{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:00:44Z","timestamp":1791273644609,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2006,6,11]],"date-time":"2006-06-11T00:00:00Z","timestamp":1149984000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1038\/ncb1433","type":"journal-article","created":{"date-parts":[[2006,6,11]],"date-time":"2006-06-11T13:28:02Z","timestamp":1150032482000},"page":"756-763","source":"Crossref","is-referenced-by-count":155,"title":["Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners"],"prefix":"10.1038","volume":"8","author":[{"given":"Xiaoyang","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youngdong","family":"Yoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataly N.","family":"Okuhama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip W.","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Lin","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,6,11]]},"reference":[{"key":"BFncb1433_CR1","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.tcb.2004.07.009","volume":"14","author":"CA Blessing","year":"2004","unstructured":"Blessing, C. A., Ugrinova, G. T. & Goodson, H. V. Actin and ARPs: action in the nucleus. Trends Cell Biol. 14, 435\u2013442 (2004).","journal-title":"Trends Cell Biol."},{"key":"BFncb1433_CR2","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/nrm1370","volume":"5","author":"BT Bettinger","year":"2004","unstructured":"Bettinger, B. T., Gilbert, D. M. & Amberg, D. C. Actin up in the nucleus. Nature Rev. Mol. Cell Biol. 5, 410\u2013415 (2004).","journal-title":"Nature Rev. Mol. Cell Biol."},{"key":"BFncb1433_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S1047-8477(02)00528-2","volume":"140","author":"T Pederson","year":"2002","unstructured":"Pederson, T. & Aebi, U. Actin in the nucleus: what form and what for? J. Struct. Biol. 140, 3\u20139 (2002).","journal-title":"J. Struct. Biol."},{"key":"BFncb1433_CR4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/S0092-8674(00)80732-1","volume":"97","author":"R Rohatgi","year":"1999","unstructured":"Rohatgi, R. et al. The interaction between N-WASP and the Arp2\/3 complex links Cdc42-dependent signals to actin assembly. Cell 97, 221\u2013231 (1999).","journal-title":"Cell"},{"key":"BFncb1433_CR5","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1242\/jcs.114.10.1801","volume":"114","author":"T Takenawa","year":"2001","unstructured":"Takenawa, T. & Miki, H. WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement. J. Cell Sci. 114, 1801\u20131809 (2001).","journal-title":"J. Cell Sci."},{"key":"BFncb1433_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj20040176","volume":"380","author":"TH Millard","year":"2004","unstructured":"Millard, T. H., Sharp, S. J. & Machesky, L. M. Signalling to actin assembly via the WASP (Wiskott\u2013Aldrich syndrome protein)-family proteins and the Arp2\/3 complex. Biochem. J. 380, 1\u201317 (2004).","journal-title":"Biochem. J."},{"key":"BFncb1433_CR7","doi-asserted-by":"publisher","first-page":"9565","DOI":"10.1074\/jbc.M310739200","volume":"279","author":"X Wu","year":"2004","unstructured":"Wu, X., Suetsugu, S., Cooper, L. A., Takenawa, T. & Guan, J. L. Focal adhesion kinase regulation of N-WASP subcellular localization and function. J. Biol. Chem. 279, 9565\u20139576 (2004).","journal-title":"J. Biol. Chem."},{"key":"BFncb1433_CR8","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/S0955-0674(00)00193-9","volume":"13","author":"JE Bear","year":"2001","unstructured":"Bear, J. E., Krause, M. & Gertler, F. B. Regulating cellular actin assembly. Curr. Opin. Cell Biol. 13, 158\u2013166 (2001).","journal-title":"Curr. Opin. Cell Biol."},{"key":"BFncb1433_CR9","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1074\/jbc.M104555200","volume":"277","author":"S Vetterkind","year":"2002","unstructured":"Vetterkind, S. et al. The rat homologue of Wiskott\u2013Aldrich syndrome protein (WASP)-interacting protein (WIP) associates with actin filaments, recruits N-WASP from the nucleus, and mediates mobilization of actin from stress fibers in favor of filopodia formation. J. Biol. Chem. 277, 87\u201395 (2002).","journal-title":"J. Biol. Chem."},{"key":"BFncb1433_CR10","doi-asserted-by":"publisher","first-page":"5326","DOI":"10.1002\/j.1460-2075.1996.tb00917.x","volume":"15","author":"H Miki","year":"1996","unstructured":"Miki, H., Miura, K. & Takenawa, T. N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J. 15, 5326\u20135335 (1996).","journal-title":"EMBO J."