{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:45:16Z","timestamp":1790437516785,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T00:00:00Z","timestamp":1503273600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nature Chem"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1038\/nchem.2847","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T15:01:38Z","timestamp":1503327698000},"page":"45-50","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Dynamic covalent chemistry enables formation of antimicrobial peptide quaternary assemblies in a completely abiotic manner"],"prefix":"10.1038","volume":"10","author":[{"given":"James F.","family":"Reuther","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine L.","family":"Dees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor V.","family":"Kolesnichenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik T.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitri V.","family":"Ukraintsev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusheel","family":"Guduru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin","family":"Whiteley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric V.","family":"Anslyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,21]]},"reference":[{"key":"BFnchem2847_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev.biochem.71.090501.150041","volume":"71","author":"U Hubscher","year":"2002","unstructured":"Hubscher, U., Maga, G. & Spadari, S. Eukaryotic DNA polymerases. Annu. Rev. Biochem. 71, 133\u2013163 (2002).","journal-title":"Annu. Rev. Biochem."},{"key":"BFnchem2847_CR2","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1093\/nar\/gkg056","volume":"31","author":"GD Bader","year":"2003","unstructured":"Bader, G. D., Betel, D. & Hogue, C. W. V. BIND: the biomolecular interaction network database. Nucleic Acids Res. 31, 248\u2013250 (2003).","journal-title":"Nucleic Acids Res."},{"key":"BFnchem2847_CR3","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1126\/science.1151651","volume":"319","author":"O Hobert","year":"2008","unstructured":"Hobert, O. Gene regulation by transcription factors and microRNAs. Science 319, 1785\u20131786 (2008).","journal-title":"Science"},{"key":"BFnchem2847_CR4","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1021\/cr0503097","volume":"106","author":"MA Fischbach","year":"2006","unstructured":"Fischbach, M. A. & Walsh, C. T. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem. Rev. 106, 3468\u20133496 (2006).","journal-title":"Chem. Rev."},{"key":"BFnchem2847_CR5","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/35081178","volume":"411","author":"RA Dixon","year":"2001","unstructured":"Dixon, R. A. Natural products and plant disease resistance. Nature 411, 843\u2013847 (2001).","journal-title":"Nature"},{"key":"BFnchem2847_CR6","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1146\/annurev.biochem.71.110601.135458","volume":"71","author":"JD Esko","year":"2002","unstructured":"Esko, J. D. & Selleck, S. B. Order out of chaos: assembly of ligand binding sites in heparan sulfate. Annu. Rev. Biochem. 71, 435\u2013471 (2002).","journal-title":"Annu. Rev. Biochem."},{"key":"BFnchem2847_CR7","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1126\/science.1058714","volume":"291","author":"L Wells","year":"2001","unstructured":"Wells, L., Vosseller, K. & Hart, G. W. Glycosylation of nucleocytoplasmic proteins: signal transduction and O-GlcNAc. Science 291, 2376\u20132378 (2001).","journal-title":"Science"},{"key":"BFnchem2847_CR8","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1111\/j.1574-6976.2007.00081.x","volume":"31","author":"AM Lasica","year":"2007","unstructured":"Lasica, A. M. & Jagusztyn-Krynicka, E. K. The role of Dsb proteins of Gram-negative bacteria in the process of pathogenesis. FEMS Microbiol. Rev. 31, 626\u2013636 (2007).","journal-title":"FEMS Microbiol. Rev."