{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:13:52Z","timestamp":1791400432839,"version":"4.3.3"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Biotechnol"],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1038\/nbt.1904","type":"journal-article","created":{"date-parts":[[2011,7,24]],"date-time":"2011-07-24T18:04:35Z","timestamp":1311530675000},"page":"723-730","source":"Crossref","is-referenced-by-count":106,"title":["Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly"],"prefix":"10.1038","volume":"29","author":[{"given":"Yingrui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hancheng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujia","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haojing","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhou","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuijian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songgang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Bolund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karsten","family":"Kristiansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J","family":"de Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra I F","family":"Blakemore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachlan J M","family":"Coin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,1]]},"reference":[{"key":"BFnbt1904_CR1","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/35057062","volume":"409","author":"ES Lander","year":"2001","unstructured":"Lander, E.S. et al. Initial sequencing and analysis of the human genome. Nature 409, 860\u2013921 (2001).","journal-title":"Nature"},{"key":"BFnbt1904_CR2","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1126\/science.1058040","volume":"291","author":"JC Venter","year":"2001","unstructured":"Venter, J.C. et al. The sequence of the human genome. Science 291, 1304\u20131351 (2001).","journal-title":"Science"},{"key":"BFnbt1904_CR3","doi-asserted-by":"crossref","unstructured":"International Human Genome Sequencing Consortium. Finishing the euchromatic sequence of the human genome. Nature 431, 931\u2013945 (2004).","DOI":"10.1038\/nature03001"},{"key":"BFnbt1904_CR4","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1126\/science.1105436","volume":"307","author":"DA Hinds","year":"2005","unstructured":"Hinds, D.A. et al. Whole-genome patterns of common DNA variation in three human populations. Science 307, 1072\u20131079 (2005).","journal-title":"Science"},{"key":"BFnbt1904_CR5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/ng1508","volume":"37","author":"H Stefansson","year":"2005","unstructured":"Stefansson, H. et al. A common inversion under selection in Europeans. Nat. Genet. 37, 129\u2013137 (2005).","journal-title":"Nat. Genet."},{"key":"BFnbt1904_CR6","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.ajhg.2007.09.014","volume":"82","author":"S Ben-Shachar","year":"2008","unstructured":"Ben-Shachar, S. et al. 22q11.2 distal deletion: a recurrent genomic disorder distinct from DiGeorge syndrome and velocardiofacial syndrome. Am. J. Hum. Genet. 82, 214\u2013221 (2008).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnbt1904_CR7","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1038\/nrc1299","volume":"4","author":"PA Futreal","year":"2004","unstructured":"Futreal, P.A. et al. A census of human cancer genes. Nat. Rev. Cancer 4, 177\u2013183 (2004).","journal-title":"Nat. Rev. Cancer"},{"key":"BFnbt1904_CR8","doi-asserted-by":"crossref","unstructured":"The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061\u20131068 (2008).","DOI":"10.1038\/nature07385"},{"key":"BFnbt1904_CR9","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nrc2091","volume":"7","author":"F Mitelman","year":"2007","unstructured":"Mitelman, F., Johansson, B. & Mertens, F. The impact of translocations and gene fusions on cancer causation. Nat. Rev. Cancer 7, 233\u2013245 (2007).","journal-title":"Nat. Rev. Cancer"},{"key":"BFnbt1904_CR10","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/nrg2554","volume":"10","author":"KA Frazer","year":"2009","unstructured":"Frazer, K.A., Murray, S.S., Schork, N.J. & Topol, E.J. Human genetic variation and its contribution to complex traits. Nat. Rev. Genet. 10, 241\u2013251 (2009).","journal-title":"Nat. Rev. Genet."