},{"key":"BFncb1433_CR11","doi-asserted-by":"publisher","first-page":"42515","DOI":"10.1074\/jbc.M302177200","volume":"278","author":"S Suetsugu","year":"2003","unstructured":"Suetsugu, S. & Takenawa, T. Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90. J. Biol. Chem. 278, 42515\u201342523 (2003).","journal-title":"J. Biol. Chem."},{"key":"BFncb1433_CR12","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0014-5793(02)03447-6","volume":"531","author":"Y Shav-Tal","year":"2002","unstructured":"Shav-Tal, Y. & Zipori, D. PSF and p54(nrb)\/NonO-multi-functional nuclear proteins. FEBS Lett. 531, 109\u2013114 (2002).","journal-title":"FEBS Lett."},{"key":"BFncb1433_CR13","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1042\/bj2900267","volume":"290","author":"WW Zhang","year":"1993","unstructured":"Zhang, W. W., Zhang, L. X., Busch, R. K., Farres, J. & Busch, H. Purification and characterization of a DNA-binding heterodimer of 52 and 100 kDa from HeLa cells. Biochem. J. 290, 267\u2013272 (1993).","journal-title":"Biochem. J."},{"key":"BFncb1433_CR14","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1017\/S1355838202022070","volume":"8","author":"R Peng","year":"2002","unstructured":"Peng, R. et al. PSF and p54nrb bind a conserved stem in U5 snRNA. RNA 8, 1334\u20131347 (2002).","journal-title":"RNA"},{"key":"BFncb1433_CR15","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1017\/S1355838202025037","volume":"8","author":"A Emili","year":"2002","unstructured":"Emili, A. et al. Splicing and transcription-associated proteins PSF and p54nrb\/nonO bind to the RNA polymerase II CTD. RNA 8, 1102\u20131111 (2002).","journal-title":"RNA"},{"key":"BFncb1433_CR16","doi-asserted-by":"publisher","first-page":"6475","DOI":"10.1073\/pnas.1131933100","volume":"100","author":"P Percipalle","year":"2003","unstructured":"Percipalle, P. et al. An actin-ribonucleoprotein interaction is involved in transcription by RNA polymerase II. Proc. Natl Acad. Sci. USA 100, 6475\u20136480 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb1433_CR17","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1006\/bbrc.1997.8064","volume":"243","author":"H Miki","year":"1998","unstructured":"Miki, H. & Takenawa, T. Direct binding of the verprolin-homology domain in N-WASP to actin is essential for cytoskeletal reorganization. Biochem. Biophys. Res. Commun. 243, 73\u201378 (1998).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"BFncb1433_CR18","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1038\/ncb1182","volume":"6","author":"WA Hofmann","year":"2004","unstructured":"Hofmann, W. A. et al. Actin is part of pre-initiation complexes and is necessary for transcription by RNA polymerase II. Nature Cell Biol. 6, 1094\u20131101 (2004).","journal-title":"Nature Cell Biol."},{"key":"BFncb1433_CR19","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/0092-8674(84)90196-X","volume":"39","author":"U Scheer","year":"1984","unstructured":"Scheer, U., Hinssen, H., Franke, W. W. & Jockusch, B. M. Microinjection of actin-binding proteins and actin antibodies demonstrates involvement of nuclear actin in transcription of lampbrush chromosomes. Cell 39, 111\u2013122 (1984).","journal-title":"Cell"},{"key":"BFncb1433_CR20","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1101\/gad.1250804","volume":"18","author":"P Hu","year":"2004","unstructured":"Hu, P., Wu, S. & Hernandez, N. A role for \u03b2-actin in RNA polymerase III transcription. Genes Dev. 18, 3010\u20133015 (2004).","journal-title":"Genes Dev."},{"key":"BFncb1433_CR21","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1038\/ncb1190","volume":"6","author":"VV Philimonenko","year":"2004","unstructured":"Philimonenko, V. V. et al. Nuclear actin and myosin I are required for RNA polymerase I transcription. Nature Cell Biol. 6, 1165\u20131172 (2004).","journal-title":"Nature Cell Biol."},{"key":"BFncb1433_CR22","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nsmb904","volume":"12","author":"A Kukalev","year":"2005","unstructured":"Kukalev, A., Nord, Y., Palmberg, C., Bergman, T. & Percipalle, P. Actin and hnRNP U cooperate for productive transcription by RNA polymerase II. Nature Struct. Mol. Biol. 12, 238\u2013244 (2005).","journal-title":"Nature Struct. Mol. Biol."