{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:40:27Z","timestamp":1784950827213,"version":"3.55.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T00:00:00Z","timestamp":1467590400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Biotechnol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1038\/nbt.3587","type":"journal-article","created":{"date-parts":[[2016,7,4]],"date-time":"2016-07-04T15:48:35Z","timestamp":1467647315000},"page":"838-844","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Large-scale phenome analysis defines a behavioral signature for Huntington's disease genotype in mice"],"prefix":"10.1038","volume":"34","author":[{"given":"Vadim","family":"Alexandrov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana B","family":"Menalled","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Kudwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy","family":"Watson-Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Mazzella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda C","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Torello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Sabath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Filipov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Cox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Ghavami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Ramboz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Lager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa C","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff","family":"Aaronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Rosinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F","family":"Gusella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcy E","family":"MacDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Howland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,7,4]]},"reference":[{"key":"BFnbt3587_CR1","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/nbt.2749","volume":"31","author":"JC Denny","year":"2013","unstructured":"Denny, J.C. et al. Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data. Nat. Biotechnol. 31, 1102\u20131110 (2013).","journal-title":"Nat. Biotechnol."},{"issue":"6","key":"BFnbt3587_CR2","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"M MACDONALD","year":"1993","unstructured":"The Huntington's Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 72, 971\u2013983 (1993).","journal-title":"Cell"},{"key":"BFnbt3587_CR3","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/ajmg.b.30992","volume":"153B","author":"DR Langbehn","year":"2010","unstructured":"Langbehn, D.R., Hayden, M.R. & Paulsen, J.S. CAG-repeat length and the age of onset in Huntington disease (HD): a review and validation study of statistical approaches. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 153B, 397\u2013408 (2010).","journal-title":"Am. J. Med. Genet. B. Neuropsychiatr. Genet."},{"key":"BFnbt3587_CR4","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1136\/jmg.30.12.1008","volume":"30","author":"D Craufurd","year":"1993","unstructured":"Craufurd, D. & Dodge, A. Mutation size and age at onset in Huntington's disease. J. Med. Genet. 30, 1008\u20131011 (1993).","journal-title":"J. Med. Genet."},{"key":"BFnbt3587_CR5","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neuroscience.2011.08.052","volume":"198","author":"LA Raymond","year":"2011","unstructured":"Raymond, L.A. et al. Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function. Neuroscience 198, 252\u2013273 (2011).","journal-title":"Neuroscience"},{"key":"BFnbt3587_CR6","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/0022-510X(85)90084-X","volume":"70","author":"I Kanazawa","year":"1985","unstructured":"Kanazawa, I. et al. Studies on neurotransmitter markers and striatal neuronal cell density in Huntington's disease and dentatorubropallidoluysian atrophy. J. Neurol. Sci. 70, 151\u2013165 (1985).","journal-title":"J. Neurol. Sci."},{"key":"BFnbt3587_CR7","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1093\/hmg\/8.10.1955","volume":"8","author":"MJ Justice","year":"1999","unstructured":"Justice, M.J., Noveroske, J.K., Weber, J.S., Zheng, B. & Bradley, A. Mouse ENU mutagenesis. Hum. Mol. Genet. 8, 1955\u20131963 (1999).","journal-title":"Hum. Mol. Genet."},{"key":"BFnbt3587_CR8","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.nbd.2012.01.014","volume":"46","author":"K Suzuki","year":"2012","unstructured":"Suzuki, K. et al. DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles. Neurobiol. Dis. 46, 336\u2013350 (2012).","journal-title":"Neurobiol. Dis."