{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:16:52Z","timestamp":1790659012811,"version":"4.1.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T00:00:00Z","timestamp":1486944000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1038\/ncb3474","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T13:42:21Z","timestamp":1486993341000},"page":"177-188","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":123,"title":["G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells"],"prefix":"10.1038","volume":"19","author":[{"given":"Lijun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Michowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Inuzuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kouhei","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoe Taira","family":"Nihira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Chick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice Y.","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4924-8520","authenticated-orcid":false,"given":"Alban","family":"Ordureau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Ko\u0142odziejczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith L.","family":"Ligon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick\u00a0T.","family":"Bronson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kornelia","family":"Polyak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Wade","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven P.","family":"Gygi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Sicinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,2,13]]},"reference":[{"key":"BFncb3474_CR1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/gb4184","volume":"15","author":"M Malumbres","year":"2014","unstructured":"Malumbres, M. Cyclin-dependent kinases. Genome Biol. 15, 122\u2013131 (2014).","journal-title":"Genome Biol."},{"key":"BFncb3474_CR2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cell.2004.07.025","volume":"118","author":"K Kozar","year":"2004","unstructured":"Kozar, K. et al. Mouse development and cell proliferation in the absence of D-cyclins. Cell 118, 477\u2013491 (2004).","journal-title":"Cell"},{"key":"BFncb3474_CR3","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0092-8674(03)00645-7","volume":"114","author":"Y Geng","year":"2003","unstructured":"Geng, Y. et al. Cyclin E ablation in the mouse. Cell 114, 431\u2013443 (2003).","journal-title":"Cell"},{"key":"BFncb3474_CR4","doi-asserted-by":"crossref","first-page":"4794","DOI":"10.1093\/emboj\/cdg482","volume":"22","author":"T Parisi","year":"2003","unstructured":"Parisi, T. et al. Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells. EMBO J. 22, 4794\u20134803 (2003).","journal-title":"EMBO J."},{"key":"BFncb3474_CR5","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.stem.2012.06.008","volume":"11","author":"G Martello","year":"2012","unstructured":"Martello, G. et al. Esrrb is a pivotal target of the Gsk3\/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell 11, 491\u2013504 (2012).","journal-title":"Cell Stem Cell"},{"key":"BFncb3474_CR6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1101\/gad.224503","volume":"17","author":"AA Avilion","year":"2003","unstructured":"Avilion, A. A. et al. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 17, 126\u2013140 (2003).","journal-title":"Genes Dev."},{"key":"BFncb3474_CR7","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/nature04915","volume":"442","author":"N Ivanova","year":"2006","unstructured":"Ivanova, N. et al. Dissecting self-renewal in stem cells with RNA interference. Nature 442, 533\u2013538 (2006).","journal-title":"Nature"},{"key":"BFncb3474_CR8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0092-8674(03)00393-3","volume":"113","author":"K Mitsui","year":"2003","unstructured":"Mitsui, K. et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113, 631\u2013642 (2003).","journal-title":"Cell"},{"key":"BFncb3474_CR9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0092-8674(00)81769-9","volume":"95","author":"J Nichols","year":"1998","unstructured":"Nichols, J. et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95, 379\u2013391 (1998).","journal-title":"Cell"},{"key":"BFncb3474_CR10","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1002\/stem.2345","volume":"34","author":"B Boward","year":"2016","unstructured":"Boward, B., Wu, T. & Dalton, S. Concise review: control of cell fate through cell cycle and pluripotency networks. Stem Cells 34, 1427\u20131436 (2016).","journal-title":"Stem Cells"},{"key":"BFncb3474_CR11","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.cell.2005.08.040","volume":"123","author":"H Niwa","year":"2005","unstructured":"Niwa, H. et al. Interaction between Oct3\/4 and Cdx2 determines trophectoderm differentiation. Cell 123, 917\u2013929 (2005).","journal-title":"Cell"},{"key":"BFncb3474_CR12","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ydbio.2007.10.054","volume":"313","author":"A Ralston","year":"2008","unstructured":"Ralston, A. & Rossant, J. Cdx2 acts downstream of cell polarization to cell-autonomously promote trophectoderm fate in the early mouse embryo. Dev. Biol. 313, 614\u2013629 (2008).","journal-title":"Dev. Biol."