{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:16:52Z","timestamp":1791605812575,"version":"4.3.4"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T00:00:00Z","timestamp":1428278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1038\/ncb3149","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T09:28:17Z","timestamp":1428398897000},"page":"627-638","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":651,"title":["ERBB2 triggers mammalian heart regeneration by\u00a0promoting cardiomyocyte dedifferentiation and\u00a0proliferation"],"prefix":"10.1038","volume":"17","author":[{"given":"Gabriele","family":"D\u2019Uva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alla","family":"Aharonov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Lauriola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yfat","family":"Yahalom-Ronen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Weisinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elad","family":"Bassat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Rajchman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oren","family":"Yifa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Lysenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Konfino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julius","family":"Hegesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ori","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Neeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosef","family":"Yarden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Leor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Sarig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eldad","family":"Tzahor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"BFncb3149_CR1","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1164680","volume":"324","author":"O Bergmann","year":"2009","unstructured":"Bergmann, O. et al. Evidence for cardiomyocyte renewal in humans. Science 324, 98\u2013102 (2009).","journal-title":"Science"},{"key":"BFncb3149_CR2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature11682","volume":"493","author":"SE Senyo","year":"2013","unstructured":"Senyo, S. E. et al. Mammalian heart renewal by pre-existing cardiomyocytes. Nature 493, 433\u2013436 (2013).","journal-title":"Nature"},{"key":"BFncb3149_CR3","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nbt1117","volume":"23","author":"MA Laflamme","year":"2005","unstructured":"Laflamme, M. A. & Murry, C. E. Regenerating the heart. Nat. Biotechnol. 23, 845\u2013856 (2005).","journal-title":"Nat. Biotechnol."},{"key":"BFncb3149_CR4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.semcdb.2006.11.009","volume":"18","author":"KD Poss","year":"2007","unstructured":"Poss, K. D. Getting to the heart of regeneration in zebrafish. Semin. Cell Dev. Biol. 18, 36\u201345 (2007).","journal-title":"Semin. Cell Dev. Biol."},{"key":"BFncb3149_CR5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1083\/jcb.200810094","volume":"184","author":"S Ausoni","year":"2009","unstructured":"Ausoni, S. & Sartore, S. From fish to amphibians to mammals: in search of novel strategies to optimize cardiac regeneration. J.\u00a0Cell Biol. 184, 357\u2013364 (2009).","journal-title":"J.\u00a0Cell Biol."},{"key":"BFncb3149_CR6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1101\/gad.2018411","volume":"25","author":"M Mercola","year":"2011","unstructured":"Mercola, M., Ruiz-Lozano, P. & Schneider, M. D. Cardiac muscle regeneration: lessons from development. Genes Dev. 25, 299\u2013309 (2011).","journal-title":"Genes Dev."},{"key":"BFncb3149_CR7","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.stem.2013.05.008","volume":"12","author":"JC Garbern","year":"2013","unstructured":"Garbern, J. C. & Lee, R. T. Cardiac stem cell therapy and the promise of heart regeneration. Cell Stem Cell 12, 689\u2013698 (2013).","journal-title":"Cell Stem Cell"},{"key":"BFncb3149_CR8","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1006\/jmcc.1996.0163","volume":"28","author":"F Li","year":"1996","unstructured":"Li, F., Wang, X., Capasso, J. M. & Gerdes, A. M. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J.\u00a0Mol. Cell. Cardiol. 