{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:30:21Z","timestamp":1790429421520,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Biotechnol"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1038\/nbt.3942","type":"journal-article","created":{"date-parts":[[2017,8,22]],"date-time":"2017-08-22T14:51:54Z","timestamp":1503413514000},"page":"879-884","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":181,"title":["An atlas of B-cell clonal distribution in the human body"],"prefix":"10.1038","volume":"35","author":[{"given":"Wenzhao","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bochao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory W","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M","family":"Rosenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqiu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J C","family":"Thome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6008-5868","authenticated-orcid":false,"given":"Dustin J","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhide","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harvey","family":"Lerner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy L","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomer","family":"Granot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna L","family":"Farber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J","family":"Shlomchik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uri","family":"Hershberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9478-9211","authenticated-orcid":false,"given":"Eline T","family":"Luning Prak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,21]]},"reference":[{"key":"BFnbt3942_CR1","doi-asserted-by":"publisher","first-page":"3180","DOI":"10.1073\/pnas.81.10.3180","volume":"81","author":"D McKean","year":"1984","unstructured":"McKean, D. et al. Generation of antibody diversity in the immune response of BALB\/c mice to influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA 81, 3180\u20133184 (1984).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt3942_CR2","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/0092-8674(91)90289-B","volume":"67","author":"C Berek","year":"1991","unstructured":"Berek, C., Berger, A. & Apel, M. Maturation of the immune response in germinal centers. Cell 67, 1121\u20131129 (1991).","journal-title":"Cell"},{"key":"BFnbt3942_CR3","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1038\/2281045a0","volume":"228","author":"MG Weigert","year":"1970","unstructured":"Weigert, M.G., Cesari, I.M., Yonkovich, S.J. & Cohn, M. Variability in the lambda light chain sequences of mouse antibody. Nature 228, 1045\u20131047 (1970).","journal-title":"Nature"},{"key":"BFnbt3942_CR4","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/354389a0","volume":"354","author":"J Jacob","year":"1991","unstructured":"Jacob, J., Kelsoe, G., Rajewsky, K. & Weiss, U. Intraclonal generation of antibody mutants in germinal centres. Nature 354, 389\u2013392 (1991).","journal-title":"Nature"},{"key":"BFnbt3942_CR5","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1038\/1811419a0","volume":"181","author":"GJ Nossal","year":"1958","unstructured":"Nossal, G.J. & Lederberg, J. Antibody production by single cells. Nature 181, 1419\u20131420 (1958).","journal-title":"Nature"},{"issue":"Suppl. 2","key":"BFnbt3942_CR6","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1016\/j.jaci.2009.09.046","volume":"125","author":"HW Schroeder Jr.","year":"2010","unstructured":"Schroeder, H.W. Jr. & Cavacini, L. Structure and function of immunoglobulins. J. Allergy Clin. Immunol. 125 (Suppl. 2), S41\u2013S52 (2010).","journal-title":"J. Allergy Clin. Immunol."},{"key":"BFnbt3942_CR7","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1006\/smim.1996.0003","volume":"8","author":"FG Kroese","year":"1996","unstructured":"Kroese, F.G., de Waard, R. & Bos, N.A. B-1 cells and their reactivity with the murine intestinal microflora. Semin. Immunol. 