},{"key":"BFncb3474_CR13","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1242\/dev.017178","volume":"136","author":"J Rossant","year":"2009","unstructured":"Rossant, J. & Tam, P. P. Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development 136, 701\u2013713 (2009).","journal-title":"Development"},{"key":"BFncb3474_CR14","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/ncb1589","volume":"9","author":"S Masui","year":"2007","unstructured":"Masui, S. et al. Pluripotency governed by Sox2 via regulation of Oct3\/4 expression in mouse embryonic stem cells. Nat. Cell Biol. 9, 625\u2013635 (2007).","journal-title":"Nat. Cell Biol."},{"key":"BFncb3474_CR15","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/74199","volume":"24","author":"H Niwa","year":"2000","unstructured":"Niwa, H., Miyazaki, J. & Smith, A. G. Quantitative expression of Oct-3\/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 24, 372\u2013376 (2000).","journal-title":"Nat. Genet."},{"key":"BFncb3474_CR16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","volume":"21","author":"P Soriano","year":"1999","unstructured":"Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70\u201371 (1999).","journal-title":"Nat. Genet."},{"key":"BFncb3474_CR17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nature04277","volume":"439","author":"Y Chung","year":"2006","unstructured":"Chung, Y. et al. Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres. Nature 439, 216\u2013219 (2006).","journal-title":"Nature"},{"key":"BFncb3474_CR18","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/stem.168","volume":"27","author":"GA Baltus","year":"2009","unstructured":"Baltus, G. A. et al. Acetylation of sox2 induces its nuclear export in embryonic stem cells. Stem Cells 27, 2175\u20132184 (2009).","journal-title":"Stem Cells"},{"key":"BFncb3474_CR19","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1089\/scd.2010.0410","volume":"20","author":"S Ramakrishna","year":"2011","unstructured":"Ramakrishna, S. et al. PEST motif sequence regulating human NANOG for proteasomal degradation. Stem Cells Dev. 20, 1511\u20131519 (2011).","journal-title":"Stem Cells Dev."},{"key":"BFncb3474_CR20","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/cr.2009.31","volume":"19","author":"H Xu","year":"2009","unstructured":"Xu, H. et al. WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells. Cell Res. 19, 561\u2013573 (2009).","journal-title":"Cell Res."},{"key":"BFncb3474_CR21","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.molcel.2011.11.005","volume":"44","author":"MR Banko","year":"2011","unstructured":"Banko, M. R. et al. Chemical genetic screen for AMPK\u03b12 substrates uncovers a network of proteins involved in mitosis. Mol. Cell 44, 878\u2013892 (2011).","journal-title":"Mol. Cell"},{"key":"BFncb3474_CR22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/9780470559277.ch090201","volume":"2","author":"NT Hertz","year":"2010","unstructured":"Hertz, N. T. et al. Chemical genetic approach for kinase-substrate mapping by covalent capture of thiophosphopeptides and analysis by mass spectrometry. Curr. Protoc. Chem. Biol. 2, 15\u201336 (2010).","journal-title":"Curr. Protoc. Chem. Biol."},{"key":"BFncb3474_CR23","doi-asserted-by":"crossref","first-page":"13312","DOI":"10.1073\/pnas.1005847107","volume":"107","author":"M Moretto-Zita","year":"2010","unstructured":"Moretto-Zita, M. et al. Phosphorylation stabilizes Nanog by promoting its interaction with Pin1. Proc. Natl Acad. Sci. USA 107, 13312\u201313317 (2010).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb3474_CR24","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1101\/gad.12.5.706","volume":"12","author":"M Shen","year":"1998","unstructured":"Shen, M., Stukenberg, P. T., Kirschner, M. W. & Lu, K. P. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev. 12, 706\u2013720 (1998).","journal-title":"Genes Dev."