{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:33:43Z","timestamp":1792564423597,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"7683","license":[{"start":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T00:00:00Z","timestamp":1510531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1038\/nature24676","type":"journal-article","created":{"date-parts":[[2017,11,13]],"date-time":"2017-11-13T10:03:56Z","timestamp":1510567436000},"page":"110-115","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":647,"title":["IL-11 is a crucial determinant of cardiovascular fibrosis"],"prefix":"10.1038","volume":"552","author":[{"given":"Sebastian","family":"Schafer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivakumar","family":"Viswanathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anissa A.","family":"Widjaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Wen","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"Moreno-Moral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel M.","family":"DeLaughter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giannino","family":"Patone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kingsley","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Khin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia P.","family":"Chothani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen J. L.","family":"Rackham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole S. J.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norliza E.","family":"Sahib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee Jian","family":"Pua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole T. G.","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrike","family":"Maatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Saar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Blachut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Petretto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Putoczki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno","family":"Guimar\u00e3es-Camboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Wakimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiaan","family":"van Heesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristmundur","family":"Sigmundsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"See L.","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia L.","family":"Soon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor T. T.","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeow L.","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teing E.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia M.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee J.","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad H.","family":"Jamal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim K.","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim C.","family":"Chua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon-Hean","family":"Ong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathew J.","family":"Chakaramakkil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan G.","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E.","family":"Seidman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Hubner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenny Y. K.","family":"Sin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart A.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,11,13]]},"reference":[{"key":"BFnature24676_CR1","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1056\/NEJMra1300575","volume":"372","author":"DC Rockey","year":"2015","unstructured":"Rockey, D. C., Bell, P. D. & Hill, J. A. Fibrosis\u2014a common pathway to organ injury and failure. N. Engl. J. Med. 372, 1138\u20131149 (2015)","journal-title":"N. Engl. J. Med."},{"key":"BFnature24676_CR2","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.jacc.2007.09.064","volume":"51","author":"B Burstein","year":"2008","unstructured":"Burstein, B. & Nattel, S. Atrial fibrosis: mechanisms and clinical relevance in atrial fibrillation. J. Am. Coll. Cardiol. 51, 802\u2013809 (2008)","journal-title":"J. Am. Coll. Cardiol."},{"key":"BFnature24676_CR3","doi-asserted-by":"publisher","first-page":"i89","DOI":"10.1093\/ndt\/gfw388","volume":"32","author":"IA Leaf","year":"2017","unstructured":"Leaf, I. A. & Duffield, J. S. What can target kidney fibrosis? Nephrol. Dial. Transplant. 32 (suppl. 1), i89\u2013i97 (2017)","journal-title":"Nephrol. Dial. Transplant."