{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:58:14Z","timestamp":1791194294402,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2012,3,4]],"date-time":"2012-03-04T00:00:00Z","timestamp":1330819200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1038\/ncb2447","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T06:07:44Z","timestamp":1330927664000},"page":"409-415","source":"Crossref","is-referenced-by-count":84,"title":["CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model"],"prefix":"10.1038","volume":"14","author":[{"given":"Min-Ji","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaehoon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Don","family":"Ryoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,3,4]]},"reference":[{"key":"BFncb2447_CR1","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1038\/343364a0","volume":"343","author":"T Dryja","year":"1990","unstructured":"Dryja, T. et al. A point mutation of the rhodopsin gene in one form of retinitis pigmentosa. Nature 343, 364\u2013366 (1990).","journal-title":"Nature"},{"key":"BFncb2447_CR2","doi-asserted-by":"publisher","first-page":"6481","DOI":"10.1073\/pnas.88.15.6481","volume":"88","author":"CH Sung","year":"1991","unstructured":"Sung, C. H. et al. Rhdopsin mutations in autosomal dominant retinitis pigmentosa. Proc. Natl Acad. Sci. USA 88, 6481\u20136485 (1991).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb2447_CR3","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/sj.emboj.7601477","volume":"26","author":"HD Ryoo","year":"2007","unstructured":"Ryoo, H. D., Domingos, P. M., Kang, M. J. & Steller, H. Unfolded protein response in a Drosophila model for retinal degeneration. EMBO J. 26, 242\u2013252 (2007).","journal-title":"EMBO J."},{"key":"BFncb2447_CR4","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1126\/science.1209038","volume":"334","author":"P Walter","year":"2011","unstructured":"Walter, P. & Ron, D. The unfolded protein response: from stress pathway to hemeostatic regulation. Science 334, 1081\u20131086 (2011).","journal-title":"Science"},{"key":"BFncb2447_CR5","doi-asserted-by":"publisher","first-page":"17043","DOI":"10.1073\/pnas.0905566106","volume":"106","author":"M-J Kang","year":"2009","unstructured":"Kang, M-J. & Ryoo, H.D. Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation. Proc. Natl Acad. Sci. USA 106, 17043\u201317048 (2009).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb2447_CR6","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/S0092-8674(00)80835-1","volume":"101","author":"KJ Travers","year":"2000","unstructured":"Travers, K. J. et al. Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation. Cell 101, 249\u2013258 (2000).","journal-title":"Cell"},{"key":"BFncb2447_CR7","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S1097-2765(03)00105-9","volume":"11","author":"HP Harding","year":"2003","unstructured":"Harding, H. P. et al. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol. Cell 11, 619\u2013633 (2003).","journal-title":"Mol. Cell"},{"key":"BFncb2447_CR8","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.devcel.2007.07.018","volume":"13","author":"K Yamamoto","year":"2007","unstructured":"Yamamoto, K. et al. Transcriptional induction of mammalian ER quality control proteins is mediated by single, or combined action of ATF6\u03b1 and xbp1. Dev. Cell 13, 365\u2013376 (2007).","journal-title":"Dev. Cell"},{"key":"BFncb2447_CR9","doi-asserted-by":"publisher","first-page":"3070","DOI":"10.1073\/pnas.92.7.3070","volume":"92","author":"NJ Colley","year":"1995","unstructured":"Colley, N. J., Cassill, J. A., Baker, E. K. & Zuker, C. S. Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration. Proc. Natl Acad. Sci. USA 92, 3070\u20133074 (1995).