{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T10:35:19Z","timestamp":1778236519585,"version":"3.51.4"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Biotechnol"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1038\/nbt.3195","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T20:30:41Z","timestamp":1428438641000},"page":"357-359","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Genetic variation and alternative splicing"],"prefix":"10.1038","volume":"33","author":[{"given":"Xavier","family":"Estivill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,4,7]]},"reference":[{"key":"BFnbt3195_CR1","doi-asserted-by":"publisher","first-page":"1254806","DOI":"10.1126\/science.1254806","volume":"347","author":"HY Xiong","year":"2015","unstructured":"Xiong, H.Y. et al. Science 347, 1254806 (2015).","journal-title":"Science"},{"key":"BFnbt3195_CR2","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nature10532","volume":"478","author":"D Brawand","year":"2011","unstructured":"Brawand, D. et al. Nature 478, 343\u2013348 (2011).","journal-title":"Nature"},{"key":"BFnbt3195_CR3","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nature12531","volume":"501","author":"T Lappalainen","year":"2013","unstructured":"Lappalainen, T. et al. Nature 501, 506\u2013511 (2013).","journal-title":"Nature"},{"key":"BFnbt3195_CR4","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1093\/hmg\/9.2.237","volume":"9","author":"E Ars","year":"2000","unstructured":"Ars, E. et al. Hum. Mol. Genet. 9, 237\u2013247 (2000).","journal-title":"Hum. Mol. Genet."},{"key":"BFnbt3195_CR5","first-page":"623","volume":"56","author":"M Chill\u00f3n","year":"1995","unstructured":"Chill\u00f3n, M. et al. Am. J. Hum. Genet. 56, 623\u2013629 (1995).","journal-title":"Am. J. Hum. Genet."},{"key":"BFnbt3195_CR6","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","volume":"34","author":"Y Zhang","year":"2014","unstructured":"Zhang, Y. et al. J. Neurosci. 34, 11929\u201311947 (2014).","journal-title":"J. Neurosci."},{"key":"BFnbt3195_CR7","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/nmeth.1528","volume":"7","author":"Y Katz","year":"2010","unstructured":"Katz, Y. et al. Nat. Methods 7, 1009\u20131015 (2010).","journal-title":"Nat. Methods"},{"issue":"Suppl. 6","key":"BFnbt3195_CR8","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1186\/1471-2105-13-S6-S11","volume":"13","author":"B Kakaradov","year":"2012","unstructured":"Kakaradov, B. et al. BMC Bioinformatics 13 (Suppl. 6), S11 (2012).","journal-title":"BMC Bioinformatics"},{"key":"BFnbt3195_CR9","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1056\/NEJM199506013322204","volume":"332","author":"M Chill\u00f3n","year":"1995","unstructured":"Chill\u00f3n, M. et al. N. Engl. J. Med. 332, 1475\u20131480 (1995).","journal-title":"N. Engl. J. Med."},{"key":"BFnbt3195_CR10","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1016\/j.cell.2014.11.035","volume":"159","author":"M Irimia","year":"2014","unstructured":"Irimia, M. et al. Cell 159, 1511\u20131523 (2014).","journal-title":"Cell"}],"container-title":["Nature Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nbt.3195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt.3195","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt.3195.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:30:49Z","timestamp":1684434649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nbt.3195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,4]]}},"alternative-id":["BFnbt3195"],"URL":"https:\/\/doi.org\/10.1038\/nbt.3195","relation":{},"ISSN":["1087-0156","1546-1696"],"issn-type":[{"value":"1087-0156","type":"print"},{"value":"1546-1696","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"7 April 2015","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The author declares no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}