8, 11\u201318 (1996).","journal-title":"Semin. Immunol."},{"key":"BFnbt3942_CR8","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/ni.3213","volume":"16","author":"C Lindner","year":"2015","unstructured":"Lindner, C. et al. Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nat. Immunol. 16, 880\u2013888 (2015).","journal-title":"Nat. Immunol."},{"key":"BFnbt3942_CR9","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.4049\/jimmunol.172.2.1118","volume":"172","author":"KJ Rhee","year":"2004","unstructured":"Rhee, K.J., Sethupathi, P., Driks, A., Lanning, D.K. & Knight, K.L. Role of commensal bacteria in development of gut-associated lymphoid tissues and preimmune antibody repertoire. J. Immunol. 172, 1118\u20131124 (2004).","journal-title":"J. Immunol."},{"key":"BFnbt3942_CR10","doi-asserted-by":"publisher","first-page":"4610","DOI":"10.4049\/jimmunol.1300692","volume":"192","author":"A Benitez","year":"2014","unstructured":"Benitez, A. et al. Differences in mouse and human nonmemory B cell pools. J. Immunol. 192, 4610\u20134619 (2014).","journal-title":"J. Immunol."},{"key":"BFnbt3942_CR11","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1111\/imm.12469","volume":"145","author":"BS Steiniger","year":"2015","unstructured":"Steiniger, B.S. Human spleen microanatomy: why mice do not suffice. Immunology 145, 334\u2013346 (2015).","journal-title":"Immunology"},{"key":"BFnbt3942_CR12","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/j.cell.2014.10.026","volume":"159","author":"JJ Thome","year":"2014","unstructured":"Thome, J.J. et al. Spatial map of human T cell compartmentalization and maintenance over decades of life. Cell 159, 814\u2013828 (2014).","journal-title":"Cell"},{"key":"BFnbt3942_CR13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.immuni.2012.09.020","volume":"38","author":"T Sathaliyawala","year":"2013","unstructured":"Sathaliyawala, T. et al. Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity 38, 187\u2013197 (2013).","journal-title":"Immunity"},{"key":"BFnbt3942_CR14","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/nm.4008","volume":"22","author":"JJ Thome","year":"2016","unstructured":"Thome, J.J. et al. Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues. Nat. Med. 22, 72\u201377 (2016).","journal-title":"Nat. Med."},{"key":"BFnbt3942_CR15","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/cyto.b.21322","volume":"90","author":"BD Vallangeon","year":"2016","unstructured":"Vallangeon, B.D., Tyer, C., Williams, B. & Lagoo, A.S. Improved detection of diffuse large B-cell lymphoma by flow cytometric immunophenotyping-Effect of tissue disaggregation method. Cytometry B Clin. Cytom. 90, 455\u2013461 (2016).","journal-title":"Cytometry B Clin. Cytom."},{"key":"BFnbt3942_CR16","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1038\/290562a0","volume":"290","author":"H Sakano","year":"1981","unstructured":"Sakano, H., Kurosawa, Y., Weigert, M. & Tonegawa, S. Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genes. Nature 290, 562\u2013565 (1981).","journal-title":"Nature"},{"key":"BFnbt3942_CR17","doi-asserted-by":"publisher","first-page":"20216","DOI":"10.1073\/pnas.0909775106","volume":"106","author":"J Glanville","year":"2009","unstructured":"Glanville, J. et al. Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire. Proc. Natl. Acad. Sci. USA 106, 20216\u201320221 (2009).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt3942_CR18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.jim.2015.10.009","volume":"427","author":"B Zhang","year":"2015","unstructured":"Zhang, B., Meng, W., Luning Prak, E.T. & Hershberg, U. Discrimination of germline V genes at different sequencing lengths and mutational burdens: A new tool for identifying and evaluating the reliability of V gene assignment. J. Immunol. Methods 427, 105\u2013116 (2015).","journal-title":"J. Immunol. Methods"},{"key":"BFnbt3942_CR19","doi-asserted-by":"publisher","first-page":"20140239","DOI":"10.1098\/rstb.2014.0239","volume":"370","author":"U Hershberg","year":"2015","unstructured":"Hershberg, U. & Luning Prak, E.T. The analysis of clonal expansions in normal and autoimmune B cell repertoires. Phil. Trans. R. Soc. Lond. B 370, 20140239 (2015).","journal-title":"Phil. Trans. R. Soc. Lond. B"},{"key":"BFnbt3942_CR20","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13073-015-0243-2","volume":"7","author":"G Yaari","year":"2015","unstructured":"Yaari, G. & Kleinstein, S.H. Practical guidelines for B-cell receptor repertoire sequencing analysis. Genome Med. 7, 121 (2015).","journal-title":"Genome Med."