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb2447_CR10","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/0896-6273(95)90313-5","volume":"14","author":"P Kurada","year":"1995","unstructured":"Kurada, P. & O\u2019Tousa, J. E. Retinal degeneration caused by dominant rhodopsin mutations in Drosophila. Neuron 14, 571\u2013579 (1995).","journal-title":"Neuron"},{"key":"BFncb2447_CR11","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1093\/genetics\/155.4.1711","volume":"155","author":"RS Hewes","year":"2000","unstructured":"Hewes, R. S., Schaefer, A. M. & Taghert, P. H. The cryptocephal gene (ATF4) encodes multiple basic-leucine zipper proteins controlling molting and metamorphosis in Drosophila. Genetics 155, 1711\u20131723 (2000).","journal-title":"Genetics"},{"key":"BFncb2447_CR12","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1016\/S1097-2765(00)00108-8","volume":"6","author":"HP Harding","year":"2000","unstructured":"Harding, H. P. et al. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol. Cell 6, 1099\u20131108 (2000).","journal-title":"Mol. Cell"},{"key":"BFncb2447_CR13","doi-asserted-by":"publisher","first-page":"3066","DOI":"10.1101\/gad.1250704","volume":"18","author":"SJ Marciniak","year":"2004","unstructured":"Marciniak, S. J. et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 18, 3066\u20133077 (2004).","journal-title":"Genes Dev."},{"key":"BFncb2447_CR14","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1083\/jcb.201006121","volume":"191","author":"G Li","year":"2010","unstructured":"Li, G., Scull, C., Ozcan, L. & Tabas, I. NADPH oxidase links endoplasmic reticulum stress, oxidative stress and PKR activation to induce apoptosis. J. Cell Biol. 191, 1113\u20131125 (2010).","journal-title":"J. Cell Biol."},{"key":"BFncb2447_CR15","doi-asserted-by":"publisher","first-page":"3378","DOI":"10.1172\/JCI34587","volume":"118","author":"B Song","year":"2008","unstructured":"Song, B. et al. Chop deletion reduces oxidative stress, improves \u03b2 cell function, and promotes cell survival in multiple mouse models of diabetes. J. Clin. Invest. 118, 3378\u20133389 (2008).","journal-title":"J. Clin. Invest."},{"key":"BFncb2447_CR16","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1172\/JCI38857","volume":"119","author":"JM Timmins","year":"2009","unstructured":"Timmins, J. M. et al. Calcium\/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J. Clin. Invest. 119, 2925\u20132941 (2009).","journal-title":"J. Clin. Invest."},{"key":"BFncb2447_CR17","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1083\/jcb.200311055","volume":"164","author":"BP Tu","year":"2004","unstructured":"Tu, B. P. & Weissman, J. S. Oxidative protein folding in eukaryotes: mechanisms and consequences. J. Cell Biol. 164, 341\u2013346 (2004).","journal-title":"J. Cell Biol."},{"key":"BFncb2447_CR18","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1083\/jcb.150.2.F57","volume":"150","author":"DK Morrison","year":"2000","unstructured":"Morrison, D. K., Murakami, M. S. & Cleghon, V. Protein kinases and phosphatases in the Drosophila genome. J. Cell Biol. 150, 57\u201362 (2000).","journal-title":"J. Cell Biol."},{"key":"BFncb2447_CR19","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0960-9822(00)00487-5","volume":"10","author":"L Connell-Crowley","year":"2000","unstructured":"Connell-Crowley, L., Le Gall, M. & Giniger, E. The cyclin-dependent kinase CDK5\u00a0controls multiple aspects of axon patterning in\u00a0vivo. Curr. Biol. 10, 599\u2013602 (2000).","journal-title":"Curr. Biol."},{"key":"BFncb2447_CR20","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1038\/371419a0","volume":"371","author":"LH Tsai","year":"1994","unstructured":"Tsai, L. H., Delalle, I., Caviness, V. S., Chae, T. & Harlow, E. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371, 419\u2013423 (1994).","journal-title":"Nature"},{"key":"BFncb2447_CR21","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/nature09291","volume":"466","author":"JH Choi","year":"2010","unstructured":"Choi, J. H. et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR\u03b3 by CDK5. Nature 466, 451\u2013456 (2010).","journal-title":"Nature"},{"key":"BFncb2447_CR22","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/nm1299","volume":"11","author":"FY Wei","year":"2005","unstructured":"Wei, F. Y. et al. CDK5-dependent regulation of glucose-stimulated insulin secretion. Nat. Med. 11, 1104\u20131108 (2005).","journal-title":"Nat. Med."