{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:54:31Z","timestamp":1793066071117,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T00:00:00Z","timestamp":1500854400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nat Cell Biol"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1038\/ncb3582","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T11:05:21Z","timestamp":1500894321000},"page":"962-973","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":206,"title":["ARID1A-mutated ovarian cancers depend on HDAC6\u00a0activity"],"prefix":"10.1038","volume":"19","author":[{"given":"Benjamin G.","family":"Bitler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pyoung Hwa","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2039-5367","authenticated-orcid":false,"given":"Yang","family":"Hai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine M.","family":"Aird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2970-9510","authenticated-orcid":false,"given":"Yemin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew V.","family":"Kossenkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Vara-Ailor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J.","family":"Rauscher III","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Speicher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0G.","family":"Huntsman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R.","family":"Conejo-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen R.","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Christianson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7255-2360","authenticated-orcid":false,"given":"Rugang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"BFncb3582_CR1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nrc3068","volume":"11","author":"BG Wilson","year":"2011","unstructured":"Wilson, B. G. & Roberts, C. W. SWI\/SNF nucleosome remodellers and cancer. Nat.\u00a0Rev. Cancer 11, 481\u2013492 (2011).","journal-title":"Nat.\u00a0Rev. Cancer"},{"key":"BFncb3582_CR2","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/ng.2628","volume":"45","author":"C Kadoch","year":"2013","unstructured":"Kadoch, C. et al. Proteomic and bioinformatic analysis of mammalian SWI\/SNF complexes identifies extensive roles in human malignancy. Nat. Genet. 45, 592\u2013601 (2013).","journal-title":"Nat. Genet."},{"key":"BFncb3582_CR3","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nature12912","volume":"505","author":"MS Lawrence","year":"2014","unstructured":"Lawrence, M. S. et al. Discovery and saturation analysis of cancer genes across 21 tumour types. Nature 505, 495\u2013501 (2014).","journal-title":"Nature"},{"key":"BFncb3582_CR4","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1126\/science.1196333","volume":"330","author":"S Jones","year":"2010","unstructured":"Jones, S. et al. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science 330, 228\u2013231 (2010).","journal-title":"Science"},{"key":"BFncb3582_CR5","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1056\/NEJMoa1008433","volume":"363","author":"KC Wiegand","year":"2010","unstructured":"Wiegand, K. C. et al. ARID1A mutations in endometriosis-associated ovarian carcinomas. N. Engl. J. Med. 363, 1532\u20131543 (2010).","journal-title":"N. Engl. J. Med."},{"key":"BFncb3582_CR6","doi-asserted-by":"publisher","first-page":"6118","DOI":"10.1038\/ncomms7118","volume":"6","author":"RL Chandler","year":"2015","unstructured":"Chandler, R. L. et al. Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling. Nat.\u00a0Commun. 6, 6118 (2015).","journal-title":"Nat.\u00a0Commun."},{"key":"BFncb3582_CR7","doi-asserted-by":"publisher","first-page":"dju146","DOI":"10.1093\/jnci\/dju146","volume":"106","author":"B Guan","year":"2014","unstructured":"Guan, B. et al. Roles of deletion of Arid1a, a tumor suppressor, in mouse ovarian tumorigenesis. J. Natl Cancer Inst. 106, dju146 (2014).","journal-title":"J. Natl Cancer Inst."},{"key":"BFncb3582_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/path.4599","volume":"238","author":"Y Zhai","year":"2016","unstructured":"Zhai, Y. et al. Arid1a inactivation in an Apc- and Pten-defective mouse ovarian cancer model enhances epithelial differentiation and prolongs survival. J. Pathol. 238, 21\u201330 (2016).","journal-title":"J. Pathol."