28, 1737\u20131746 (1996).","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"BFncb3149_CR9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1161\/01.RES.83.1.15","volume":"83","author":"MH Soonpaa","year":"1998","unstructured":"Soonpaa, M. H. & Field, L. J. Survey of studies examining mammalian cardiomyocyte DNA synthesis. Circ. Res. 83, 15\u201326 (1998).","journal-title":"Circ. Res."},{"key":"BFncb3149_CR10","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cell.2014.03.035","volume":"157","author":"N Naqvi","year":"2014","unstructured":"Naqvi, N. et al. A proliferative burst during preadolescence establishes the final cardiomyocyte number. Cell 157, 795\u2013807 (2014).","journal-title":"Cell"},{"key":"BFncb3149_CR11","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/nature08899","volume":"464","author":"C Jopling","year":"2010","unstructured":"Jopling, C. et al. Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation. Nature 464, 606\u2013609 (2010).","journal-title":"Nature"},{"key":"BFncb3149_CR12","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","volume":"331","author":"ER Porrello","year":"2011","unstructured":"Porrello, E. R. et al. Transient regenerative potential of the neonatal mouse heart. Science 331, 1078\u20131080 (2011).","journal-title":"Science"},{"key":"BFncb3149_CR13","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/nm.3764","volume":"20","author":"JH van Berlo","year":"2014","unstructured":"van Berlo, J. H. & Molkentin, J. D. An emerging consensus on cardiac regeneration. Nat. Med. 20, 1386\u20131393 (2014).","journal-title":"Nat. Med."},{"key":"BFncb3149_CR14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrm3619","volume":"14","author":"M Xin","year":"2013","unstructured":"Xin, M., Olson, E. N. & Bassel-Duby, R. Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair. Nat. Rev. Mol. Cell Biol. 14, 529\u2013541 (2013).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFncb3149_CR15","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/378390a0","volume":"378","author":"M Gassmann","year":"1995","unstructured":"Gassmann, M. et al. Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. Nature 378, 390\u2013394 (1995).","journal-title":"Nature"},{"key":"BFncb3149_CR16","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/378394a0","volume":"378","author":"KF Lee","year":"1995","unstructured":"Lee, K. F. et al. Requirement for neuregulin receptor erbB2 in neural and cardiac development. Nature 378, 394\u2013398 (1995).","journal-title":"Nature"},{"key":"BFncb3149_CR17","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/378386a0","volume":"378","author":"D Meyer","year":"1995","unstructured":"Meyer, D. & Birchmeier, C. Multiple essential functions of neuregulin in development. Nature 378, 386\u2013390 (1995).","journal-title":"Nature"},{"key":"BFncb3149_CR18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1161\/CIRCRESAHA.110.218693","volume":"107","author":"D Lai","year":"2010","unstructured":"Lai, D. et al. Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium. Circ. Res. 107, 715\u2013727 (2010).","journal-title":"Circ. Res."},{"key":"BFncb3149_CR19","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1242\/dev.053736","volume":"137","author":"J Liu","year":"2010","unstructured":"Liu, J. et al. A dual role for ErbB2 signaling in cardiac trabeculation. Development 137, 3867\u20133875 (2010).","journal-title":"Development"},{"key":"BFncb3149_CR20","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1242\/dev.098632","volume":"141","author":"DW Staudt","year":"2014","unstructured":"Staudt, D. W. et al. High-resolution imaging of cardiomyocyte behavior reveals two distinct steps in ventricular trabeculation. Development 141, 585\u2013593 (2014).","journal-title":"Development"},{"key":"BFncb3149_CR21","doi-asserted-by":"crossref","first-page":"10261","DOI":"10.1074\/jbc.273.17.10261","volume":"273","author":"YY Zhao","year":"1998","unstructured":"Zhao, Y. Y. et al. Neuregulins promote survival and growth of cardiac myocytes. Persistence of ErbB2 and ErbB4 expression in neonatal and adult ventricular myocytes. J.\u00a0Biol. Chem. 273, 10261\u201310269 (1998).","journal-title":"J.\u00a0Biol. Chem."