},{"key":"BFncb2447_CR23","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1471-4159.2007.04540.x","volume":"102","author":"T Saito","year":"2007","unstructured":"Saito, T. et al. p25\/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons. J. Neurochem. 102, 133\u2013140 (2007).","journal-title":"J. Neurochem."},{"key":"BFncb2447_CR24","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/45159","volume":"402","author":"GN Patrick","year":"1999","unstructured":"Patrick, G. N. et al. Conversion of p35 to p25 deregulates CDK5 activity and promotes neurodegeneration. Nature 402, 615\u2013622 (1999).","journal-title":"Nature"},{"key":"BFncb2447_CR25","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.neuron.2007.05.033","volume":"55","author":"D Qu","year":"2007","unstructured":"Qu, D. et al. Role of CDK5-mediated phosphorylation of Prx2 in MPTP toxicity and Parkinson\u2019s disease. Neuron 55, 37\u201352 (2007).","journal-title":"Neuron"},{"key":"BFncb2447_CR26","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0076-6879(83)98144-2","volume":"98","author":"AD Elbein","year":"1983","unstructured":"Elbein, A. D. Inhibitors of glycoprotein synthesis. Methods Enzymol. 98, 135\u2013154 (1983).","journal-title":"Methods Enzymol."},{"key":"BFncb2447_CR27","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.mod.2007.02.002","volume":"124","author":"L Connell-Crowley","year":"2007","unstructured":"Connell-Crowley, L., Vo, D., Luke, L. & Giniger, E. Drosophila lacking the CDK5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Mech. Dev. 124, 341\u2013349 (2007).","journal-title":"Mech. Dev."},{"key":"BFncb2447_CR28","doi-asserted-by":"publisher","first-page":"12418","DOI":"10.1073\/pnas.93.22.12418","volume":"93","author":"P Rorth","year":"1996","unstructured":"Rorth, P. A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. Proc. Natl Acad. Sci. USA 93, 12418\u201312422 (1996).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb2447_CR29","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/0092-8674(95)90150-7","volume":"83","author":"BA Hay","year":"1995","unstructured":"Hay, B. A., Wasserman, D. A. & Rubin, G. M. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell 83, 1253\u20131262 (1995).","journal-title":"Cell"},{"key":"BFncb2447_CR30","doi-asserted-by":"publisher","first-page":"5421","DOI":"10.1093\/emboj\/20.19.5421","volume":"20","author":"H Inoue","year":"2001","unstructured":"Inoue, H. et al. A Drosophila MAPKKK, D-MEKK1, mediates stress response through activation of p38 MAPK. EMBO J. 20, 5421\u20135430 (2001).","journal-title":"EMBO J."},{"key":"BFncb2447_CR31","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.cell.2011.05.029","volume":"145","author":"KH Seong","year":"2011","unstructured":"Seong, K. H., Li, D., Shimizu, H., Nakamura, R. & Ishii, S. Inheritance of stress-induced, ATF-2-dependent epigenetic change. Cell 145, 1049\u20131061 (2011).","journal-title":"Cell"},{"key":"BFncb2447_CR32","doi-asserted-by":"crossref","first-page":"17067","DOI":"10.1016\/S0021-9258(19)47340-7","volume":"266","author":"J Lytton","year":"1991","unstructured":"Lytton, J., Westlin, M. & Hanley, M. R. Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps. J. Biol. Chem. 266, 17067\u201317071 (1991).","journal-title":"J. Biol. Chem."},{"key":"BFncb2447_CR33","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.devcel.2004.09.016","volume":"7","author":"SK Chew","year":"2004","unstructured":"Chew, S. K. et al. The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila. Dev. Cell 7, 897\u2013907 (2004).","journal-title":"Dev. Cell"},{"key":"BFncb2447_CR34","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1242\/dev.01790","volume":"132","author":"D Xu","year":"2005","unstructured":"Xu, D., Li, Y., Arcaro, M., Lackey, M. & Bergmann, A. The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development 132, 2125\u20132134 (2005).","journal-title":"Development"},{"key":"BFncb2447_CR35","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1242\/dev.128.6.815","volume":"128","author":"F Pichaud","year":"2001","unstructured":"Pichaud, F. & Desplan, C. A new visualization approach for identifying mutations that affect differentiation and organization of the Drosophila ommatidia. Development 128, 815\u2013826 (2001).","journal-title":"Development"},{"key":"BFncb2447_CR36","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/35012636","volume":"405","author":"MS Lee","year":"2000","unstructured":"Lee, M. S. et al. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405, 360\u2013364 (2000).","journal-title":"Nature"},{"key":"BFncb2447_CR37","doi-asserted-by":"publisher","first-page":"7879","DOI":"10.1523\/JNEUROSCI.22-18-07879.2002","volume":"22","author":"R Dhavan","year":"2002","unstructured":"Dhavan, R., Greer, P. L., Morabit, M. A., Orlando, L. R. & Tsai, L. H. et al. J. Neurosci. 22, 7879\u20137891 (2002).","journal-title":"J. Neurosci."},{"key":"BFncb2447_CR38","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1083\/jcb.150.4.887","volume":"150","author":"T Nakagawa","year":"2000","unstructured":"Nakagawa, T. & Yuan, J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 150, 887\u2013894 (2000).","journal-title":"J. Cell Biol."},{"key":"BFncb2447_CR39","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.devcel.2008.01.018","volume":"14","author":"Y Zhang","year":"2008","unstructured":"Zhang, Y. et al. Epigenetic blocking of an enhancer region controls irradiation-induced proapoptotic gene expression in Drosophila embryos. Dev. Cell 14, 481\u2013493 (2008).","journal-title":"Dev. Cell"},{"key":"BFncb2447_CR40","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","volume":"118","author":"AH Brand","year":"1993","unstructured":"Brand, A. H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401\u2013415 (1993).","journal-title":"Development"},{"key":"BFncb2447_CR41","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1242\/dev.117.4.1223","volume":"117","author":"T Xu","year":"1993","unstructured":"Xu, T. & Rubin, G. M. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117, 1223\u20131237 (1993).","journal-title":"Development"},{"key":"BFncb2447_CR42","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1101\/gad.10.21.2759","volume":"10","author":"JR Riesgo-Escovar","year":"1996","unstructured":"Riesgo-Escovar, J. R., Jenni, M., Fritz, A. & Hafen, E. The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye. Genes Dev. 10, 2759\u20132768 (1996).","journal-title":"Genes Dev."},{"key":"BFncb2447_CR43","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1101\/gad.11.13.1738","volume":"11","author":"B Glise","year":"1997","unstructured":"Glise, B. & Noselli, S. Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis. Genes Dev. 11, 1738\u20131747 (1997).","journal-title":"Genes Dev."},{"key":"BFncb2447_CR44","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/S0076-6879(04)92004-6","volume":"392","author":"S Armknecht","year":"2005","unstructured":"Armknecht, S. et al. High-throughput RNA interference screens in Drosophila tissue culture cells. Methods Enzymol. 392, 55\u201373 (2005).","journal-title":"Methods Enzymol."},{"key":"BFncb2447_CR45","doi-asserted-by":"crossref","unstructured":"Tomlinson, A. The cellular dynamics of pattern formation in the eye of Drosophila. J. Embryol. Exp. Morphol. 89 (1985).","DOI":"10.1242\/dev.89.1.313"}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb2447.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb2447","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb2447.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:37:06Z","timestamp":1684424226000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb2447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,4]]},"references-count":45,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["BFncb2447"],"URL":"https:\/\/doi.org\/10.1038\/ncb2447","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.714997801.790402802","asserted-by":"object"}]},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,4]]}}}