},{"key":"BFnbt3587_CR9","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/2040-2392-5-11","volume":"5","author":"H Bruining","year":"2014","unstructured":"Bruining, H. et al. Behavioral signatures related to genetic disorders in autism. Mol. Autism 5, 11 (2014).","journal-title":"Mol. Autism"},{"key":"BFnbt3587_CR10","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ejphar.2014.11.047","volume":"750","author":"V Alexandrov","year":"2015","unstructured":"Alexandrov, V., Brunner, D., Hanania, T. & Leahy, E. High-throughput analysis of behavior for drug discovery. Eur. J. Pharmacol. 750, 82\u201389 (2015).","journal-title":"Eur. J. Pharmacol."},{"key":"BFnbt3587_CR11","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nn.4256","volume":"19","author":"P Langfelder","year":"2016","unstructured":"Langfelder, P. et al. Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nat. Neurosci. 19, 623\u2013633 (2016).","journal-title":"Nat. Neurosci."},{"key":"BFnbt3587_CR12","unstructured":"Harper, P.S. Huntington's Disease (W.B. Saunders, London, 1996)."},{"key":"BFnbt3587_CR13","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","volume":"57","author":"JP Vonsattel","year":"1998","unstructured":"Vonsattel, J.P. & DiFiglia, M. Huntington disease. J. Neuropathol. Exp. Neurol. 57, 369\u2013384 (1998).","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"BFnbt3587_CR14","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1177\/7010.2006.00244","volume":"21","author":"K Wojaczyn\u0144ska-Stanek","year":"2006","unstructured":"Wojaczyn\u0144ska-Stanek, K., Adamek, D., Marszal, E. & Hoffman-Zacharska, D. Huntington disease in a 9-year-old boy: clinical course and neuropathologic examination. J. Child Neurol. 21, 1068\u20131073 (2006).","journal-title":"J. Child Neurol."},{"key":"BFnbt3587_CR15","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1093\/hmg\/ddr195","volume":"20","author":"JC Jacobsen","year":"2011","unstructured":"Jacobsen, J.C. et al. HD CAG-correlated gene expression changes support a simple dominant gain of function. Hum. Mol. Genet. 20, 2846\u20132860 (2011).","journal-title":"Hum. Mol. Genet."},{"key":"BFnbt3587_CR16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1002\/cne.10776","volume":"465","author":"LB Menalled","year":"2003","unstructured":"Menalled, L.B., Sison, J.D., Dragatsis, I., Zeitlin, S. & Chesselet, M.F. Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats. J. Comp. Neurol. 465, 11\u201326 (2003).","journal-title":"J. Comp. Neurol."},{"key":"BFnbt3587_CR17","doi-asserted-by":"publisher","first-page":"e49838","DOI":"10.1371\/journal.pone.0049838","volume":"7","author":"LB Menalled","year":"2012","unstructured":"Menalled, L.B. et al. Comprehensive behavioral and molecular characterization of a new knock-in mouse model of Huntington's disease: zQ175. PLoS One 7, e49838 (2012).","journal-title":"PLoS One"},{"key":"BFnbt3587_CR18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3233\/JHD-130061","volume":"3","author":"AM Farrar","year":"2014","unstructured":"Farrar, A.M. et al. Cognitive deficits in transgenic and knock-in HTT mice parallel those in Huntington's disease. J. Huntingtons Dis. 3, 145\u2013158 (2014).","journal-title":"J. Huntingtons Dis."},{"key":"BFnbt3587_CR19","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/ng1297-404","volume":"17","author":"JK White","year":"1997","unstructured":"White, J.K. et al. Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. Nat. Genet. 17, 404\u2013410 (1997).","journal-title":"Nat. Genet."},{"key":"BFnbt3587_CR20","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.nbd.2008.10.009","volume":"33","author":"I Dragatsis","year":"2009","unstructured":"Dragatsis, I. et al. CAG repeat lengths > or = 335 attenuate the phenotype in the R6\/2 Huntington's disease transgenic mouse. Neurobiol. Dis. 33, 315\u2013330 (2009).","journal-title":"Neurobiol. Dis."},{"key":"BFnbt3587_CR21","doi-asserted-by":"crossref","unstructured":"Meghanathan, N., Nagamalai, D. & Chaki, N. Advances in Computing and Information Technology Vol. 177 (Springer, 2013).","DOI":"10.1007\/978-3-642-31552-7"},{"key":"BFnbt3587_CR22","doi-asserted-by":"crossref","unstructured":"Geisser, S. Predictive Inference: An Introduction (Springer Science + Business Media, 1993).","DOI":"10.1007\/978-1-4899-4467-2"},{"key":"BFnbt3587_CR23","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.brainresbull.2011.03.012","volume":"88","author":"RC Trueman","year":"2012","unstructured":"Trueman, R.C., Jones, L., Dunnett, S.B. & Brooks, S.P. Early onset deficits on the delayed alternation task in the Hdh(Q92) knock-in mouse model of Huntington's disease. Brain Res. Bull. 88, 156\u2013162 (2012).","journal-title":"Brain Res. Bull."