},{"key":"BFnbt1904_CR11","doi-asserted-by":"crossref","unstructured":"The International HapMap Consortium. A haplotype map of the human genome. Nature 437, 1299\u20131320 (2005).","DOI":"10.1038\/nature04226"},{"key":"BFnbt1904_CR12","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/ng0709-765","volume":"41","author":"S Chanock","year":"2009","unstructured":"Chanock, S. High marks for GWAS. Nat. Genet. 41, 765\u2013766 (2009).","journal-title":"Nat. Genet."},{"key":"BFnbt1904_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1038\/nrg1521","volume":"6","author":"JN Hirschhorn","year":"2005","unstructured":"Hirschhorn, J.N. & Daly, M.J. Genome-wide association studies for common diseases and complex traits. Nat. Rev. Genet. 6, 95\u2013108 (2005).","journal-title":"Nat. Rev. Genet."},{"key":"BFnbt1904_CR14","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/ng.128","volume":"40","author":"PJ Campbell","year":"2008","unstructured":"Campbell, P.J. et al. Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat. Genet. 40, 722\u2013729 (2008).","journal-title":"Nat. Genet."},{"key":"BFnbt1904_CR15","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/ng1562","volume":"37","author":"E Tuzun","year":"2005","unstructured":"Tuzun, E. et al. Fine-scale structural variation of the human genome. Nat. Genet. 37, 727\u2013732 (2005).","journal-title":"Nat. Genet."},{"key":"BFnbt1904_CR16","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1126\/science.1149504","volume":"318","author":"JO Korbel","year":"2007","unstructured":"Korbel, J.O. et al. Paired-end mapping reveals extensive structural variation in the human genome. Science 318, 420\u2013426 (2007).","journal-title":"Science"},{"key":"BFnbt1904_CR17","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nature06862","volume":"453","author":"JM Kidd","year":"2008","unstructured":"Kidd, J.M. et al. Mapping and sequencing of structural variation from eight human genomes. Nature 453, 56\u201364 (2008).","journal-title":"Nature"},{"key":"BFnbt1904_CR18","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/nature05329","volume":"444","author":"R Redon","year":"2006","unstructured":"Redon, R. et al. Global variation in copy number in the human genome. Nature 444, 444\u2013454 (2006).","journal-title":"Nature"},{"key":"BFnbt1904_CR19","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/nature07517","volume":"456","author":"DR Bentley","year":"2008","unstructured":"Bentley, D.R. et al. Accurate whole human genome sequencing using reversible terminator chemistry. Nature 456, 53\u201359 (2008).","journal-title":"Nature"},{"key":"BFnbt1904_CR20","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nmeth.1363","volume":"6","author":"K Chen","year":"2009","unstructured":"Chen, K. et al. BreakDancer: an algorithm for high-resolution mapping of genomic structural variation. Nat. Methods 6, 677\u2013681 (2009).","journal-title":"Nat. Methods"},{"key":"BFnbt1904_CR21","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nbt.1600","volume":"28","author":"HY Lam","year":"2010","unstructured":"Lam, H.Y. et al. Nucleotide-resolution analysis of structural variants using BreakSeq and a breakpoint library. Nat. Biotechnol. 28, 47\u201355 (2010).","journal-title":"Nat. Biotechnol."},{"key":"BFnbt1904_CR22","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nature08516","volume":"464","author":"DF Conrad","year":"2010","unstructured":"Conrad, D.F. et al. Origins and functional impact of copy number variation in the human genome. Nature 464, 704\u2013712 (2010).","journal-title":"Nature"},{"key":"BFnbt1904_CR23","doi-asserted-by":"publisher","first-page":"R52","DOI":"10.1186\/gb-2010-11-5-r52","volume":"11","author":"AW Pang","year":"2010","unstructured":"Pang, A.W. et al. Towards a comprehensive structural variation map of an individual human genome. Genome Biol. 11, R52 (2010).","journal-title":"Genome Biol."},{"key":"BFnbt1904_CR24","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1101\/gr.088633.108","volume":"19","author":"F Hormozdiari","year":"2009","unstructured":"Hormozdiari, F., Alkan, C., Eichler, E.E. & Sahinalp, S.C. Combinatorial algorithms for structural variation detection in high-throughput sequenced genomes. Genome Res. 19, 1270\u20131278 (2009).","journal-title":"Genome Res."