},{"key":"BFncb1433_CR23","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1083\/jcb.200507101","volume":"172","author":"D McDonald","year":"2006","unstructured":"McDonald, D., Carrero, G., Andrin, C., de Vries, G. & Hendzel, M. J. Nucleoplasmic \u03b2-actin exists in a dynamic equilibrium between low-mobility polymeric species and rapidly diffusing populations. J. Cell Biol. 172, 541\u2013552 (2006).","journal-title":"J. Cell Biol."},{"key":"BFncb1433_CR24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1083\/jcb.152.1.75","volume":"152","author":"L Pellizzoni","year":"2001","unstructured":"Pellizzoni, L., Charroux, B., Rappsilber, J., Mann, M. & Dreyfuss, G. A functional interaction between the survival motor neuron complex and RNA polymerase II. J. Cell Biol. 152, 75\u201385 (2001).","journal-title":"J. Cell Biol."},{"key":"BFncb1433_CR25","doi-asserted-by":"publisher","first-page":"5593","DOI":"10.1128\/MCB.13.9.5593","volume":"13","author":"YS Yang","year":"1993","unstructured":"Yang, Y. S. et al. NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. Mol. Cell Biol. 13, 5593\u20135603 (1993).","journal-title":"Mol. Cell Biol."},{"key":"BFncb1433_CR26","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1038\/sj.emboj.7600187","volume":"23","author":"S Kameoka","year":"2004","unstructured":"Kameoka, S., Duque, P. & Konarska, M. M. p54(nrb) associates with the 5\u2032 splice site within large transcription\/splicing complexes. EMBO J. 23, 1782\u20131791 (2004).","journal-title":"EMBO J."},{"key":"BFncb1433_CR27","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1093\/nar\/25.12.2284","volume":"25","author":"YS Yang","year":"1997","unstructured":"Yang, Y. S., Yang, M. C., Tucker, P. W. & Capra, J. D. NonO enhances the association of many DNA-binding proteins to their targets. Nucleic Acids Res. 25, 2284\u20132292 (1997).","journal-title":"Nucleic Acids Res."},{"key":"BFncb1433_CR28","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1242\/jcs.01098","volume":"117","author":"E Kiseleva","year":"2004","unstructured":"Kiseleva, E. et al. Actin- and protein-4.1-containing filaments link nuclear pore complexes to subnuclear organelles in Xenopus oocyte nuclei. J. Cell Sci. 117, 2481\u20132490 (2004).","journal-title":"J. Cell Sci."},{"key":"BFncb1433_CR29","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1101\/gad.987602","volume":"16","author":"AM Naar","year":"2002","unstructured":"Naar, A. M., Taatjes, D. J., Zhai, W., Nogales, E. & Tjian, R. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev. 16, 1339\u20131344 (2002).","journal-title":"Genes Dev."},{"key":"BFncb1433_CR30","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/0076-6879(90)81108-7","volume":"181","author":"KA Lee","year":"1990","unstructured":"Lee, K. A. & Green, M. R. Small-scale preparation of extracts from radiolabeled cells efficient in pre-mRNA splicing. Methods Enzymol. 181, 20\u201330 (1990).","journal-title":"Methods Enzymol."},{"key":"BFncb1433_CR31","doi-asserted-by":"crossref","first-page":"21657","DOI":"10.1016\/S0021-9258(17)31856-2","volume":"269","author":"T Redmond","year":"1994","unstructured":"Redmond, T., Tardif, M. & Zigmond, S. H. Induction of actin polymerization in permeabilized neutrophils. Role of ATP. J. Biol. Chem. 269, 21657\u201321663 (1994).","journal-title":"J. Biol. Chem."},{"key":"BFncb1433_CR32","doi-asserted-by":"publisher","first-page":"2425","DOI":"10.1242\/jcs.02371","volume":"118","author":"LA Mingle","year":"2005","unstructured":"Mingle, L. A. et al. Localization of all seven messenger RNAs for the actin-polymerization nucleator Arp2\/3 complex in the protrusions of fibroblasts. J. Cell Sci. 118, 2425\u20132433 (2005).","journal-title":"J. Cell Sci."}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb1433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1433","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:28:25Z","timestamp":1684423705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb1433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,11]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["BFncb1433"],"URL":"https:\/\/doi.org\/10.1038\/ncb1433","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1032707.374675","asserted-by":"object"},{"id-type":"doi","id":"10.3410\/f.1032707.388755","asserted-by":"object"}]},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,11]]}}}