{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:07:07Z","timestamp":1791140827982,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2008,8,10]],"date-time":"2008-08-10T00:00:00Z","timestamp":1218326400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1038\/ncb1769","type":"journal-article","created":{"date-parts":[[2008,8,10]],"date-time":"2008-08-10T18:29:49Z","timestamp":1218392989000},"page":"1090-1097","source":"Crossref","is-referenced-by-count":82,"title":["Reduced cytosolic protein synthesis suppresses mitochondrial degeneration"],"prefix":"10.1038","volume":"10","author":[{"given":"Xiaowen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanka","family":"Kucejova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,8,10]]},"reference":[{"key":"BFncb1769_CR1","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1146\/annurev.genet.39.110304.095751","volume":"39","author":"DC Wallace","year":"2005","unstructured":"Wallace, D. C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 39, 359\u2013407 (2005).","journal-title":"Annu. Rev. Genet."},{"key":"BFncb1769_CR2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.gene.2005.03.025","volume":"354","author":"A Spinazzola","year":"2005","unstructured":"Spinazzola, A. & Zeviani, M. Disorders of nuclear-mitochondrial intergenomic signaling. Gene 354, 162\u2013168 (2005).","journal-title":"Gene"},{"key":"BFncb1769_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/ajmg.1379","volume":"106","author":"A Suomalainen","year":"2001","unstructured":"Suomalainen, A. & Kaukonen, J. Diseases caused by nuclear genes affecting mtDNA stability. Am. J. Med. Genet. 106, 53\u201361 (2001).","journal-title":"Am. J. Med. Genet."},{"key":"BFncb1769_CR4","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1126\/science.289.5480.782","volume":"289","author":"J Kaukonen","year":"2000","unstructured":"Kaukonen, J. et al. Role of adenine nucleotide translocator 1 in mtDNA maintenance. Science 289, 782\u2013785 (2000).","journal-title":"Science"},{"key":"BFncb1769_CR5","doi-asserted-by":"publisher","first-page":"4820","DOI":"10.1073\/pnas.96.9.4820","volume":"96","author":"LA Esposito","year":"1999","unstructured":"Esposito, L. A., Melov, S., Panov, A., Cottrell, B. A. & Wallace, D. C. Mitochondrial disease in mouse results in increased oxidative stress. Proc. Natl Acad. Sci. USA 96, 4820\u20134825 (1999).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb1769_CR6","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/hmg\/ddh108","volume":"13","author":"F Fontanesi","year":"2004","unstructured":"Fontanesi, F. et al. Mutations in AAC2, equivalent to human adPEO-associated ANT1 mutations, lead to defective oxidative phosphorylation in Saccharomyces cerevisiae and affect mitochondrial DNA stability. Hum. Mol. Genet. 13, 923\u2013934 (2004).","journal-title":"Hum. Mol. Genet."},{"key":"BFncb1769_CR7","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1093\/hmg\/11.16.1835","volume":"11","author":"XJ Chen","year":"2002","unstructured":"Chen, X. J. Induction of an unregulated channel by mutations in adenine nucleotide translocase suggests an explanation for human ophthalmoplegia. Hum. Mol. Genet. 11, 1835\u20131843 (2002).","journal-title":"Hum. Mol. Genet."},{"key":"BFncb1769_CR8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1038\/nature02056","volume":"426","author":"E Pebay-Peyroula","year":"2003","unstructured":"Pebay-Peyroula, E. et al. Structure of mitochondrial ADP\/ATP carrier in complex with carboxyatractyloside. Nature 426, 39\u201344 (2003).","journal-title":"Nature"},{"key":"BFncb1769_CR9","doi-asserted-by":"publisher","first-page":"16144","DOI":"10.1021\/bi960668j","volume":"35","author":"D Heidkamper","year":"1996","unstructured":"Heidkamper, D., Muller, V., Nelson, D. R. & Klingenberg, M. Probing the role of positive residues in the ADP\/ATP carrier from yeast. The effect of six arginine mutations on transport and the four ATP versus ADP exchange modes. Biochemistry 35, 16144\u201316152 (1996).","journal-title":"Biochemistry"},{"key":"BFncb1769_CR10","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/S0014-5793(03)01462-5","volume":"557","author":"P Fabrizio","year":"2004","unstructured":"Fabrizio, P., Pletcher, S. D., Minois, N., Vaupel, J. W. & Longo, V. D. Chronological aging-independent replicative life span regulation by Msn2\/Msn4 and Sod2 in Saccharomyces cerevisiae. FEBS Lett. 557, 136\u2013142 (2004).","journal-title":"FEBS Lett."},{"key":"BFncb1769_CR11","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1126\/science.1115535","volume":"310","author":"M Kaeberlein","year":"2005","unstructured":"Kaeberlein, M. et al. Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193\u20131196 (2005).","journal-title":"Science"},{"key":"BFncb1769_CR12","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.cell.2008.02.037","volume":"133","author":"KK Steffen","year":"2008","unstructured":"Steffen, K. K. et al. Yeast life span extension by depletion of 60S ribosomal subunit is mediated by Gcn4. Cell 133, 292\u2013302 (2008).","journal-title":"Cell"},{"key":"BFncb1769_CR13","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1126\/science.289.5487.2126","volume":"289","author":"SJ Lin","year":"2000","unstructured":"Lin, S. J., Defossez, P. A. & Guarente, L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289, 2126\u20132128 (2000).","journal-title":"Science"},{"key":"BFncb1769_CR14","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S0092-8674(00)80493-6","volume":"91","author":"DA Sinclair","year":"1997","unstructured":"Sinclair, D. A. & Guarente, L. Extrachromosomal rDNA circles \u2014 a cause of aging in yeast. Cell 91, 1033\u20131042 (1997).","journal-title":"Cell"},{"key":"BFncb1769_CR15","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S1097-2765(00)80472-4","volume":"3","author":"PA Defossez","year":"1999","unstructured":"Defossez, P. A. et al. Elimination of replication block protein Fob1 extends the life span of yeast mother cells. Mol. Cell 3, 447\u2013455 (1999).","journal-title":"Mol. Cell"},{"key":"BFncb1769_CR16","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1083\/jcb.200510080","volume":"173","author":"A Lebreton","year":"2006","unstructured":"Lebreton, A. et al. A functional network involved in the recycling of nucleocytoplasmic pre-60S factors. J. Cell Biol. 173, 349\u2013360 (2006).","journal-title":"J. Cell Biol."},{"key":"BFncb1769_CR17","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1096\/fj.00-0242fje","volume":"14","author":"JC Jiang","year":"2000","unstructured":"Jiang, J. C., Jaruga, E., Repnevskaya, M. V. & Jazwinski, S. M. An intervention resembling caloric restriction prolongs life span and retards aging in yeast. FASEB J. 14, 2135\u20132137 (2000).","journal-title":"FASEB J."},{"key":"BFncb1769_CR18","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.bbabio.2006.05.022","volume":"1757","author":"M Rinnerthaler","year":"2006","unstructured":"Rinnerthaler, M. et al. MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria. Biochim. Biophys. Acta 1757, 631\u2013638 (2006).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFncb1769_CR19","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1091\/mbc.10.10.3125","volume":"10","author":"S Kim","year":"1999","unstructured":"Kim, S., Benguria, A., Lai, C. Y. & Jazwinski, S. M. Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae. Mol Biol Cell 10, 3125\u20133136 (1999).","journal-title":"Mol Biol Cell"},{"key":"BFncb1769_CR20","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1101\/gad.1422006","volume":"20","author":"TC Fleischer","year":"2006","unstructured":"Fleischer, T. C., Weaver, C. M., McAfee, K. J., Jennings, J. L. & Link, A. J. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev. 20, 1294\u20131307 (2006).","journal-title":"Genes Dev."},{"key":"BFncb1769_CR21","doi-asserted-by":"publisher","first-page":"1602","DOI":"10.1128\/MCB.23.5.1602-1613.2003","volume":"23","author":"A Meskauskas","year":"2003","unstructured":"Meskauskas, A. et al. Delayed rRNA processing results in significant ribosome biogenesis and functional defects. Mol. Cell Biol. 23, 1602\u20131613 (2003).","journal-title":"Mol. Cell Biol."},{"key":"BFncb1769_CR22","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/genetics\/162.1.73","volume":"162","author":"CY Lai","year":"2002","unstructured":"Lai, C. Y., Jaruga, E., Borghouts, C. & Jazwinski, S. M. A mutation in the ATP2 gene abrogates the age asymmetry between mother and daughter cells of the yeast Saccharomyces cerevisiae. Genetics 162, 73\u201387 (2002).","journal-title":"Genetics"},{"key":"BFncb1769_CR23","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/S0960-9822(06)00261-2","volume":"7","author":"PJ Coates","year":"1997","unstructured":"Coates, P. J., Jamieson, D. J., Smart, K., Prescott, A. R. & Hall, P. A. The prohibitin family of mitochondrial proteins regulate replicative lifespan. Curr. Biol. 7, 607\u2013610 (1997).","journal-title":"Curr. Biol."},{"key":"BFncb1769_CR24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0167-4889(02)00267-7","volume":"1592","author":"I Arnold","year":"2002","unstructured":"Arnold, I. & Langer, T. Membrane protein degradation by AAA proteases in mitochondria. Biochim. Biophys. Acta 1592, 89\u201396 (2002).","journal-title":"Biochim. Biophys. Acta"},{"key":"BFncb1769_CR25","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/j.1365-313X.2005.02505.x","volume":"44","author":"JC Chen","year":"2005","unstructured":"Chen, J. C., Jiang, C. Z. & Reid, M. S. Silencing a prohibitin alters plant development and senescence. Plant J. 44, 16\u201324 (2005).","journal-title":"Plant J."