{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:23:18Z","timestamp":1784128998110,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[1997,10,1]],"date-time":"1997-10-01T00:00:00Z","timestamp":875664000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Biotechnol"],"published-print":{"date-parts":[[1997,10]]},"DOI":"10.1038\/nbt1097-992","type":"journal-article","created":{"date-parts":[[2004,8,18]],"date-time":"2004-08-18T22:34:07Z","timestamp":1092868447000},"page":"992-996","source":"Crossref","is-referenced-by-count":65,"title":["Plant resistance to fungal infection induced by nontoxic pokeweed antiviral protein mutants"],"prefix":"10.1038","volume":"15","author":[{"given":"Oleg","family":"Zoubenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"Uckun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonkang","family":"Hur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IIan","family":"Chet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilgun","family":"Tumer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"BFnbt1097992_CR1","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1105\/tpc.8.10.1809","volume":"8","author":"JA Ryals","year":"1996","unstructured":"Ryals, J.A., Neuenschwander, U.H., Willits, M.G., Molina, A., Steiner, H.-Y., and Hunt, M. 1996. Systemic acquired resistance. Plant Cell 8: 1809\u20131819.","journal-title":"Plant Cell"},{"key":"BFnbt1097992_CR2","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1105\/tpc.8.10.1773","volume":"8","author":"KE Hammond-Kosack","year":"1996","unstructured":"Hammond-Kosack, K.E. and Jones, J.D.G. 1996. Resistance gene-dependent plant defense responses. Plant Cell 8: 1773\u20131791.","journal-title":"Plant Cell"},{"key":"BFnbt1097992_CR3","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1105\/tpc.8.10.1793","volume":"8","author":"JL Dangl","year":"1996","unstructured":"Dangl, J.L., Dietrich, R.A., and Richberg, M.H. 1996. Death don't have no mercy: Cell death programs in plant-microbe interactions. Plant Cell 8: 1793\u20131807.","journal-title":"Plant Cell"},{"key":"BFnbt1097992_CR4","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/0042-6822(61)90319-1","volume":"14","author":"AF Ross","year":"1961","unstructured":"Ross, A.F. 1961. Systemic acquired resistance induced by localized virus infections in plants. Virology 14: 340\u2013358.","journal-title":"Virology"},{"key":"BFnbt1097992_CR5","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1105\/tpc.7.10.1691","volume":"7","author":"V Shulaev","year":"1995","unstructured":"Shulaev, V., Leon, J., and Raskin, L. 1995. Is salicylic acid a translocated signal of systemic acquired resistance in tobacco? Plant Cell 7: 1691\u20131701.","journal-title":"Plant Cell"},{"key":"BFnbt1097992_CR6","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1105\/tpc.6.7.959","volume":"6","author":"B Vernooij","year":"1994","unstructured":"Vernooij, B., Friedrich, L., Morse, A., Reist, R., Kolditz-Jawhar, R., Ward, E., et al. 1994. Salicylic acid is not the translocated signal responsible for inducing systemic acquired resistance but is required in signal transduction. Plant Cell 6: 959\u2013965.","journal-title":"Plant Cell"},{"key":"BFnbt1097992_CR7","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1126\/science.254.5035.1194","volume":"264","author":"K Broglie","year":"1991","unstructured":"Broglie, K., Chet, I., Holliday, M., Cressman, R., Biddle, P., Knowlton, S., et al. 1991. Transgenic plants with enhanced resistance to the fungal pathogen Rhizoctonia solani. Science 264: 1194\u20131197.","journal-title":"Science"},{"key":"BFnbt1097992_CR8","doi-asserted-by":"publisher","first-page":"7327","DOI":"10.1073\/pnas.90.15.7327","volume":"90","author":"D Alexander","year":"1993","unstructured":"Alexander, D., Goodman, R.M., Gut-Relfa, M., Glascock, C., Weymann, K., Friedrich, L., et al. 1993. Increased tolerance to two Oomycete pathogens in transgenic tobacco expressing pathogenesis-related protein 1a. Proc. Natl. Acad. Sci. USA 90: 7327\u20137331.