},{"key":"BFnbt3587_CR24","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.bbr.2009.05.006","volume":"203","author":"RC Trueman","year":"2009","unstructured":"Trueman, R.C., Brooks, S.P., Jones, L. & Dunnett, S.B. Rule learning, visuospatial function and motor performance in the Hdh(Q92) knock-in mouse model of Huntington's disease. Behav. Brain Res. 203, 215\u2013222 (2009).","journal-title":"Behav. Brain Res."},{"key":"BFnbt3587_CR25","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.bbr.2008.01.020","volume":"189","author":"RC Trueman","year":"2008","unstructured":"Trueman, R.C., Brooks, S.P., Jones, L. & Dunnett, S.B. Time course of choice reaction time deficits in the Hdh(Q92) knock-in mouse model of Huntington's disease in the operant serial implicit learning task (SILT). Behav. Brain Res. 189, 317\u2013324 (2008).","journal-title":"Behav. Brain Res."},{"key":"BFnbt3587_CR26","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.brainresbull.2010.05.003","volume":"88","author":"S Brooks","year":"2010","unstructured":"Brooks, S., Higgs, G., Jones, L. & Dunnett, S.B. Longitudinal analysis of the behavioural phenotype in Hdh(Q92) Huntington's disease knock-in mice. Brain Res. Bull. 88, 148\u2013155 (2010).","journal-title":"Brain Res. Bull."},{"key":"BFnbt3587_CR27","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/0091-3057(86)90266-2","volume":"25","author":"MA Geyer","year":"1986","unstructured":"Geyer, M.A., Russo, P.V. & Masten, V.L. Multivariate assessment of locomotor behavior: pharmacological and behavioral analyses. Pharmacol. Biochem. Behav. 25, 277\u2013288 (1986).","journal-title":"Pharmacol. Biochem. Behav."},{"key":"BFnbt3587_CR28","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1021\/cc7001205","volume":"10","author":"RA Houghten","year":"2008","unstructured":"Houghten, R.A. et al. Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods. J. Comb. Chem. 10, 3\u201319 (2008).","journal-title":"J. Comb. Chem."},{"key":"BFnbt3587_CR29","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fnins.2011.00103","volume":"5","author":"SL Roberds","year":"2011","unstructured":"Roberds, S.L., Filippov, I., Alexandrov, V., Hanania, T. & Brunner, D. Rapid, computer vision-enabled murine screening system identifies neuropharmacological potential of two new mechanisms. Front. Neurosci. 5, 103 (2011).","journal-title":"Front. Neurosci."},{"key":"BFnbt3587_CR30","first-page":"RRN1225","volume":"3","author":"S Oakeshott","year":"2011","unstructured":"Oakeshott, S. et al. Circadian abnormalities in motor activity in a BAC transgenic mouse model of Huntington's disease. PLoS Curr. 3, RRN1225 (2011).","journal-title":"PLoS Curr."},{"key":"BFnbt3587_CR31","first-page":"e4f972cffe982c9","volume":"4","author":"S Oakeshott","year":"2012","unstructured":"Oakeshott, S. et al. A mixed fixed ratio\/progressive ratio procedure reveals an apathy phenotype in the BAC HD and the z_Q175 KI mouse models of Huntington's disease. PLoS Curr. 4, e4f972cffe982c970 (2012).","journal-title":"PLoS Curr."},{"key":"BFnbt3587_CR32","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.nbd.2006.09.015","volume":"25","author":"NI Wood","year":"2007","unstructured":"Wood, N.I., Pallier, P.N., Wanderer, J. & Morton, A.J. Systemic administration of Congo red does not improve motor or cognitive function in R6\/2 mice. Neurobiol. Dis. 25, 342\u2013353 (2007).","journal-title":"Neurobiol. Dis."},{"key":"BFnbt3587_CR33","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.beproc.2011.10.011","volume":"89","author":"D Brunner","year":"2012","unstructured":"Brunner, D., Balci, F. & Ludvig, E.A. Comparative psychology and the grand challenge of drug discovery in psychiatry and neurodegeneration. Behav. Processes 89, 187\u2013195 (2012).","journal-title":"Behav. Processes"},{"key":"BFnbt3587_CR34","doi-asserted-by":"publisher","first-page":"e9793","DOI":"10.1371\/journal.pone.0009793","volume":"5","author":"LB Menalled","year":"2010","unstructured":"Menalled, L.B. et al. Comprehensive behavioral testing in the R6\/2 mouse model of Huntington's disease shows no benefit from CoQ10 or minocycline. PLoS One 5, e9793 (2010).","journal-title":"PLoS One"},{"key":"BFnbt3587_CR35","doi-asserted-by":"crossref","unstructured":"Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 57, 397\u2013404 (2001).","DOI":"10.1212\/WNL.57.3.397"},{"key":"BFnbt3587_CR36","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s00401-008-0465-0","volume":"117","author":"CD Keene","year":"2009","unstructured":"Keene, C.D. et al. A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesions. Acta Neuropathol. 