},{"key":"BFnchem2847_CR9","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0945-053X(98)90009-9","volume":"16","author":"KI Kivirikko","year":"1998","unstructured":"Kivirikko, K. I. & Myllyharju, J. Prolyl 4-hydroxylases and their protein disulfide isomerase subunit. Matrix Biol. 16, 357\u2013368 (1998).","journal-title":"Matrix Biol."},{"key":"BFnchem2847_CR10","doi-asserted-by":"publisher","first-page":"4379","DOI":"10.1021\/acs.macromol.6b00439","volume":"49","author":"AS Carlini","year":"2016","unstructured":"Carlini, A. S., Adamiak, L. & Gianneschi, N. C. Biosynthetic polymers as functional materials. Macromolecules 49, 4379\u20134394 (2016).","journal-title":"Macromolecules"},{"key":"BFnchem2847_CR11","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/nchem.1577","volume":"5","author":"J Niu","year":"2013","unstructured":"Niu, J., Hili, R. & Liu, D. R. Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally unrelated to nucleic acids. Nat. Chem. 5, 282\u2013292 (2013).","journal-title":"Nat. Chem."},{"key":"BFnchem2847_CR12","doi-asserted-by":"publisher","first-page":"13924","DOI":"10.1021\/ja038058b","volume":"125","author":"DM Rosenbaum","year":"2003","unstructured":"Rosenbaum, D. M. & Liu, D. R. Efficient and sequence-specific DNA-templated polymerization of peptide nucleic acid aldehydes. J. Am. Chem. Soc. 125, 13924\u201313925 (2003).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchem2847_CR13","doi-asserted-by":"publisher","first-page":"14462","DOI":"10.1002\/anie.201506711","volume":"54","author":"W Xi","year":"2015","unstructured":"Xi, W. et al. Clickable nucleic acids: sequence-controlled periodic copolymer\/oligomer synthesis by orthogonal thiol-X reactions. Angew. Chem. Int. Ed. 54, 14462\u201314467 (2015).","journal-title":"Angew. Chem. Int. Ed."},{"key":"BFnchem2847_CR14","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1038\/nchem.2508","volume":"8","author":"M Porel","year":"2016","unstructured":"Porel, M., Thornlow, D. N., Phan, N. N. & Alabi, C. A. Sequence-defined bioactive macrocycles via an acid-catalysed cascade reaction. Nat. Chem. 8, 590\u2013596 (2016).","journal-title":"Nat. Chem."},{"key":"BFnchem2847_CR15","doi-asserted-by":"publisher","first-page":"13162","DOI":"10.1021\/ja507262t","volume":"136","author":"M Porel","year":"2014","unstructured":"Porel, M. & Alabi, C. A. Sequence-defined polymers via orthogonal allyl acrylamide building blocks. J. Am. Chem. Soc. 136, 13162\u201313165 (2014).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchem2847_CR16","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/nchem.2346","volume":"7","author":"JC Barnes","year":"2015","unstructured":"Barnes, J. C. et al. Iterative exponential growth of stereo- and sequence-controlled polymers. Nat. Chem. 7, 810\u2013815 (2015).","journal-title":"Nat. Chem."},{"key":"BFnchem2847_CR17","doi-asserted-by":"publisher","first-page":"8038","DOI":"10.1021\/jacs.5b04940","volume":"137","author":"WR Gutekunst","year":"2015","unstructured":"Gutekunst, W. R. & Hawker, C. J. A general approach to sequence-controlled polymers using macrocyclic ring opening metathesis polymerization. J. Am. Chem. Soc. 137, 8038\u20138041 (2015).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchem2847_CR18","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1126\/science.1174577","volume":"325","author":"Y Ura","year":"2009","unstructured":"Ura, Y., Beierle, J. M., Leman, L. J., Orgel, L. E. & Ghadiri, M. R. Self-assembling sequence-adaptive peptide nucleic acids. Science 325, 73\u201377 (2009).","journal-title":"Science"},{"key":"BFnchem2847_CR19","doi-asserted-by":"publisher","first-page":"16196","DOI":"10.1021\/jacs.5b11251","volume":"137","author":"T Wei","year":"2015","unstructured":"Wei, T., Jung, J. H. & Scott, T. F. Dynamic covalent assembly of peptoid-based ladder oligomers by vernier templating. J. Am. Chem. Soc. 137, 16196\u201316202 (2015).