{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:57:18Z","timestamp":1791208638672,"version":"4.1.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,12,6]],"date-time":"2009-12-06T00:00:00Z","timestamp":1260057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2010,1]]},"DOI":"10.1038\/ncb2002","type":"journal-article","created":{"date-parts":[[2009,12,6]],"date-time":"2009-12-06T16:56:16Z","timestamp":1260118576000},"page":"41-46","source":"Crossref","is-referenced-by-count":200,"title":["Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure"],"prefix":"10.1038","volume":"12","author":[{"given":"Janna","family":"Merte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sarsfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanshu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randy","family":"Schekman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D.","family":"Ginty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,12,6]]},"reference":[{"key":"BFncb2002_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1111\/j.1399-0004.2007.00793.x","volume":"71","author":"Z Kibar","year":"2007","unstructured":"Kibar, Z., Capra, V. & Gros, P. Toward understanding the genetic basis of neural tube defects. Clin. Genet. 71, 295\u2013310 (2007).","journal-title":"Clin. Genet."},{"key":"BFncb2002_CR2","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s10048-006-0052-2","volume":"7","author":"P De Marco","year":"2006","unstructured":"De Marco, P., Merello, E., Mascelli, S. & Capra, V. Current perspectives on the genetic causes of neural tube defects. Neurogenetics 7, 201\u2013221 (2006).","journal-title":"Neurogenetics"},{"key":"BFncb2002_CR3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1006\/geno.2000.6493","volume":"72","author":"Z Kibar","year":"2001","unstructured":"Kibar, Z. Identification of a new chemically induced allele (Lpm1Jus) at the loop-tail locus: morphology, histology, and genetic mapping. Genomics 72, 331\u2013337 (2001).","journal-title":"Genomics"},{"key":"BFncb2002_CR4","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nature01618","volume":"423","author":"M Montcouquiol","year":"2003","unstructured":"Montcouquiol, M. et al. Identification of Vangl2 and Scrb1 as planar polarity genes in mammals. Nature 423, 173\u2013177 (2003).","journal-title":"Nature"},{"key":"BFncb2002_CR5","doi-asserted-by":"publisher","first-page":"2147","DOI":"10.1523\/JNEUROSCI.4698-05.2005","volume":"26","author":"Y Wang","year":"2006","unstructured":"Wang, Y., N., G. & Nathans, J. The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J. Neurosci. 26, 2147\u20132156 (2006).","journal-title":"J. Neurosci."},{"key":"BFncb2002_CR6","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/S0960-9822(03)00374-9","volume":"13","author":"J Curtin","year":"2003","unstructured":"Curtin, J. Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouse. Curr. Biol. 13, 1129\u20131133 (2003).","journal-title":"Curr. Biol."},{"key":"BFncb2002_CR7","doi-asserted-by":"publisher","first-page":"5827","DOI":"10.1242\/dev.00164","volume":"129","author":"N Hamblet","year":"2002","unstructured":"Hamblet, N. et al. Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development 129, 5827\u20135838 (2002).","journal-title":"Development"},{"key":"BFncb2002_CR8","doi-asserted-by":"publisher","first-page":"e1000259","DOI":"10.1371\/journal.pgen.1000259","volume":"4","author":"SL Etheridge","year":"2008","unstructured":"Etheridge, S. L. et al. Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet. 4, e1000259 (2008).","journal-title":"PLoS Genet."},{"key":"BFncb2002_CR9","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nature02677","volume":"430","author":"X Lu","year":"2004","unstructured":"Lu, X. et al. PTK7\/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 430, 93\u201398 (2004).","journal-title":"Nature"},{"key":"BFncb2002_CR10","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1006\/geno.2001.6638","volume":"78","author":"J Murdoch","year":"2001","unstructured":"Murdoch, J. et al. Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutation. Genomics 78, 55\u201363 (2001).","journal-title":"Genomics"},{"key":"BFncb2002_CR11","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1093\/hmg\/ddg014","volume":"12","author":"J Murdoch","year":"2003","unstructured":"Murdoch, J. et al. Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse. Hum. Mol. Genet. 12, 87\u201398 (2003).","journal-title":"Hum. Mol. Genet."},{"key":"BFncb2002_CR12","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1242\/dev.000380","volume":"134","author":"P Ybot-Gonzalez","year":"2007","unstructured":"Ybot-Gonzalez, P. et al. Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development 134, 789\u2013799 (2007).","journal-title":"Development"},{"key":"BFncb2002_CR13","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/S0168-9525(02)02770-1","volume":"18","author":"M Mlodzik","year":"2002","unstructured":"Mlodzik, M. Planar cell polarization: do the same mechanisms regulate Drosophila tissue polarity and vertebrate gastrulation? Trends Genet. 18, 564\u2013571 (2002).","journal-title":"Trends Genet."},{"key":"BFncb2002_CR14","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/S1534-5807(02)00197-1","volume":"2","author":"J Wallingford","year":"2002","unstructured":"Wallingford, J., Fraser, S. E. & Harland, R. M. Convergent extension: the molecular control of polarized cell movement during embryonic development. Dev. Cell 2, 695\u2013706 (2002).","journal-title":"Dev. Cell"},{"key":"BFncb2002_CR15","doi-asserted-by":"publisher","first-page":"7485","DOI":"10.1073\/pnas.95.13.7485","volume":"95","author":"A Kasarskis","year":"1998","unstructured":"Kasarskis, A., Manova, K. & Anderson, K. V. A phenotype-based screen for embryonic lethal mutations in the mouse. Proc. Natl Acad. Sci. USA 95, 7485\u20137490 (1998).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb2002_CR16","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/sj.embor.7400893","volume":"8","author":"M Wendeler","year":"2007","unstructured":"Wendeler, M., Paccaud, J. & Hauri, H. Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulum. EMBO Rep. 8, 258\u2013264 (2007).","journal-title":"EMBO Rep."},{"key":"BFncb2002_CR17","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1083\/jcb.151.5.973","volume":"151","author":"Y Shimoni","year":"2000","unstructured":"Shimoni, Y. et al. Lst1p and Sec24p cooperate in sorting of the plasma membrane ATPase into COPII vesicles in Saccharomyces cerevisiae. J. Cell Biol. 151, 973\u2013984 (2000).","journal-title":"J. Cell Biol."},{"key":"BFncb2002_CR18","doi-asserted-by":"publisher","first-page":"6105","DOI":"10.1093\/emboj\/cdf605","volume":"21","author":"E Miller","year":"2002","unstructured":"Miller, E., Antonny, B., Hamamoto, S. & Schekman, R. Cargo selection into COPII vesicles is driven by the Sec24p subunit. EMBO J. 21, 6105\u20136113 (2002).","journal-title":"EMBO J."},{"key":"BFncb2002_CR19","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/S0092-8674(03)00609-3","volume":"114","author":"EA Miller","year":"2003","unstructured":"Miller, E. A. et al. Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Cell 114, 497\u2013509 (2003).","journal-title":"Cell"},{"key":"BFncb2002_CR20","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/nature01040","volume":"419","author":"X Bi","year":"2002","unstructured":"Bi, X., Corpina, R. A. & Goldberg, J. Structure of the Sec23\/24-Sar1 pre-budding complex of the COPII vesicle coat. Nature 419, 271\u2013277 (2002).","journal-title":"Nature"},{"key":"BFncb2002_CR21","doi-asserted-by":"publisher","first-page":"5815","DOI":"10.1242\/dev.00123","volume":"129","author":"J Wallingford","year":"2002","unstructured":"Wallingford, J. & Harland, R. Neural tube closure requires Dishevelled-dependent convergent extension of the midline. Development 129, 5815\u20135825 (2002).","journal-title":"Development"},{"key":"BFncb2002_CR22","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/bies.20526","volume":"29","author":"C Jones","year":"2007","unstructured":"Jones, C. & Chen, P. Planar cell polarity signaling in vertebrates. Bioessays 29, 120\u2013132 (2007).","journal-title":"Bioessays"},{"key":"BFncb2002_CR23","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1006\/dbio.1994.1230","volume":"165","author":"AJ Copp","year":"1994","unstructured":"Copp, A. J., Checiu, I. & Henson, J. N. Developmental basis of severe neural tube defects in the loop-tail (Lp) mutant mouse: use of microsatellite DNA markers to identify embryonic genotype. Dev. Biol. 165, 20\u201329 (1994).","journal-title":"Dev. Biol."