},{"key":"BFnbt3942_CR21","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1093\/jpe\/rtr044","volume":"5","author":"RK Colwell","year":"2012","unstructured":"Colwell, R.K. et al. Models and estimators linking individual-based and sample based rarefaction, extrapolation and comparison of assemblages. J. Plant Ecol. 5, 3\u201321 (2012).","journal-title":"J. Plant Ecol."},{"key":"BFnbt3942_CR22","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1158\/1055-9965.EPI-12-1348","volume":"22","author":"LR Goldin","year":"2013","unstructured":"Goldin, L.R., McMaster, M.L. & Caporaso, N.E. Precursors to lymphoproliferative malignancies. Cancer Epidemiol. Biomarkers Prev. 22, 533\u2013539 (2013).","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"BFnbt3942_CR23","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/bioinformatics\/btw593","volume":"33","author":"AM Rosenfeld","year":"2017","unstructured":"Rosenfeld, A.M., Meng, W., Luning Prak, E.T. & Hershberg, U. ImmuneDB: a system for the analysis and exploration of high-throughput adaptive immune receptor sequencing data. Bioinformatics 33, 292\u2013293 (2017).","journal-title":"Bioinformatics"},{"key":"BFnbt3942_CR24","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1093\/bioinformatics\/btl478","volume":"22","author":"L Sheneman","year":"2006","unstructured":"Sheneman, L., Evans, J. & Foster, J.A. Clearcut: a fast implementation of relaxed neighbor joining. Bioinformatics 22, 2823\u20132824 (2006).","journal-title":"Bioinformatics"},{"key":"BFnbt3942_CR25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.patrec.2016.01.011","volume":"74","author":"GW Schwartz","year":"2016","unstructured":"Schwartz, G.W., Shokoufandeh, A., Ontanon, S. & Hershberg, U. Using a novel clumpiness measure to unite data with metadata: Finding common sequence patterns in immune receptor germline V genes. Pattern Recognit. Lett. 74, 24\u201329 (2016).","journal-title":"Pattern Recognit. Lett."},{"key":"BFnbt3942_CR26","doi-asserted-by":"publisher","first-page":"4871","DOI":"10.4049\/jimmunol.0901315","volume":"183","author":"S Yuvaraj","year":"2009","unstructured":"Yuvaraj, S. et al. Evidence for local expansion of IgA plasma cell precursors in human ileum. J. Immunol. 183, 4871\u20134878 (2009).","journal-title":"J. Immunol."},{"key":"BFnbt3942_CR27","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1098\/rspb.1964.0001","volume":"159","author":"JL Gowans","year":"1964","unstructured":"Gowans, J.L. & Knight, E.J. The route of re-circulation of lymphocytes in the rat. Proc. R. Soc. Lond. B Biol. Sci. 159, 257\u2013282 (1964).","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"BFnbt3942_CR28","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.4049\/jimmunol.122.5.1892","volume":"122","author":"MR McDermott","year":"1979","unstructured":"McDermott, M.R. & Bienenstock, J. Evidence for a common mucosal immunologic system. I. Migration of B immunoblasts into intestinal, respiratory, and genital tissues. J. Immunol. 122, 1892\u20131898 (1979).","journal-title":"J. Immunol."},{"key":"BFnbt3942_CR29","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1073\/pnas.81.7.2162","volume":"81","author":"S Rudikoff","year":"1984","unstructured":"Rudikoff, S., Pawlita, M., Pumphrey, J. & Heller, M. Somatic diversification of immunoglobulins. Proc. Natl. Acad. Sci. USA 81, 2162\u20132166 (1984).