},{"key":"BFnature24676_CR4","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.yjmcc.2013.10.019","volume":"70","author":"J Davis","year":"2014","unstructured":"Davis, J. & Molkentin, J. D. Myofibroblasts: trust your heart and let fate decide. J. Mol. Cell. Cardiol. 70, 9\u201318 (2014)","journal-title":"J. Mol. Cell. Cardiol."},{"key":"BFnature24676_CR5","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/nrd3810","volume":"11","author":"RJ Akhurst","year":"2012","unstructured":"Akhurst, R. J. & Hata, A. Targeting the TGF\u03b2 signalling pathway in disease. Nat. Rev. Drug Discov. 11, 790\u2013811 (2012)","journal-title":"Nat. Rev. Drug Discov."},{"key":"BFnature24676_CR6","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1172\/JCI37480","volume":"119","author":"B Bierie","year":"2009","unstructured":"Bierie, B. et al. Abrogation of TGF-\u03b2 signaling enhances chemokine production and correlates with prognosis in human breast cancer. J. Clin. Invest. 119, 1571\u20131582 (2009)","journal-title":"J. Clin. Invest."},{"key":"BFnature24676_CR7","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/359693a0","volume":"359","author":"MM Shull","year":"1992","unstructured":"Shull, M. M. et al. Targeted disruption of the mouse transforming growth factor-\u03b21 gene results in multifocal inflammatory disease. Nature 359, 693\u2013699 (1992)","journal-title":"Nature"},{"key":"BFnature24676_CR8","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1002\/path.2277","volume":"214","author":"TA Wynn","year":"2008","unstructured":"Wynn, T. A. Cellular and molecular mechanisms of fibrosis. J. Pathol. 214, 199\u2013210 (2008)","journal-title":"J. Pathol."},{"key":"BFnature24676_CR9","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1161\/01.RES.0000187457.24338.3D","volume":"97","author":"I Cucoranu","year":"2005","unstructured":"Cucoranu, I. et al. NAD(P)H oxidase 4 mediates transforming growth factor-\u03b21-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ. Res. 97, 900\u2013907 (2005)","journal-title":"Circ. Res."},{"key":"BFnature24676_CR10","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014)","journal-title":"Genome Biol."},{"key":"BFnature24676_CR11","doi-asserted-by":"crossref","unstructured":"GTEx Consortium. The Genotype-Tissue Expression (GTEx) project. Nat. Genet. 45, 580\u2013585 (2013)","DOI":"10.1038\/ng.2653"},{"key":"BFnature24676_CR12","doi-asserted-by":"crossref","unstructured":"FANTOM Consortium and the RIKEN PMI and CLST (DGT). A promoter-level mammalian expression atlas. Nature 507, 462\u2013470 (2014)","DOI":"10.1038\/nature13182"},{"key":"BFnature24676_CR13","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.1126\/science.1081578","volume":"299","author":"JP Schmitt","year":"2003","unstructured":"Schmitt, J. P. et al. Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science 299, 1410\u20131413 (2003)","journal-title":"Science"},{"key":"BFnature24676_CR14","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1182\/blood.V81.1.27.27","volume":"81","author":"XX Du","year":"1993","unstructured":"Du, X. X., Neben, T., Goldman, S. & Williams, D. A. Effects of recombinant human interleukin-11 on hematopoietic reconstitution in transplant mice: acceleration of recovery of peripheral blood neutrophils and platelets. Blood 81, 27\u201334 (1993)","journal-title":"Blood"},{"key":"BFnature24676_CR15","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.ccr.2013.06.017","volume":"24","author":"TL Putoczki","year":"2013","unstructured":"Putoczki, T. L. et al. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer Cell 24, 257\u2013271 (2013)","journal-title":"Cancer Cell"},{"key":"BFnature24676_CR16","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1161\/CIRCULATIONAHA.109.893677","volume":"121","author":"M Obana","year":"2010","unstructured":"Obana, M. et al. Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction. Circulation 121, 684\u2013691 (2010)","journal-title":"Circulation"},{"key":"BFnature24676_CR17","doi-asserted-by":"publisher","first-page":"5579","DOI":"10.1158\/1078-0432.CCR-13-2492","volume":"20","author":"M Ernst","year":"2014","unstructured":"Ernst, M. & Putoczki, T. L. Molecular pathways: IL11 as a tumor-promoting cytokine\u2014translational implications for cancers. Clin. Cancer Res. 20, 5579\u20135588 (2014)","journal-title":"Clin. Cancer Res."