},{"key":"BFncb3149_CR22","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1161\/CIRCRESAHA.112.267286","volume":"111","author":"O Odiete","year":"2012","unstructured":"Odiete, O., Hill, M. F. & Sawyer, D. B. Neuregulin in cardiovascular development and disease. Circ. Res. 111, 1376\u20131385 (2012).","journal-title":"Circ. Res."},{"key":"BFncb3149_CR23","doi-asserted-by":"crossref","first-page":"H2139","DOI":"10.1152\/ajpheart.00063.2012","volume":"302","author":"B Wadugu","year":"2012","unstructured":"Wadugu, B. & Kuhn, B. The role of neuregulin\/ErbB2\/ErbB4 signaling in the heart with special focus on effects on cardiomyocyte proliferation. Am. J. Physiol. Heart Circ. Physiol. 302, H2139\u2013H2147 (2012).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"BFncb3149_CR24","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.yjmcc.2003.09.012","volume":"35","author":"R Fukazawa","year":"2003","unstructured":"Fukazawa, R. et al. Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase\/Akt. J.\u00a0Mol. Cell. Cardiol. 35, 1473\u20131479 (2003).","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"BFncb3149_CR25","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.jacc.2006.05.057","volume":"48","author":"X Liu","year":"2006","unstructured":"Liu, X. et al. Neuregulin-1\/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy. J.\u00a0Am. Coll. Cardiol. 48, 1438\u20131447 (2006).","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"BFncb3149_CR26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2009.04.060","volume":"138","author":"K Bersell","year":"2009","unstructured":"Bersell, K., Arab, S., Haring, B. & Kuhn, B. Neuregulin1\/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell 138, 257\u2013270 (2009).","journal-title":"Cell"},{"key":"BFncb3149_CR27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1054-3589(10)59002-1","volume":"59","author":"Y Xu","year":"2010","unstructured":"Xu, Y., Li, X., Liu, X. & Zhou, M. Neuregulin-1\/ErbB signaling and chronic heart failure. Adv. Pharmacol. 59, 31\u201351 (2010).","journal-title":"Adv. Pharmacol."},{"key":"BFncb3149_CR28","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.yexcr.2008.08.015","volume":"315","author":"L Pentassuglia","year":"2009","unstructured":"Pentassuglia, L. & Sawyer, D. B. The role of Neuregulin-1\u03b2\/ErbB signaling in the heart. Exp. Cell Res. 315, 627\u2013637 (2009).","journal-title":"Exp. Cell Res."},{"key":"BFncb3149_CR29","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.jacc.2009.12.044","volume":"55","author":"R Gao","year":"2010","unstructured":"Gao, R. et al. A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure. J.\u00a0Am. Coll. Cardiol. 55, 1907\u20131914 (2010).","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"BFncb3149_CR30","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/eurjhf\/hfq152","volume":"13","author":"A Jabbour","year":"2011","unstructured":"Jabbour, A. et al. Parenteral administration of recombinant human neuregulin-1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses. Eur. J. Heart Fail. 13, 83\u201392 (2011).","journal-title":"Eur. J. Heart Fail."},{"key":"BFncb3149_CR31","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.yjmcc.2011.06.016","volume":"51","author":"DB Sawyer","year":"2011","unstructured":"Sawyer, D. B. & Caggiano, A. Neuregulin-1beta for the treatment of systolic heart failure. J.\u00a0Mol. Cell. Cardiol. 51, 501\u2013505 (2011).","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"BFncb3149_CR32","doi-asserted-by":"crossref","first-page":"e115871","DOI":"10.1371\/journal.pone.0115871","volume":"9","author":"S Reuter","year":"2014","unstructured":"Reuter, S., Soonpaa, M. H., Firulli, A. B., Chang, A. N. & Field, L. J. Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice. PLoS ONE 9, e115871 (2014).","journal-title":"PLoS ONE"},{"key":"BFncb3149_CR33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/35052073","volume":"2","author":"Y Yarden","year":"2001","unstructured":"Yarden, Y. & Sliwkowski, M. X. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. 2, 127\u2013137 (2001).