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt3942_CR30","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1002\/j.1460-2075.1985.tb03635.x","volume":"4","author":"F Sablitzky","year":"1985","unstructured":"Sablitzky, F., Wildner, G. & Rajewsky, K. Somatic mutation and clonal expansion of B cells in an antigen-driven immune response. EMBO J. 4, 345\u2013350 (1985).","journal-title":"EMBO J."},{"key":"BFnbt3942_CR31","doi-asserted-by":"publisher","first-page":"e100839","DOI":"10.1371\/journal.pone.0100839","volume":"9","author":"BS Briney","year":"2014","unstructured":"Briney, B.S., Willis, J.R., Finn, J.A., McKinney, B.A. & Crowe, J.E. Jr. Tissue-specific expressed antibody variable gene repertoires. PLoS One 9, e100839 (2014).","journal-title":"PLoS One"},{"key":"BFnbt3942_CR32","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.smim.2009.01.003","volume":"21","author":"J Spencer","year":"2009","unstructured":"Spencer, J., Barone, F. & Dunn-Walters, D. Generation of immunoglobulin diversity in human gut-associated lymphoid tissue. Semin. Immunol. 21, 139\u2013146 (2009).","journal-title":"Semin. Immunol."},{"key":"BFnbt3942_CR33","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/eji.1830270217","volume":"27","author":"DK Dunn-Walters","year":"1997","unstructured":"Dunn-Walters, D.K., Isaacson, P.G. & Spencer, J. Sequence analysis of human IgVH genes indicates that ileal lamina propria plasma cells are derived from Peyer's patches. Eur. J. Immunol. 27, 463\u2013467 (1997).","journal-title":"Eur. J. Immunol."},{"key":"BFnbt3942_CR34","doi-asserted-by":"publisher","first-page":"W499","DOI":"10.1093\/nar\/gkr413","volume":"39","author":"M Uduman","year":"2011","unstructured":"Uduman, M. et al. Detecting selection in immunoglobulin sequences. Nucleic Acids Res. 39, W499\u2013W504 (2011).","journal-title":"Nucleic Acids Res."},{"key":"BFnbt3942_CR35","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1093\/intimm\/dxn026","volume":"20","author":"U Hershberg","year":"2008","unstructured":"Hershberg, U., Uduman, M., Shlomchik, M.J. & Kleinstein, S.H. Improved methods for detecting selection by mutation analysis of Ig V region sequences. Int. Immunol. 20, 683\u2013694 (2008).","journal-title":"Int. Immunol."},{"key":"BFnbt3942_CR36","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1053\/gast.2000.20219","volume":"119","author":"W Holtmeier","year":"2000","unstructured":"Holtmeier, W., Hennemann, A. & Caspary, W.F. IgA and IgM V(H) repertoires in human colon: evidence for clonally expanded B cells that are widely disseminated. Gastroenterology 119, 1253\u20131266 (2000).","journal-title":"Gastroenterology"},{"key":"BFnbt3942_CR37","doi-asserted-by":"publisher","first-page":"3704","DOI":"10.1038\/ncomms4704","volume":"5","author":"K Masahata","year":"2014","unstructured":"Masahata, K. et al. Generation of colonic IgA-secreting cells in the caecal patch. Nat. Commun. 5, 3704 (2014).","journal-title":"Nat. Commun."},{"key":"BFnbt3942_CR38","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.4049\/jimmunol.1402708","volume":"195","author":"MA Berkowska","year":"2015","unstructured":"Berkowska, M.A. et al. Circulating human CD27-IgA+ memory B cells recognize bacteria with polyreactive Igs. J. Immunol. 195, 1417\u20131426 (2015).","journal-title":"J. Immunol."},{"key":"BFnbt3942_CR39","doi-asserted-by":"publisher","first-page":"e1501371","DOI":"10.1126\/sciadv.1501371","volume":"2","author":"TA Khan","year":"2016","unstructured":"Khan, T.A. et al. Accurate and predictive antibody repertoire profiling by molecular amplification fingerprinting. Sci. Adv. 2, e1501371 (2016).","journal-title":"Sci. Adv."},{"key":"BFnbt3942_CR40","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.4049\/jimmunol.1601850","volume":"198","author":"NT Gupta","year":"2017","unstructured":"Gupta, N.T. et al. Hierarchical clustering can identify B cell clones with high confidence in ig repertoire sequencing data. J. Immunol. 198, 2489\u20132499 (2017).","journal-title":"J. Immunol."