},{"key":"BFncb3582_CR9","doi-asserted-by":"publisher","first-page":"6718","DOI":"10.1158\/0008-5472.CAN-11-1562","volume":"71","author":"B Guan","year":"2011","unstructured":"Guan, B., Wang, T. L. & Shih Ie, M. ARID1A, a factor that promotes formation of SWI\/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers. Cancer Res. 71, 6718\u20136727 (2011).","journal-title":"Cancer Res."},{"key":"BFncb3582_CR10","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1593\/neo.121218","volume":"14","author":"B Guan","year":"2012","unstructured":"Guan, B., Gao, M., Wu, C. H., Wang, T. L. & Shih Ie, M. Functional analysis of in-frame indel ARID1A mutations reveals new regulatory mechanisms of its tumor suppressor functions. Neoplasia 14, 986\u2013993 (2012).","journal-title":"Neoplasia"},{"key":"BFncb3582_CR11","doi-asserted-by":"publisher","first-page":"e3003","DOI":"10.1097\/MD.0000000000003003","volume":"95","author":"S Ye","year":"2016","unstructured":"Ye, S. et al. Clinicopathologic significance of HNF-1\u03b2, AIRD1A, and PIK3CA expression in ovarian clear cell carcinoma: a tissue microarray study of 130 cases. Medicine (Baltimore) 95, e3003 (2016).","journal-title":"Medicine (Baltimore)"},{"key":"BFncb3582_CR12","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/PGP.0b013e3181c042b6","volume":"29","author":"M Kobel","year":"2010","unstructured":"Kobel, M. et al. Differences in tumor type in low-stage versus high-stage ovarian carcinomas. Int. J. Gynecol. Pathol. 29, 203\u2013211 (2010).","journal-title":"Int. J. Gynecol. Pathol."},{"key":"BFncb3582_CR13","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.ygyno.2008.02.006","volume":"109","author":"JK Chan","year":"2008","unstructured":"Chan, J. K. et al. Do clear cell ovarian carcinomas have poorer prognosis compared to other epithelial cell types? A study of 1411 clear cell ovarian cancers. Gynecol. Oncol. 109, 370\u2013376 (2008).","journal-title":"Gynecol. Oncol."},{"key":"BFncb3582_CR14","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1111\/IGC.0b013e3181dd0110","volume":"20","author":"HJ Mackay","year":"2010","unstructured":"Mackay, H. J. et al. Prognostic relevance of uncommon ovarian histology in women with stage III\/IV epithelial ovarian cancer. Int. J. Gynecol. Cancer 20, 945\u2013952 (2010).","journal-title":"Int. J. Gynecol. Cancer"},{"key":"BFncb3582_CR15","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1111\/jog.13043","volume":"42","author":"T Saito","year":"2016","unstructured":"Saito, T. & Katabuchi, H. Annual Report of the Committee on Gynecologic Oncology, Japan Society of Obstetrics and Gynecology: patient annual report for 2013 and treatment annual report for 2008. J. Obstet. Gynaecol. Res. 42, 1069\u20131079 (2016).","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"BFncb3582_CR16","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/febs.12079","volume":"280","author":"Y Li","year":"2013","unstructured":"Li, Y., Shin, D. & Kwon, S. H. Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes. FEBS J. 280, 775\u2013793 (2013).","journal-title":"FEBS J."},{"key":"BFncb3582_CR17","doi-asserted-by":"publisher","first-page":"7340","DOI":"10.1158\/1078-0432.CCR-08-0642","volume":"14","author":"M Bazzaro","year":"2008","unstructured":"Bazzaro, M. et al. Ubiquitin proteasome system stress underlies synergistic killing of ovarian cancer cells by bortezomib and a novel HDAC6 inhibitor. Clin. Cancer Res. 14, 7340\u20137347 (2008).","journal-title":"Clin. Cancer Res."},{"key":"BFncb3582_CR18","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.1182\/blood-2011-10-387365","volume":"119","author":"L Santo","year":"2012","unstructured":"Santo, L. et al. Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY1215, in combination with bortezomib in multiple myeloma. Blood 119, 2579\u20132589 (2012).","journal-title":"Blood"},{"key":"BFncb3582_CR19","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nm.3799","volume":"21","author":"BG Bitler","year":"2015","unstructured":"Bitler, B. G. et al. Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers. Nat. Med. 21, 231\u2013238 (2015).","journal-title":"Nat. Med."},{"key":"BFncb3582_CR20","doi-asserted-by":"publisher","first-page":"12372","DOI":"10.1073\/pnas.1109363108","volume":"108","author":"HW Cheung","year":"2011","unstructured":"Cheung, H. W. et al. Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc. Natl Acad. Sci. USA 108, 12372\u201312377 (2011).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb3582_CR21","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1016\/S0092-8674(03)00939-5","volume":"115","author":"Y Kawaguchi","year":"2003","unstructured":"Kawaguchi, Y. et al. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 115, 727\u2013738 (2003).","journal-title":"Cell"},{"key":"BFncb3582_CR22","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/sj.onc.1210204","volume":"26","author":"PA Marks","year":"2007","unstructured":"Marks, P. A. Discovery and development of SAHA as an anticancer agent. Oncogene 26, 1351\u20131356 (2007).","journal-title":"Oncogene"},{"key":"BFncb3582_CR23","doi-asserted-by":"publisher","first-page":"4389","DOI":"10.1073\/pnas.0430973100","volume":"100","author":"SJ Haggarty","year":"2003","unstructured":"Haggarty, S. J., Koeller, K. M., Wong, J. C., Grozinger, C. M. & Schreiber, S. L. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc. Natl Acad. Sci. USA 100, 4389\u20134394 (2003).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb3582_CR24","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev.biochem.69.1.217","volume":"69","author":"A Strasser","year":"2000","unstructured":"Strasser, A., O\u2019Connor, L. & Dixit, V. M. Apoptosis signaling. Annu. Rev. Biochem. 69, 217\u2013245 (2000).","journal-title":"Annu. Rev. Biochem."},{"key":"BFncb3582_CR25","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/nature11003","volume":"483","author":"J Barretina","year":"2012","unstructured":"Barretina, J. et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 483, 603\u2013607 (2012).","journal-title":"Nature"},{"key":"BFncb3582_CR26","doi-asserted-by":"publisher","first-page":"e21121","DOI":"10.1371\/journal.pone.0021121","volume":"6","author":"MP Stany","year":"2011","unstructured":"Stany, M. P. et al. Identification of novel therapeutic targets in microdissected clear cell ovarian cancers. PLoS ONE 6, e21121 (2011).","journal-title":"PLoS ONE"},{"key":"BFncb3582_CR27","doi-asserted-by":"publisher","first-page":"e1005748","DOI":"10.1371\/journal.pgen.1005748","volume":"11","author":"JR Raab","year":"2015","unstructured":"Raab, J. R., Resnick, S. & Magnuson, T. Genome-wide transcriptional regulation mediated by biochemically distinct SWI\/SNF complexes. PLoS Genet. 11, e1005748 (2015).","journal-title":"PLoS Genet."},{"key":"BFncb3582_CR28","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/nchembio.2134","volume":"12","author":"Y Hai","year":"2016","unstructured":"Hai, Y. & Christianson, D. W. Histone deacetylase 6 structure and molecular basis of catalysis and inhibition. Nat. Chem. Biol. 12, 741\u2013747 (2016).","journal-title":"Nat. Chem. Biol."},{"key":"BFncb3582_CR29","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.molcel.2006.11.026","volume":"24","author":"SM Sykes","year":"2006","unstructured":"Sykes, S. M. et al. Acetylation of the p53 DNA-binding domain regulates apoptosis induction. Mol. Cell 24, 841\u2013851 (2006).","journal-title":"Mol. Cell"},{"key":"BFncb3582_CR30","doi-asserted-by":"publisher","first-page":"20197","DOI":"10.1074\/jbc.M109.026096","volume":"284","author":"SM Sykes","year":"2009","unstructured":"Sykes, S. M., Stanek, T. J., Frank, A., Murphy, M. E. & McMahon, S. B. Acetylation of the DNA binding domain regulates transcription-independent apoptosis by p53. J.\u00a0Biol. Chem. 284, 20197\u201320205 (2009).","journal-title":"J.\u00a0Biol. Chem."},{"key":"BFncb3582_CR31","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.tibs.2009.06.010","volume":"34","author":"HS Mellert","year":"2009","unstructured":"Mellert, H. S. & McMahon, S. B. Biochemical pathways that regulate acetyltransferase and deacetylase activity in mammalian cells. Trends Biochem. Sci. 34, 571\u2013578 (2009).","journal-title":"Trends Biochem. Sci."