},{"key":"BFncb3474_CR25","doi-asserted-by":"crossref","first-page":"11593","DOI":"10.1074\/jbc.M110.187989","volume":"286","author":"M Nishi","year":"2011","unstructured":"Nishi, M. et al. A distinct role for Pin1 in the induction and maintenance of pluripotency. J. Biol. Chem. 286, 11593\u201311603 (2011).","journal-title":"J. Biol. Chem."},{"key":"BFncb3474_CR26","doi-asserted-by":"crossref","first-page":"29207","DOI":"10.1074\/jbc.272.46.29207","volume":"272","author":"EE Brooks","year":"1997","unstructured":"Brooks, E. E. et al. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation. J. Biol. Chem. 272, 29207\u201329211 (1997).","journal-title":"J. Biol. Chem."},{"key":"BFncb3474_CR27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ccr.2014.05.005","volume":"26","author":"RJ Vanner","year":"2014","unstructured":"Vanner, R. J. et al. Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma. Cancer Cell 26, 33\u201347 (2014).","journal-title":"Cancer Cell"},{"key":"BFncb3474_CR28","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/nature13305","volume":"511","author":"S Boumahdi","year":"2014","unstructured":"Boumahdi, S. et al. SOX2 controls tumour initiation and cancer stem-cell functions in squamous-cell carcinoma. Nature 511, 246\u2013250 (2014).","journal-title":"Nature"},{"key":"BFncb3474_CR29","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nrc3655","volume":"14","author":"D Sturm","year":"2014","unstructured":"Sturm, D. et al. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat. Rev. Cancer 14, 92\u2013107 (2014).","journal-title":"Nat. Rev. Cancer"},{"key":"BFncb3474_CR30","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/nature03128","volume":"432","author":"SK Singh","year":"2004","unstructured":"Singh, S. K. et al. Identification of human brain tumour initiating cells. Nature 432, 396\u2013401 (2004).","journal-title":"Nature"},{"key":"BFncb3474_CR31","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1038\/onc.2014.334","volume":"34","author":"H Lopez-Bertoni","year":"2015","unstructured":"Lopez-Bertoni, H. et al. DNMT-dependent suppression of microRNA regulates the induction of GBM tumor-propagating phenotype by Oct4 and Sox2. Oncogene 34, 3994\u20134004 (2015).","journal-title":"Oncogene"},{"key":"BFncb3474_CR32","doi-asserted-by":"crossref","first-page":"e18454","DOI":"10.1371\/journal.pone.0018454","volume":"6","author":"J Holmberg","year":"2011","unstructured":"Holmberg, J. et al. Activation of neural and pluripotent stem cell signatures correlates with increased malignancy in human glioma. PLoS ONE 6, e18454 (2011).","journal-title":"PLoS ONE"},{"key":"BFncb3474_CR33","first-page":"312","volume":"4","author":"AM de la Rocha","year":"2014","unstructured":"de la Rocha, A. M., Sampron, N., Alonso, M. M. & Matheu, A. Role of SOX family of transcription factors in central nervous system tumors. Am. J. Cancer Res. 4, 312\u2013324 (2014).","journal-title":"Am. J. Cancer Res."},{"key":"BFncb3474_CR34","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.cellsig.2013.02.013","volume":"25","author":"K Liu","year":"2013","unstructured":"Liu, K. et al. The multiple roles for Sox2 in stem cell maintenance and tumorigenesis. Cell. Signal. 25, 1264\u20131271 (2013).","journal-title":"Cell. Signal."},{"key":"BFncb3474_CR35","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1634\/stemcells.2008-0493","volume":"27","author":"RM Gangemi","year":"2009","unstructured":"Gangemi, R. M. et al. SOX2 silencing in glioblastoma tumor-initiating cells causes stop of proliferation and loss of tumorigenicity. Stem Cells 27, 40\u201348 (2009).","journal-title":"Stem Cells"},{"key":"BFncb3474_CR36","doi-asserted-by":"crossref","first-page":"e26740","DOI":"10.1371\/journal.pone.0026740","volume":"6","author":"MM Alonso","year":"2011","unstructured":"Alonso, M. M. et al. Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas. PLoS ONE 6, e26740 (2011).","journal-title":"PLoS ONE"},{"key":"BFncb3474_CR37","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1093\/neuonc\/nor113","volume":"13","author":"D Hagerstrand","year":"2011","unstructured":"Hagerstrand, D. et al. Identification of a SOX2-dependent subset of tumor- and sphere-forming glioblastoma cells with a distinct tyrosine kinase inhibitor sensitivity profile. Neuro-oncol. 13, 1178\u20131191 (2011).","journal-title":"Neuro-oncol."},{"key":"BFncb3474_CR38","doi-asserted-by":"crossref","first-page":"e106694","DOI":"10.1371\/journal.pone.0106694","volume":"9","author":"K Holmberg Olausson","year":"2014","unstructured":"Holmberg Olausson, K. et al. Prominin-1 (CD133) defines both stem and non-stem cell populations in CNS development and gliomas. PLoS ONE 9, e106694 (2014).","journal-title":"PLoS ONE"},{"key":"BFncb3474_CR39","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/ng.127","volume":"40","author":"I Ben-Porath","year":"2008","unstructured":"Ben-Porath, I. et al. An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat. Genet. 