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt1097992_CR9","unstructured":"Vierheilig, H., Alt, M., Neuhaus, J., Boiler, T., and Wiemken, A. 1993. Colonization of transgenic Nicotiana sylvestris plants, expressing different forms of Nicotiana tabacum chitinase, by the root pathogen Rhizoctonia solani and by the mycor-rhizal symbiont Glomus mosseae. Mol. Plant Microbe Interact. 6: 261\u2013264."},{"key":"BFnbt1097992_CR10","first-page":"807","volume":"12","author":"Q Zhu","year":"1994","unstructured":"Zhu, Q., Maher, E.A., Masoud, S., Dixon, R.A., and Lamb, C.J. 1994. Enhanced protection against fungal attack by constitutive co-expression of chitinase and glucanase genes in transgenic tobacco. Bio\/Technology 12: 807\u2013812.","journal-title":"Bio\/Technology"},{"key":"BFnbt1097992_CR11","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nbt0492-405","volume":"10","author":"F Stirpe","year":"1992","unstructured":"Stirpe, F., Barbieri, L., Battelli, L.G., Soria, M., and Lappi, D.A. 1992. Ribosome-inactivating proteins from plants: present status and future prospects. Bio\/Technology 10: 405\u2013412.","journal-title":"Bio\/Technology"},{"key":"BFnbt1097992_CR12","first-page":"237","volume":"1154","author":"L Barbieri","year":"1993","unstructured":"Barbieri, L., Battelli, M.G., and Stirpe, F. 1993. Ribosome-inactivating proteins from plants. Biochem. Biophys. Acta. 1154: 237\u2013282.","journal-title":"Biochem. Biophys. Acta."},{"key":"BFnbt1097992_CR13","first-page":"65","volume-title":"Antiviral proteins in higher plants","author":"JD Irvin","year":"1995","unstructured":"Irvin, J.D. 1995. Antiviral proteins from Phytolacca. pp. 65\u201394.in Antiviral proteins in higher plants. Chessin, M., DeBorde, D., and Zipf, A. (eds.) CRC Press, Boca Raton, FL."},{"key":"BFnbt1097992_CR14","first-page":"224","volume":"994","author":"Y Endo","year":"1988","unstructured":"Endo, Y., Tsurugi, K., and Ebert, R.F. 1988. The mechanism of action of barley toxin: a type 1 ribosome-inactivating protein with RNA N-glycosidase activity. Biochem. Biophys. Acta. 994: 224\u2013226.","journal-title":"Biochem. Biophys. Acta."},{"key":"BFnbt1097992_CR15","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1046\/j.1365-313X.1994.5060827.x","volume":"5","author":"S Taylor","year":"1994","unstructured":"Taylor, S., Massiach, A., Lomonossoff, G., Roberts, L.M., Lord, J.M., and Hartley, M. 1994. Correlation between the activities of five ribosome-inactivating proteins in depurination of tobacco ribosomes and inhibition of tobacco mosaic virus infection. Plant. J. 5: 827\u2013835.","journal-title":"Plant. J."},{"key":"BFnbt1097992_CR16","first-page":"305","volume":"10","author":"J Logemann","year":"1992","unstructured":"Logemann, J., Jach, G., Tommerup, H., Mundy, J., and Schell, J. 1992. Expression of barley ribosome-inactivating protein leads to increased fungal protection in transgenic tobacco plants. Bio\/Technology 10: 305\u2013308.","journal-title":"Bio\/Technology"},{"key":"BFnbt1097992_CR17","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1046\/j.1365-313X.1995.08010097.x","volume":"8","author":"G Jach","year":"1995","unstructured":"Jach, G., Gomhardt, B., Mundy, J., Logemann, J., Pinsdorf, E., Leah, R., et al. 1995. Enhanced quantitative resistance against fungal disease by combinatorial expression of different barley antifungal proteins in transgenic tobacco. Plant J. 8: 97\u2013109.","journal-title":"Plant J."