis","year":"2013","unstructured":"Davis, G. W. Homeostatic signaling and the stabilization of neural function. Neuron 80, 718\u2013728 (2013)","journal-title":"Neuron"},{"key":"BFnature24017_CR2","doi-asserted-by":"publisher","first-page":"15542","DOI":"10.1073\/pnas.1010674108","volume":"108","author":"E Marder","year":"2011","unstructured":"Marder, E. Variability, compensation, and modulation in neurons and circuits. Proc. Natl Acad. Sci. USA 108, 15542\u201315548 (2011)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature24017_CR3","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev-neuro-060909-153238","volume":"34","author":"G Turrigiano","year":"2011","unstructured":"Turrigiano, G. Too many cooks? Intrinsic and synaptic homeostatic mechanisms in cortical circuit refinement. Annu. Rev. Neurosci. 34, 89\u2013103 (2011)","journal-title":"Annu. Rev. Neurosci."},{"key":"BFnature24017_CR4","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/nature07457","volume":"455","author":"MB Ramocki","year":"2008","unstructured":"Ramocki, M. B. & Zoghbi, H. Y. Failure of neuronal homeostasis results in common neuropsychiatric phenotypes. Nature 455, 912\u2013918 (2008)","journal-title":"Nature"},{"key":"BFnature24017_CR5","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1113\/jphysiol.1980.sp013145","volume":"299","author":"SG Cull-Candy","year":"1980","unstructured":"Cull-Candy, S. G., Miledi, R., Trautmann, A. & Uchitel, O. D. On the release of transmitter at normal, myasthenia gravis and myasthenic syndrome affected human end-plates. J. Physiol. (Lond.) 299, 621\u2013638 (1980)","journal-title":"J. Physiol. (Lond.)"},{"key":"BFnature24017_CR6","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1038\/nature08724","volume":"463","author":"RJ Hung","year":"2010","unstructured":"Hung, R. J. et al. Mical links semaphorins to F-actin disassembly. Nature 463, 823\u2013827 (2010)","journal-title":"Nature"},{"key":"BFnature24017_CR7","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1126\/science.1211956","volume":"334","author":"R-J Hung","year":"2011","unstructured":"Hung, R.-J., Pak, C. W. & Terman, J. R. Direct redox regulation of F-actin assembly and disassembly by Mical. Science 334, 1710\u20131713 (2011)","journal-title":"Science"},{"key":"BFnature24017_CR8","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/0896-6273(92)90237-8","volume":"9","author":"AL Kolodkin","year":"1992","unstructured":"Kolodkin, A. L. et al. Fasciclin IV: sequence, expression, and function during growth cone guidance in the grasshopper embryo. Neuron 9, 831\u2013845 (1992)","journal-title":"Neuron"},{"key":"BFnature24017_CR9","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/0092-8674(93)80064-L","volume":"75","author":"Y Luo","year":"1993","unstructured":"Luo, Y., Raible, D. & Raper, J. A. Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell 75, 217\u2013227 (1993)","journal-title":"Cell"},{"key":"BFnature24017_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.conb.2014.02.005","volume":"27","author":"E Koropouli","year":"2014","unstructured":"Koropouli, E. & Kolodkin, A. L. Semaphorins and the dynamic regulation of synapse assembly, refinement, and function. Curr. Opin. Neurobiol. 27, 1\u20137 (2014)","journal-title":"Curr. Opin. Neurobiol."},{"key":"BFnature24017_CR11","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1038\/nature08628","volume":"462","author":"TS Tran","year":"2009","unstructured":"Tran, T. S. et al. Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS. Nature 462, 1065\u20131069 (2009)","journal-title":"Nature"},{"key":"BFnature24017_CR12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.pneurobio.2003.06.001","volume":"71","author":"J de Wit","year":"2003","unstructured":"de Wit, J. & Verhaagen, J. Role of semaphorins in the adult nervous system. Prog. Neurobiol. 71, 249\u2013267 (2003)","journal-title":"Prog. Neurobiol."},{"key":"BFnature24017_CR13","doi-asserted-by":"publisher","first-page":"3613","DOI":"10.1523\/JNEUROSCI.5255-04.2005","volume":"25","author":"A Sahay","year":"2005","unstructured":"Sahay, A. et al. Secreted semaphorins modulate synaptic transmission in the adult hippocampus. J. Neurosci. 25, 3613\u20133620 (2005)","journal-title":"J. Neurosci."