117, 329\u2013338 (2009).","journal-title":"Acta Neuropathol."},{"key":"BFnbt3587_CR37","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1358\/dnp.2010.23.8.1500435","volume":"23","author":"I Bezprozvanny","year":"2010","unstructured":"Bezprozvanny, I. The rise and fall of Dimebon. Drug News Perspect. 23, 518\u2013523 (2010).","journal-title":"Drug News Perspect."},{"key":"BFnbt3587_CR38","unstructured":"Huntington Study Group TREND-HD Investigators. Randomized controlled trial of ethyl-eicosapentaenoic acid in Huntington disease: the TREND-HD study. Arch. Neurol. 65, 1582\u20131589 (2008)."},{"key":"BFnbt3587_CR39","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/j.neuropharm.2010.10.025","volume":"60","author":"S Subramaniam","year":"2011","unstructured":"Subramaniam, S. & Snyder, S.H. Huntington's disease is a disorder of the corpus striatum: focus on Rhes (Ras homologue enriched in the striatum). Neuropharmacology 60, 1187\u20131192 (2011).","journal-title":"Neuropharmacology"},{"key":"BFnbt3587_CR40","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/nchembio.79","volume":"4","author":"A Williams","year":"2008","unstructured":"Williams, A. et al. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat. Chem. Biol. 4, 295\u2013305 (2008).","journal-title":"Nat. Chem. Biol."},{"key":"BFnbt3587_CR41","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1038\/ng1542","volume":"37","author":"F Giorgini","year":"2005","unstructured":"Giorgini, F., Guidetti, P., Nguyen, Q., Bennett, S.C. & Muchowski, P.J. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Nat. Genet. 37, 526\u2013531 (2005).","journal-title":"Nat. Genet."},{"key":"BFnbt3587_CR42","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nrd870","volume":"1","author":"TW Stone","year":"2002","unstructured":"Stone, T.W. & Darlington, L.G. Endogenous kynurenines as targets for drug discovery and development. Nat. Rev. Drug Discov. 1, 609\u2013620 (2002).","journal-title":"Nat. Rev. Drug Discov."},{"key":"BFnbt3587_CR43","doi-asserted-by":"publisher","first-page":"e6536","DOI":"10.1371\/journal.pone.0006536","volume":"4","author":"G Hu","year":"2009","unstructured":"Hu, G. & Agarwal, P. Human disease-drug network based on genomic expression profiles. PLoS One 4, e6536 (2009).","journal-title":"PLoS One"},{"key":"BFnbt3587_CR44","doi-asserted-by":"publisher","unstructured":"Balci, F. et al. High-throughput automated phenotyping of two genetic mouse models of Huntington's disease. PLoS Curr. http:\/\/dx.doi.org\/10.1371\/currents.hd.124aa0d16753f88215776fba102ceb29 (2013).","DOI":"10.1371\/currents.hd.124aa0d16753f88215776fba102ceb29"},{"key":"BFnbt3587_CR45","unstructured":"Cichocki, A. & Amari, S. Adaptive Blind Signal and Image Processing: Learning Algorithms and Applications (Wiley, 2006)."},{"key":"BFnbt3587_CR46","doi-asserted-by":"crossref","unstructured":"Chang, C.-C. & Lin, C.-J. in LIBSVM: A Library for Support Vector Machines Vol. 2 (ACM, 2011).","DOI":"10.1145\/1961189.1961199"},{"key":"BFnbt3587_CR47","unstructured":"Steel, R.G.D. & Torrie, J.H. Principles and Procedures of Statistics with Special Reference to the Biological Sciences (McGraw-Hill, 1960)."}],"container-title":["Nature Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nbt.3587.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt.3587","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt.3587.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T18:34:00Z","timestamp":1684434840000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nbt.3587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,4]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["BFnbt3587"],"URL":"https:\/\/doi.org\/10.1038\/nbt.3587","relation":{},"ISSN":["1087-0156","1546-1696"],"issn-type":[{"value":"1087-0156","type":"print"},{"value":"1546-1696","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,4]]},"assertion":[{"value":"11 March 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2016","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2016","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"V.A., D.B., L.B.M., A.K., J.W.-J., M.M., I.R., M.C.R., J.T., E.S., A.S., M.G., I.F., K.C., M.K., A.G. and S.R. are employees of PsychoGenics.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}