40, 499\u2013507 (2008).","journal-title":"Nat. Genet."},{"key":"BFncb3474_CR40","doi-asserted-by":"crossref","first-page":"8320","DOI":"10.1038\/sj.onc.1206015","volume":"28","author":"E Stead","year":"2002","unstructured":"Stead, E. et al. Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A\/E and E2F activities. Oncogene 28, 8320\u20138333 (2002).","journal-title":"Oncogene"},{"key":"BFncb3474_CR41","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1091\/mbc.e04-12-1056","volume":"16","author":"J White","year":"2005","unstructured":"White, J., Stead, E., Faast, R., Conn, S. C. P. & Dalton, S. Developmental activation of the Rb-E2F pathway and establishment of cell cycle-regulated cyclin-dependent kinase activity during embryonic stem cell differentiation. Mol. Biol. Cell 16, 2018\u20132027 (2005).","journal-title":"Mol. Biol. Cell"},{"key":"BFncb3474_CR42","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.scr.2007.09.002","volume":"1","author":"AA Filipczyk","year":"2007","unstructured":"Filipczyk, A. A., Laslett, A. L., Mummery, C. & Pera, M. F. Differentiation is coupled to changes in the cell cycle regulatory apparatus of human embryonic stem cells. Stem Cell Res. 1, 45\u201360 (2007).","journal-title":"Stem Cell Res."},{"key":"BFncb3474_CR43","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/onc.2008.358","volume":"28","author":"I Neganova","year":"2009","unstructured":"Neganova, I., Zhang, X., Atkinson, S. & Lako, M. Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells. Oncogene 28, 20\u201330 (2009).","journal-title":"Oncogene"},{"key":"BFncb3474_CR44","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cub.2010.11.049","volume":"21","author":"S Raiz","year":"2011","unstructured":"Raiz, S. et al. A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr. Biol. 21, 45\u201352 (2011).","journal-title":"Curr. Biol."},{"key":"BFncb3474_CR45","doi-asserted-by":"crossref","first-page":"22782","DOI":"10.1074\/jbc.M115.658195","volume":"290","author":"J Ouyang","year":"2015","unstructured":"Ouyang, J. et al. Cyclin-dependent kinase-mediated Sox2 phosphorylation enhances the ability of Sox2 to establish the pluripotent state. J. Biol. Chem. 290, 22782\u201322794 (2015).","journal-title":"J. Biol. Chem."},{"key":"BFncb3474_CR46","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cell.2013.08.031","volume":"155","author":"S Pauklin","year":"2013","unstructured":"Pauklin, S. & Vallier, L. The cell-cycle state of stem cells determines cell fate propensity. Cell 155, 135\u2013147 (2013).","journal-title":"Cell"},{"key":"BFncb3474_CR47","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1242\/dev.105.4.733","volume":"105","author":"RS Beddington","year":"1989","unstructured":"Beddington, R. S. & Robertson, E. J. An assessment of the developmental potential of embryonic stem cells in the midgestation mouse embryo. Development 105, 733\u2013737 (1989).","journal-title":"Development"},{"key":"BFncb3474_CR48","first-page":"875","volume":"145","author":"M Thomson","year":"2011","unstructured":"Thomson, M. et al. Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell Cycle 145, 875\u2013889 (2011).","journal-title":"Cell Cycle"},{"key":"BFncb3474_CR49","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.cell.2014.02.030","volume":"157","author":"ML Suva","year":"2014","unstructured":"Suva, M. L. et al. Reconstructing and reprogramming the tumor-propagating potential of glioblastoma stem-like cells. Cell 157, 580\u2013594 (2014).","journal-title":"Cell"},{"key":"BFncb3474_CR50","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1172\/JCI44745","volume":"121","author":"LL Marotta","year":"2011","unstructured":"Marotta, L. L. et al. The JAK2\/STAT3 signaling pathway is required for growth of CD44(+)CD24(-) stem cell-like breast cancer cells in human tumors. J. Clin. Invest. 121, 2723\u20132735 (2011).","journal-title":"J. Clin. Invest."},{"key":"BFncb3474_CR51","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/0092-8674(95)90034-9","volume":"82","author":"P Sicinski","year":"1995","unstructured":"Sicinski, P. et al. Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82, 621\u2013630 (1995).","journal-title":"Cell"},{"key":"BFncb3474_CR52","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/384470a0","volume":"384","author":"P Sicinski","year":"1996","unstructured":"Sicinski, P. et al. Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis. Nature 384, 470\u2013474 (1996).","journal-title":"Nature"},{"key":"BFncb3474_CR53","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1535-6108(03)00301-5","volume":"4","author":"E Sicinska","year":"2003","unstructured":"Sicinska, E. et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4, 451\u2013461 (2003).","journal-title":"Cancer Cell"},{"key":"BFncb3474_CR54","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.devcel.2011.08.009","volume":"21","author":"J Odajima","year":"2011","unstructured":"Odajima, J. et al. Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev. Cell 21, 655\u2013668 (2011).","journal-title":"Dev. Cell"},{"key":"BFncb3474_CR55","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature06968","volume":"453","author":"QL Ying","year":"2008","unstructured":"Ying, Q. L. et al. The ground state of embryonic stem cell self-renewal. Nature 453, 519\u2013523 (2008).","journal-title":"Nature"},{"key":"BFncb3474_CR56","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1126\/science.1248882","volume":"344","author":"SJ Dunn","year":"2014","unstructured":"Dunn, S. J., Martello, G., Yordanov, B., Emmott, S. & Smith, A. G. Defining an essential transcription factor program for naive pluripotency. Science 344, 1156\u20131160 (2014).","journal-title":"Science"},{"key":"BFncb3474_CR57","first-page":"13985","volume":"101","author":"RH Blelloch","year":"2004","unstructured":"Blelloch, R. H. et al. Nuclear cloning of embryonal carcinoma cells. Proc. Natl Acad. Sci. USA 101, 13985\u201313990 (2004).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb3474_CR58","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.molcel.2014.09.007","volume":"56","author":"A Ordureau","year":"2014","unstructured":"Ordureau, A. et al. Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Mol. Cell 56, 360\u2013375 (2014).","journal-title":"Mol. Cell"},{"key":"BFncb3474_CR59","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1038\/ncb3046","volume":"16","author":"N Li","year":"2014","unstructured":"Li, N. et al. Cyclin C is a haploinsufficient tumour suppressor. Nat. Cell Biol. 16, 1080\u20131091 (2014).","journal-title":"Nat. Cell Biol."},{"key":"BFncb3474_CR60","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/nature18270","volume":"534","author":"JM Chick","year":"2016","unstructured":"Chick, J. M. et al. Defining the consequences of genetic variation on a proteome-wide scale. Nature 534, 500\u2013505 (2016).","journal-title":"Nature"},{"key":"BFncb3474_CR61","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.cell.2010.12.001","volume":"143","author":"EL Huttlin","year":"2010","unstructured":"Huttlin, E. L. et al. A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174\u20131189 (2010).","journal-title":"Cell"},{"key":"BFncb3474_CR62","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/1044-0305(94)80016-2","volume":"5","author":"JK Eng","year":"1994","unstructured":"Eng, J. K., McCormack, A. L. & Yates, J. R. An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database. J. Am. Soc. Mass Spectrom. 5, 976\u2013989 (1994).","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"BFncb3474_CR63","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nmeth1019","volume":"4","author":"JE Elias","year":"2007","unstructured":"Elias, J. E. & Gygi, S. P. Target\u2013decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nat. Methods 4, 207\u2013214 (2007).","journal-title":"Nat. Methods"},{"key":"BFncb3474_CR64","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/gcc.10300","volume":"39","author":"A Pandita","year":"2004","unstructured":"Pandita, A., Aldape, K. D., Zadeh, G., Guha, A. & James, C. D. Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR. Genes Chromosomes Cancer 39, 29\u201336 (2004).","journal-title":"Genes Chromosomes Cancer"}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb3474.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb3474","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb3474.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T15:48:34Z","timestamp":1684424914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb3474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,13]]},"references-count":64,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["BFncb3474"],"URL":"https:\/\/doi.org\/10.1038\/ncb3474","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.727301539.793532417","asserted-by":"object"}]},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,13]]},"assertion":[{"value":"1 May 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Dr. Sicinski is a consultant and a recipient of a research grant from Novartis.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}