},{"key":"BFnature24017_CR14","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1111\/j.1460-9568.2006.04783.x","volume":"23","author":"F Bouzioukh","year":"2006","unstructured":"Bouzioukh, F. et al. Semaphorin3a regulates synaptic function of differentiated hippocampal neurons. Eur. J. Neurosci. 23, 2247\u20132254 (2006)","journal-title":"Eur. J. Neurosci."},{"key":"BFnature24017_CR15","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1126\/science.1252514","volume":"344","author":"N Uesaka","year":"2014","unstructured":"Uesaka, N. et al. Retrograde semaphorin signaling regulates synapse elimination in the developing mouse brain. Science 344, 1020\u20131023 (2014)","journal-title":"Science"},{"key":"BFnature24017_CR16","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.neuron.2010.09.005","volume":"68","author":"RA Carrillo","year":"2010","unstructured":"Carrillo, R. A., Olsen, D. P., Yoon, K. S. & Keshishian, H. Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement. Neuron 68, 32\u201344 (2010)","journal-title":"Neuron"},{"key":"BFnature24017_CR17","doi-asserted-by":"publisher","first-page":"e11572","DOI":"10.7554\/eLife.11572","volume":"5","author":"DS Syed","year":"2016","unstructured":"Syed, D. S., Gowda, S. B. M., Reddy, O. V., Reichert, H. & VijayRaghavan, K. Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking. eLife 5, e11572 (2016)","journal-title":"eLife"},{"key":"BFnature24017_CR18","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.neuron.2016.01.020","volume":"89","author":"S Meltzer","year":"2016","unstructured":"Meltzer, S. et al. Epidermis-derived Semaphorin promotes dendrite self-avoidance by regulating dendrite-substrate adhesion in Drosophila sensory neurons. Neuron 89, 741\u2013755 (2016)","journal-title":"Neuron"},{"key":"BFnature24017_CR19","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1016\/S0092-8674(02)00794-8","volume":"109","author":"JR Terman","year":"2002","unstructured":"Terman, J. R., Mao, T., Pasterkamp, R. J., Yu, H. H. & Kolodkin, A. L. MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion. Cell 109, 887\u2013900 (2002)","journal-title":"Cell"},{"key":"BFnature24017_CR20","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1242\/dev.02380","volume":"133","author":"JC Ayoob","year":"2006","unstructured":"Ayoob, J. C., Terman, J. R. & Kolodkin, A. L. Drosophila Plexin B is a Sema-2a receptor required for axon guidance. Development 133, 2125\u20132135 (2006)","journal-title":"Development"},{"key":"BFnature24017_CR21","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.neuron.2011.02.050","volume":"70","author":"Z Wu","year":"2011","unstructured":"Wu, Z. et al. A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS. Neuron 70, 281\u2013298 (2011)","journal-title":"Neuron"},{"key":"BFnature24017_CR22","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1016\/S0896-6273(00)80415-8","volume":"19","author":"SA Petersen","year":"1997","unstructured":"Petersen, S. A., Fetter, R. D., Noordermeer, J. N., Goodman, C. S. & DiAntonio, A. Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release. Neuron 19, 1237\u20131248 (1997)","journal-title":"Neuron"},{"key":"BFnature24017_CR23","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.modgep.2005.07.006","volume":"6","author":"A Mahr","year":"2006","unstructured":"Mahr, A. & Aberle, H. The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain. Gene Expr. Patterns 6, 299\u2013309 (2006)","journal-title":"Gene Expr. Patterns"},{"key":"BFnature24017_CR24","doi-asserted-by":"publisher","first-page":"16574","DOI":"10.1523\/JNEUROSCI.0981-12.2012","volume":"32","author":"M M\u00fcller","year":"2012","unstructured":"M\u00fcller, M., Liu, K. S. Y., Sigrist, S. J. & Davis, G. W. RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool. J. Neurosci. 32, 16574\u201316585 (2012)","journal-title":"J. Neurosci."},{"key":"BFnature24017_CR25","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/ncb2871","volume":"15","author":"R-J Hung","year":"2013","unstructured":"Hung, R.-J., Spaeth, C. S., Yesilyurt, H. G. & Terman, J. R. SelR reverses Mical-mediated oxidation of actin to regulate F-actin dynamics. Nat. Cell Biol. 15, 1445\u20131454 (2013)","journal-title":"Nat. Cell Biol."},{"key":"BFnature24017_CR26","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.neuron.2006.09.029","volume":"52","author":"CA Frank","year":"2006","unstructured":"Frank, C. A., Kennedy, M. J., Goold, C. P., Marek, K. W. & Davis, G. W. Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis. Neuron 52, 663\u2013677 (2006)","journal-title":"Neuron"},{"key":"BFnature24017_CR27","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.neuron.2008.12.028","volume":"61","author":"CA Frank","year":"2009","unstructured":"Frank, C. A., Pielage, J. & Davis, G. W. A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels. Neuron 61, 556\u2013569 (2009)","journal-title":"Neuron"},{"key":"BFnature24017_CR28","doi-asserted-by":"publisher","first-page":"e05473","DOI":"10.7554\/eLife.05473","volume":"4","author":"MA Gavi\u00f1o","year":"2015","unstructured":"Gavi\u00f1o, M. A., Ford, K. J., Archila, S. & Davis, G. W. Homeostatic synaptic depression is achieved through a regulated decrease in presynaptic calcium channel abundance. eLife 4, e05473 (2015)","journal-title":"eLife"},{"key":"BFnature24017_CR29","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1016\/j.neuron.2015.10.049","volume":"88","author":"N Harris","year":"2015","unstructured":"Harris, N. et al. The innate immune receptor PGRP-LC controls presynaptic homeostatic plasticity. Neuron 88, 1157\u20131164 (2015)","journal-title":"Neuron"},{"key":"BFnature24017_CR30","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1534\/genetics.104.026427","volume":"167","author":"HJ Bellen","year":"2004","unstructured":"Bellen, H. J. et al. The BDGP gene disruption project: single transposon insertions associated with 40% of Drosophila genes. Genetics 167, 761\u2013781 (2004)","journal-title":"Genetics"},{"key":"BFnature24017_CR31","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1534\/genetics.107.085555","volume":"180","author":"AL Franciscovich","year":"2008","unstructured":"Franciscovich, A. L., Mortimer, A. D. V., Freeman, A. A., Gu, J. & Sanyal, S. Overexpression screen in Drosophila identifies neuronal roles of GSK-3\u03b2\/shaggy as a regulator of AP-1-dependent developmental plasticity. Genetics 180, 2057\u20132071 (2008)","journal-title":"Genetics"},{"key":"BFnature24017_CR32","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1038\/nmeth.1662","volume":"8","author":"KJT Venken","year":"2011","unstructured":"Venken, K. J. T. et al. MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nat. Methods 8, 737\u2013743 (2011)","journal-title":"Nat. Methods"},{"key":"BFnature24017_CR33","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/j.neuron.2013.06.048","volume":"79","author":"MA Younger","year":"2013","unstructured":"Younger, M. A., M\u00fcller, M., Tong, A., Pym, E. C. & Davis, G. W. A presynaptic ENaC channel drives homeostatic plasticity. Neuron 79, 1183\u20131196 (2013)","journal-title":"Neuron"},{"key":"BFnature24017_CR34","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1016\/j.celrep.2016.08.030","volume":"16","author":"T Wang","year":"2016","unstructured":"Wang, T., Jones, R. T., Whippen, J. M. & Davis, G. W. \u03b12\u03b4-3 is required for rapid transsynaptic homeostatic signaling. Cell Reports 16, 2875\u20132888 (2016)","journal-title":"Cell Reports"},{"key":"BFnature24017_CR35","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.neuron.2014.07.003","volume":"83","author":"T Wang","year":"2014","unstructured":"Wang, T., Hauswirth, A. G., Tong, A., Dickman, D. K. & Davis, G. W. Endostatin is a trans-synaptic signal for homeostatic synaptic plasticity. Neuron 83, 616\u2013629 (2014)","journal-title":"Neuron"}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature24017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature24017","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nature24017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nature24017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T14:05:29Z","timestamp":1684418729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature24017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,27]]},"references-count":35,"journal-issue":{"issue":"7674","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["BFnature24017"],"URL":"https:\/\/doi.org\/10.1038\/nature24017","relation":{},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,27]]},"assertion":[{"value":"29 July 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}