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchem2847_CR20","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1039\/C3CS60342C","volume":"43","author":"A Wilson","year":"2014","unstructured":"Wilson, A., Gasparini, G. & Matile, S. Functional systems with orthogonal dynamic covalent bonds. Chem. Soc. Rev. 43, 1948\u20131962 (2014).","journal-title":"Chem. Soc. Rev."},{"key":"BFnchem2847_CR21","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1002\/1521-3773(20020315)41:6<898::AID-ANIE898>3.0.CO;2-E","volume":"41","author":"SJ Rowan","year":"2002","unstructured":"Rowan, S. J., Cantrill, S. J., Cousins, G. R. L., Sanders, J. K. M. & Stoddart, J. F. Dynamic covalent chemistry. Angew. Chem. Int. Ed. 41, 899\u2013952 (2002).","journal-title":"Angew. Chem. Int. Ed."},{"key":"BFnchem2847_CR22","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.copbio.2010.05.010","volume":"21","author":"JW Sadownik","year":"2010","unstructured":"Sadownik, J. W. & Ulijn, R. V. Dynamic covalent chemistry in aid of peptide self-assembly. Curr. Opin. Biotechnol. 21, 401\u2013411 (2010).","journal-title":"Curr. Opin. Biotechnol."},{"key":"BFnchem2847_CR23","doi-asserted-by":"publisher","first-page":"15602","DOI":"10.1021\/ja067189k","volume":"128","author":"A Dirksen","year":"2006","unstructured":"Dirksen, A., Dirksen, S., Hackeng, T. M. & Dawson, P. E. Nucleophilic catalysis of hydrazone formation and transimination: implications for dynamic covalent chemistry. J. Am. Chem. Soc. 128, 15602\u201315603 (2006).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchem2847_CR24","doi-asserted-by":"publisher","first-page":"6333","DOI":"10.1021\/ja4129845","volume":"136","author":"Y Ruff","year":"2014","unstructured":"Ruff, Y., Garavini, V. & Giuseppone, N. Reversible native chemical ligation: a facile access to dynamic covalent peptides. J. Am. Chem. Soc. 136, 6333\u20136339 (2014).","journal-title":"J. Am. Chem. Soc."},{"key":"BFnchem2847_CR25","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nchem.2419","volume":"8","author":"JW Sadownik","year":"2016","unstructured":"Sadownik, J. W., Mattia, E., Nowak, P. & Otto, S. Diversification of self-replicating molecules. Nat. Chem. 8, 264\u2013269 (2016).","journal-title":"Nat. Chem."},{"key":"BFnchem2847_CR26","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1002\/anie.200250551","volume":"42","author":"Y Krishnan-Ghosh","year":"2003","unstructured":"Krishnan-Ghosh, Y. & Balasubramanian, S. Dynamic covalent chemistry on self-templating peptides: formation of a disulfide-linked \u03b2-hairpin mimic. Angew. Chem. Int. Ed. 42, 2171\u20132173 (2003).","journal-title":"Angew. Chem. Int. Ed."},{"key":"BFnchem2847_CR27","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1126\/science.1109999","volume":"308","author":"RTS Lam","year":"2005","unstructured":"Lam, R. T. S. et al. Amplification of acetylcholine-binding catenanes from dynamic combinatorial libraries. Science 308, 667\u2013669 (2005).","journal-title":"Science"},{"key":"BFnchem2847_CR28","doi-asserted-by":"publisher","first-page":"10915","DOI":"10.1039\/c1cc12010g","volume":"47","author":"CM Haney","year":"2011","unstructured":"Haney, C. M., Loch, M. T. & Horne, W. S. Promoting peptide \u03b1-helix formation with dynamic covalent oxime side-chain cross-links. Chem. Commun. 47, 10915\u201310917 (2011).","journal-title":"Chem. Commun."},{"key":"BFnchem2847_CR29","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/psc.2596","volume":"20","author":"CM Haney","year":"2014","unstructured":"Haney, C. M. & Horne, W. S. Dynamic covalent side-chain cross-links via intermolecular oxime or hydrazone formation from bifunctional peptides and simple organic linkers. J. Pept. Sci. 20, 108\u2013114 (2014).","journal-title":"J. Pept. Sci."