},{"key":"BFnature24676_CR18","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/j.celrep.2016.01.053","volume":"14","author":"J Lokau","year":"2016","unstructured":"Lokau, J. et al. Proteolytic cleavage governs interleukin-11 trans-signaling. Cell Reports 14, 1761\u20131773 (2016)","journal-title":"Cell Reports"},{"key":"BFnature24676_CR19","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1472-6750-12-8","volume":"12","author":"H Dams-Kozlowska","year":"2012","unstructured":"Dams-Kozlowska, H. et al. A designer hyper interleukin 11 (H11) is a biologically active cytokine. BMC Biotechnol. 12, 8 (2012)","journal-title":"BMC Biotechnol."},{"key":"BFnature24676_CR20","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1182\/blood.V90.6.2148","volume":"90","author":"HH Nandurkar","year":"1997","unstructured":"Nandurkar, H. H. et al. Adult mice with targeted mutation of the interleukin-11 receptor (IL11Ra) display normal hematopoiesis. Blood 90, 2148\u20132159 (1997)","journal-title":"Blood"},{"key":"BFnature24676_CR21","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/emboj.2011.418","volume":"31","author":"J Duan","year":"2012","unstructured":"Duan, J. et al. Wnt1\/\u03b2catenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. EMBO J. 31, 429\u2013442 (2012)","journal-title":"EMBO J."},{"key":"BFnature24676_CR22","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1002\/stem.5530160724","volume":"16","author":"JA Kaye","year":"1998","unstructured":"Kaye, J. A. FDA licensure of NEUMEGA to prevent severe chemotherapy-induced thrombocytopenia. Stem Cells 16 (Suppl 2), 207\u2013223 (1998)","journal-title":"Stem Cells"},{"key":"BFnature24676_CR23","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1172\/JCI74783","volume":"124","author":"T Moore-Morris","year":"2014","unstructured":"Moore-Morris, T. et al. Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J. Clin. Invest. 124, 2921\u20132934 (2014)","journal-title":"J. Clin. Invest."},{"key":"BFnature24676_CR24","doi-asserted-by":"publisher","first-page":"7512","DOI":"10.1073\/pnas.87.19.7512","volume":"87","author":"SR Paul","year":"1990","unstructured":"Paul, S. R. et al. Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc. Natl Acad. Sci. USA 87, 7512\u20137516 (1990)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature24676_CR25","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1007\/s00380-015-0788-4","volume":"31","author":"M Nakagawa","year":"2016","unstructured":"Nakagawa, M. et al. Four cases of investigational therapy with interleukin-11 against acute myocardial infarction. Heart Vessels 31, 1574\u20131578 (2016)","journal-title":"Heart Vessels"},{"key":"BFnature24676_CR26","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1465-9921-14-80","volume":"14","author":"GE Lindahl","year":"2013","unstructured":"Lindahl, G. E. et al. Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease. Respir. Res. 14, 80 (2013)","journal-title":"Respir. Res."},{"key":"BFnature24676_CR27","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ajhg.2011.05.024","volume":"89","author":"P Nieminen","year":"2011","unstructured":"Nieminen, P. et al. Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth. Am. J. Hum. Genet. 89, 67\u201381 (2011)","journal-title":"Am. J. Hum. Genet."},{"key":"BFnature24676_CR28","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nbt.3192","volume":"33","author":"R Satija","year":"2015","unstructured":"Satija, R., Farrell, J. A., Gennert, D., Schier, A. F. & Regev. A. Spatial reconstruction of single-cell gene expression data. Nat. Biotechnol. 33, 495\u2013502 (2015)","journal-title":"Nat. Biotechnol."},{"key":"BFnature24676_CR29","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","volume":"25","author":"C Trapnell","year":"2009","unstructured":"Trapnell, C., Pachter, L. & Salzberg, S. L. TopHat: discovering splice junctions with RNA-seq. Bioinformatics 25, 1105\u20131111 (2009)","journal-title":"Bioinformatics"},{"key":"BFnature24676_CR30","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders, S., Pyl, P. T. & Huber, W. HTSeq\u2014a Python framework to work with high-throughput sequencing data. Bioinformatics 31, 166\u2013169 (2015)","journal-title":"Bioinformatics"},{"key":"BFnature24676_CR31","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian, A. et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl Acad. Sci. USA 102, 15545\u201315550 (2005)","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnature24676_CR32","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder, P. & Horvath, S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9, 559 (2008)","journal-title":"BMC Bioinformatics"},{"key":"BFnature24676_CR33","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger, A. M., Lohse, M. & Usadel, B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30, 