},{"key":"BFncb3582_CR32","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.molcel.2006.11.021","volume":"24","author":"Y Tang","year":"2006","unstructured":"Tang, Y., Luo, J., Zhang, W. & Gu, W. Tip60-dependent acetylation of p53 modulates\u00a0the decision between cell-cycle arrest and apoptosis. Mol. Cell 24, 827\u2013839 (2006).","journal-title":"Mol. Cell"},{"key":"BFncb3582_CR33","doi-asserted-by":"publisher","first-page":"103","DOI":"10.2217\/epi.14.69","volume":"7","author":"C Seidel","year":"2015","unstructured":"Seidel, C., Schnekenburger, M., Dicato, M. & Diederich, M. Histone deacetylase 6 in health and disease. Epigenomics 7, 103\u2013118 (2015).","journal-title":"Epigenomics"},{"key":"BFncb3582_CR34","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1158\/1541-7786.MCR-10-0471","volume":"9","author":"X Chen","year":"2011","unstructured":"Chen, X., Wong, J. Y., Wong, P. & Radany, E. H. Low-dose valproic acid enhances radiosensitivity of prostate cancer through acetylated p53-dependent modulation of mitochondrial membrane potential and apoptosis. Mol. Cancer Res. 9, 448\u2013461 (2011).","journal-title":"Mol. Cancer Res."},{"key":"BFncb3582_CR35","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s13058-015-0658-0","volume":"17","author":"P Putcha","year":"2015","unstructured":"Putcha, P. et al. HDAC6 activity is a non-oncogene addiction hub for inflammatory breast cancers. Breast Cancer Res. 17, 149 (2015).","journal-title":"Breast Cancer Res."},{"key":"BFncb3582_CR36","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1146\/annurev.pathol.4.110807.092246","volume":"4","author":"KR Cho","year":"2009","unstructured":"Cho, K. R. & Shih Ie, M. Ovarian cancer. Annu. Rev. Pathol. 4, 287\u2013313 (2009).","journal-title":"Annu. Rev. Pathol."},{"key":"BFncb3582_CR37","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/S1046-2023(03)00032-X","volume":"30","author":"J Debnath","year":"2003","unstructured":"Debnath, J., Muthuswamy, S. K. & Brugge, J. S. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 30, 256\u2013268 (2003).","journal-title":"Methods"},{"key":"BFncb3582_CR38","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1016\/j.celrep.2013.03.004","volume":"3","author":"KM Aird","year":"2013","unstructured":"Aird, K. M. et al. Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence. Cell Rep. 3, 1252\u20131265 (2013).","journal-title":"Cell Rep."},{"key":"BFncb3582_CR39","doi-asserted-by":"publisher","first-page":"6184","DOI":"10.1158\/0008-5472.CAN-11-1341","volume":"71","author":"BG Bitler","year":"2011","unstructured":"Bitler, B. G. et al. Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res. 71, 6184\u20136194 (2011).","journal-title":"Cancer Res."},{"key":"BFncb3582_CR40","first-page":"4244s","volume":"46","author":"KS McCarty Jr","year":"1986","unstructured":"McCarty, K. S. Jr et al. Use of a monoclonal anti-estrogen receptor antibody in the immunohistochemical evaluation of human tumors. Cancer Res. 46, 4244s\u20134248s (1986).","journal-title":"Cancer Res."},{"key":"BFncb3582_CR41","doi-asserted-by":"publisher","first-page":"6656","DOI":"10.1073\/pnas.0801802105","volume":"105","author":"X Gao","year":"2008","unstructured":"Gao, X. et al. ES cell pluripotency and germ-layer formation require the SWI\/SNF chromatin remodeling component BAF250a. Proc. Natl Acad. Sci. USA 105, 6656\u20136661 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFncb3582_CR42","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1084\/jem.20111413","volume":"209","author":"UK Scarlett","year":"2012","unstructured":"Scarlett, U. K. et al. Ovarian cancer progression is controlled by phenotypic changes in dendritic cells. J. Exp. Med. 209, 495\u2013506 (2012).","journal-title":"J. Exp. Med."}],"container-title":["Nature Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/ncb3582.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/ncb3582","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/ncb3582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/ncb3582.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T15:10:30Z","timestamp":1719328230000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/ncb3582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,24]]},"references-count":42,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["BFncb3582"],"URL":"https:\/\/doi.org\/10.1038\/ncb3582","relation":{},"ISSN":["1465-7392","1476-4679"],"issn-type":[{"value":"1465-7392","type":"print"},{"value":"1476-4679","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,24]]},"assertion":[{"value":"23 March 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}