},{"key":"BFnbt3942_CR41","doi-asserted-by":"publisher","first-page":"e1005086","DOI":"10.1371\/journal.pcbi.1005086","volume":"12","author":"DK Ralph","year":"2016","unstructured":"Ralph, D.K. & Matsen, F.A. IV Likelihood-based inference of B cell clonal families. PLoS Comput. Biol. 12, e1005086 (2016).","journal-title":"PLoS Comput. Biol."},{"key":"BFnbt3942_CR42","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","volume":"17","author":"JJ van Dongen","year":"2003","unstructured":"van Dongen, J.J. et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia 17, 2257\u20132317 (2003).","journal-title":"Leukemia"},{"key":"BFnbt3942_CR43","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fimmu.2014.00010","volume":"5","author":"W Meng","year":"2014","unstructured":"Meng, W. et al. Trials and tribulations with VH replacement. Front. Immunol. 5, 10 (2014).","journal-title":"Front. Immunol."},{"key":"BFnbt3942_CR44","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1093\/bioinformatics\/btu138","volume":"30","author":"JA Vander Heiden","year":"2014","unstructured":"Vander Heiden, J.A. et al. pRESTO: a toolkit for processing high-throughput sequencing raw reads of lymphocyte receptor repertoires. Bioinformatics 30, 1930\u20131932 (2014).","journal-title":"Bioinformatics"},{"key":"BFnbt3942_CR45","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.1093\/nar\/gku1341","volume":"43","author":"M Schirmer","year":"2015","unstructured":"Schirmer, M. et al. Insight into biases and sequencing errors for amplicon sequencing with the Illumina MiSeq platform. Nucleic Acids Res. 43, e37 (2015).","journal-title":"Nucleic Acids Res."},{"key":"BFnbt3942_CR46","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3389\/fimmu.2013.00357","volume":"4","author":"GW Schwartz","year":"2013","unstructured":"Schwartz, G.W. & Hershberg, U. Germline amino acid diversity in B cell receptors is a good predictor of somatic selection pressures. Front. Immunol. 4, 357 (2013).","journal-title":"Front. Immunol."},{"key":"BFnbt3942_CR47","doi-asserted-by":"publisher","first-page":"035005","DOI":"10.1088\/1478-3975\/10\/3\/035005","volume":"10","author":"GW Schwartz","year":"2013","unstructured":"Schwartz, G.W. & Hershberg, U. Conserved variation: identifying patterns of stability and variability in BCR and TCR V genes with different diversity and richness metrics. Phys. Biol. 10, 035005 (2013).","journal-title":"Phys. Biol."},{"key":"BFnbt3942_CR48","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/nmeth.3364","volume":"12","author":"DA Bolotin","year":"2015","unstructured":"Bolotin, D.A. et al. MiXCR: software for comprehensive adaptive immunity profiling. Nat. Methods 12, 380\u2013381 (2015).","journal-title":"Nat. Methods"},{"key":"BFnbt3942_CR49","doi-asserted-by":"publisher","first-page":"e1004503","DOI":"10.1371\/journal.pcbi.1004503","volume":"11","author":"M Shugay","year":"2015","unstructured":"Shugay, M. et al. VDJtools: unifying post-analysis of T cell receptor repertoires. PLoS Comput. Biol. 11, e1004503 (2015).","journal-title":"PLoS Comput. Biol."}],"container-title":["Nature Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/nbt.3942.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/nbt.3942","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nbt.3942","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/www.nature.com\/articles\/nbt.3942.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T05:40:07Z","timestamp":1692942007000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nbt.3942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,21]]},"references-count":49,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["BFnbt3942"],"URL":"https:\/\/doi.org\/10.1038\/nbt.3942","relation":{},"ISSN":["1087-0156","1546-1696"],"issn-type":[{"value":"1087-0156","type":"print"},{"value":"1546-1696","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,21]]},"assertion":[{"value":"20 December 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}