},{"key":"BFnbt1904_CR25","doi-asserted-by":"publisher","first-page":"R128","DOI":"10.1186\/gb-2010-11-12-r128","volume":"11","author":"K Wong","year":"2010","unstructured":"Wong, K., Keane, T.M., Stalker, J. & Adams, D.J. Enhanced structural variant and breakpoint detection using SVMerge by integration of multiple detection methods and local assembly. Genome Biol. 11, R128 (2010).","journal-title":"Genome Biol."},{"key":"BFnbt1904_CR26","doi-asserted-by":"publisher","first-page":"e254","DOI":"10.1371\/journal.pbio.0050254","volume":"5","author":"S Levy","year":"2007","unstructured":"Levy, S. et al. The diploid genome sequence of an individual human. PLoS Biol. 5, e254 (2007).","journal-title":"PLoS Biol."},{"key":"BFnbt1904_CR27","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1101\/gr.089532.108","volume":"19","author":"JT Simpson","year":"2009","unstructured":"Simpson, J.T. et al. ABySS: a parallel assembler for short read sequence data. Genome Res. 19, 1117\u20131123 (2009).","journal-title":"Genome Res."},{"key":"BFnbt1904_CR28","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1101\/gr.074492.107","volume":"18","author":"DR Zerbino","year":"2008","unstructured":"Zerbino, D.R. & Birney, E. Velvet: algorithms for de novo short read assembly using de Bruijn graphs. Genome Res. 18, 821\u2013829 (2008).","journal-title":"Genome Res."},{"key":"BFnbt1904_CR29","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1101\/gr.097261.109","volume":"20","author":"R Li","year":"2010","unstructured":"Li, R. et al. De novo assembly of human genomes with massively parallel short read sequencing. Genome Res. 20, 265\u2013272 (2010).","journal-title":"Genome Res."},{"key":"BFnbt1904_CR30","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1073\/pnas.1017351108","volume":"108","author":"S Gnerre","year":"2010","unstructured":"Gnerre, S. et al. High-quality draft assemblies of mammalian genomes from massively parallel sequence data. Proc. Natl. Acad. Sci. USA 108, 1513\u20131518 (2010).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt1904_CR31","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1038\/nature09534","volume":"467","author":"TG Consortium","year":"2010","unstructured":"Consortium, T.G. A map of human genome variation from population scale sequencing. Nature 467, 1061\u20131073 (2010).","journal-title":"Nature"},{"key":"BFnbt1904_CR32","unstructured":"Harris, R.S. Improved pairwise alignment of genomic DNA. PhD thesis, Penn State Univ. (2007)."},{"key":"BFnbt1904_CR33","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1101\/gr.809403","volume":"13","author":"S Schwartz","year":"2003","unstructured":"Schwartz, S. et al. Human-mouse alignments with BLASTZ. Genome Res. 13, 103\u2013107 (2003).","journal-title":"Genome Res."},{"key":"BFnbt1904_CR34","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1101\/gr.097261.109","volume":"20","author":"R Li","year":"2009","unstructured":"Li, R. et al. De novo assembly of human genomes with massively parallel short read sequencing. Genome Res. 20, 265\u2013272 (2009).","journal-title":"Genome Res."},{"key":"BFnbt1904_CR35","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","volume":"25","author":"H Li","year":"2009","unstructured":"Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 1754\u20131760 (2009).","journal-title":"Bioinformatics"},{"key":"BFnbt1904_CR36","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1101\/gr.091868.109","volume":"19","author":"KJ McKernan","year":"2009","unstructured":"McKernan, K.J. et al. Sequence and structural variation in a human genome uncovered by short-read, massively parallel ligation sequencing using two-base encoding. Genome Res. 19, 1527\u20131541 (2009).","journal-title":"Genome Res."},{"key":"BFnbt1904_CR37","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/nature07484","volume":"456","author":"J Wang","year":"2008","unstructured":"Wang, J. et al. The diploid genome sequence of an Asian individual. Nature 456, 60\u201365 (2008).","journal-title":"Nature"},{"key":"BFnbt1904_CR38","doi-asserted-by":"crossref","unstructured":"Tarailo-Graovac, M. & Chen, N. Using RepeatMasker to identify repetitive elements in genomic sequences. Curr. Protoc. Bioinformatics, chapter 4, unit 4.10 (Wiley, 2009).","DOI":"10.1002\/0471250953.bi0410s25"},{"key":"BFnbt1904_CR39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/nmeth.1527","volume":"8","author":"C Alkan","year":"2011","unstructured":"Alkan, C., Sajjadian, S. & Eichler, E.E. Limitations of next-generation genome sequence assembly. Nat. Methods 8, 61\u201365 (2011).","journal-title":"Nat. Methods"},{"key":"BFnbt1904_CR40","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/nrg2958","volume":"12","author":"C Alkan","year":"2011","unstructured":"Alkan, C., Coe, B.P. & Eichler, E.E. Genome structural variation discovery and genotyping. Nat. Rev. Genet. 