2114\u20132120 (2014)","journal-title":"Bioinformatics"},{"key":"BFnature24676_CR34","unstructured":"Babraham Bioinformatics. FastQC, a quality control tool for high throughput sequence data. http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc\/"},{"key":"BFnature24676_CR35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29, 15\u201321 (2013)","journal-title":"Bioinformatics"},{"key":"BFnature24676_CR36","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao, Y., Smyth, G. K. & Shi, W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30, 923\u2013930 (2014)","journal-title":"Bioinformatics"},{"key":"BFnature24676_CR37","doi-asserted-by":"publisher","first-page":"e86898","DOI":"10.1172\/jci.insight.86898","volume":"1","author":"MA Burke","year":"2016","unstructured":"Burke, M. A. et al. Molecular profiling of dilated cardiomyopathy that progresses to heart failure. JCI Insight 1, e86898 (2016)","journal-title":"JCI Insight"},{"key":"BFnature24676_CR38","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1152\/physiolgenomics.00041.2003","volume":"16","author":"O Tarnavski","year":"2004","unstructured":"Tarnavski, O. et al. Mouse cardiac surgery: comprehensive techniques for the generation of mouse models of human diseases and their application for genomic studies. Physiol. Genomics 16, 349\u2013360 (2004)","journal-title":"Physiol. Genomics"},{"key":"BFnature24676_CR39","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/S0002-9440(10)61108-X","volume":"160","author":"B Zheng","year":"2002","unstructured":"Zheng, B., Zhang, Z., Black, C. M., de Crombrugghe, B. & Denton, C. P. Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis. Am. J. Pathol. 160, 1609\u20131617 (2002)","journal-title":"Am. J. Pathol."},{"key":"BFnature24676_CR40","doi-asserted-by":"publisher","first-page":"S32","DOI":"10.1161\/CIRCULATIONAHA.112.000025","volume":"128","author":"L Ye","year":"2013","unstructured":"Ye, L. et al. Thymosin \u03b24 increases the potency of transplanted mesenchymal stem cells for myocardial repair. Circulation 128 (Suppl 1), S32\u2013S41 (2013)","journal-title":"Circulation"},{"key":"BFnature24676_CR41","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/9780470942390.mo100130","volume":"1","author":"S Gao","year":"2011","unstructured":"Gao, S., Ho, D., Vatner, D. E. & Vatner, S. F. Echocardiography in mice. Curr. Protoc. Mouse Biol. 1, 71\u201383 (2011)","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"BFnature24676_CR42","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1161\/01.CIR.67.3.579","volume":"67","author":"FA Tortoledo","year":"1983","unstructured":"Tortoledo, F. A., Quinones, M. A., Fernandez, G. C., Waggoner, A. D. & Winters, W. L. Jr. Quantification of left ventricular volumes by two-dimensional echocardiography: a simplified and accurate approach. Circulation 67, 579\u2013584 (1983)","journal-title":"Circulation"},{"key":"BFnature24676_CR43","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1007\/978-1-62703-989-5_17","volume":"1130","author":"TJ Mead","year":"2014","unstructured":"Mead, T. J. & Lefebvre, V. Proliferation assays (BrdU and EdU) on skeletal tissue sections. Methods Mol. Biol. 1130, 233\u2013243 (2014)","journal-title":"Methods Mol. Biol."}],"container-title":["Nature"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nature24676.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nature24676","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nature24676","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nature24676.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:16:17Z","timestamp":1693210577000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nature24676"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,13]]},"references-count":43,"journal-issue":{"issue":"7683","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["BFnature24676"],"URL":"https:\/\/doi.org\/10.1038\/nature24676","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732141712.793540869","asserted-by":"object"}]},"ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,13]]},"assertion":[{"value":"22 March 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"S.A.C. and S.Scha. are co-inventors of the patent application (WO2017103108) \u2018Treatment of fibrosis\u2019. S.A.C. and S.Scha. are co-founders and shareholders of Enleofen Bio PTE LTD, a company that develops therapeutics based on findings described in this manuscript.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}