},{"key":"BFncb1769_CR26","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1091\/mbc.e05-06-0585","volume":"17","author":"CD Dunn","year":"2006","unstructured":"Dunn, C. D., Lee, M. S., Spencer, F. A. & Jensen, R. E. A genomewide screen for petite-negative yeast strains yields a new subunit of the i-AAA protease complex. Mol. Biol. Cell 17, 213\u2013226 (2006).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb1769_CR27","doi-asserted-by":"publisher","first-page":"5418","DOI":"10.1128\/MCB.13.9.5418","volume":"13","author":"PE Thorsness","year":"1993","unstructured":"Thorsness, P. E., White, K. H. & Fox, T. D. Inactivation of YME1, a member of the ftsH-SEC18-PAS1-CDC48 family of putative ATPase-encoding genes, causes increased escape of DNA from mitochondria in Saccharomyces cerevisiae. Mol. Cell Biol. 13, 5418\u20135426 (1993).","journal-title":"Mol. Cell Biol."},{"key":"BFncb1769_CR28","doi-asserted-by":"publisher","first-page":"20879","DOI":"10.1074\/jbc.270.36.20879","volume":"270","author":"DA Pearce","year":"1995","unstructured":"Pearce, D. A. & Sherman, F. Degradation of cytochrome oxidase subunits in mutants of yeast lacking cytochrome c and suppression of the degradation by mutation of yme1. J. Biol. Chem. 270, 20879\u201320882 (1995).","journal-title":"J. Biol. Chem."},{"key":"BFncb1769_CR29","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1042\/BJ20050890","volume":"392","author":"MD Brand","year":"2005","unstructured":"Brand, M. D. et al. The basal proton conductance of mitochondria depends on adenine nucleotide translocase content. Biochem. J. 392, 353\u2013362 (2005).","journal-title":"Biochem. J."},{"key":"BFncb1769_CR30","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1111\/j.1474-9726.2005.00152.x","volume":"4","author":"RA Miller","year":"2005","unstructured":"Miller, R. A. et al. Methionine-deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF-I and insulin levels, and increases hepatocyte MIF levels and stress resistance. Aging Cell 4, 119\u2013125 (2005).","journal-title":"Aging Cell"},{"key":"BFncb1769_CR31","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nature00829","volume":"418","author":"SJ Lin","year":"2002","unstructured":"Lin, S. J. et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418, 344\u2013348 (2002).","journal-title":"Nature"},{"key":"BFncb1769_CR32","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1038\/ng2004","volume":"39","author":"JJ Tong","year":"2007","unstructured":"Tong, J. J., Schriner, S. E., McCleary, D., Day, B. J. & Wallace, D. C. Life extension through neurofibromin mitochondrial regulation and antioxidant therapy for neurofibromatosis-1 in Drosophila melanogaster. Nature Genet. 39, 476\u2013485 (2007).","journal-title":"Nature Genet."},{"key":"BFncb1769_CR33","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.cmet.2007.02.009","volume":"5","author":"ND Bonawitz","year":"2007","unstructured":"Bonawitz, N. D., Chatenay-Lapointe, M., Pan, Y. & Shadel, G. S. Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression. Cell Metab. 5, 265\u2013277 (2007).","journal-title":"Cell Metab."},{"key":"BFncb1769_CR34","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.tcb.2008.02.004","volume":"18","author":"N Tavernarakis","year":"2008","unstructured":"Tavernarakis, N. Ageing and the regulation of protein synthesis: a balancing act? Trends Cell Biol. 18, 228\u2013235 (2008).","journal-title":"Trends Cell Biol."},{"key":"BFncb1769_CR35","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.exger.2006.11.002","volume":"42","author":"A Chiocchetti","year":"2007","unstructured":"Chiocchetti, A. et al. Ribosomal proteins Rpl10 and Rps6 are potent regulators of yeast replicative life span. Exp. Gerontol. 42, 275\u2013286 (2007).","journal-title":"Exp. Gerontol."}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb1769.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1769","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb1769.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:31:41Z","timestamp":1684438301000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb1769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,10]]},"references-count":35,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["BFncb1769"],"URL":"https:\/\/doi.org\/10.1038\/ncb1769","relation":{},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,10]]}}}