12, 363\u2013376 (2011).","journal-title":"Nat. Rev. Genet."},{"key":"BFnbt1904_CR41","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nmeth.1451","volume":"7","author":"JM Kidd","year":"2010","unstructured":"Kidd, J.M. et al. Characterization of missing human genome sequences and copy-number polymorphic insertions. Nat. Methods 7, 365\u2013371 (2010).","journal-title":"Nat. Methods"},{"key":"BFnbt1904_CR42","doi-asserted-by":"publisher","first-page":"2865","DOI":"10.1093\/bioinformatics\/btp394","volume":"25","author":"K Ye","year":"2009","unstructured":"Ye, K., Schulz, M.H., Long, Q., Apweiler, R. & Ning, Z. Pindel: a pattern growth approach to detect break points of large deletions and medium sized insertions from paired-end short reads. Bioinformatics 25, 2865\u20132871 (2009).","journal-title":"Bioinformatics"},{"key":"BFnbt1904_CR43","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/nrg1767","volume":"7","author":"L Feuk","year":"2006","unstructured":"Feuk, L., Carson, A.R. & Scherer, S.W. Structural variation in the human genome. Nat. Rev. Genet. 7, 85\u201397 (2006).","journal-title":"Nat. Rev. Genet."},{"key":"BFnbt1904_CR44","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nbt.1596","volume":"28","author":"R Li","year":"2010","unstructured":"Li, R. et al. Building the sequence map of the human pan-genome. Nat. Biotechnol. 28, 57\u201363 (2010).","journal-title":"Nat. Biotechnol."},{"key":"BFnbt1904_CR45","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nbt.1600","volume":"28","author":"HY Lam","year":"2010","unstructured":"Lam, H.Y. et al. Nucleotide-resolution analysis of structural variants using BreakSeq and a breakpoint library. Nat. Biotechnol. 28, 47\u201355 (2010).","journal-title":"Nat. Biotechnol."},{"key":"BFnbt1904_CR46","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1098\/rstb.1987.0080","volume":"317","author":"AA Travers","year":"1987","unstructured":"Travers, A.A. & Klug, A. The bending of DNA in nucleosomes and its wider implications. Phil. Trans. R. Soc. Lond. B 317, 537\u2013561 (1987).","journal-title":"Phil. Trans. R. Soc. Lond. B"},{"key":"BFnbt1904_CR47","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1101\/gr.5429606","volume":"17","author":"FC Chen","year":"2007","unstructured":"Chen, F.C., Chen, C.J., Li, W.H. & Chuang, T.J. Human-specific insertions and deletions inferred from mammalian genome sequences. Genome Res. 17, 16\u201322 (2007).","journal-title":"Genome Res."},{"key":"BFnbt1904_CR48","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1038\/ng.529","volume":"42","author":"L Yi","year":"2010","unstructured":"Yi, L. Resequencing of 200 human exomes identifies an excess of low frequency non-synonymous coding variants.pdf. Nat. Genet. 42, 969\u2013972 (2010).","journal-title":"Nat. Genet."},{"key":"BFnbt1904_CR49","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1101\/gr.229202","volume":"12","author":"WJ Kent","year":"2002","unstructured":"Kent, W.J. BLAT\u2013the BLAST-like alignment tool. Genome Res. 12, 656\u2013664 (2002).","journal-title":"Genome Res."},{"key":"BFnbt1904_CR50","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1093\/bioinformatics\/btp336","volume":"25","author":"R Li","year":"2009","unstructured":"Li, R. et al. SOAP2: an improved ultrafast tool for short read alignment. Bioinformatics 25, 1966\u20131967 (2009).","journal-title":"Bioinformatics"}],"container-title":["Nature Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nbt.1904","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt.1904.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt.1904.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:18:42Z","timestamp":1684433922000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nbt.1904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2011,8]]}},"alternative-id":["BFnbt1904"],"URL":"https:\/\/doi.org\/10.1038\/nbt.1904","relation":{},"ISSN":["1087-0156","1546-1696"],"issn-type":[{"value":"1087-0156","type":"print"},{"value":"1546-1696","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}