},{"key":"BFnbt1097992_CR18","doi-asserted-by":"publisher","first-page":"7089","DOI":"10.1073\/pnas.90.15.7089","volume":"90","author":"JK Lodge","year":"1993","unstructured":"Lodge, J.K., Kaniewski, W.K., and Turner, N.E. 1993. Broad-spectrum virus resistance in transgenic plants expressing pokeweed antiviral protein. Proc. Natl. Acad. Sci. USA 90: 7089\u20137093.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt1097992_CR19","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1111\/j.1365-313X.1994.00397.x","volume":"5","author":"R Mittler","year":"1994","unstructured":"Mittler, R. and Zilinskas, B.A. 1994. Regulation of pea cytosolic ascorbate perox-idase and other antioxidant enzymes during the progression of draught stress and following recovery from draught. Plant J. 5: 397\u2013405.","journal-title":"Plant J."},{"key":"BFnbt1097992_CR20","doi-asserted-by":"publisher","first-page":"8448","DOI":"10.1073\/pnas.92.18.8448","volume":"92","author":"Y Hur","year":"1995","unstructured":"Hur, Y., Hwang, D.-J., Zoubenko, O., Coetzer, C., Uckun, F., and Turner, N.E. 1995. Isolation and characterization of pokeweed antiviral protein in Saccharomyces cerevisiae: identification of residues important for toxicity. Proc. Natl. Acad. Sci. USA 92: 8448\u20138452.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt1097992_CR21","doi-asserted-by":"publisher","first-page":"3866","DOI":"10.1073\/pnas.94.17.9063","volume":"94","author":"NE Turner","year":"1997","unstructured":"Turner, N.E., Hwang, D.J., and Bonness, M. 1997. C-terminal deletion mutant of pokeweed antiviral protein inhibits viral infection but does not depurinate host ribosomes. Proc. Natl. Acad. Sci. USA 94: 3866\u20133871.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"BFnbt1097992_CR22","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1094\/MPMI-3-252","volume":"3","author":"HJM Linthorst","year":"1990","unstructured":"Linthorst, H.J.M., van Loon, L.C., van Rossum, C.M.A., Mayer, A., Bol, J.F., van Roekel, J.S.C., et al. 1990. Analysis of acidic and basic chitinases from tobacco and petunia and their constitutive expression in transgenic tobacco. Mol. Plant Microbe Interact 3: 252\u2013258.","journal-title":"Mol. Plant Microbe Interact"},{"key":"BFnbt1097992_CR23","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1105\/tpc.3.8.809","volume":"3","author":"N Yalpani","year":"1991","unstructured":"Yalpani, N., Silverman, P., Wilson, T.M.A., Kleler, D.A., and Raskin, I. 1991. Salicylic acid is a systemic signal and an inducer of pathogenesis-related proteins in virus-infected tobacco. Plant Cell 3: 809\u2013818.","journal-title":"Plant Cell"},{"key":"BFnbt1097992_CR24","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1104\/pp.104.4.1109","volume":"104","author":"J Ryals","year":"1994","unstructured":"Ryals, J., Uknes, S., and Ward, E. 1994. Systemic acquired resistance. Plant Physiol. 104: 1109\u20131112.","journal-title":"Plant Physiol."},{"key":"BFnbt1097992_CR25","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1104\/pp.114.3.1113","volume":"114","author":"S Smirnov","year":"1997","unstructured":"Smirnov, S., Shulaev, V., and Turner, N.E. 1997. Expression of pokeweed antiviral protein in transgenic plants induces virus resistance in grafted wild type plants independent of salicylic acid accumulation and pathogenesis-related protein synthesis. Plant Physiol. 114: 1113\u20131121.","journal-title":"Plant Physiol."