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFncb3149_CR34","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrm1962","volume":"7","author":"A Citri","year":"2006","unstructured":"Citri, A. & Yarden, Y. EGF-ERBB signalling: towards the systems level. Nat. Rev. Mol. Cell Biol. 7, 505\u2013516 (2006).","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"BFncb3149_CR35","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1038\/onc.2011.547","volume":"31","author":"CR Pradeep","year":"2012","unstructured":"Pradeep, C. R. et al. Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions. Oncogene 31, 3569\u20133583 (2012).","journal-title":"Oncogene"},{"key":"BFncb3149_CR36","doi-asserted-by":"crossref","first-page":"5276","DOI":"10.1128\/MCB.16.10.5276","volume":"16","author":"E Tzahar","year":"1996","unstructured":"Tzahar, E. et al. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor\/neuregulin and epidermal growth factor. Mol. Cell Biol. 16, 5276\u20135287 (1996).","journal-title":"Mol. Cell Biol."},{"key":"BFncb3149_CR37","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/emboj\/16.7.1647","volume":"16","author":"D Graus-Porta","year":"1997","unstructured":"Graus-Porta, D., Beerli, R. R., Daly, J. M. & Hynes, N. E. ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling. EMBO\u00a0J. 16, 1647\u20131655 (1997).","journal-title":"EMBO\u00a0J."},{"key":"BFncb3149_CR38","doi-asserted-by":"crossref","first-page":"5042","DOI":"10.1128\/MCB.18.9.5042","volume":"18","author":"MA Olayioye","year":"1998","unstructured":"Olayioye, M. A. et al. ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner. Mol. Cell Biol. 18, 5042\u20135051 (1998).","journal-title":"Mol. Cell Biol."},{"key":"BFncb3149_CR39","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1097-2765(03)00048-0","volume":"11","author":"TP Garrett","year":"2003","unstructured":"Garrett, T. P. et al. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. Mol. Cell 11, 495\u2013505 (2003).","journal-title":"Mol. Cell"},{"key":"BFncb3149_CR40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI119509","volume":"100","author":"R Agah","year":"1997","unstructured":"Agah, R. et al. Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo. J.\u00a0Clin. Invest. 100, 169\u2013179 (1997).","journal-title":"J.\u00a0Clin. Invest."},{"key":"BFncb3149_CR41","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1073\/pnas.122249299","volume":"99","author":"C Ozcelik","year":"2002","unstructured":"Ozcelik, C. et al. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc. Natl Acad. Sci. USA 99, 8880\u20138885 (2002).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb3149_CR42","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1101\/gad.12.12.1825","volume":"12","author":"S Britsch","year":"1998","unstructured":"Britsch, S. et al. The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system. Genes Dev. 12, 1825\u20131836 (1998).","journal-title":"Genes Dev."},{"key":"BFncb3149_CR43","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0092-8674(86)90779-8","volume":"45","author":"CI Bargmann","year":"1986","unstructured":"Bargmann, C. I., Hung, M. C. & Weinberg, R. A. Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185. Cell 45, 649\u2013657 (1986).","journal-title":"Cell"},{"key":"BFncb3149_CR44","doi-asserted-by":"crossref","first-page":"28468","DOI":"10.1074\/jbc.M202510200","volume":"277","author":"E Penuel","year":"2002","unstructured":"Penuel, E., Akita, R. W. & Sliwkowski, M. X. Identification of a region within the ErbB2\/HER2 intracellular domain that is necessary for ligand-independent association. J.\u00a0Biol. Chem. 277, 28468\u201328473 (2002).","journal-title":"J.\u00a0Biol. Chem."},{"key":"BFncb3149_CR45","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1101\/gad.1580407","volume":"21","author":"HT Ghashghaei","year":"2007","unstructured":"Ghashghaei, H. T. et al. Reinduction of ErbB2 in astrocytes promotes radial glial progenitor identity in adult cerebral cortex. Genes Dev. 21, 3258\u20133271 (2007).","journal-title":"Genes Dev."},{"key":"BFncb3149_CR46","doi-asserted-by":"crossref","first-page":"e42805","DOI":"10.1371\/journal.pone.0042805","volume":"7","author":"P Sysa-Shah","year":"2012","unstructured":"Sysa-Shah, P. et al. Cardiac-specific over-expression of epidermal growth factor receptor 2 (ErbB2) induces pro-survival pathways and hypertrophic cardiomyopathy in mice. PLoS ONE 7, e42805 (2012).","journal-title":"PLoS ONE"},{"key":"BFncb3149_CR47","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/nmeth.1403","volume":"7","author":"F Hattori","year":"2010","unstructured":"Hattori, F. et al. Nongenetic method for purifying stem cell-derived cardiomyocytes. Nat. Methods 7, 61\u201366 (2010).","journal-title":"Nat. Methods"},{"key":"BFncb3149_CR48","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.stem.2011.08.013","volume":"9","author":"T Kubin","year":"2011","unstructured":"Kubin, T. et al. Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling. Cell Stem Cell 9, 420\u2013432 (2011).","journal-title":"Cell Stem Cell"},{"key":"BFncb3149_CR49","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.chembiol.2006.08.004","volume":"13","author":"AS Tseng","year":"2006","unstructured":"Tseng, A. S., Engel, F. B. & Keating, M. T. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chem. Biol. 13, 957\u2013963 (2006).","journal-title":"Chem. Biol."},{"key":"BFncb3149_CR50","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1161\/CIRCGENETICS.113.000330","volume":"6","author":"H Uosaki","year":"2013","unstructured":"Uosaki, H. et al. Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells. Circ. Cardiovasc. Genet. 6, 624\u2013633 (2013).","journal-title":"Circ. Cardiovasc. Genet."},{"key":"BFncb3149_CR51","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1158\/0008-5472.CAN-12-3925","volume":"73","author":"B Schade","year":"2013","unstructured":"Schade, B. et al. beta-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression. Cancer Res. 73, 4474\u20134487 (2013).","journal-title":"Cancer Res."},{"key":"BFncb3149_CR52","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1038\/nature03319","volume":"434","author":"T Reya","year":"2005","unstructured":"Reya, T. & Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 843\u2013850 (2005).","journal-title":"Nature"},{"key":"BFncb3149_CR53","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1158\/0008-5472.CAN-07-6094","volume":"68","author":"A Plotnikov","year":"2008","unstructured":"Plotnikov, A. et al. Oncogene-mediated inhibition of glycogen synthase kinase 3 beta impairs degradation of prolactin receptor. Cancer Res. 68, 1354\u20131361 (2008).","journal-title":"Cancer Res."},{"key":"BFncb3149_CR54","doi-asserted-by":"crossref","first-page":"18517","DOI":"10.1073\/pnas.1000975107","volume":"107","author":"K Zaoui","year":"2010","unstructured":"Zaoui, K., Benseddik, K., Daou, P., Salaun, D. & Badache, A. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc. Natl Acad. Sci. USA 107, 18517\u201318522 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb3149_CR55","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1101\/gad.1306705","volume":"19","author":"FB Engel","year":"2005","unstructured":"Engel, F. B. et al. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev. 19, 1175\u20131187 (2005).","journal-title":"Genes Dev."},{"key":"BFncb3149_CR56","doi-asserted-by":"crossref","first-page":"15546","DOI":"10.1073\/pnas.0607382103","volume":"103","author":"FB Engel","year":"2006","unstructured":"Engel, F. B., Hsieh, P. C., Lee, R. T. & Keating, M. T. FGF1\/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc. Natl Acad. Sci. USA 103, 15546\u201315551 (2006).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb3149_CR57","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/nm1619","volume":"13","author":"B Kuhn","year":"2007","unstructured":"Kuhn, B. et al. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nat. Med. 13, 962\u2013969 (2007).","journal-title":"Nat. Med."},{"key":"BFncb3149_CR58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1146\/annurev.physiol.010908.163111","volume":"72","author":"RS Whelan","year":"2010","unstructured":"Whelan, R. S., Kaplinskiy, V. & Kitsis, R. N. Cell death in the pathogenesis of heart disease: mechanisms and significance. Annu. Rev. Physiol. 72, 19\u201344 (2010).","journal-title":"Annu. Rev. Physiol."},{"key":"BFncb3149_CR59","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/jcp.55.11.801","volume":"55","author":"PA Krijnen","year":"2002","unstructured":"Krijnen, P. A. et al. Apoptosis in myocardial ischaemia and infarction. J.\u00a0Clin. Pathol. 55, 801\u2013811 (2002).","journal-title":"J.\u00a0Clin. Pathol."