},{"key":"BFncb2002_CR24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ydbio.2007.03.011","volume":"306","author":"D Qian","year":"2007","unstructured":"Qian, D. et al. Wnt5a functions in planar cell polarity regulation in mice. Dev. Biol. 306, 121\u2013133 (2007).","journal-title":"Dev. Biol."},{"key":"BFncb2002_CR25","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1083\/jcb.200709012","volume":"179","author":"J Kim","year":"2007","unstructured":"Kim, J. et al. Biogenesis of \u03b3-secretase early in the secretory pathway. J. Cell Biol. 179, 951\u2013963 (2007).","journal-title":"J. Cell Biol."},{"key":"BFncb2002_CR26","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.modgep.2006.07.007","volume":"7","author":"E Torban","year":"2007","unstructured":"Torban, E. et al. Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation. Gene Expr. Patterns 7, 346\u2013354 (2007).","journal-title":"Gene Expr. Patterns"},{"key":"BFncb2002_CR27","first-page":"484","volume":"11","author":"M Justice","year":"2000","unstructured":"Justice, M. et al. Mamm. Effects of ENU dosage on mouse strains. Genome 11, 484\u2013488 (2000).","journal-title":"Genome"},{"key":"BFncb2002_CR28","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1093\/hmg\/8.10.1955","volume":"8","author":"MJ Justice","year":"1999","unstructured":"Justice, M. J., Noveroske, J. K., Weber, J. S., Zheng, B. & Bradley, A. Mouse ENU mutagenesis. Hum. Mol. Genet. 8, 1955\u20131963 (1999).","journal-title":"Hum. Mol. Genet."},{"key":"BFncb2002_CR29","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/(SICI)1526-968X(200004)26:4<230::AID-GENE20>3.0.CO;2-S","volume":"26","author":"JS Weber","year":"2000","unstructured":"Weber, J. S., Salinger, A. & Justice, M. J. Optimal N-ethyl-N-nitrosourea (ENU) doses for inbred mouse strains. Genesis 26, 230\u2013233 (2000).","journal-title":"Genesis"},{"key":"BFncb2002_CR30","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1042\/bj3070679","volume":"307","author":"R Wilson","year":"1995","unstructured":"Wilson, R. et al. The translocation, folding, assembly and redox-dependent degradation of secretory and membrane proteins in semi-permeabilized mammalian cells. Biochem. J. 307, 679\u2013687 (1995).","journal-title":"Biochem. J."},{"key":"BFncb2002_CR31","doi-asserted-by":"publisher","first-page":"7758","DOI":"10.1074\/jbc.M411091200","volume":"280","author":"J Kim","year":"2005","unstructured":"Kim, J., Hamamoto, S., Ravazzola, M., Orci, L. & Schekman, R. Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles. J. Biol. Chem. 280, 7758\u20137768 (2005).","journal-title":"J. Biol. Chem."},{"key":"BFncb2002_CR32","first-page":"623","volume":"13","author":"J Fromme","year":"2007","unstructured":"Fromme, J. et al. The genetic basis of a craniofacial disease provides insight into COPII coat assembly Dev. Cell 13, 623\u2013634 (2007).","journal-title":"Cell"}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb2002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb2002","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb2002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:33:33Z","timestamp":1684424013000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,6]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,1]]}},"alternative-id":["BFncb2002"],"URL":"https:\/\/doi.org\/10.1038\/ncb2002","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.2889957.2559055","asserted-by":"object"}]},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,6]]}}}