},{"key":"BFnbt1097992_CR26","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1094\/Phyto-83-702","volume":"83","author":"N Yalpani","year":"1993","unstructured":"Yalpani, N., Shulaev, V., and Raskin, I., 1993. Endogenous salicylic acid levels correlate with accumulation of pathogenesis-related proteins and virus resistance in tobacco. Phytopathology. 83: 702\u2013708.","journal-title":"Phytopathology."},{"key":"BFnbt1097992_CR27","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1146\/annurev.py.20.090182.001553","volume":"20","author":"NA Anderson","year":"1982","unstructured":"Anderson, N.A., 1982. The genetics and pathology of Rhizoctonia solani. Annu. Rev. Phytopathol. 20: 329\u2013327.","journal-title":"Annu. Rev. Phytopathol."},{"key":"BFnbt1097992_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1146\/annurev.py.25.090187.001013","volume":"25","author":"A Ogoshi","year":"1987","unstructured":"Ogoshi, A., 1987. Ecology and pathogenicity of anastomosis and intraspecific groups of Rhizoctonia solani Kuhn. Ann. Rev. Phytopathol. 25: 125\u2013143.","journal-title":"Ann. Rev. Phytopathol."},{"key":"BFnbt1097992_CR29","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1046\/j.1365-313X.1993.04020327.x","volume":"4","author":"JT Greenberg","year":"1993","unstructured":"Greenberg, J.T. and Ausubel, F.M. 1993. Arabidopsis mutants compromised for the control of cellular damage during pathogenesis and aging. Plant J. 4: 327\u2013341.","journal-title":"Plant J."},{"key":"BFnbt1097992_CR30","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/0092-8674(94)90218-6","volume":"77","author":"RA Dietrich","year":"1994","unstructured":"Dietrich, R.A., Delaney, T.P., Uknes, S.J., Ward, E.R., Ryals, J.A., and Dangl, J.L. 1994. Arabidopsis mutants stimulating disease response. Cell. 77: 565\u2013578.","journal-title":"Cell."},{"key":"BFnbt1097992_CR31","doi-asserted-by":"publisher","first-page":"5753","DOI":"10.1002\/j.1460-2075.1995.tb00264.x","volume":"14","author":"R Beffa","year":"1995","unstructured":"Beffa, R., Szell, M., Meuwly, P., Pay, A., Vogeli-Lange, R., Metraux, J.-P., et al. 1995. Cholera toxin elevates pathogen resistance and induces pathogenesis-related gene expression in tobacco. EMBO J. 14: 5753\u20135761.","journal-title":"EMBO J."},{"key":"BFnbt1097992_CR32","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1111\/j.1365-3059.1991.tb02426.x","volume":"40","author":"ZC Chen","year":"1991","unstructured":"Chen, Z.C., White, R.F., Antoniw, J.F., and Lin, Q. 1991. Effect of pokeweed antiviral protein (PAP) on the infection of plant viruses. Plant Pathology 40: 612\u2013620.","journal-title":"Plant Pathology"},{"key":"BFnbt1097992_CR33","first-page":"201","volume-title":"Statistical methods","author":"GW Snedecor","year":"1980","unstructured":"Snedecor, G.W. and Cochran, W.G. 1980. pp. 201\u2013202 in Statistical methods, 7th Ed. Iowa State University Press, Ames, IA."}],"container-title":["Nature Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nbt1097-992","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt1097-992.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nbt1097-992.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:37:44Z","timestamp":1684438664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nbt1097-992"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,10]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1997,10]]}},"alternative-id":["BFnbt1097992"],"URL":"https:\/\/doi.org\/10.1038\/nbt1097-992","relation":{},"ISSN":["1087-0156","1546-1696"],"issn-type":[{"value":"1087-0156","type":"print"},{"value":"1546-1696","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,10]]}}}