},{"key":"BFncb3149_CR60","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nature12054","volume":"497","author":"AI Mahmoud","year":"2013","unstructured":"Mahmoud, A. I. et al. Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature 497, 249\u2013253 (2013).","journal-title":"Nature"},{"key":"BFncb3149_CR61","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.cell.2014.03.032","volume":"157","author":"BN Puente","year":"2014","unstructured":"Puente, B. N. et al. The oxygen-rich postnatal environment induces cardiomyocyte cell-cycle arrest through DNA damage response. Cell 157, 565\u2013579 (2014).","journal-title":"Cell"},{"key":"BFncb3149_CR62","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1172\/JCI72181","volume":"124","author":"AB Aurora","year":"2014","unstructured":"Aurora, A. B. et al. Macrophages are required for neonatal heart regeneration. J.\u00a0Clin. Invest. 124, 1382\u20131392 (2014).","journal-title":"J.\u00a0Clin. Invest."},{"key":"BFncb3149_CR63","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1242\/dev.102798","volume":"140","author":"T Heallen","year":"2013","unstructured":"Heallen, T. et al. Hippo signaling impedes adult heart regeneration. Development 140, 4683\u20134690 (2013).","journal-title":"Development"},{"key":"BFncb3149_CR64","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","volume":"13","author":"L Madisen","year":"2010","unstructured":"Madisen, L. et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain. Nat. Neurosci. 13, 133\u2013140 (2010).","journal-title":"Nat. Neurosci."},{"key":"BFncb3149_CR65","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1038\/sj.onc.1202673","volume":"18","author":"W Xie","year":"1999","unstructured":"Xie, W., Chow, L. T., Paterson, A. J., Chin, E. & Kudlow, J. E. Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFalpha expression in transgenic mice. Oncogene 18, 3593\u20133607 (1999).","journal-title":"Oncogene"},{"key":"BFncb3149_CR66","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1161\/01.RES.79.4.691","volume":"79","author":"Z Yu","year":"1996","unstructured":"Yu, Z., Redfern, C. S. & Fishman, G. I. Conditional transgene expression in the heart. Circ. Res. 79, 691\u2013697 (1996).","journal-title":"Circ. Res."},{"key":"BFncb3149_CR67","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nprot.2014.021","volume":"9","author":"AI Mahmoud","year":"2014","unstructured":"Mahmoud, A. I., Porrello, E. R., Kimura, W., Olson, E. N. & Sadek, H. A. Surgical models for cardiac regeneration in neonatal mice. Nat. Protoc. 9, 305\u2013311 (2014).","journal-title":"Nat. Protoc."},{"key":"BFncb3149_CR68","doi-asserted-by":"crossref","first-page":"35858","DOI":"10.1074\/jbc.M404975200","volume":"279","author":"HW Chaudhry","year":"2004","unstructured":"Chaudhry, H. W. et al. Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. J.\u00a0Biol. Chem. 279, 35858\u201335866 (2004).","journal-title":"J.\u00a0Biol. Chem."},{"key":"BFncb3149_CR69","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1128\/MCB.10.7.3709","volume":"10","author":"T Jackson","year":"1990","unstructured":"Jackson, T. et al. The c-myc proto-oncogene regulates cardiac development in transgenic mice. Mol. Cell Biol. 10, 3709\u20133716 (1990).","journal-title":"Mol. Cell Biol."},{"key":"BFncb3149_CR70","doi-asserted-by":"crossref","first-page":"e00143","DOI":"10.1002\/phy2.143","volume":"1","author":"K Vandoorne","year":"2013","unstructured":"Vandoorne, K. et al. Multimodal imaging reveals a role for Akt1 in fetal cardiac development. Physiol. Rep. 1, e00143 (2013).","journal-title":"Physiol. Rep."}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb3149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb3149","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb3149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:45:29Z","timestamp":1684424729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb3149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,6]]},"references-count":70,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["BFncb3149"],"URL":"https:\/\/doi.org\/10.1038\/ncb3149","relation":{},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,6]]},"assertion":[{"value":"26 June 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 April 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}