},{"key":"BFnchem2847_CR30","doi-asserted-by":"publisher","first-page":"15739","DOI":"10.1002\/anie.201507186","volume":"54","author":"L Rocard","year":"2015","unstructured":"Rocard, L., Berezin, A., De Leo, F. & Bonifazi, D. Templated chromophore assembly by dynamic covalent bonds. Angew. Chem. Int. Ed. 54, 15739\u201315743 (2015).","journal-title":"Angew. Chem. Int. Ed."},{"key":"BFnchem2847_CR31","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/35086601","volume":"412","author":"S Fernandez-Lopez","year":"2001","unstructured":"Fernandez-Lopez, S. et al. Antibacterial agents based on the cyclic D,L-\u03b1-peptide architecture. Nature 412, 452\u2013456 (2001).","journal-title":"Nature"},{"key":"BFnchem2847_CR32","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1073\/pnas.0710217105","volume":"105","author":"AD Kennedy","year":"2008","unstructured":"Kennedy, A. D. et al. Epidemic community-associated methicillin-resistant Staphylococcus aureus: recent clonal expansion and diversification. Proc. Natl Acad. Sci. USA 105, 1327\u20131332 (2008).","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"BFnchem2847_CR33","doi-asserted-by":"publisher","first-page":"6634","DOI":"10.1039\/c3cs60044k","volume":"42","author":"Y Jin","year":"2013","unstructured":"Jin, Y., Yu, C., Denman, R. J. & Zhang, W. Recent advances in dynamic covalent chemistry. Chem. Soc. Rev. 42, 6634\u20136654 (2013).","journal-title":"Chem. Soc. Rev."},{"key":"BFnchem2847_CR34","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1039\/B714599C","volume":"6","author":"S Ladame","year":"2008","unstructured":"Ladame, S. Dynamic combinatorial chemistry: on the road to fulfilling the promise. Org. Biomol. Chem. 6, 219\u2013226 (2008).","journal-title":"Org. Biomol. Chem."},{"key":"BFnchem2847_CR35","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1126\/science.1060066","volume":"291","author":"J-M Lehn","year":"2001","unstructured":"Lehn, J.-M. & Eliseev, A. V. Dynamic combinatorial chemistry. Science 291, 2331\u20132332 (2001).","journal-title":"Science"},{"key":"BFnchem2847_CR36","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/nprot.2006.4","volume":"1","author":"H Schagger","year":"2006","unstructured":"Schagger, H. Tricine-SDS\u2013PAGE. Nat. Protoc. 1, 16\u201322 (2006).","journal-title":"Nat. Protoc."},{"key":"BFnchem2847_CR37","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/nchembio.1605","volume":"10","author":"C Heinis","year":"2014","unstructured":"Heinis, C. Drug discovery: tools and rules for macrocycles. Nat. Chem. Biol. 10, 696\u2013698 (2014).","journal-title":"Nat. Chem. Biol."},{"key":"BFnchem2847_CR38","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/nrd2590","volume":"7","author":"EM Driggers","year":"2008","unstructured":"Driggers, E. M., Hale, S. P., Lee, J. & Terrett, N. K. The exploration of macrocycles for drug discovery\u2014an underexploited structural class. Nat. Rev. Drug. Discov. 7, 608\u2013624 (2008).","journal-title":"Nat. Rev. Drug. Discov."}],"container-title":["Nature Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.nature.com\/articles\/nchem.2847.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/articles\/nchem.2847","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.nature.com\/doifinder\/10.1038\/nchem.2847","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/www.nature.com\/articles\/nchem.2847.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T19:20:29Z","timestamp":1684437629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/nchem.2847"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,21]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["BFnchem2847"],"URL":"https:\/\/doi.org\/10.1038\/nchem.2847","relation":{},"ISSN":["1755-4330","1755-4349"],"issn-type":[{"value":"1755-4330","type":"print"},{"value":"1755-4349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,21]]},"assertion":[{"value":"14 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing financial interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}